Adalimumab 40mg Injection: Complete Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Fever, chills, or persistent cough
- Shortness of breath or difficulty breathing
- Swelling of face, lips, or throat
- Severe abdominal pain or blood in stool
- Numbness, tingling, or vision changes
- Unusual bruising or bleeding
- Yellowing of skin or eyes
- Sudden weight gain or swelling of legs
If experiencing severe symptoms, call emergency services immediately.
What is adalirel 40mg injection used for?
Adalimumab 40mg injection is a TNF inhibitor used to treat autoimmune and inflammatory conditions such as rheumatoid arthritis, Crohn's disease, and psoriasis. It is given subcutaneously, usually every other week, and works by reducing inflammation.
- Generic Name: Adalimumab
- Manufacturer: Reliance Life Sciences
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 adalirel 40mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा एडालिमुमैब 40mg इंजेक्शन के रूप में एक बायोलॉजिक दवा है जिसका उपयोग रूमेटॉइड आर्थराइटिस, सोरियाटिक आर्थराइटिस, एंकिलोज़िंग स्पॉन्डिलाइटिस, क्रोहन रोग, अल्सरेटिव कोलाइटिस, सोरायसिस, हाइड्राडेनाइटिस सप्पुराटिवा और यूवाइटिस जैसी पुरानी सूजन संबंधी बीमारियों के इलाज के लिए किया जाता है। यह शरीर में टीएनएफ-अल्फा नामक प्रोटीन को ब्लॉक करके सूजन को कम करती है। यह दवा त्वचा के नीचे इंजेक्शन द्वारा दी जाती है और आमतौर पर हर दूसरे सप्ताह लगाई जाती है। इसका उपयोग डॉक्टर की सलाह पर ही करें।
साइड इफेक्ट्स: आम दुष्प्रभावों में इंजेक्शन स्थल पर लालिमा, दर्द, सूजन या खुजली, ऊपरी श्वसन संक्रमण, सिरदर्द और दाने शामिल हैं। गंभीर दुष्प्रभावों में गंभीर संक्रमण जैसे तपेदिक, सेप्सिस, एलर्जी प्रतिक्रियाएं, तंत्रिका तंत्र विकार, हृदय विफलता, रक्त विकार और कैंसर का खतरा शामिल है। यदि आपको बुखार, खांसी, सांस लेने में कठिनाई, चेहरे या गले में सूजन, या असामान्य खून बहना दिखे तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को शुरू करने से पहले तपेदिक और हेपेटाइटिस बी की जांच करवाना आवश्यक है। इस दवा के साथ लाइव वैक्सीन न लगवाएं। संक्रमण से बचने के लिए हाथों की सफाई रखें और बीमार लोगों से दूर रहें। बुखार, खांसी या फ्लू जैसे लक्षण दिखने पर तुरंत डॉक्टर को बताएं। इस दवा को डॉक्टर की सलाह के बिना बंद न करें। गर्भवती महिलाएं या गर्भधारण की योजना बना रही महिलाएं डॉक्टर से परामर्श करें। इस दवा को फ्रिज में 2-8°C पर स्टोर करें और जमने न दें।
💊 adalirel 40mg injection Uses & Benefits
[{"condition":"Rheumatoid arthritis","description":"Reduces signs and symptoms, improves physical function, and inhibits progression of structural damage in adults with moderately to severely active rheumatoid arthritis.","evidence":"Well-established"},{"condition":"Psoriatic arthritis","description":"Reduces signs and symptoms, improves physical function, and inhibits progression of structural damage in adults with active psoriatic arthritis.","evidence":"Well-established"},{"condition":"Ankylosing spondylitis","description":"Reduces signs and symptoms in adults with active ankylosing spondylitis.","evidence":"Well-established"},{"condition":"Crohn's disease","description":"Reduces signs and symptoms and induces and maintains clinical remission in adults with moderately to severely active Crohn's disease who have had an inadequate response to