angistat 6.5 capsule tr - Nitroglycerin (6.5mg) medicine

Angiplat 6.5 Capsule Tr (nitroglycerin): Complete Medicine Guide

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🏭 Sun Pharmaceutical Industries Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 29, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Well-established for angina prophylaxis.
Reviewed by
SaathiMed Expert Panel | Oct 29, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Fainting or severe dizziness
  • Chest pain that is more frequent, severe, or lasts longer than usual
  • Bluish discoloration of lips, skin, or nails
  • Shortness of breath or difficulty breathing
  • Swelling of the face, lips, tongue, or throat
  • Severe headache that does not go away
  • Irregular or very slow heartbeat
  • Sudden weakness or numbness on one side of the body

If experiencing severe symptoms, call emergency services immediately.

What is angistat 6.5 capsule tr used for?

This medicine is an oral nitrate used to prevent angina chest pain in people with coronary artery disease. It works by relaxing blood vessels to improve blood flow to the heart and reduce its workload. It is not for immediate relief of an ongoing angina attack.

  • Generic Name: Nitroglycerin
  • Manufacturer: Sun Pharmaceutical Industries Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 angistat 6.5 capsule tr के बारे में (Hindi Summary)

उपयोग: यह दवा नाइट्रोग्लिसरिन 6.5 मिलीग्राम कैप्सूल है, जिसका उपयोग एंजाइना (सीने में दर्द) को रोकने के लिए किया जाता है। यह रक्त वाहिकाओं को फैलाकर हृदय तक रक्त का प्रवाह बढ़ाती है और हृदय पर दबाव कम करती है। यह दवा तीव्र एंजाइना हमले के इलाज के लिए नहीं है, बल्कि इससे बचाव के लिए है। इसे डॉक्टर के निर्देशानुसार ही लें।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में सिरदर्द, चक्कर आना, चेहरे पर लालिमा, और धड़कन तेज होना शामिल हैं। ये आमतौर पर शुरुआत में होते हैं और कुछ दिनों में ठीक हो जाते हैं। यदि आपको बेहोशी, सीने में तेज दर्द, या सांस लेने में कठिनाई हो, तो तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे चबाएं या तोड़ें नहीं। शराब का सेवन न करें क्योंकि इससे रक्तचाप बहुत कम हो सकता है। सिल्डेनाफिल, टैडालाफिल जैसी दवाएं इस दवा के साथ बिल्कुल न लें। अचानक दवा बंद न करें। गर्भावस्था या स्तनपान के दौरान डॉक्टर से सलाह लें।

💡 Did You Know? The Indian pharmaceutical market is expected to reach $130 billion by 2030.

💊 angistat 6.5 capsule tr Uses & Benefits

[{"condition":"Chronic stable angina prophylaxis","description":"This medicine is used to prevent angina attacks in patients with coronary artery disease by reducing cardiac workload and improving coronary blood flow.","evidence":"Well-established"},{"condition":"Vasospastic angina","description":"It helps prevent chest pain caused by coronary artery spasm by relaxing the blood vessels.","evidence":"Well-established"},{"condition":"Heart failure with reduced ejection fraction","description":"In combination with other heart failure medicines, it may be used to reduce symptoms and improve exercise tolerance under specialist care.","evidence":"Moderate"},{"condition":"Esophageal spasm","description":"Nitroglycerin can relieve chest pain caused by esophageal spasm by relaxing smooth muscle.","evidence":"Limited"}]

Off-label uses: [{"condition":"Anal fissure","description":"Topical nitroglycerin is sometimes used off-label to relieve pain from anal fissures, but this oral form is not standard for that purpose.","evidence":"Limited"},{"condition":"Biliary colic","description":"Nitroglycerin may be used off-label to relax the sphincter of Oddi and relieve biliary colic pain in some settings.","evidence":"Limited"}]

