Paclitaxel Injection: Comprehensive Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing, wheezing, or swelling of the face, lips, or throat during or after infusion.
- Fever of 100.4°F (38°C) or higher, chills, or other signs of infection.
- Unusual bleeding or bruising, such as blood in urine or stool, or vomiting blood.
- Severe chest pain, palpitations, or fainting.
- Severe numbness, tingling, or weakness in hands or feet.
- Yellowing of the skin or eyes, dark urine, or severe abdominal pain.
- Severe skin rash, blistering, or peeling.
If experiencing severe symptoms, call emergency services immediately.
What is abra bound suspension for injection used for?
This medicine contains paclitaxel, a chemotherapy medicine used to treat breast cancer, ovarian cancer, lung cancer, and Kaposi's sarcoma. It works by stopping cancer cells from dividing. It is given as an intravenous infusion by a healthcare professional.
- Generic Name: Paclitaxel (1000mg)
- Manufacturer: Arechar Healthcare
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 abra bound suspension for injection के बारे में (Hindi Summary)
उपयोग: यह दवा पैक्लिटैक्सेल नामक सक्रिय तत्व युक्त एक कीमोथेरेपी दवा है, जिसका उपयोग कैंसर के इलाज के लिए किया जाता है। यह स्तन कैंसर, डिम्बग्रंथि कैंसर, फेफड़ों के कैंसर और कपोसी सारकोमा जैसे कैंसर के इलाज में प्रभावी है। यह दवा कैंसर कोशिकाओं को विभाजित होने से रोकती है, जिससे वे नष्ट हो जाती हैं। यह दवा केवल एक योग्य डॉक्टर की देखरेख में अस्पताल या कैंसर डे-केयर सेंटर में नस के माध्यम से दी जाती है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में बालों का झड़ना, थकान, मतली, उल्टी, दस्त, मुंह के छाले, मांसपेशियों और जोड़ों में दर्द, हाथ-पैरों में झुनझुनी या सुन्नपन, और रक्त कोशिकाओं की संख्या में कमी शामिल है। गंभीर दुष्प्रभावों में गंभीर एलर्जी प्रतिक्रिया, गंभीर संक्रमण, और हृदय की लय में गड़बड़ी शामिल हो सकती है। यदि आपको सांस लेने में कठिनाई, चेहरे या गले में सूजन, या गंभीर दाने दिखाई दें, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: यह दवा केवल एक योग्य स्वास्थ्य पेशेवर द्वारा अस्पताल में दी जानी चाहिए। उपचार के दौरान अपने डॉक्टर को सभी दवाओं के बारे में बताएं जो आप ले रहे हैं। गर्भवती महिलाओं को यह दवा नहीं दी जानी चाहिए क्योंकि यह भ्रूण को नुकसान पहुंचा सकती है। उपचार के दौरान स्तनपान न करें। यदि आपको बुखार, ठंड लगना, या संक्रमण के कोई अन्य लक्षण दिखाई दें, तो तुरंत डॉक्टर को बताएं। नियमित रक्त परीक्षण करवाएं।
💊 abra bound suspension for injection Uses & Benefits
[{"condition":"Breast cancer","description":"Used as part of combination chemotherapy or as a single agent for the treatment of early-stage and advanced breast cancer.","evidence":"Well-established"},{"condition":"Ovarian cancer","description":"Used in combination with platinum-based chemotherapy for first-line treatment of advanced ovarian cancer, and as a single agent for recurrent disease.","evidence":"Well-established"},{"condition":"Non-small cell lung cancer","description":"Used in combination with other chemotherapy agents for the treatment of advanced or metastatic non-small cell lung cancer.","evidence":"Well-established"},{"condition":"Kaposi's sarcoma","description":"Used for the treatment of AIDS-related Kaposi's sarcoma when other treatments have not been effective.","evidence":"Well-established"},{"condition":"Gastric cancer","description":"Sometimes used in combination regimens for advanced gastric or gastroesophageal junction cancer.","evidence":"Emerging"}]
Off-label uses: [{"condition":"Head and neck cancer","description":"Occasionally used in combination chemotherapy for recurrent or metastatic head and neck squamous cell carcinoma.","evidence":"Limited"},{"condition":"Bladder cancer","description":"Sometimes used as part of combination therapy for advanced bladder cancer.","evidence":"Limited"},{"condition":"Cervical cancer","description":"May be used in some treatment protocols for advanced cervical cancer.","evidence":"Limited"}]
Primary treatment for: Cancer (various types)
Also treats: Breast cancer, Ovarian cancer, Non-small cell lung cancer, Kaposi's sarcoma, Gastric cancer
📋 Drug Information
| Generic Name(s) | Paclitaxel (1000mg) |
| Brand Name | abra bound suspension for injection |
| Manufacturer | Arechar Healthcare |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | Antimicrotubule agents- Taxanes |
| Route of Administration | Parenteral (intravenous infusion) |