conventional therapy.","evidence":"Well-established"},{"condition":"Ulcerative colitis","description":"Induces and maintains clinical remission in adults with moderately to severely active ulcerative colitis who have had an inadequate response to conventional therapy.","evidence":"Well-established"},{"condition":"Plaque psoriasis","description":"Treats adults with moderate to severe chronic plaque psoriasis who are candidates for systemic therapy or phototherapy.","evidence":"Well-established"},{"condition":"Hidradenitis suppurativa","description":"Treats adults with moderate to severe hidradenitis suppurativa.","evidence":"Well-established"},{"condition":"Uveitis","description":"Treats non-infectious intermediate, posterior, and panuveitis in adults.","evidence":"Well-established"},{"condition":"Juvenile idiopathic arthritis","description":"Reduces signs and symptoms in pediatric patients with moderately to severely active polyarticular juvenile idiopathic arthritis.","evidence":"Well-established"},{"condition":"Pediatric Crohn's disease","description":"Reduces signs and symptoms and induces and maintains clinical remission in pediatric patients with moderately to severely active Crohn's disease.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Behçet's disease","description":"Sometimes used off-label for severe Behçet's disease with ocular or gastrointestinal involvement.","evidence":"Limited"},{"condition":"Sarcoidosis","description":"May be used off-label for refractory sarcoidosis, particularly with eye or skin involvement.","evidence":"Limited"},{"condition":"Pyoderma gangrenosum","description":"Occasionally used off-label for this painful skin condition.","evidence":"Limited"}]
Primary treatment for: Rheumatoid arthritis
Also treats: Psoriatic arthritis, Ankylosing spondylitis, Crohn's disease, Ulcerative colitis, Plaque psoriasis, Hidradenitis suppurativa, Uveitis, Juvenile idiopathic arthritis
📋 Drug Information
| Generic Name(s) | Adalimumab |
| Brand Name | Adalipca 40mg Injection |
| Manufacturer | Reliance Life Sciences |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | Disease Modifying Anti-Rheumatoid Drugs (DMARDs)- Biologics |
| Route of Administration | Subcutaneous |
| Storage | Store in the refrigerator at 2°C to 8°C (36°F to 46°F). Do not freeze. Keep the pre-filled syringe or pen in the original carton to protect from light. If needed, this medicine may be stored at room temperature up to 25°C (77°F) for a maximum of 14 days. Once removed from the refrigerator, do not put it back. Do not shake. |
| Shelf Life | The shelf life is typically 24 months from the date of manufacture when stored properly. Check the expiry date on the packaging. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Adalimumab is a recombinant human immunoglobulin G1 monoclonal antibody that binds specifically to tumour necrosis factor alpha (TNF-alpha) and neutralizes its biological activity. By binding to TNF-alpha, it prevents the cytokine from interacting with its receptors, thereby reducing inflammation and the cascade of events that lead to tissue destruction in autoimmune and inflammatory diseases.