Primary treatment for: Angina pectoris

Also treats: Coronary artery disease, Heart failure, Esophageal spasm

📋 Drug Information

Generic Name(s)Nitroglycerin
Brand NameAngispan - TR 2.5mg Capsule
ManufacturerSun Pharmaceutical Industries Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassCARDIAC
Action ClassNO Donors
Route of AdministrationOral
StorageStore at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep the capsules in their original container, tightly closed.
Shelf Life24 months from the date of manufacture, or as printed on the packaging.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine at the same time each day to maintain consistent levels and reduce tolerance.
2
Rise slowly from sitting or lying down to prevent dizziness and fainting.
3
Avoid alcohol completely while on this medicine, as it can cause a dangerous drop in blood pressure.
4
Never take erectile dysfunction drugs like sildenafil or tadalafil with this medicine.
5
Keep a record of your angina attacks and inform your doctor if they become more frequent or severe.
6
Do not stop this medicine abruptly without consulting your doctor, as it can worsen angina.
7
Inform all your healthcare providers, including your dentist, that you are taking this medicine.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Chest pain on exertion
This medicine is commonly prescribed to prevent angina.
Likely Use
❌
Acute angina attack
This medicine is not for immediate relief; sublingual nitroglycerin is used.
Not Primary
❌
High blood pressure
This medicine is not a primary antihypertensive.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionNitroglycerin is rapidly absorbed from the gastrointestinal tract after oral administration, but it undergoes extensive first-pass metabolism in the liver, which significantly reduces its systemic bioavailability. The immediate-release oral capsule is designed to provide a sustained effect, but absorption can be variable.
DistributionNitroglycerin is widely distributed throughout the body. It has a large volume of distribution, approximately 3 L/kg. It crosses the placenta and is distributed into breast milk in small amounts.
Protein BindingNitroglycerin is approximately 60% bound to plasma proteins.
MetabolismNitroglycerin is extensively metabolized in the liver by glutathione-dependent organic nitrate reductase and other enzymes to form dinitrate and mononitrate metabolites, which are less active. It also undergoes denitration in the blood vessels.
Half-LifeThe elimination half-life of nitroglycerin is approximately 1 to 4 minutes, but the clinical effect of the oral capsule lasts longer due to its release characteristics.
ExcretionMetabolites of nitroglycerin are primarily excreted in the urine, with some excretion in feces.
BioavailabilityThe oral bioavailability of nitroglycerin is low, approximately 10% to 20%, due to extensive first-pass metabolism. The immediate-release capsule may have a slightly higher bioavailability than the sublingual form but still variable.
Onset of ActionThe onset of action for the oral immediate-release capsule is typically within 30 to 60 minutes, but this can vary. It is not intended for acute relief of angina.
Peak Plasma TimePeak plasma concentration is usually reached within 1 to 2 hours after oral administration of the immediate-release capsule.
Duration of ActionThe duration of action for the oral capsule is approximately 4 to 6 hours, but this can vary depending on the individual and the dose.

How It Works

Nitroglycerin is a nitrate that is converted in the body to nitric oxide, which activates guanylate cyclase and increases cyclic guanosine monophosphate (cGMP). This leads to relaxation of vascular smooth muscle, resulting in vasodilation. The primary effect is on venous capacitance vessels, which reduces preload and cardiac workload. At higher doses, it also dilates coronary arteries and improves collateral blood flow to ischemic myocardium. This reduces myocardial oxygen demand and helps prevent angina.

Mechanism Steps

1
Conversion to nitric oxide: Nitroglycerin is metabolized in the body to release nitric oxide, the active signaling molecule.
2
Activation of guanylate cyclase: Nitric oxide binds to and activates the enzyme guanylate cyclase in vascular smooth muscle cells.
3
Increase in cGMP: Activated guanylate cyclase converts GTP to cyclic GMP, which serves as a second messenger.
4
Smooth muscle relaxation: Elevated cGMP activates protein kinase G, leading to decreased intracellular calcium and relaxation of vascular smooth muscle.
5
Vasodilation and reduced cardiac workload: Venodilation reduces preload, and coronary dilation improves blood flow, decreasing myocardial oxygen demand and preventing angina.