| Storage | Store this medicine in its original container in a refrigerator at 2°C to 8°C. Do not freeze. Protect from light. Keep out of reach of children. Once prepared for infusion, the solution should be used within the time specified by the manufacturer or as directed by the pharmacist. |
| Shelf Life | The shelf life of this medicine is typically 24 months from the date of manufacture when stored under the recommended conditions. Always check the expiry date on the packaging before use. |
| WHO Guideline | Paclitaxel is included in the WHO Model List of Essential Medicines for the treatment of various cancers. However, specific recommendations depend on the type and stage of cancer. Consult your oncologist for guidance. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine contains paclitaxel, which belongs to the taxane class of anticancer agents. It works by binding to the beta-tubulin subunit of microtubules, which are essential structures that help cells divide. Normally, microtubules assemble and disassemble dynamically during cell division. Paclitaxel stabilises these microtubules and prevents their disassembly, leading to a frozen microtubule structure. This disrupts the normal mitotic spindle formation, causing the cell cycle to arrest in the G2/M phase. As a result, cancer cells cannot divide and eventually undergo programmed cell death (apoptosis). This medicine is cell-cycle specific, meaning it primarily affects cells that are actively dividing, which is why it is effective against rapidly growing cancer cells.
Mechanism Steps
💡 How to Take abra bound suspension for injection
Strength: This medicine is a suspension for injection containing paclitaxel 1000 mg. It is supplied as a sterile, non-pyrogenic suspension that must be diluted before intravenous infusion.
Dosage Information
| Adult Dosage | The dose of this medicine is determined by your oncologist based on the type of cancer, your body surface area, your blood counts, and how well you tolerate the treatment. It is given as an intravenous infusion over 1 to 24 hours, usually once every 1 to 3 weeks. Premedication with corticosteroids, antihistamines, and H2 blockers is often given before the infusion to prevent allergic reactions. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatric oncologist. |
| Elderly Dosage | Elderly patients (above 65 years) may be more sensitive to the side effects of this medicine, especially peripheral neuropathy and bone marrow suppression. Dose adjustments may be necessary based on kidney and liver function and overall health status. Close monitoring is recommended. |
| Renal Impairment | Renal impairment is not expected to significantly affect the elimination of this medicine, as it is primarily excreted in the bile and faeces. However, dose adjustments may be considered in severe renal impairment based on clinical judgment. |
| Hepatic Impairment | Patients with liver impairment may require dose reduction. For mild to moderate liver impairment, a reduced dose may be recommended. For severe liver impairment, this medicine is generally not recommended. Dose must be individualized by a qualified clinician based on liver function tests. |
| Maximum Daily Dose | The maximum daily dose is not fixed and depends on the treatment protocol. It is determined by the oncologist based on body surface area and indication. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of abra bound suspension for injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Ketoconazole | Major | |
| Rifampicin | Major | |
| Warfarin | Moderate | |
| Cisplatin | Moderate | |
| Doxorubicin | Moderate | |
| Live vaccines | Major | |
| Grapefruit juice | Minor | |
| St. John's wort | Minor | |
| NSAIDs | Moderate | |
| Gemfibrozil | Major |
🚨 Major Interactions
- CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, ritonavir)
- CYP2C8 inhibitors (e.g., gemfibrozil)
- CYP3A4 inducers (e.g., rifampicin, carbamazepine, phenytoin)
- Live vaccines
⚡ Moderate Interactions
- Warfarin and other anticoagulants
- NSAIDs (e.g., ibuprofen, naproxen)
- Cisplatin
- Doxorubicin
🍷 Alcohol Interaction
