Azadual 100mg Injection (Azacitidine): Comprehensive Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Fever above 38°C (100.4°F) or chills
- Easy bruising or unusual bleeding
- Severe nausea, vomiting, or diarrhea
- Shortness of breath or difficulty breathing
- Yellowing of skin or eyes
- Decreased urine output
- Rapid heartbeat or palpitations
- Swelling of face, lips, or throat
If experiencing severe symptoms, call emergency services immediately.
What is azishil 100mg injection used for?
Azadual 100mg injection contains azacitidine, a chemotherapy medicine used to treat myelodysplastic syndromes, acute myeloid leukemia, and chronic myelomonocytic leukemia. It works by modifying DNA to slow the growth of abnormal blood cells. It is given by a healthcare professional as an injection.
- Generic Name: Azacitidine (100mg)
- Manufacturer: Shilpa Medicare Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 azishil 100mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा एज़ासिटिडीन नामक सक्रिय तत्व युक्त एक कीमोथेरेपी इंजेक्शन है, जिसका उपयोग मायलोडिसप्लास्टिक सिंड्रोम, तीव्र माइलॉयड ल्यूकेमिया और क्रोनिक मायलोमोनोसाइटिक ल्यूकेमिया जैसे रक्त कैंसर के इलाज के लिए किया जाता है। यह असामान्य रक्त कोशिकाओं की वृद्धि को धीमा करने में मदद करता है। यह दवा डॉक्टर या नर्स द्वारा इंजेक्शन के रूप में दी जाती है, आमतौर पर त्वचा के नीचे या नस में। उपचार चक्रों में दिया जाता है, जिसमें 7 दिन दवा और 21 दिन आराम शामिल है।
साइड इफेक्ट्स: आम दुष्प्रभावों में मतली, उल्टी, दस्त, कब्ज, थकान, बुखार, भूख न लगना और इंजेक्शन स्थल पर दर्द या लालिमा शामिल हैं। गंभीर दुष्प्रभावों में रक्त कोशिकाओं की कमी, गंभीर संक्रमण, रक्तस्राव, और यकृत की समस्या शामिल हो सकती है। यदि आपको बुखार, ठंड लगना, गले में खराश, आसान चोट लगना, या असामान्य रक्तस्राव हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: यह दवा केवल योग्य स्वास्थ्य पेशेवर द्वारा क्लिनिक या अस्पताल में दी जानी चाहिए। स्वयं इंजेक्शन न लगाएं। उपचार के दौरान नियमित रक्त परीक्षण आवश्यक है। बुखार, संक्रमण, या असामान्य रक्तस्राव होने पर तुरंत डॉक्टर को बताएं। गर्भावस्था के दौरान इस दवा का उपयोग न करें; उपचार के दौरान और बाद में प्रभावी गर्भनिरोधक उपाय अपनाएं। अन्य दवाओं या टीकों के बारे में डॉक्टर को सूचित करें।
💊 azishil 100mg injection Uses & Benefits
[{"condition":"Myelodysplastic syndromes (MDS)","description":"Used to treat adults with myelodysplastic syndromes, including refractory anemia with excess blasts, refractory anemia with excess blasts in transformation, and chronic myelomonocytic leukemia.","evidence":"Well-established"},{"condition":"Acute myeloid leukemia (AML)","description":"Used for the treatment of adults with acute myeloid leukemia, particularly in older patients or those who are not candidates for intensive chemotherapy.","evidence":"Well-established"},{"condition":"Chronic myelomonocytic leukemia (CMML)","description":"Indicated for the treatment of chronic myelomonocytic leukemia, a type of myelodysplastic/myeloproliferative neoplasm.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Relapsed or refractory acute lymphoblastic leukemia (ALL)","description":"Sometimes used off-label in certain patients with relapsed or refractory acute lymphoblastic leukemia, often in combination with other agents.","evidence":"Limited"},{"condition":"Myelofibrosis","description":"Occasionally used off-label for the treatment of myelofibrosis, a rare bone marrow disorder.","evidence":"Limited"}]
Primary treatment for: Myelodysplastic syndromes (MDS)
Also treats: Acute myeloid leukemia (AML), Chronic myelomonocytic leukemia (CMML)
📋 Drug Information
| Generic Name(s) | Azacitidine (100mg) |
| Brand Name | azishil 100mg injection |
| Manufacturer | Shilpa Medicare Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | Antimetabolites |
| Route of Administration | Parenteral (subcutaneous or intravenous) |
| Storage | Store unopened vials at 20°C to 25°C (68°F to 77°F); excursions permitted to 15°C to 30°C (59°F to 86°F). Store in the original carton to protect from light. Once reconstituted, the solution should be used immediately; if not used immediately, store at 2°C to 8°C (36°F to 46°F) for up to 8 hours. Do not freeze. |
| Shelf Life | Refer to the expiration date on the vial. Do not use after the expiry date. |
| WHO Guideline | Azacitidine is recommended by the World Health Organization (WHO) for the treatment of myelodysplastic syndromes and acute myeloid leukemia in certain patients. However, specific recommendations should be verified with current guidelines. |
| ICMR Guideline | The Indian Council of Medical Research (ICMR) has not published specific guidelines for azacitidine. Consult local guidelines and your oncologist for recommendations. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Azacitidine is a pyrimidine nucleoside analog that exerts its antineoplastic effects through two main mechanisms: incorporation into DNA and RNA, leading to hypomethylation of DNA and direct cytotoxicity. By inhibiting DNA methyltransferase, it reduces abnormal DNA methylation, which can restore normal gene expression and promote differentiation of abnormal blood cells. It also causes direct damage to rapidly dividing cells, leading to cell death.
