aroximat plus 12.5mg/0.5mg tablet cr allopathy (Paroxetine (12.5mg) + Clonazepam (0.5mg)) - Uses in Hindi, Side Effects, Substitutes & Price in India
aroximat plus 12.5mg/0.5mg tablet cr allopathy (Paroxetine (12.5mg) + Clonazepam (0.5mg)) - Uses in Hindi, Side Effects, Substitutes & Price in India manufactured by Matteo Healthcare Pvt Ltd. Contains Paroxetine (12.5mg) + Clonazepam (0.5mg).

aroximat plus 12.5mg/0.5mg tablet cr - Uses, Price, Side Effects & Substitutes

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🏭 Matteo Healthcare Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Jun 20, 2026
Medically Reviewed
By SaathiMed Expert Medical Panel

What is aroximat plus 12.5mg/0.5mg tablet cr used for?

Aroximat Plus 12.5mg/0.5mg Tablet CR (Paroxetine + Clonazepam) is used to treat Major depressive disorder. It contains Paroxetine (12.5mg) + Clonazepam (0.5mg), which Paroxetine: Inhibits serotonin reuptake; Clonazepam: Enhances GABA-A receptor ac. Always consult your doctor before use. Take as prescribed.

  • Generic Name: Paroxetine + Clonazepam
  • Manufacturer: Matteo Healthcare Pvt Ltd
  • Medicine Form: Allopathy
  • Pregnancy Category: A

🇮🇳 aroximat plus 12.5mg/0.5mg tablet cr के बारे में संक्षिप्त जानकारी (Hindi Summary)

aroximat plus 12.5mg/0.5mg tablet cr का उपयोग मुख्य रूप से neuro cns और उससे जुड़ी समस्याओं के इलाज के लिए किया जाता है। इस दवा में मुख्य सामग्री के रूप में Paroxetine (12.5mg) + Clonazepam (0.5mg) मौजूद है। इसे डॉक्टर की सलाह के बिना नहीं लेना चाहिए, खासकर गर्भावस्था (pregnancy) और लिवर (liver) की समस्याओं में।

मुख्य फायदे (Key Benefits): Detailed medical information is being added to our database.... Read more below.

💡 Did You Know? The Indian pharmaceutical market is expected to reach $130 billion by 2030.

📋 Drug Information

Generic Name(s)Paroxetine + Clonazepam
Brand NameAroximat Plus 12.5mg/0.5mg Tablet CR
ManufacturerMatteo Healthcare Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassNEURO CNS
Action ClassSelective Serotonin Reuptake Inhibitor (SSRI) + Benzodiazepine
Route of AdministrationOral
StorageStore at 20-25°C, protect from light and moisture
Shelf LifeAs per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionParoxetine: Well absorbed orally; Clonazepam: Well absorbed orally
DistributionParoxetine: Extensive distribution; Clonazepam: Highly lipophilic, crosses blood-brain barrier
Protein BindingParoxetine: ~95%; Clonazepam: ~85%
MetabolismParoxetine: Hepatic via CYP2D6; Clonazepam: Hepatic via CYP3A4
Half-LifeParoxetine: ~21 hours; Clonazepam: ~30-40 hours
ExcretionParoxetine: Urine (64% as metabolites, 2% unchanged); Clonazepam: Urine (<2% unchanged)
BioavailabilityParoxetine: ~50-100%; Clonazepam: ~90%
Onset of ActionParoxetine: 1-2 weeks; Clonazepam: 30-60 minutes
Peak Plasma TimeParoxetine: 5-6 hours; Clonazepam: 1-4 hours
Duration of ActionParoxetine: 24 hours; Clonazepam: 6-12 hours

Pharmacodynamics

Mechanism of ActionParoxetine: Inhibits serotonin reuptake; Clonazepam: Enhances GABA-A receptor activity
Target ReceptorParoxetine: Serotonin transporter (SERT); Clonazepam: GABA-A receptor benzodiazepine site
Pharmacodynamic EffectsIncreased serotonergic neurotransmission; enhanced GABAergic inhibition

💡 How and when to take aroximat plus 12.5mg/0.5mg tablet cr?

