Asginase 10000IU Injection: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing, wheezing, or swelling of the face, lips, or throat
- Severe abdominal pain radiating to the back, with nausea and vomiting
- Unusual bleeding or bruising, blood in stool or urine
- Chest pain, shortness of breath, or swelling in one leg
- Yellowing of the skin or eyes, dark urine, or severe fatigue
- High fever with chills, suggesting infection
- Confusion, seizures, or severe headache
If experiencing severe symptoms, call emergency services immediately.
What is asparshil 10000iu injection used for?
This medicine is an intravenous enzyme used to treat acute lymphoblastic leukemia by depleting asparagine, which leukemia cells need to survive. It is given in a hospital setting under close supervision.
- Generic Name: Asparaginase
- Manufacturer: Shilpa Medicare Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 asparshil 10000iu injection के बारे में (Hindi Summary)
उपयोग: यह दवा एस्पेरागिनेज (10000 IU) इंजेक्शन है, जिसका उपयोग मुख्य रूप से तीव्र लिम्फोब्लास्टिक ल्यूकेमिया (ALL) और कुछ अन्य रक्त कैंसर के इलाज में किया जाता है। यह एक एंजाइम है जो कैंसर कोशिकाओं को मारने में मदद करता है। यह दवा केवल अस्पताल में डॉक्टर की देखरेख में दी जाती है।
साइड इफेक्ट्स: आम दुष्प्रभावों में मतली, उल्टी, थकान, भूख में कमी, और इंजेक्शन स्थल पर दर्द या सूजन शामिल हैं। गंभीर दुष्प्रभावों में एलर्जी, अग्न्याशय की सूजन (पैन्क्रियाटाइटिस), रक्त के थक्के बनना, और लीवर की समस्या शामिल हो सकती है। किसी भी असामान्य लक्षण पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: यह दवा केवल योग्य कैंसर विशेषज्ञ की देखरेख में अस्पताल में दी जानी चाहिए। इसे घर पर स्वयं न लगाएं। एलर्जी के लक्षण जैसे सांस लेने में कठिनाई, चेहरे या गले में सूजन होने पर तुरंत डॉक्टर को बताएं। पेट में तेज दर्द होने पर तुरंत चिकित्सा सहायता लें। नियमित रूप से रक्त परीक्षण करवाएं।
💊 asparshil 10000iu injection Uses & Benefits
[{"condition":"Acute lymphoblastic leukemia (ALL)","description":"This medicine is a key component of multi-agent chemotherapy regimens for both pediatric and adult ALL, particularly in induction and consolidation phases.","evidence":"Well-established"},{"condition":"Lymphoblastic lymphoma","description":"Sometimes used in the treatment of lymphoblastic lymphoma, a rare type of non-Hodgkin lymphoma.","evidence":"Limited"},{"condition":"Acute myeloid leukemia (AML)","description":"Rarely used in specific subtypes of AML, but not as a standard first-line agent.","evidence":"Limited"}]
Off-label uses: [{"condition":"Extranodal NK/T-cell lymphoma","description":"Asparaginase-containing regimens have been used off-label in some cases of NK/T-cell lymphoma, especially in Asia.","evidence":"Limited"},{"condition":"Other hematological malignancies","description":"Occasionally used in other rare leukemias or lymphomas where asparagine dependence is suspected.","evidence":"Limited"}]
Primary treatment for: Acute lymphoblastic leukemia (ALL)
Also treats: Lymphoblastic lymphoma, Acute myeloid leukemia (rare)
📋 Drug Information
| Generic Name(s) | Asparaginase |
| Brand Name | Asginase |
| Manufacturer | Shilpa Medicare Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | Anticancer-others |
| Route of Administration | Intravenous (IV) |
| Storage | Store refrigerated at 2°C to 8°C (36°F to 46°F). Do not freeze. Protect from light. Keep in the original carton until use. |
| Shelf Life | Refer to the product label for the specific shelf life. Typically 24 months from the date of manufacture when stored properly. |
| WHO Guideline | Not established from the available information. Asparaginase is included in many national and international treatment protocols for ALL, but specific WHO guidelines are not available. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by catalyzing the hydrolysis of the amino acid L-asparagine into L-aspartic acid and ammonia. Leukemic cells, especially in acute lymphoblastic leukemia, have low levels of asparagine synthetase and rely on circulating asparagine for protein synthesis and survival. By rapidly depleting serum asparagine, this medicine selectively inhibits protein synthesis in these malignant cells, leading to cell death. Normal cells can synthesize asparagine and are less affected.