Mechanism Steps
💡 How to Take azishil 100mg injection
Strength: 100 mg lyophilized powder for injection, single-use vial.
Dosage Information
| Adult Dosage | The recommended adult dose of this medicine is 75 mg/m² of body surface area, given subcutaneously or intravenously once daily for 7 days, followed by a rest period of 21 days, which constitutes one cycle of 28 days. For patients with myelodysplastic syndromes, the same dose is used. Dose adjustments may be necessary based on blood counts and toxicity. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | No specific dose adjustment is required for elderly patients based on age alone. However, elderly patients may be more sensitive to the effects of this medicine, and close monitoring of blood counts and organ function is recommended. Dose must be individualized by a qualified clinician. |
| Renal Impairment | No specific dose adjustment is recommended for patients with renal impairment. However, patients with severe renal impairment should be monitored closely for toxicity. Dose must be individualized by a qualified clinician. |
| Hepatic Impairment | No specific dose adjustment is recommended for patients with hepatic impairment. However, patients with severe hepatic impairment should be monitored closely for toxicity. Dose must be individualized by a qualified clinician. |
| Maximum Daily Dose | The maximum recommended daily dose is 75 mg/m². Do not exceed the dose prescribed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of azishil 100mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Live vaccines | Major | |
| Warfarin | Moderate | |
| NSAIDs | Moderate | |
| Myelosuppressive agents | Major |
🚨 Major Interactions
- Live vaccines
- Myelosuppressive agents (e.g., chemotherapy, radiation)
⚡ Moderate Interactions
- Warfarin
- NSAIDs
🍷 Alcohol Interaction
Alcohol may worsen liver toxicity and increase the risk of bleeding or gastrointestinal side effects. It is advisable to avoid alcohol during treatment with this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to azacitidine or any component of the formulation","Pregnancy","Breastfeeding","Severe liver impairment","Severe kidney impairment"]
⚠️ Warnings & Precautions
["This medicine can cause severe bone marrow suppression; monitor blood counts regularly.","Serious infections may occur; report fever or signs of infection immediately.","Bleeding complications may occur; report unusual bleeding or bruising.","Liver and kidney function should be monitored.","Avoid live vaccines during treatment.","Use effective contraception during treatment and for a period after.","This medicine may cause fatigue; use caution when driving or operating machinery.","Tumor lysis syndrome and differentiation syndrome are rare but serious; seek immediate medical attention if symptoms occur."]
🤱 Lactation Safety
It is not known whether azacitidine is excreted in human milk. Because of the potential for serious adverse reactions in breastfed infants, breastfeeding should be discontinued during treatment and for at least 1 week after the last dose.
💊 Overdose Management
There is no specific antidote for azacitidine overdose. In case of overdose, treatment should be symptomatic and supportive. Monitor blood counts, liver and kidney function, and provide appropriate care. Contact a poison control center or emergency department immediately.
⏰ Missed Dose
If you miss an appointment for your injection, contact your healthcare provider as soon as possible to reschedule. Do not attempt to self-administer a double dose. Your treatment schedule will be adjusted by your doctor.