💡 How to Take angistat 6.5 capsule tr

Strength: Immediate-release capsule containing 6.5 mg of Nitroglycerin.

1Take this medicine exactly as prescribed by your doctor.
2Swallow the capsule whole with a glass of water. Do not crush, chew, or open it.
3You can take it with or without food, but if it upsets your stomach, take it with a meal.
4Take it at the same time(s) each day to maintain consistent levels.
5If you feel dizzy after taking it, sit or lie down until the feeling passes.
6Do not stop taking this medicine suddenly without talking to your doctor.

Dosage Information

Adult DosageThe usual adult dose of this medicine is one capsule (6.5 mg) taken orally once or twice daily, or as directed by your doctor. The dose may be adjusted based on your response and tolerance. This medicine is not for immediate relief of an acute angina attack. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and other medications you are taking. Do not change the dose without consulting your doctor.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may be more sensitive to the blood pressure-lowering effects of this medicine. Start with a lower dose and monitor blood pressure closely. Dose must be individualized by a qualified clinician.
Renal ImpairmentNo specific dose adjustment is established for renal impairment. Use with caution and monitor blood pressure. Consult your doctor for individualized dosing.
Hepatic ImpairmentNo specific dose adjustment is established for hepatic impairment. Use with caution as metabolism may be altered. Consult your doctor for individualized dosing.
Maximum Daily DoseThe maximum recommended daily dose is generally 13 mg (two 6.5 mg capsules) per day, but this may vary. Do not exceed the dose prescribed by your doctor.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Can take with or without food
Food does not significantly affect absorption, but taking with food may reduce stomach upset.
Grapefruit
Avoid large amounts
May increase drug levels, though interaction is not well established.
Alcohol
Avoid
Can cause severe hypotension and dizziness.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of angistat 6.5 capsule tr

✅ Common Side Effects

Headache (Common (up to 50%))
This often improves after the first few days. If it persists or is severe, consult your doctor. Over-the-counter pain relievers may help, but ask your doctor first.
Dizziness (Common (10-20%))
Rise slowly from sitting or lying positions. Avoid driving if you feel dizzy. If dizziness is severe or persistent, contact your doctor.
Flushing (Common (10-20%))
This usually subsides with continued use. If it bothers you, discuss with your doctor.
Tachycardia (Common (5-10%))
A fast heartbeat may occur as a reflex to blood pressure changes. If it is persistent or accompanied by palpitations, consult your doctor.
Nausea (Uncommon (1-5%))
Take the medicine with food if it upsets your stomach. If nausea continues, speak to your doctor.

🚨 Serious Side Effects

Severe hypotension (Rare (<0.1%))
Seek immediate medical attention if you experience fainting, cold sweat, blurred vision, or a very slow heartbeat.
Methemoglobinemia (Very rare (<0.01%))
Symptoms include bluish lips or skin, shortness of breath, and confusion. This is a medical emergency; go to the nearest hospital.
Allergic reaction (Rare (<0.1%))
Stop the medicine and seek immediate help if you develop rash, itching, swelling of the face, lips, tongue, or throat, or difficulty breathing.
Worsening angina (Rare (<0.1%))
If chest pain becomes more frequent or severe, contact your doctor immediately. Do not increase the dose on your own.

⚠️ Rare Side Effects

Exfoliative dermatitis
Seek medical attention if you notice peeling or blistering skin.
Thrombocytopenia
Report unusual bruising or bleeding to your doctor promptly.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Sildenafil Major
Tadalafil Major
Vardenafil Major
Riociguat Major
Alcohol Major
Beta-blockers Moderate
Calcium channel blockers Moderate
Tricyclic antidepressants Moderate
Ergotamine Moderate
Heparin Minor

🚨 Major Interactions

  • Phosphodiesterase-5 inhibitors (sildenafil, tadalafil, vardenafil)
  • Riociguat
  • Alcohol

