What is Angispan-TR 6.5mg Capsule used for?

This medicine is a sustained-release capsule containing Nitroglycerin 6.5 mg. It is used to prevent angina (chest pain) in people with heart disease. It works by relaxing blood vessels to improve blood flow to the heart. It is not for immediate relief of an acute angina attack.

Generic Name: Nitroglycerin (6.5mg)
Manufacturer: USV Ltd
Form: Allopathy
Pregnancy Category: Consult doctor
Prescription Required: Yes

🇮🇳 Angispan-TR 6.5mg Capsule के बारे में (Hindi Summary)

उपयोग: यह दवा नाइट्रोग्लिसरीन 6.5 मिलीग्राम का धीमी गति से छोड़ने वाला कैप्सूल है। इसका उपयोग हृदय रोगियों में सीने के दर्द (एंजाइना) को रोकने के लिए किया जाता है। यह रक्त वाहिकाओं को फैलाकर हृदय तक रक्त का प्रवाह बढ़ाती है और हृदय पर दबाव कम करती है। यह दवा तीव्र दर्द के दौरे के लिए नहीं है, बल्कि नियमित रूप से लेने पर दर्द को रोकने में मदद करती है। यह गुदा की दरार के इलाज में भी कभी-कभी उपयोग की जाती है। इसे डॉक्टर के निर्देशानुसार ही लें।

साइड इफेक्ट्स: आम दुष्प्रभावों में सिरदर्द, चक्कर आना, चेहरे पर गर्मी लगना, और धड़कन तेज होना शामिल हैं। ये आमतौर पर हल्के होते हैं और समय के साथ कम हो जाते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन अत्यधिक निम्न रक्तचाप, बेहोशी, और एलर्जी प्रतिक्रिया हो सकती है। यदि सांस लेने में कठिनाई, चेहरे या गले में सूजन, या छाती में दर्द हो तो तुरंत डॉक्टर से मिलें।

सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। शराब का सेवन न करें क्योंकि इससे रक्तचाप कम हो सकता है और चक्कर आ सकते हैं। बैठने या लेटने से उठते समय धीरे-धीरे उठें। यदि आप गर्भवती हैं या स्तनपान करा रही हैं तो डॉक्टर को बताएं। इरेक्टाइल डिसफंक्शन की दवाओं के साथ इसका सेवन न करें। इसे बच्चों की पहुंच से दूर रखें।

💊 Angispan-TR 6.5mg Capsule Uses & Benefits

[{"condition":"Prevention of angina pectoris","description":"This medicine is used regularly to reduce the frequency and severity of angina attacks in patients with coronary artery disease.","evidence":"Well-established"},{"condition":"Chronic anal fissure","description":"This medicine may be used to help heal chronic anal fissures by relaxing the sphincter muscle and improving blood flow.","evidence":"Moderate"}]

Off-label uses: [{"condition":"Esophageal spasm","description":"Sometimes used to relieve esophageal spasm, but evidence is limited.","evidence":"Limited"}]

Primary treatment for: Angina pectoris

Also treats: Chronic anal fissure

📋 Drug Information

Generic Name(s)	Nitroglycerin (6.5mg)
Brand Name	Angispan-TR 6.5mg Capsule
Manufacturer	USV Ltd
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class
Action Class
Route of Administration	Oral
Storage	Store at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep in the original container.
Shelf Life	24 months from the date of manufacture.
WHO Guideline	Not established from the available information.
ICMR Guideline	Not established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1

Take this medicine at the same time each day to maintain consistent levels.

2

Swallow the capsule whole; do not crush or chew it.

3

Avoid alcohol while taking this medicine to prevent severe dizziness.

4

Rise slowly from sitting or lying positions to avoid lightheadedness.

5

Do not stop this medicine suddenly without consulting your doctor.

6

Inform your doctor if you experience frequent headaches or dizziness.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅

Chest pain (angina)

This medicine is commonly prescribed for prevention of angina.

Likely Use

✅

Anal fissure pain

This medicine may be used off-label for chronic anal fissure.

Likely Use

❌

Fever

This medicine is not a fever reducer.

Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionNitroglycerin is rapidly absorbed from the gastrointestinal tract, but extensive first-pass metabolism reduces systemic bioavailability. The sustained-release formulation is designed to release the drug slowly over time.

DistributionNitroglycerin is widely distributed in the body and has a large volume of distribution. It is not significantly bound to plasma proteins.

Protein BindingNot established from the available information.