Alcohol should be avoided while receiving this medicine. Alcohol can worsen side effects such as nausea, vomiting, dizziness, and fatigue. It can also increase the risk of liver problems and bleeding. It is best to discuss alcohol use with your doctor.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known severe hypersensitivity to paclitaxel or any component of the formulation","Baseline neutrophil count less than 1,500 cells/mm³","Pregnancy (unless the potential benefit justifies the risk)","Breastfeeding","Severe liver impairment","Concurrent use of live vaccines"]
⚠️ Warnings & Precautions
["This medicine should only be administered by a qualified healthcare professional in a setting with adequate facilities for monitoring and emergency treatment.","Severe allergic reactions can occur, especially during the first infusion. Premedication with corticosteroids, antihistamines, and H2 blockers is often given to reduce this risk.","Bone marrow suppression is common and can lead to serious infections or bleeding. Blood counts should be monitored regularly.","Peripheral neuropathy can occur and may be dose-limiting. Report any numbness, tingling, or weakness in hands or feet.","This medicine can cause fetal harm. Effective contraception is required for both men and women during treatment and for some time afterwards.","Avoid live vaccines during treatment.","Patients with liver impairment may require dose reduction.","This medicine may impair the ability to drive or operate machinery. Avoid these activities if you feel dizzy or tired."]
🤱 Lactation Safety
It is not known whether paclitaxel passes into breast milk. Because of the potential for serious side effects in a nursing infant, breastfeeding should be discontinued during treatment and for at least 2 weeks after the last dose. Consult your doctor for guidance.
💊 Overdose Management
Overdose with this medicine is unlikely because it is given by healthcare professionals. If an overdose occurs, it can cause severe bone marrow suppression, peripheral neuropathy, and mucositis. There is no specific antidote. Treatment is supportive and symptomatic, including close monitoring of blood counts and management of complications. In case of suspected overdose, contact your doctor or go to the nearest emergency department immediately.
⏰ Missed Dose
This medicine is given as an intravenous infusion in a hospital or clinic setting. If you miss an appointment for your infusion, contact your doctor or treatment centre as soon as possible to reschedule. Do not attempt to self-administer this medicine. Your doctor will determine the appropriate schedule.
Additional Safety Advice
This medicine must only be given by a qualified healthcare professional in a setting where emergency equipment is available. Before each dose, tell your doctor if you have an active infection, fever, or any signs of bleeding. Inform your doctor about all other medicines you are taking, including over-the-counter drugs and herbal supplements, as many can interact with this medicine. Avoid live vaccines while receiving treatment. Use effective contraception during treatment and for some time afterwards, as this medicine can harm an unborn baby. Do not breastfeed while receiving this medicine. If you experience any difficulty breathing, chest tightness, swelling of the face or throat, or a severe rash during or after the infusion, seek immediate medical help. Regular blood tests are needed to check your blood counts, liver function, and kidney function. Do not attempt to drive or operate machinery if you feel dizzy or tired after treatment.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more susceptible to the side effects of this medicine, particularly peripheral neuropathy, bone marrow suppression, and heart problems. Close monitoring and dose adjustments may be necessary. Discuss the risks and benefits with your doctor.
🤰 Pregnancy Planning (TTC)
This medicine can cause harm to an unborn baby. Women of childbearing potential should use effective contraception during treatment and for at least 6 months after the last dose. Men should also use effective contraception during treatment and for at least 3 months after the last dose. If you are planning to become pregnant, consult your doctor before starting treatment.
🏥 Post-Surgery Considerations
If you have recently had surgery, inform your doctor before receiving this medicine. Chemotherapy can affect wound healing and increase the risk of infection. Your doctor will assess whether it is safe to proceed with treatment.