Follow your doctor's prescription exactly.

  • ✅ Take exactly as prescribed by your doctor.
  • ✅ Do not exceed the recommended dose
  • ✅ Complete the full course of medication
  • ✅ Store at 20-25°C, protect from light and moisture

⚙️ How aroximat plus 12.5mg/0.5mg tablet cr Works

Paroxetine: Inhibits serotonin reuptake; Clonazepam: Enhances GABA-A receptor activity

1 Paroxetine binds to SERT, blocking serotonin reuptake into presynaptic neuron
⬇️
2 Increased synaptic serotonin activates postsynaptic receptors (5-HT1A, etc.)
⬇️
3 Clonazepam binds to benzodiazepine site on GABA-A receptor
⬇️
4 Enhances GABA affinity, increasing chloride ion influx
⬇️
5 Hyperpolarization of neuron reduces excitability

💊 aroximat plus 12.5mg/0.5mg tablet cr Uses in Hindi (Ke Fayde), Benefits & Indications

Major depressive disorder, panic disorder, generalized anxiety disorder, social anxiety disorder, obsessive-compulsive disorder

Off-label uses: Premenstrual dysphoric disorder, post-traumatic stress disorder, chronic pain

⚠️ What are the side effects of aroximat plus 12.5mg/0.5mg tablet cr?

✅ Common Side Effects

  • Nausea
  • Drowsiness
  • Dizziness
  • Dry mouth
  • Constipation
  • Fatigue
  • Weight gain

🚨 Serious Side Effects

  • Serotonin syndrome
  • Suicidal thoughts
  • Seizures
  • Severe hypotension
  • Respiratory depression

⚠️ Rare Side Effects

  • Hyponatremia
  • QT prolongation
  • Hepatic failure
  • Stevens-Johnson syndrome
  • Blood dyscrasias

Consult your doctor if you experience any unusual symptoms.

🔄 Best Substitutes for aroximat plus 12.5mg/0.5mg tablet cr

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Alternative medicines with exact same composition and strength (Paroxetine (12.5mg) + Clonazepam (0.5mg)):

  1. oxitin plus 12.5mg/0.5mg tablet cr
    Psycormedies₹90.00💰 19.3% CHEAPER
  2. paroxta plus 12.5 mg/0.5 mg tablet
    Arinna Lifescience Pvt Ltd₹100.00💰 10.4% CHEAPER
  3. clonotril p 12.5mg/0.5mg tablet
    Torrent Pharmaceuticals Ltd₹107.83💰 3.3% CHEAPER
  4. freshika px 12.5mg/0.5mg tablet
    Amwin Pharmaceuticals₹110.00💰 1.4% CHEAPER
  5. paro cr plus tablet
    D D Pharmaceuticals₹110.00💰 1.4% CHEAPER
  6. paxotus plus 12.5mg/0.5mg tablet
    Emcure Pharmaceuticals Ltd₹110.30💰 1.1% CHEAPER
  7. aroximat plus 12.5mg/0.5mg tablet cr
    Matteo Healthcare Pvt Ltd₹111.56💰 Same price
  8. patroxta plus 12.5 tablet cr
    Arinna Lifescience Pvt Ltd₹112.00📈 0.4% COSTLIER
  9. lupizep plus 12.5 mg/0.5 mg tablet
    Lupin Ltd₹115.00📈 3.1% COSTLIER
  10. fordep plus 12.5mg/0.5mg tablet
    Tas Med India Pvt Ltd₹115.50📈 3.5% COSTLIER

Medical Note: Always consult your doctor before switching medications. Generic alternatives with same salts are therapeutically equivalent.