MetabolismNitroglycerin is metabolized in the liver and also in the blood by glutathione-organic nitrate reductase, leading to the formation of nitric oxide and other metabolites.

Half-LifeThe elimination half-life of nitroglycerin is approximately 1 to 4 minutes for the parent compound, but the sustained-release formulation provides prolonged effects.

ExcretionMetabolites are primarily excreted in the urine.

BioavailabilityThe oral bioavailability of nitroglycerin is low due to extensive first-pass metabolism, typically less than 10% for conventional forms. The sustained-release formulation may have altered bioavailability.

Onset of ActionThe onset of action for the sustained-release capsule is gradual, typically within 30 to 60 minutes after oral administration.

Peak Plasma TimePeak plasma concentrations are typically reached within 1 to 2 hours after oral administration of the sustained-release capsule.

Duration of ActionThe duration of action is approximately 8 to 12 hours, allowing for once or twice daily dosing.

How It Works

Nitroglycerin is converted in the body to nitric oxide, which activates guanylate cyclase. This leads to increased cyclic GMP, causing smooth muscle relaxation and vasodilation. The dilation of veins and arteries reduces preload and afterload, decreasing myocardial oxygen demand and improving blood flow to the heart.

Mechanism Steps

1

Conversion to nitric oxide: Nitroglycerin is metabolized to release nitric oxide in smooth muscle cells.

2

Activation of guanylate cyclase: Nitric oxide activates the enzyme guanylate cyclase, increasing cyclic GMP levels.

3

Smooth muscle relaxation: Increased cyclic GMP leads to relaxation of vascular smooth muscle.

4

Vasodilation: Relaxation of smooth muscle causes dilation of veins and arteries.

5

Reduced cardiac workload: Vasodilation reduces preload and afterload, decreasing myocardial oxygen demand.

💡 How to Take Angispan-TR 6.5mg Capsule

Strength: Sustained-release capsule containing 6.5 mg of Nitroglycerin.

1Swallow the capsule whole with a glass of water.

2Do not crush, chew, or open the capsule.

3Take it at the same time each day as prescribed.

4You can take it with or without food, but taking it with food may reduce stomach upset.

5Avoid alcohol while taking this medicine.

Dosage Information

Adult Dosage	The usual adult dose is one capsule (6.5 mg) taken orally once or twice daily, as prescribed by your doctor. The dose may be adjusted based on your condition and response. Do not crush or chew the capsule; swallow it whole. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function.
Pediatric Dosage	Pediatric dosing is not established from available information. Consult a pediatrician.
Elderly Dosage	Elderly patients may be more sensitive to the effects of this medicine, especially dizziness and low blood pressure. Start with a lower dose and monitor closely.
Renal Impairment	No specific dose adjustment is established from available information. Use with caution in patients with severe renal impairment.
Hepatic Impairment	No specific dose adjustment is established from available information. Use with caution in patients with severe hepatic impairment.
Maximum Daily Dose	The maximum recommended daily dose is 13 mg (two 6.5 mg capsules) per day, but this may vary based on individual patient needs and doctor's prescription.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food

Take with meals

Reduces stomach upset.

Grapefruit

Avoid

May increase drug levels and side effects.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed

→ Take the missed dose as soon as you remember.

💡 Continue with the regular schedule.

📌 More than half the dosing interval has passed

→ Skip the missed dose.

💡 Do not double dose to catch up.

⚠️ Side Effects of Angispan-TR 6.5mg Capsule

✅ Common Side Effects

Headache (Common (5-10%))

Usually resolves with continued use. Consult your doctor if it persists or is severe.

Dizziness (Common (5-10%))

Rise slowly from sitting or lying positions. Avoid driving if affected.

Flushing (Common (5-10%))

Usually harmless and temporary. Consult doctor if bothersome.

Fast heartbeat (Common (5-10%))

Report to your doctor if it persists or is accompanied by palpitations.

🚨 Serious Side Effects

Severe hypotension (Rare (<0.1%))

Seek immediate medical attention if you experience fainting, severe dizziness, or blurred vision.

Allergic reaction (Rare (<0.1%))

Seek emergency help if you notice rash, itching, swelling of face, lips, or throat, or difficulty breathing.