🦷 Dental Procedures
Inform your dentist that you are receiving this medicine before any dental procedure. Chemotherapy can increase the risk of bleeding and infection. Your dentist may recommend postponing non-urgent procedures until your blood counts have recovered. Maintain good oral hygiene to prevent mouth sores and infections.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Exercise should be tailored to your energy levels and overall condition. Gentle activities like walking, stretching, or yoga can help maintain mobility and reduce fatigue. Avoid strenuous exercise or activities that increase the risk of falls or injury, especially if you have peripheral neuropathy or low blood counts. Consult your doctor before starting any exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause fatigue, dizziness, and peripheral neuropathy, which may affect your ability to work or perform daily activities. You may need to take time off work during treatment cycles. Discuss your work situation with your doctor and employer to make necessary adjustments. Avoid driving or operating heavy machinery if you feel dizzy or tired.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your oncologist. Treatment is usually continued for a specific number of cycles or until the cancer progresses or side effects become intolerable. Your doctor will decide when to stop based on your response and overall health. If you experience severe side effects, contact your doctor immediately; they may adjust the dose or switch to another treatment.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to persistent peripheral neuropathy, which can affect quality of life. Regular monitoring of blood counts, liver function, and neurological status is important. Some patients may experience long-term heart effects, especially if other cardiotoxic medicines are used. Fertility may be affected. Discuss any long-term concerns with your oncologist.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Depending on the type of cancer, other chemotherapy medicines such as docetaxel or platinum-based agents may be used.
Evidence: Well-establishedFor some cancers, targeted therapies that specifically attack cancer cells may be an option.
Evidence: Well-establishedImmunotherapy drugs that help the immune system fight cancer may be used in certain cases.
Evidence: Well-establishedParticipation in clinical trials may provide access to new treatments.
Evidence: Varies💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Live vaccines should be avoided during treatment with this medicine because of the increased risk of infection. Inactivated vaccines may be given, but their effectiveness may be reduced due to the immunosuppressive effects of chemotherapy. Consult your doctor before receiving any vaccine.
📦 Storage Guide
✅ DO
Store in the refrigerator at 2°C to 8°C.
❌ DON'T
Do not freeze.
✅ DO
Keep in the original container to protect from light.
❌ DON'T
Do not transfer to another container.
✅ DO
Keep out of reach of children.
❌ DON'T
Do not use after the expiry date.
✈️ Traveling with This Medicine
This medicine is given in a hospital or clinic setting, so you will not need to carry it while traveling. However, if you are traveling for treatment, carry a copy of your prescription and medical records. Inform your doctor about your travel plans so that your treatment schedule can be adjusted if needed. If you are traveling to a different city or country, ensure that you have access to a medical facility that can provide the infusion. Keep your emergency contact information handy.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: The effects of this medicine on cancer cells begin soon after infusion, but it may take several weeks to months to see a noticeable reduction in tumour size. Your doctor will monitor your response with regular scans and tests.
A: No, this medicine must be given by a healthcare professional in a hospital or clinic setting because of the risk of severe allergic reactions and other side effects.
A: Report any side effects to your doctor promptly. Some side effects can be managed with medications or dose adjustments. Do not try to self-treat.
A: No, this medicine can harm an unborn baby. Use effective contraception during treatment and for at least 6 months after the last dose. Consult your doctor if you are planning pregnancy.
A: No, breastfeeding is not recommended during treatment and for at least 2 weeks after the last dose because this medicine may pass into breast milk and harm the baby.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: This medicine can cure all types of cancer.
Fact: This medicine is effective against specific types of cancer. It is not a cure for all cancers and is used as part of a comprehensive treatment plan. - Myth: This medicine is safe to take at home.
Fact: This medicine must be given by a healthcare professional in a hospital or clinic setting because of the risk of severe allergic reactions and other side effects. - Myth: Hair loss caused by this medicine is permanent.
Fact: Hair loss is usually temporary. Hair typically grows back after treatment is completed. - Myth: You can stop taking this medicine if you feel better.
Fact: You should never stop or change your treatment without consulting your oncologist. Completing the prescribed course is important for the best outcome.
🔄 Alternative Options
Generic Alternatives
- Paclitaxel injection
Brand Alternatives
- Abra Bound Suspension for Injection