abevmy 400mg injection

4.5 (15 reviews)

Bevacizumab (400mg)

🏭 Mylan Pharmaceuticals Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Aug 21, 2026

📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Aug 21, 2026

What is abevmy 400mg injection used for?

Avastin (Bevacizumab) is used to treat ANTI NEOPLASTICS. It contains Bevacizumab (400mg), which Bevacizumab binds to vascular endothelial growth factor (VEGF), preventing its i. Always consult your doctor before use. Take as prescribed.

Generic Name: Bevacizumab
Manufacturer: Mylan Pharmaceuticals Pvt Ltd
Form: Allopathy
Pregnancy Category: A
Prescription Required: Yes

💡 Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

💊 abevmy 400mg injection Uses & Benefits

Metastatic colorectal cancer, non-small cell lung cancer, glioblastoma, renal cell carcinoma, ovarian cancer, cervical cancer.

Off-label uses: Age-related macular degeneration (intravitreal), diabetic retinopathy, other solid tumors.

📋 Drug Information

Generic Name(s)	Bevacizumab
Brand Name	Avastin
Manufacturer	Mylan Pharmaceuticals Pvt Ltd
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	ANTI NEOPLASTICS
Action Class	Vascular endothelial growth factor (VEGF) inhibitor
Route of Administration	Intravenous infusion.
Storage	Store at 2-8°C (36-46°F). Do not freeze. Protect from light.
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionSlow absorption after subcutaneous administration; intravenous administration results in complete bioavailability.

DistributionDistributes primarily in plasma and extracellular fluid; limited penetration into certain tissues.

Protein BindingNo significant protein binding (monoclonal antibody).

MetabolismMetabolized by proteolytic degradation into small peptides and amino acids.

Half-LifeApproximately 20 days (range 11-50 days).

ExcretionNot excreted renally; eliminated via intracellular catabolism.

Bioavailability100% (intravenous).

Onset of ActionWithin days to weeks.

Peak Plasma TimeAt end of intravenous infusion.

Duration of ActionSeveral weeks.

How It Works

Bevacizumab binds to vascular endothelial growth factor (VEGF), preventing its interaction with VEGF receptors on endothelial cells, thereby inhibiting angiogenesis.

Mechanism Steps

1Bevacizumab binds to circulating VEGF-A.

2Prevents VEGF-A from interacting with VEGFR-1 and VEGFR-2 on endothelial cells.

3Inhibits VEGF receptor dimerization and activation.

💡 How to Take abevmy 400mg injection

Follow your doctor's prescription exactly.

⚠️ Side Effects of abevmy 400mg injection

✅ Common Side Effects

Hypertension
Fatigue
Diarrhea
Nausea
Headache
Proteinuria
Epistaxis

🚨 Serious Side Effects

Gastrointestinal perforation
Hemorrhage
Arterial thromboembolism
Wound dehiscence
Congestive heart failure
Reversible posterior leukoencephalopathy syndrome

⚠️ Rare Side Effects

Osteonecrosis of the jaw
Nephrotic syndrome
Pulmonary hypertension
Ovarian failure

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug	Severity	Effect
Sunitinib	Major	Increased risk of microangiopathic hemolytic anemia
Anthracyclines	Major	Increased cardiotoxicity risk
Alkylating agents	Major	Increased risk of neutropenia and infections
Anticoagulants	Moderate	Increased bleeding risk
Antiplatelet agents	Moderate	Increased bleeding risk
NSAIDs	Moderate	Increased bleeding risk
ACE inhibitors	Minor	Increased risk of proteinuria
Diuretics	Minor	Increased risk of electrolyte imbalance

🚨 Major Interactions

Sunitinib
Anthracyclines
Alkylating agents

⚡ Moderate Interactions

Anticoagulants
Antiplatelet agents
NSAIDs

ℹ️ Minor Interactions

ACE inhibitors
Diuretics

🍽️ Food Interactions

No significant food interactions.

🍷 Alcohol Interaction

No known interaction.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to bevacizumab or any excipients; untreated CNS metastases; recent surgery or wound healing complications; severe bleeding disorders.

📊 Monitoring Parameters

Blood pressure, urine protein, signs of bleeding, wound healing, infusion reactions.

🤱 Lactation Safety

Not recommended; excreted in human milk? Unknown, but potential for harm.

💊 Overdose Management

No specific antidote; manage symptoms and monitor for adverse effects.

⏰ Missed Dose

Administer as soon as possible; do not double dose.

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 21, 2026

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🔄 Substitutes for abevmy 400mg injection

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Alternative brands with exact same active ingredient (Bevacizumab (400mg)):

Medical Note: Always consult your doctor before switching medications.

⭐ User Reviews

Trusted Reviewer Jul 10, 2026

Found this to be a helpful product. Good results.