Mechanism Steps
💡 How to Take adalirel 40mg injection
Strength: 40mg/0.8mL subcutaneous injection in a pre-filled syringe or pen.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 40mg administered subcutaneously every other week. For some conditions, an initial loading dose of 80mg or 160mg may be given, followed by 40mg every other week. The exact dose and schedule depend on the condition being treated, its severity, and the patient's response. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | No specific dose adjustment is required for elderly patients based on age alone. However, elderly patients may be more susceptible to infections and should be monitored closely. Dose must be individualized by a qualified clinician. |
| Renal Impairment | No dose adjustment is required for renal impairment. However, monitor closely as adalimumab has not been studied extensively in patients with severe renal impairment. |
| Hepatic Impairment | No dose adjustment is required for hepatic impairment. However, caution is advised in patients with severe hepatic impairment, and liver function should be monitored. |
| Maximum Daily Dose | The maximum recommended dose is 40mg every other week, though in some conditions a higher induction dose may be used initially. Do not exceed the dose prescribed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of adalirel 40mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Live vaccines | Major | |
| Anakinra | Major | |
| Abatacept | Major | |
| Methotrexate | Moderate | |
| Other TNF inhibitors | Moderate | |
| Corticosteroids | Minor |
🚨 Major Interactions
- Live vaccines
- Anakinra
- Abatacept
⚡ Moderate Interactions
- Methotrexate
- Other TNF inhibitors
🍷 Alcohol Interaction
Alcohol may increase the risk of liver problems and can worsen the underlying inflammatory condition. It is advisable to limit or avoid alcohol while on this medicine, especially if you have liver disease or are taking other medications that affect the liver.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Active serious infections such as tuberculosis, sepsis, or opportunistic infections","Known hypersensitivity to adalimumab or any of its excipients","Concurrent use of live vaccines"]
⚠️ Warnings & Precautions
["Serious infections: Patients are at increased risk of serious infections. Screen for tuberculosis before starting and monitor for signs of infection during therapy.","Malignancies: There is a small increased risk of lymphoma and other cancers. Use with caution in patients with a history of cancer.","Demyelinating disorders: Rare cases of new-onset or exacerbation of demyelinating disorders have been reported. Discontinue if symptoms occur.","Heart failure: Worsening heart failure has been reported. Use with caution and monitor.","Hematologic reactions: Rare cases of pancytopenia, leukopenia, and thrombocytopenia have been reported. Monitor blood counts.","Hypersensitivity reactions: Allergic reactions, including anaphylaxis, can occur. Discontinue and seek emergency care if severe.","Immunosuppression: May increase risk of infections. Avoid live vaccines.","Latex allergy: The needle cover may contain natural rubber latex. Check with your healthcare provider if you have a latex allergy."]
🤱 Lactation Safety
Limited data suggest that adalimumab is present in human milk in very low amounts. It is unlikely to be absorbed significantly by a nursing infant because it is a large protein. However, consult your doctor before breastfeeding while on this medicine.
💊 Overdose Management
There is no specific antidote for adalimumab overdose. In case of overdose, monitor the patient for any signs of adverse effects and provide supportive care. Contact a poison control center or emergency department if a large dose is taken.
⏰ Missed Dose
If you miss a dose of this medicine, take it as soon as you remember, unless it is almost time for your next dose. Do not take two doses at the same time to make up for a missed dose. Consult your doctor or pharmacist for specific advice.
Additional Safety Advice
Before starting this medicine, you must be tested for tuberculosis and hepatitis B, as dormant infections can reactivate. Do not receive live vaccines while on this medicine. Avoid close contact with people who have serious infections, and practice good hand hygiene. Inform your doctor if you develop any signs of infection such as fever, cough, or flu-like symptoms. Do not stop this medicine abruptly without consulting your specialist, as symptoms may flare. Use effective contraception during treatment and for at least five months after the last dose if you are a woman of childbearing potential. Inform any healthcare provider, including dentists, that you are on this medicine before any procedure. Store this medicine in the refrigerator and do not freeze or shake the injection pen or syringe.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may have a higher risk of infections and should be monitored closely. No specific dose adjustment is required based on age alone, but individual assessment of renal and hepatic function is advised.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, discuss with your doctor before starting or continuing adalimumab. Use effective contraception during treatment and for at least 5 months after the last dose. Adalimumab may be continued during pregnancy if needed, but only after specialist evaluation.
🏥 Post-Surgery Considerations
Adalimumab may increase the risk of infection after surgery. Your doctor may advise temporarily stopping the medicine before elective surgery. Discuss with your surgeon and rheumatologist to plan the timing of your doses.