Mechanism Steps
💡 How to Take asparshil 10000iu injection
Strength: Injection: 10,000 IU per vial
Dosage Information
| Adult Dosage | The dose of this medicine is highly individualized and depends on the specific treatment protocol, indication, and patient factors. It is typically given as part of a combination chemotherapy regimen. Common doses range from 6,000 to 10,000 IU/m² intravenously every 2-3 days. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and response to therapy. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatric oncologist for appropriate dosing. |
| Elderly Dosage | Elderly patients may be more susceptible to toxicities. Dose should be individualized based on renal and hepatic function and overall health status. |
| Renal Impairment | Dose adjustment may be necessary in patients with renal impairment. Consult a clinician for specific recommendations. |
| Hepatic Impairment | Use with caution in patients with hepatic impairment. Dose reduction may be required. Monitor liver function closely. |
| Maximum Daily Dose | Not established from the available information. Dosing is protocol-specific. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of asparshil 10000iu injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Live vaccines | Major | |
| Corticosteroids | Moderate | |
| Methotrexate | Moderate | |
| Cisplatin | Moderate | |
| Azathioprine | Moderate | |
| Aminoglycosides | Moderate | |
| Oral hypoglycemics | Minor |
🚨 Major Interactions
- Live vaccines
- Warfarin and other anticoagulants
- Asparaginase (other formulations)
⚡ Moderate Interactions
- Corticosteroids
- Hepatotoxic drugs (e.g., methotrexate, azathioprine)
- Nephrotoxic drugs (e.g., cisplatin, aminoglycosides)
🍷 Alcohol Interaction
Alcohol may increase the risk of liver toxicity and pancreatitis. It is advisable to avoid alcohol during treatment with this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["History of severe allergic reaction to asparaginase or any component of the formulation","History of pancreatitis","Severe hepatic impairment","Active bleeding or severe coagulopathy","Pregnancy (unless benefit outweighs risk)","Breastfeeding"]
⚠️ Warnings & Precautions
["Hypersensitivity reactions: Anaphylaxis can occur. Premedication with antihistamines and corticosteroids may be given. Emergency equipment should be available.","Pancreatitis: Can be severe. Monitor amylase and lipase. Discontinue if pancreatitis occurs.","Coagulopathy: May cause bleeding or thrombosis. Monitor coagulation parameters.","Hepatotoxicity: Monitor liver function. Discontinue if severe.","Hyperglycemia: Monitor blood glucose, especially in diabetic patients.","Immunosuppression: May increase risk of infections. Avoid live vaccines.","Neurological effects: Rarely, seizures or confusion may occur.","Renal impairment: Use with caution; dose adjustment may be needed."]
🤱 Lactation Safety
It is not known whether this medicine is excreted in human milk. Because of the potential for serious adverse reactions in nursing infants, breastfeeding should be discontinued during treatment.
💊 Overdose Management
There is no specific antidote for overdose with this medicine. Management should be symptomatic and supportive. Monitor for signs of toxicity such as severe pancreatitis, bleeding, or allergic reactions. Close medical supervision is required.
⏰ Missed Dose
This medicine is administered by a healthcare professional in a clinical setting. If a dose is missed, contact your healthcare provider immediately to reschedule. Do not attempt to self-administer.
Additional Safety Advice
This medicine must be given only under the supervision of a qualified oncologist in a hospital setting. Do not attempt to administer it at home. Inform your doctor immediately if you experience any signs of allergic reaction, such as difficulty breathing, swelling of the face or throat, or a sudden rash. Report any severe abdominal pain, which could indicate pancreatitis. Regular blood tests are necessary to monitor liver function, blood clotting, and blood sugar levels. Avoid contact with people who have infections, as this medicine can weaken your immune system. Do not receive any live vaccines while on this medicine. Use effective contraception during treatment and for a period after, as this medicine can harm a developing fetus.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more susceptible to toxicities such as pancreatitis, liver toxicity, and coagulopathy. Doses should be individualized based on renal and hepatic function, and close monitoring is required.
🤰 Pregnancy Planning (TTC)
This medicine can harm a developing fetus. Women of childbearing potential should use effective contraception during treatment and for a period after. Men should also use contraception. Discuss pregnancy planning with your doctor before starting treatment.
🏥 Post-Surgery Considerations
This medicine may increase the risk of bleeding and impair wound healing. Inform your surgeon if you are receiving this medicine. It is generally recommended to avoid surgery during treatment unless absolutely necessary.
