amitias plus 12.5mg/5mg tablet - Uses, Price, Side Effects & Substitutes
What is amitias plus 12.5mg/5mg tablet used for?
Amixide-H Tablet (Amitriptyline + Chlordiazepoxide) is used to treat Depression with anxiety. It contains Amitriptyline (12.5mg) + Chlordiazepoxide (5mg), which Amitriptyline inhibits reuptake of serotonin and norepinephrine; Chlordiazepoxid. Always consult your doctor before use. Take as prescribed.
- Generic Name: Amitriptyline + Chlordiazepoxide
- Manufacturer: Matteo Healthcare Pvt Ltd
- Medicine Form: Allopathy
- Pregnancy Category: D
🇮🇳 amitias plus 12.5mg/5mg tablet के बारे में संक्षिप्त जानकारी (Hindi Summary)
amitias plus 12.5mg/5mg tablet का उपयोग मुख्य रूप से neuro cns और उससे जुड़ी समस्याओं के इलाज के लिए किया जाता है। इस दवा में मुख्य सामग्री के रूप में Amitriptyline (12.5mg) + Chlordiazepoxide (5mg) मौजूद है। इसे डॉक्टर की सलाह के बिना नहीं लेना चाहिए, खासकर गर्भावस्था (pregnancy) और लिवर (liver) की समस्याओं में।
मुख्य फायदे (Key Benefits): Detailed medical information is being added to our database.... Read more below.
📋 Drug Information
| Generic Name(s) | Amitriptyline + Chlordiazepoxide |
|---|---|
| Brand Name | Amixide-H Tablet |
| Manufacturer | Matteo Healthcare Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Tricyclic antidepressant + Benzodiazepine |
| Route of Administration | Oral |
| Storage | Store at 20-25°C, protect from light and moisture |
| Shelf Life | As per manufacturer |
🔬 Pharmacology (PK/PD)
Pharmacokinetics
Pharmacodynamics
💡 How and when to take amitias plus 12.5mg/5mg tablet?
Follow your doctor's prescription exactly.
- ✅ Take exactly as prescribed by your doctor.
- ✅ Do not exceed the recommended dose
- ✅ Complete the full course of medication
- ✅ Store at 20-25°C, protect from light and moisture
⚙️ How amitias plus 12.5mg/5mg tablet Works
Amitriptyline inhibits reuptake of serotonin and norepinephrine; Chlordiazepoxide enhances GABA-A receptor activity
💊 amitias plus 12.5mg/5mg tablet Uses in Hindi (Ke Fayde), Benefits & Indications
Depression with anxiety, mixed anxiety-depressive disorder
Off-label uses: Chronic pain, fibromyalgia, insomnia, panic disorder
⚠️ What are the side effects of amitias plus 12.5mg/5mg tablet?
✅ Common Side Effects
- Drowsiness
- Dry mouth
- Constipation
- Blurred vision
- Dizziness
🚨 Serious Side Effects
- QT prolongation
- Seizures
- Serotonin syndrome
- Suicidal ideation
- Respiratory depression
⚠️ Rare Side Effects
- Agranulocytosis
- Cholestatic jaundice
- Paradoxical excitement
Consult your doctor if you experience any unusual symptoms.
🔄 Best Substitutes for amitias plus 12.5mg/5mg tablet
View AllAlternative medicines with exact same composition and strength (Amitriptyline (12.5mg) + Chlordiazepoxide (5mg)):
- calmzee-c tabletZeelab Pharmacy Pvt Ltd₹6.00💰 76% CHEAPER
- amitrol 12.5mg/5mg tabletTorrent Pharmaceuticals Ltd₹7.41💰 70.4% CHEAPER
- lodep plus 12.5mg/5mg tabletDensa Pharmaceuticals Pvt Ltd₹10.30💰 58.8% CHEAPER
- Sereval Plus H 12.5mg/5mg TabletOsho Pharma Pvt Ltd₹11.00💰 56% CHEAPER
- amypres c 12.5 mg/5 mg tabletPsycormedies₹12.19💰 51.2% CHEAPER
- amilite h 12.5mg/5mg tabletElite Pharma Pvt Ltd₹12.19💰 51.2% CHEAPER
- aptric 12.5mg/5mg tabletAps Biotech Pvt Ltd₹13.25💰 47% CHEAPER
- zepol forte 12.5mg/5mg tabletApex Laboratories Pvt Ltd₹13.40💰 46.4% CHEAPER
- triplex plus tabletAarpik Pharmaceuticals Pvt Ltd₹13.95💰 44.2% CHEAPER
- amitrix 12.5mg/5mg tabletNeuro Metrix Pharmaceuticals₹14.06💰 43.8% CHEAPER
Medical Note: Always consult your doctor before switching medications. Generic alternatives with same salts are therapeutically equivalent.
🔬 Drug Interactions
| ⚠️ Drug | Severity | Effect |
|---|---|---|
| MAOIs | Major | Hypertensive crisis, serotonin syndrome |
| CNS depressants | Major | Additive sedation, respiratory depression |
| Warfarin | Moderate | Increased anticoagulant effect |
| Grapefruit juice | Moderate | Increased chlordiazepoxide levels |
🚨 Major Interactions
- MAOIs
- CNS depressants
- Anticholinergics
- QT-prolonging agents
⚡ Moderate Interactions
- CYP2D6 inhibitors
- CYP3A4 inhibitors
- Antihypertensives
ℹ️ Minor Interactions
- Oral contraceptives
- Smoking
🍽️ Food Interactions
Avoid grapefruit juice (increases chlordiazepoxide levels)
🍷 Alcohol Interaction
Enhanced CNS depression; avoid alcohol
🛡️ Safety & Warnings
🚫 Contraindications
Recent MI, narrow-angle glaucoma, urinary retention, MAOI use within 14 days, hypersensitivity
📊 Monitoring Parameters
ECG, liver function, mental status, blood pressure, heart rate
🤱 Lactation Safety
Not recommended; excreted in breast milk
💊 Overdose Management
Activated charcoal, supportive care, physostigmine for anticholinergic symptoms, flumazenil for benzodiazepine reversal (use with caution)
⏰ Missed Dose
Take as soon as remembered unless near next dose; skip if close to next dose
🛑 Myths vs. Facts about amitias plus 12.5mg/5mg tablet
- Myth: Generic substitutes of amitias plus 12.5mg/5mg tablet are less effective.
Fact: Approved generic medicines contain the exact same active ingredients (Amitriptyline (12.5mg) + Chlordiazepoxide (5mg)) and are just as safe and effective as the branded version. - Myth: Taking a double dose will cure my symptoms faster.
Fact: Taking more than the prescribed dose of amitias plus 12.5mg/5mg tablet can lead to severe toxicity or an overdose. Stick strictly to your doctor's dosage. - Myth: This medicine is 100% safe for everyone.
Fact: No medicine is universally safe. Safety depends on your medical history, ongoing medicines, and potential allergies. Always consult a doctor.
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