🔬 Drug Interactions

⚠️ Drug Severity Effect
MAOIs Major Serotonin syndrome risk
Warfarin Moderate Increased bleeding risk
Alcohol Major Enhanced sedation and CNS depression

🚨 Major Interactions

  • MAOIs
  • Linezolid
  • Methylene Blue
  • CNS Depressants
  • CYP2D6 Inhibitors
  • CYP3A4 Inhibitors

⚡ Moderate Interactions

  • Anticoagulants
  • NSAIDs
  • Antiplatelet agents
  • Other SSRIs
  • Triptans

ℹ️ Minor Interactions

  • Cimetidine
  • Omeprazole
  • Oral Contraceptives

🍽️ Food Interactions

Avoid grapefruit juice (increases clonazepam levels); take with or without food

🍷 Alcohol Interaction

Avoid alcohol; increased CNS depression

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity, concurrent MAOI use, narrow-angle glaucoma, severe respiratory insufficiency, myasthenia gravis

📊 Monitoring Parameters

Liver function, renal function, ECG, suicidal ideation, serotonin syndrome symptoms, sedation level

🤱 Lactation Safety

Not recommended; both drugs excreted in breast milk

💊 Overdose Management

Activated charcoal, supportive care, flumazenil for clonazepam (caution in mixed overdose), serotonin syndrome management

⏰ Missed Dose

Take as soon as remembered unless near next dose; do not double dose

🛑 Myths vs. Facts about aroximat plus 12.5mg/0.5mg tablet cr

  • Myth: Generic substitutes of aroximat plus 12.5mg/0.5mg tablet cr are less effective.
    Fact: Approved generic medicines contain the exact same active ingredients (Paroxetine (12.5mg) + Clonazepam (0.5mg)) and are just as safe and effective as the branded version.
  • Myth: Taking a double dose will cure my symptoms faster.
    Fact: Taking more than the prescribed dose of aroximat plus 12.5mg/0.5mg tablet cr can lead to severe toxicity or an overdose. Stick strictly to your doctor's dosage.
  • Myth: This medicine is 100% safe for everyone.
    Fact: No medicine is universally safe. Safety depends on your medical history, ongoing medicines, and potential allergies. Always consult a doctor.

💬 Real Patient Experiences (Astitva)

Join Community

Read real stories and discussions from our patient community regarding similar health conditions.

Therapy ya sirf ameeron ka shauk? ₹1500 per session dekh ke rona aa gaya 😭

bc seriously, therapy in India is just a rich people's game now? 😤 Maine socha tha ki finally ek step lunga apne mental health ke liye. 2 saal se sleep cycle kharab hai, raat ko 3-4 baje tak jagta rehta hoon, aur din mein 12-14 ghante screen pe ghoorta rehta hoon (work from home ka curse hai bhai). Breakup ke baad se loneliness ne to aur pakad liya hai. Socha ki online therapy try karta hoon. Opened one app, one session ka price: ₹1500. Arey bhai, meri monthly savings se toh 2 sessions mein poora budget khatam ho jayega. 🥲 I'm a junior dev, abhi 2 saal ka experience hai, salary bhi kuch zyada nahi. Aur phir yeh log bolte hai "take care of your mental health" like itna affordable ho. Maine alternative try kiya — ek government helpline number dial kiya. 2 ghante ruka, koi pick nahi kiya. 😐 So now I'm back to self-medicating with Reddit memes and 4 am coding sessions. Works temporarily but yeah. Kisi ko free/affordable online therapy ka idea hai jo actually works? Ya fir yeh batao ki kya hum middle-class walon ke liye therapy is just a distant dream? Genuinely asking. 🫠