⚠️ Rare Side Effects

Methemoglobinemia

Seek immediate medical attention if you experience bluish discoloration of lips, nails, or skin, or shortness of breath.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug	Severity	Effect
Sildenafil	Major
Tadalafil	Major
Vardenafil	Major
Riociguat	Major
Alcohol	Moderate
Antihypertensives	Moderate
Aspirin	Minor

🚨 Major Interactions

Phosphodiesterase-5 inhibitors (e.g., sildenafil, tadalafil, vardenafil)
Riociguat

⚡ Moderate Interactions

Alcohol
Antihypertensive drugs

🍷 Alcohol Interaction

Alcohol can enhance the blood pressure-lowering effects of this medicine, leading to dizziness, fainting, and increased risk of heart problems. It is best to avoid alcohol while taking this medicine.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Hypersensitivity to nitroglycerin or other nitrates","Severe hypotension","Increased intracranial pressure","Severe anemia","Concomitant use with phosphodiesterase-5 inhibitors","Concomitant use with riociguat"]

⚠️ Warnings & Precautions

["Avoid abrupt discontinuation as it may cause rebound angina.","Use with caution in patients with low blood pressure or dehydration.","May cause dizziness; avoid driving or operating machinery until you know how it affects you.","Tolerance to the effects can develop with continuous use; follow prescribed dosing schedule.","Inform your doctor if you have liver or kidney disease."]

🤱 Lactation Safety

Not established from the available information. Consult your doctor before breastfeeding.

💊 Overdose Management

Overdose may cause severe hypotension, headache, confusion, and fainting. Seek immediate medical attention. Treatment is supportive and symptomatic, including measures to raise blood pressure.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not change the dose or stop taking it without consulting your doctor. Avoid alcohol while taking this medicine, as it can increase the risk of low blood pressure and dizziness. Rise slowly from sitting or lying positions to prevent dizziness. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Do not use this medicine if you are taking medicines for erectile dysfunction such as sildenafil, tadalafil, or vardenafil, as this can cause a dangerous drop in blood pressure. Keep this medicine out of reach of children. Store it at room temperature, away from moisture and heat.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients may be more sensitive to the blood pressure-lowering effects of this medicine. Start with a lower dose and monitor closely for dizziness and falls.

🤰 Pregnancy Planning (TTC)

If you are planning to become pregnant, consult your doctor. The safety of this medicine during pregnancy is not well established, and alternative treatments may be considered.

🏥 Post-Surgery Considerations

Inform your surgeon and anesthesiologist that you are taking this medicine, as it may interact with medications used during surgery and affect blood pressure.

🦷 Dental Procedures

Inform your dentist that you are taking this medicine, as it may cause dizziness or low blood pressure during dental procedures. You may need to adjust your dose or timing.

💚 Lifestyle Tips for Better Results

🏃

Maintain a healthy weight to reduce heart strain.

🥗

Engage in regular low-impact exercise like walking or swimming.

😴

Avoid smoking and limit alcohol consumption.

💧

Eat a heart-healthy diet rich in fruits, vegetables, and whole grains.

🧘

Manage stress through relaxation techniques like yoga or meditation.

🌞

Get adequate sleep to support heart health.

🏋️ Exercise Considerations

Avoid strenuous exercise until you know how this medicine affects you, as it may cause dizziness or low blood pressure. Consult your doctor before starting any new exercise regimen.

🥗 Diet Recommendations

Include omega-3 rich foods like fish and flaxseeds.

Reduce intake of processed and high-sodium foods.

Stay well hydrated throughout the day.

Eat plenty of fiber to prevent constipation, especially if using for anal fissure.

💼 Impact on Daily Work & Life

This medicine may cause dizziness or lightheadedness, affecting your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. It is generally safe to continue desk work, but take breaks if you feel dizzy.

🛑 When to Stop This Medicine

Do not stop this medicine without consulting your doctor. Abrupt discontinuation can worsen angina. Your doctor will advise you on when and how to stop safely.

📅 Long-Term Use Effects

Long-term use of this medicine may lead to tolerance, reducing its effectiveness. It is important to follow the prescribed dosing schedule to minimize tolerance. Regular monitoring of blood pressure and heart rate is advised. Do not stop the medicine abruptly without medical advice.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Lifestyle modifications

Diet, exercise, and stress management can complement medicine for heart health.

Evidence: Well-established

Other anti-anginal medicines

Beta-blockers, calcium channel blockers, or other nitrates may be alternatives.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

No specific vaccine interactions are established. However, consult your doctor before receiving any vaccine while on this medicine.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of your prescription. Store it at room temperature and protect it from moisture and heat. If traveling across time zones, consult your doctor about adjusting the dosing schedule. Keep enough supply for the entire trip and carry it in your hand luggage. Check customs regulations for carrying prescription medicines.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 60-year-old man with a history of coronary artery disease

He was prescribed this medicine to prevent angina attacks. After taking it regularly for a few weeks, he noticed fewer episodes of chest pain and could walk longer distances without discomfort. He initially experienced mild headaches, which subsided after a week.

