azalpho injection - Azacitidine (100mg) medicine

Azalpho Injection (Azacitidine 100mg) - Uses, Price, Side Effects

4.6 (9 reviews)

Azacitidine (100mg)

🏭 Arechar Healthcare 📦 Varies by brand 💊 Allopathy 📅 Updated: Aug 21, 2026

📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Aug 21, 2026

What is azalpho injection used for?

Azalpho Injection contains Azacitidine 100mg, a hypomethylating agent used to treat myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). It works by incorporating into DNA and RNA, inhibiting DNA methyltransferase, which reactivates silenced tumor suppressor genes and induces differentiation or apoptosis of cancer cells.

Generic Name: Azacitidine
Manufacturer: Arechar Healthcare
Form: Allopathy
Pregnancy Category: D
Prescription Required: Yes

💡 Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

💊 azalpho injection Uses & Benefits

Myelodysplastic syndromes (MDS), acute myeloid leukemia (AML), chronic myelomonocytic leukemia (CMML).

Off-label uses: Chronic myeloid leukemia (CML), solid tumors (investigational).

📋 Drug Information

Generic Name(s)	Azacitidine
Brand Name	Azadine Injection
Manufacturer	Arechar Healthcare
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	ANTI NEOPLASTICS
Action Class	Antimetabolites
Route of Administration	Subcutaneous injection or intravenous infusion.
Storage	Store at 25°C (77°F); excursions permitted to 15-30°C (59-86°F). Protect from light.
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionRapidly absorbed after subcutaneous administration; peak plasma concentration achieved within 30 minutes.

DistributionWidely distributed into body tissues, including bone marrow; crosses the blood-brain barrier.

Protein BindingApproximately 10-15% bound to plasma proteins.

MetabolismPrimarily metabolized by cytidine deaminase to inactive metabolites; also undergoes spontaneous hydrolysis.

Half-LifeApproximately 4 hours (subcutaneous); 1-2 hours (intravenous).

ExcretionPrimarily excreted in urine (85% as metabolites, <10% unchanged).

BioavailabilityApproximately 89% after subcutaneous administration.

Onset of ActionWithin 1-2 weeks of therapy.

Peak Plasma Time30 minutes (subcutaneous); end of infusion (intravenous).

Duration of ActionVariable; effects on hematopoiesis persist for weeks.

How It Works

Incorporates into DNA and RNA, inhibiting DNA methyltransferase, leading to hypomethylation and re-expression of silenced tumor suppressor genes.

Mechanism Steps

1Azacitidine is taken up by cells and phosphorylated to azacitidine triphosphate.

2Incorporates into RNA, disrupting RNA metabolism and protein synthesis.

3Incorporates into DNA, inhibiting DNA methyltransferase (DNMT1).

💡 How to Take azalpho injection

Follow your doctor's prescription exactly.

Dosage Timeline

🌅 Morning ✅ ☀️ Afternoon ❌ 🌆 Evening ✅ 🌙 Night ❌

⚠️ Side Effects of azalpho injection

✅ Common Side Effects

Nausea
Vomiting
Diarrhea
Constipation
Fatigue
Fever
Anemia
Thrombocytopenia
Neutropenia
Injection site reactions

🚨 Serious Side Effects

Severe myelosuppression
Hepatic failure
Renal toxicity
Tumor lysis syndrome
Cardiac arrhythmias

⚠️ Rare Side Effects

Interstitial lung disease
Sweet's syndrome
Differentiation syndrome
Hemorrhagic cystitis

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug	Severity	Effect
Warfarin	Major	Increased bleeding risk
Allopurinol	Moderate	Increased risk of azacitidine toxicity

🚨 Major Interactions

Cytarabine
Ribavirin
Gemcitabine

⚡ Moderate Interactions

Valproic acid
Hydralazine
Procainamide

ℹ️ Minor Interactions

Acetaminophen
Cimetidine
Ranitidine

🍽️ Food Interactions

No significant food interactions reported.

🍷 Alcohol Interaction

Avoid alcohol; may increase hepatotoxicity risk.

🛡️ Safety & Warnings

Liver

Moderate

Kidney

Moderate

Heart

Low

Pregnancy

Category D

🚫 Contraindications

Hypersensitivity to azacitidine or mannitol; advanced malignant hepatic tumors; pregnancy.

📊 Monitoring Parameters

Complete blood count (CBC) with differential, liver function tests, renal function tests, serum electrolytes.

🤱 Lactation Safety

Contraindicated; discontinue breastfeeding during therapy.

💊 Overdose Management

No specific antidote; supportive care with monitoring of hematologic parameters and organ function.

⏰ Missed Dose

If a dose is missed, administer as soon as possible; do not double the next dose.

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 21, 2026

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🔄 Substitutes for azalpho injection

View All

Alternative brands with exact same active ingredient (Azacitidine (100mg)):

Medical Note: Always consult your doctor before switching medications.

⭐ User Reviews

Verified User Jul 10, 2026

This medicine was effective for me. I followed the doctor's advice.

Happy Patient Jul 10, 2026

Good quality medicine. Satisfied with the outcome.

Regular Customer Jul 10, 2026

Effective and reliable. Worked as expected.

Trusted Reviewer Jul 10, 2026