🦷 Dental Procedures
This medicine can increase the risk of bleeding and infection. Inform your dentist that you are receiving this medicine. Dental procedures may need to be postponed until your blood counts recover.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Exercise may need to be modified during treatment due to fatigue, low blood counts, or risk of bleeding. Avoid contact sports or activities with a high risk of injury. Consult your doctor before starting any exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause significant fatigue, nausea, and other side effects that can impact your ability to work. You may need to take time off during treatment. Discuss your work schedule with your employer and doctor to make necessary accommodations. Avoid operating heavy machinery or driving if you feel dizzy or fatigued.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your oncologist. Treatment is typically continued for a specific number of cycles. If you experience severe side effects such as pancreatitis, severe allergic reactions, or bleeding, your doctor may decide to stop or change the treatment. Always follow your doctor's guidance.
📅 Long-Term Use Effects
Long-term effects of this medicine may include persistent liver or pancreatic dysfunction, increased risk of bleeding or clotting disorders, and potential secondary cancers. Regular follow-up with your oncologist is essential to monitor for late effects. Some patients may experience chronic fatigue or neuropathy. Fertility may be affected; discuss fertility preservation options before treatment if applicable.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
A longer-acting form of asparaginase that may be used as an alternative, especially if allergic reactions occur.
Evidence: Well-establishedA different source of asparaginase used for patients who develop allergies to E. coli-derived asparaginase.
Evidence: Well-establishedManagement of side effects and complications to improve tolerance and quality of life.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Live vaccines should be avoided during treatment with this medicine due to immunosuppression. Inactivated vaccines may be given, but their effectiveness may be reduced. Consult your doctor before receiving any vaccines.
📦 Storage Guide
✅ DO
Store refrigerated at 2°C to 8°C (36°F to 46°F)
❌ DON'T
Do not freeze
✅ DO
Keep in the original carton to protect from light
❌ DON'T
Do not remove from carton until ready to use
✅ DO
Keep out of reach of children
❌ DON'T
Do not use if the solution is cloudy or contains particles
✈️ Traveling with This Medicine
This medicine is administered in a hospital setting and is not for self-administration during travel. If you are traveling while on treatment, ensure you carry a copy of your prescription and medical records. The medicine should be stored refrigerated at 2°C to 8°C; if traveling, use a cooler with ice packs and avoid freezing. Inform airport security about your medical condition and carry a doctor's letter. Plan your travel around your treatment schedule to avoid missing doses.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine begins depleting asparagine within hours, but its full effect on leukemia cells may take days to weeks. Your doctor will monitor your response through blood tests and bone marrow examinations.
A: This medicine may cause fatigue or dizziness. It is best to avoid driving or operating heavy machinery until you know how it affects you. Arrange for someone else to drive you to and from appointments.
A: This medicine is given by a healthcare professional. If you miss an appointment, contact your doctor immediately to reschedule. Do not attempt to self-administer.
A: This medicine may harm the developing fetus. It should be used during pregnancy only if the potential benefit justifies the risk. Discuss with your doctor if you are pregnant or planning to become pregnant.
A: It is not known if this medicine passes into breast milk. Because of the potential for serious side effects in nursing infants, breastfeeding should be discontinued during treatment.
🤔 Common Patient Concerns
🔄 Substitutes for asparshil 10000iu injection
View AllAlternative brands with exact same active ingredient:
-
l-aspase 10000iu injectionMiracalus Pharma Pvt Ltd ₹1,500.00 5.2% CHEAPER
-
oncoginase 10000iu injectionChandra Bhagat Pharma Pvt Ltd ₹1,529.00 3.4% CHEAPER
-
asginase 10000iu injectionSun Pharmaceutical Industries Ltd ₹1,563.96 1.1% CHEAPER
-
onconase 10000iu injectionUnited Biotech Pvt Ltd ₹1,595.00 0.8% COSTLIER
-
bionase 10000iu injectionBiochem Pharmaceutical Industries ₹1,680.66 6.2% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be self-administered at home.
Fact: This medicine must be given by a healthcare professional in a hospital or clinic setting due to the risk of serious allergic reactions. - Myth: This medicine is a cure for all types of cancer.
Fact: This medicine is specifically used for acute lymphoblastic leukemia and certain other blood cancers, not all cancers. - Myth: This medicine has no serious side effects.
Fact: This medicine can cause serious side effects such as anaphylaxis, pancreatitis, and bleeding disorders, requiring close monitoring.
🔄 Alternative Options
Generic Alternatives
- Asparaginase (various manufacturers)
Brand Alternatives
- Asparaginase 10000 IU injection (various brands)