⚡ Moderate Interactions

  • Antihypertensives (beta-blockers, calcium channel blockers, ACE inhibitors, ARBs, diuretics)
  • Tricyclic antidepressants
  • Ergot alkaloids (ergotamine, dihydroergotamine)

🍷 Alcohol Interaction

Alcohol should be avoided while taking this medicine because it can intensify the blood pressure-lowering effect, leading to severe dizziness, fainting, and potentially dangerous hypotension. If you consume alcohol, discuss it with your doctor first.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Hypersensitivity to nitroglycerin or other nitrates","Concurrent use of phosphodiesterase-5 inhibitors (sildenafil, tadalafil, vardenafil)","Concurrent use of riociguat","Severe hypotension (systolic blood pressure

⚠️ Warnings & Precautions

["This medicine may cause severe hypotension, especially when standing up quickly. Rise slowly.","Tolerance to the effects can develop with continuous use. Follow your doctor's dosing schedule.","Avoid alcohol while taking this medicine.","Do not use erectile dysfunction drugs while on this medicine.","Use with caution in patients with liver or kidney disease.","Use with caution in the elderly due to increased risk of hypotension.","Do not abruptly stop this medicine without consulting your doctor, as it may worsen angina.","Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.","Keep out of reach of children."]

🤱 Lactation Safety

It is not known whether nitroglycerin is excreted in human breast milk. Because many drugs are excreted in human milk, caution should be exercised when this medicine is administered to a breastfeeding woman. Consult your doctor before breastfeeding.

💊 Overdose Management

Overdose of this medicine can cause severe hypotension, throbbing headache, confusion, fever, and methemoglobinemia. If you suspect an overdose, seek emergency medical attention immediately. Treatment is supportive and may include intravenous fluids, vasopressors for hypotension, and methylene blue for methemoglobinemia. Do not try to treat yourself at home.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor, usually once or twice daily with a glass of water. Do not crush, chew, or open the capsule unless your doctor instructs you to do so. To reduce the risk of dizziness, rise slowly from a sitting or lying position. Avoid alcohol while taking this medicine, as it can intensify the blood pressure-lowering effect and increase dizziness. Do not use erectile dysfunction medicines such as sildenafil, tadalafil, or vardenafil while on this medicine, as the combination can cause a life-threatening drop in blood pressure. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Keep this medicine out of reach of children. Store it at room temperature, away from moisture and direct sunlight. Do not stop taking this medicine suddenly without consulting your doctor, as this can worsen angina. Regular follow-up visits are important to monitor your blood pressure, heart rate, and overall response to treatment.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are more sensitive to the blood pressure-lowering effects of this medicine and may experience more dizziness and falls. Start with a lower dose and monitor blood pressure closely. Ensure adequate hydration and rise slowly from sitting or lying positions.

🤰 Pregnancy Planning (TTC)

If you are planning to become pregnant, consult your doctor before starting or continuing this medicine. It is classified as Pregnancy Category C, and the benefits must be weighed against potential risks. Your doctor may adjust your treatment plan.

🏥 Post-Surgery Considerations

Inform your surgeon and anesthesiologist that you are taking this medicine before any surgery. It may interact with anesthetic agents and affect blood pressure during surgery. Your doctor may advise you to stop it temporarily before surgery.

🦷 Dental Procedures

Inform your dentist that you are taking this medicine before any dental procedure. It can cause dizziness or low blood pressure during dental work. Your dentist may take precautions such as monitoring your blood pressure.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to reduce the workload on your heart.
🥗
Engage in regular low-impact exercise like walking or swimming, as advised by your doctor.
😴
Follow a heart-healthy diet low in saturated fats and salt.
💧
Avoid smoking and limit alcohol consumption.
🧘
Manage stress through relaxation techniques like deep breathing or meditation.
🌞
Get adequate sleep and rest.
🚭
Monitor your blood pressure regularly at home if advised.