💡 Lesson: Consistent use as prescribed can significantly reduce angina frequency, and mild side effects often improve with time.

👤 A 45-year-old woman with chronic anal fissure

She was prescribed this medicine off-label for her anal fissure. Within two weeks, her pain during bowel movements decreased, and the fissure began to heal. She was advised to increase fiber and water intake.

💡 Lesson: This medicine can be effective for anal fissures, but it must be used under medical supervision and with lifestyle modifications.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine starts working within 30 to 60 minutes after oral administration, but its full effects may take a few days to become noticeable.

Q: Can I take this medicine if I have low blood pressure?

A: No, this medicine is contraindicated in severe low blood pressure. Consult your doctor.

Q: Is it safe to take this medicine during pregnancy?

A: The safety of this medicine during pregnancy is not well established. Use only if clearly needed and prescribed by your doctor.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

Can I take this medicine long-term?
Will it affect my kidney function?
Can I drive after taking this medicine?
Does it interact with my blood pressure medicine?
What if I miss a dose?
Can I drink alcohol while taking this?

🔄 Substitutes for Angispan-TR 6.5mg Capsule

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

Myth: This medicine can be used to treat an acute angina attack.
Fact: This medicine is for prevention of angina, not for immediate relief of an acute attack. A fast-acting nitrate is used for acute attacks.
Myth: You can stop taking this medicine once you feel better.
Fact: Do not stop this medicine without consulting your doctor, as it may worsen angina.

🔄 Alternative Options

Generic Alternatives

Nitroglycerin sustained-release capsules

Brand Alternatives

Angispan-TR 6.5mg Capsule

📊 Comparison with Similar Medicines

[{"medicine":"Nitroglycerin sustained-release","class":"Nitrate","half_life":"1-4 minutes","duration":"8-12 hours","common_use":"Angina prevention"},{"medicine":"Isosorbide mononitrate","class":"Nitrate","half_life":"4-5 hours","duration":"12-24 hours","common_use":"Angina prevention"}]

Angispan-tr 6.5mg Capsule: Comprehensive Medicine Guide

When to Call Your Doctor IMMEDIATELY

What is Angispan-TR 6.5mg Capsule used for?

🇮🇳 Angispan-TR 6.5mg Capsule के बारे में (Hindi Summary)

💊 Angispan-TR 6.5mg Capsule Uses & Benefits

📋 Drug Information

👨‍⚕️ Doctor's Practical Tips

🔍 Is This Medicine Right for Your Symptom?

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

How It Works

Mechanism Steps

💡 How to Take Angispan-TR 6.5mg Capsule

Dosage Information

Dosage Timeline

🍽️ Food Timing Guide

⏰ What to Do If You Miss a Dose

⚠️ Side Effects of Angispan-TR 6.5mg Capsule

✅ Common Side Effects

🚨 Serious Side Effects

⚠️ Rare Side Effects

🔬 Drug Interactions

🚨 Major Interactions

⚡ Moderate Interactions

🍷 Alcohol Interaction

🔎 Check Your Other Medicines

🛡️ Safety & Warnings

🚫 Contraindications

⚠️ Warnings & Precautions

🤱 Lactation Safety

💊 Overdose Management

⏰ Missed Dose

Additional Safety Advice

👴 Special Considerations for Elderly

💡 For Patients Above 65

🤰 Pregnancy Planning (TTC)

🏥 Post-Surgery Considerations

🦷 Dental Procedures

💚 Lifestyle Tips for Better Results

🏋️ Exercise Considerations

🥗 Diet Recommendations

💼 Impact on Daily Work & Life

🛑 When to Stop This Medicine

📅 Long-Term Use Effects

🌿 Non-Medicine Approaches

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

📦 Storage Guide

✅ DO

❌ DON'T

✅ DO

❌ DON'T

✅ DO

❌ DON'T

✈️ Traveling with This Medicine

💰 Cost Analysis & Savings

👥 Real Patient Stories

💬 Questions Patients Often Ask

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

🔄 Substitutes for Angispan-TR 6.5mg Capsule

🛑 Myths vs. Facts

🔄 Alternative Options

Generic Alternatives

Brand Alternatives

📊 Comparison with Similar Medicines

😊 Was this information helpful?

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