🦷 Dental Procedures
Inform your dentist that you are on adalimumab before any dental procedure. There may be an increased risk of infection. Your dentist may recommend antibiotics or postponing the procedure if there is an active infection.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While exercise is beneficial, avoid high-impact activities that may stress joints during flare-ups. Consult a physiotherapist for a tailored exercise plan. If you experience increased pain or swelling after exercise, rest and consult your doctor.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
Adalimumab may cause dizziness or vision changes in some patients. Avoid driving or operating heavy machinery if you experience these effects. Most patients can continue their normal work and daily activities, but fatigue and joint pain may require adjustments. Discuss with your employer if you need accommodations.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. If you experience serious side effects such as severe infection, allergic reaction, or neurological symptoms, your doctor may advise discontinuation. In some cases, treatment may be paused before surgery or during pregnancy. Always follow your specialist's guidance.
📅 Long-Term Use Effects
Long-term use of adalimumab may be associated with a small increased risk of serious infections, certain cancers (especially lymphoma), and demyelinating disorders. Regular monitoring of blood counts, liver function, and signs of infection is recommended. Patients should have periodic evaluations to assess the continued benefit and risk of therapy. Long-term use should be discussed with your specialist.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can help improve joint function and reduce pain in arthritis.
Evidence: Well-establishedAnti-inflammatory diet may help manage symptoms.
Evidence: LimitedAlternatives like etanercept or infliximab may be considered if adalimumab is not effective.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Live vaccines should not be administered during treatment with adalimumab. Inactivated vaccines are generally safe, but the immune response may be reduced. Consult your doctor before receiving any vaccine. It is recommended to complete all age-appropriate vaccinations before starting adalimumab if possible.
📦 Storage Guide
✅ DO
Store in the refrigerator at 2°C to 8°C
❌ DON'T
Do not freeze
✅ DO
Keep in original carton to protect from light
❌ DON'T
Do not shake
✅ DO
May store at room temperature up to 25°C for up to 14 days
❌ DON'T
Do not return to refrigerator after room temperature storage
✈️ Traveling with This Medicine
When traveling with this medicine, carry it in its original packaging with the prescription label. Keep it in a cool bag with ice packs to maintain refrigeration (2-8°C). If flying, carry it in your hand luggage; inform security that you are carrying medication. Bring a copy of your prescription and a doctor's letter. For time zone changes, adjust your dosing schedule in consultation with your doctor. Do not leave it in a hot car or checked luggage.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Some patients notice improvement within 1-2 weeks, but it may take up to 3-6 months for full effect.
A: No, you should not take adalimumab if you have an active infection. Inform your doctor immediately if you develop signs of infection.
A: Adalimumab should be used during pregnancy only if clearly needed. Discuss with your doctor about risks and benefits.
A: Live vaccines should be avoided. Inactivated vaccines may be given, but consult your doctor first.
🤔 Common Patient Concerns
🔄 Substitutes for adalirel 40mg injection
View AllAlternative brands with exact same active ingredient:
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cipleumab 40mg injectionCipla Ltd ₹16,875.00 18.2% CHEAPER
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adalimac 40mg injectionMacleods Pharmaceuticals Pvt Ltd ₹20,926.33 1.5% COSTLIER
-
plamumab 40mg injectionCipla Ltd ₹21,780.00 5.6% COSTLIER
-
envira 40mg injectionEmcure Pharmaceuticals Ltd ₹21,972.66 6.5% COSTLIER
-
adalipca 40mg injectionIpca Laboratories Ltd ₹23,437.50 13.6% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Adalimumab is a painkiller.
Fact: Adalimumab is not a painkiller; it is a biologic medicine that reduces inflammation by targeting the immune system. - Myth: Adalimumab can be stopped as soon as you feel better.
Fact: Adalimumab should be continued as prescribed to maintain remission. Stopping abruptly can cause a flare of the underlying condition. - Myth: Adalimumab weakens the immune system permanently.
Fact: Adalimumab suppresses part of the immune response but does not permanently weaken the immune system. Effects are reversible after stopping.
🔄 Alternative Options
Brand Alternatives
- Adlumab 40mg injection
- Adalimumab 40mg injection (various manufacturers)