bortecine injection

4.7 (15 reviews)

Bortezomib (2mg)

🏭 Arechar Healthcare 📦 Varies by brand 💊 Allopathy 📅 Updated: Aug 21, 2026

📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Aug 21, 2026

What is bortecine injection used for?

Borziv (Bortezomib) is used to treat ANTI NEOPLASTICS. It contains Bortezomib (2mg), which Reversible inhibition of the 26S proteasome, disrupting protein degradation and . Always consult your doctor before use. Take as prescribed.

Generic Name: Bortezomib
Manufacturer: Arechar Healthcare
Form: Allopathy
Pregnancy Category: A
Prescription Required: Yes

💡 Did You Know? The Indian pharmaceutical market is expected to reach $130 billion by 2030.

💊 bortecine injection Uses & Benefits

Multiple myeloma (first-line and relapsed), mantle cell lymphoma.

Off-label uses: Waldenström macroglobulinemia, amyloidosis, T-cell lymphoma.

📋 Drug Information

Generic Name(s)	Bortezomib
Brand Name	Borziv
Manufacturer	Arechar Healthcare
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	ANTI NEOPLASTICS
Action Class	Proteasome inhibitor
Route of Administration	Intravenous or subcutaneous injection.
Storage	Store at 2-8°C (refrigerated); protect from light.
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionRapidly absorbed after subcutaneous administration; peak plasma concentration reached within 30-60 minutes.

DistributionWidely distributed to tissues; volume of distribution approximately 498-1884 L/m².

Protein BindingApproximately 83% bound to plasma proteins.

MetabolismPrimarily metabolized by hepatic cytochrome P450 enzymes, mainly CYP3A4 and CYP2C19.

Half-LifeElimination half-life ranges from 40 to 193 hours after multiple doses.

ExcretionExcreted primarily via bile into feces; less than 10% excreted renally.

BioavailabilitySubcutaneous administration yields approximately 100% bioavailability relative to intravenous.

Onset of ActionOnset of action is within days to weeks; proteasome inhibition occurs rapidly.

Peak Plasma TimePeak plasma concentration occurs 30-60 minutes after subcutaneous injection.

Duration of ActionDuration of proteasome inhibition persists for 48-72 hours after dosing.

How It Works

Reversible inhibition of the 26S proteasome, disrupting protein degradation and leading to cell cycle arrest and apoptosis in cancer cells.

Mechanism Steps

1Bortezomib enters cancer cells and binds reversibly to the 20S proteasome subunit.

2Inhibition of chymotrypsin-like activity of the proteasome.

3Accumulation of ubiquitinated proteins and regulatory proteins (e.g., p53, IκB).

💡 How to Take bortecine injection

Follow your doctor's prescription exactly.

⚠️ Side Effects of bortecine injection

✅ Common Side Effects

Nausea
Diarrhea
Fatigue
Thrombocytopenia
Peripheral neuropathy

🚨 Serious Side Effects

Cardiotoxicity
Hepatotoxicity
Tumor lysis syndrome
Posterior reversible encephalopathy syndrome (PRES)

⚠️ Rare Side Effects

Interstitial lung disease
Progressive multifocal leukoencephalopathy (PML)
Severe hypotension

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug	Severity	Effect
Ketoconazole	Major	Increased bortezomib exposure
Rifampin	Major	Decreased bortezomib efficacy
Warfarin	Major	Increased INR and bleeding risk

🚨 Major Interactions

CYP3A4 inhibitors (e.g., ketoconazole)
CYP3A4 inducers (e.g., rifampin)
Warfarin

⚡ Moderate Interactions

Antihypertensives
Oral hypoglycemics
Cisplatin

ℹ️ Minor Interactions

Grapefruit juice
St. John's Wort

🍽️ Food Interactions

No significant food interactions; avoid grapefruit juice.

🍷 Alcohol Interaction

Alcohol may increase risk of hepatotoxicity; avoid excessive consumption.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to bortezomib, boron, or mannitol; severe hepatic impairment.

📊 Monitoring Parameters

Complete blood count, liver function tests, renal function, peripheral neuropathy assessment.

🤱 Lactation Safety

Not recommended; discontinue breastfeeding during treatment.

💊 Overdose Management

No specific antidote; supportive care and monitoring of vital signs.

⏰ Missed Dose

If a dose is missed, do not double the dose; resume next scheduled dose.

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 21, 2026

🔗 View Profile

🔄 Substitutes for bortecine injection

View All

Alternative brands with exact same active ingredient (Bortezomib (2mg)):

Medical Note: Always consult your doctor before switching medications.

⭐ User Reviews

Trusted Reviewer Jul 10, 2026

Effective and reliable. Worked as expected.

Happy Patient Jul 10, 2026

Found this to be a helpful product. Good results.