Additional Safety Advice
This medicine must only be given by a qualified healthcare professional in a clinic or hospital setting. Do not attempt to self-administer this injection. Regular blood tests are required to monitor your blood counts, liver function, and kidney function before and during each treatment cycle. Inform your doctor immediately if you develop a fever, chills, sore throat, easy bruising, unusual bleeding, or persistent nausea and vomiting. Avoid close contact with people who have active infections, and practice good hand hygiene. Use effective contraception during treatment and for a period after the last dose, as this medicine can harm an unborn baby. Do not receive any live vaccines without your doctor's approval. Tell your doctor about all other medicines, supplements, or herbal products you are taking, as interactions may occur.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more susceptible to the side effects of azacitidine, especially bone marrow suppression and infections. Close monitoring and dose adjustments may be necessary. Frailty and comorbidities should be considered when planning treatment.
🤰 Pregnancy Planning (TTC)
Azacitidine can cause fetal harm. Women of childbearing potential should use effective contraception during treatment and for at least 6 months after the last dose. Men with female partners should use effective contraception during treatment and for at least 3 months after. Consult your doctor if you are planning pregnancy.
🏥 Post-Surgery Considerations
Azacitidine may impair wound healing due to its effects on cell division. Inform your surgeon about your treatment. Surgery may need to be timed around treatment cycles to allow for recovery of blood counts.
🦷 Dental Procedures
Azacitidine can increase the risk of bleeding and infection. Inform your dentist about your treatment. Dental procedures may need to be coordinated with your oncologist, and antibiotic prophylaxis may be recommended.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Fatigue is common during treatment. Avoid strenuous exercise and listen to your body. Light activities like walking may be beneficial, but consult your doctor before starting any exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause fatigue, dizziness, and increased risk of infections, which can affect your ability to work or perform daily activities. Avoid driving or operating machinery if you feel tired or dizzy. Discuss work modifications with your employer and doctor.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Treatment may be stopped or adjusted based on your response, side effects, or disease progression. Your doctor will determine the appropriate duration of therapy.
📅 Long-Term Use Effects
Long-term use of azacitidine may lead to persistent bone marrow suppression, increasing the risk of infections and bleeding. Regular monitoring of blood counts, liver and kidney function is essential. Some patients may develop resistance to the medicine over time. Long-term survivors should be monitored for secondary cancers.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Blood transfusions, growth factors, and antibiotics to manage symptoms.
Evidence: Well-establishedA potential curative option for eligible patients with MDS or AML.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Live vaccines should be avoided during treatment with azacitidine due to the risk of infection. Inactivated vaccines may be given, but their effectiveness may be reduced. Consult your doctor before any vaccination.
📦 Storage Guide
✅ DO
Store unopened vials at room temperature (20-25°C)
❌ DON'T
Do not freeze
✅ DO
Keep in original carton to protect from light
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Use reconstituted solution immediately or store at 2-8°C for up to 8 hours
❌ DON'T
Do not use beyond the expiration date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with the prescription label. Keep a copy of your prescription and a letter from your doctor explaining the medical need. Store the medicine at room temperature, away from direct sunlight and moisture. If traveling across time zones, consult your doctor about adjusting the dosing schedule. Check customs regulations for carrying injectable medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: It may take several treatment cycles (typically 2 to 4) to see improvement in blood counts.
A: No, this medicine must be given by a healthcare professional in a clinic or hospital setting.
A: Contact your healthcare provider as soon as possible to reschedule. Do not self-administer a double dose.
A: No, this medicine can harm an unborn baby. Use effective contraception during treatment and for a period after.
🤔 Common Patient Concerns
🔄 Substitutes for azishil 100mg injection
View AllAlternative brands with exact same active ingredient:
-
hemazide injectionCadila Pharmaceuticals Ltd ₹2,343.75 53.3% CHEAPER
-
azactiv 100mg injectionGlenmark Pharmaceuticals Ltd ₹2,430.00 51.6% CHEAPER
-
azatend injectionZydus Cadila ₹2,625.00 47.7% CHEAPER
-
myaza injectionMylan Pharmaceuticals Pvt Ltd ₹3,000.00 40.3% CHEAPER
-
azaplast injectionRPG Life Sciences Ltd ₹3,162.19 37% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Azacitidine can be self-administered at home.
Fact: Azacitidine must be given by a healthcare professional in a clinic or hospital setting. - Myth: Azacitidine is a cure for all blood cancers.
Fact: Azacitidine is used for specific types of blood disorders and may not be effective for everyone. - Myth: Azacitidine has no serious side effects.
Fact: Azacitidine can cause serious side effects, including severe bone marrow suppression and infections.
🔄 Alternative Options
Generic Alternatives
- Azacitidine 100mg injection
Brand Alternatives
- Azadual 100mg injection