Dil Ke Khamosh Signs: Heart Attack Pehchanein Aur Bachayein

Dil ka dard kabhi kabhi chupke se aata hai, aur iska pata chalne tak der ho jaati hai. Ek heart attack, ya myocardial infarction, tab hota hai jab dil tak jaane wali kisi artery mein khoon ka flow ruk jaata hai. Aap sochte honge ki heart attack ka matlab sirf seene mein jabarjast dard hota hai, lekin aisa nahi hai. Khaas taur par auraton (women) aur mardon (men) mein alag-alag khamosh (silent) warning signs hote hain jinhe hum aksar ignore kar dete hain. Aaj main aapko bataunga ki in signs ko kaise pehchanein aur kya karein. Mardon (Men) Mein Khamosh Signs Seene mein dabav ya jalan: Ye classic sign hai. Aisa nahi ki dard hi ho; kabhi kabhi sirf bhari pan ya jalne jaisa feel hota hai, jo aam gas ya acidity jaisa lagta hai. Baaen haath, kandhe ya jawaad mein dard: Dard sirf seene tak nahi rehta. Ye baaen taraf phail sakta hai. Thandi pasina (cold sweat): Bina kisi mehnat ke, achanak thandi pasina aana, jaise aap bheeg rahe hain. Saans phoolna (shortness of breath): Aaram karne par bhi saans lene mein takleef. Auraton (Women) Mein Khamosh Signs Thakaan (extreme fatigue): Achanak, bina kisi kaam ke, itni thakaan ki aap uth bhi nahi paayein. Ye kai hafton pehle bhi ho sakta hai. Peth ke upar ya pet mein dard: Heartburn, indigestion ya gas jaisa feel hona. Aksar auratein ise acidity samajh leti hain. Jawad, gala ya peeth ke beech mein dard: Seene ki jagah ye areas dard kar sakte hain. Chakkar aana ya behoshi (dizziness): Bina kisi vajah ke achanak chakkar. Ghar Par Kya Karein? (Home Remedies & Diet Tips) Heart attack ke signs dikhe to turant 108 ya apne doctor ko call karein. Ghar par sirf emergency management ho sakta hai, ilaaj nahi. Phir bhi, kuch steps hain: Aspirin chew karein (agar doctor ne pehle bataya ho): Ye khoon ko patla kar sakta hai. Lekin bina doctor ki salah ke na lein, khaas kar agar bleeding ka risk ho. Patient ko aaram se bithayein ya lete rahein: Uthaaye nahi, aur stress na lene dein. Diet mein sudhar: Heart attack ke baad, namak (salt) aur tel (oil) ka istemal kam karein. Desi ghee, nariyal tel aur olive oil healthy fats hain, lekin limit mein. Haldi wala doodh aur tulsi ki chai inflammation kam kar sakti hain, lekin ye ilaaj nahi hai. Kab Doctor Ke Paas Jaana Chahiye? Agar upar diye gaye koi bhi signs achanak dikhein, chahe dard halka hi kyun na ho. Agar 5-10 minute mein aaram karne se bhi aaram na mile. Agar aapko diabetes, high BP, ya smoking ki aadat hai, to in signs ko aur bhi serious lena chahiye. Yaad rakhein: Heart attack ka wait mat karein. Agar aapko lagta hai ki kuch galat hai, to doctor se turant milein. Astitva Health Community mein hum aapki sehat ko pehli priority dete hain. Apne dil ki suniye, aur kisi bhi silent sign ko ignore mat kijiye. Aapka ek kadam aapki zindagi bacha sakta hai.

**Angioplasty ke baad muscle pain! Koi natural alternative hai statins ka? LDL 170, Triglycerides 220!**

Yaar, ek doubt hai. 3 mahine pehle angioplasty hui thi, ab doctor ne Rosuvastatin 10mg diya hai. Lekin mujhe muscle pain ho raha hai, khas kar raat ko. Kya koi alternative hai? Maine suna hai Red Yeast Rice aur Omega-3 se cholesterol control hota hai. Kya koi try kiya hai? Maine kal apni diet change kari - subah oats, lunch me roti + sabzi (no ghee), raat ko grilled fish ya paneer. Lekin sugar cravings aa rahi hai, pata nahi kaise manage karu. Koi natural supplement suggest karo jo statins ke side effects na de. Aur kya exercise se enough control ho sakta hai? Mera LDL 170 hai, triglycerides 220. Apne experiences share karo please. Mujhe apne heart ko bachana hai, lekin in dawaiyon ke side effects se bhi dar lagta hai.

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