🏋️ Exercise Considerations

Exercise is beneficial for heart health, but you should avoid strenuous activities that trigger angina. Start slowly and gradually increase intensity. If you experience chest pain, dizziness, or shortness of breath during exercise, stop immediately and rest. Consult your doctor before starting any new exercise program.

🥗 Diet Recommendations

Include plenty of fruits, vegetables, and whole grains.
Choose lean proteins like fish, poultry, and legumes.
Limit intake of saturated fats, trans fats, and cholesterol.
Reduce salt intake to help control blood pressure.
Stay well hydrated with water.
Avoid excessive caffeine, which can increase heart rate.

💼 Impact on Daily Work & Life

This medicine may cause dizziness or lightheadedness, especially when you first start taking it. Avoid driving or operating heavy machinery until you know how it affects you. If your job involves strenuous activity, discuss with your doctor about any necessary modifications. Most people can continue their normal activities with some precautions.

🛑 When to Stop This Medicine

Do not stop taking this medicine without consulting your doctor. If you experience severe side effects or your condition changes, your doctor may adjust or stop the medicine. Abrupt withdrawal can cause rebound angina. Always follow your doctor's guidance.

📅 Long-Term Use Effects

Long-term use of this medicine can lead to tolerance, where the effect diminishes over time. To prevent tolerance, your doctor may prescribe a nitrate-free interval. Regular monitoring of blood pressure, heart rate, and angina frequency is important. Long-term use does not cause organ damage, but the underlying heart condition needs ongoing management. Periodic review with your doctor is essential.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Lifestyle modifications

Diet, exercise, and stress management can complement medicine for angina.

Evidence: Well-established
Other anti-anginal medicines

Beta-blockers, calcium channel blockers, and other nitrates may be used.

Evidence: Well-established
Revascularization procedures

Angioplasty or bypass surgery may be considered for severe coronary artery disease.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

There are no known interactions between this medicine and vaccines. However, always inform your healthcare provider about all medicines you are taking before receiving any vaccine.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid extreme temperatures in checked baggage. Store at room temperature and protect from light and moisture. If crossing time zones, consult your doctor about adjusting the dosing schedule. Carry enough supply for your entire trip. Check local customs regulations regarding prescription medicines.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 58-year-old man with a history of coronary artery disease and frequent angina on exertion.
He was prescribed this medicine to prevent angina attacks. Initially, he experienced headaches and dizziness, but these improved after a week. He learned to take it regularly and to avoid alcohol. His angina episodes reduced significantly, and he could walk longer distances without chest pain.
💡 Lesson: Consistent use and lifestyle modifications can greatly improve outcomes. Side effects often diminish with time.
👤 A 65-year-old woman with stable angina and hypertension.
She was started on this medicine along with her blood pressure medications. She was advised to monitor her blood pressure regularly. She experienced mild dizziness initially but adjusted by rising slowly. She was educated about the importance of not using erectile dysfunction drugs, which she did not need, but she shared this information with her husband who had a heart condition.
💡 Lesson: Patient education about interactions and monitoring is crucial for safety.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine starts working within 30 to 60 minutes after taking a dose, but it is not for immediate relief of an acute angina attack. It is used to prevent angina episodes.

Q: Can I take this medicine with food?

A: Yes, you can take it with or without food. If it upsets your stomach, take it with a meal.

Q: What should I do if I miss a dose?

A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.

Q: Can I stop taking this medicine suddenly?

A: No, do not stop suddenly as it can worsen angina. Consult your doctor before stopping.

Q: Is this medicine safe during pregnancy?

A: It is classified as Pregnancy Category C. Consult your doctor if you are pregnant or planning to become pregnant.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?
  • Is it safe to take with sildenafil?
  • How long does it take to work?

🔄 Substitutes for angistat 6.5 capsule tr

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can be used to treat an acute angina attack.
    Fact: This medicine is for prevention of angina, not for immediate relief. Sublingual nitroglycerin is used for acute attacks.
  • Myth: It is safe to take erectile dysfunction drugs with this medicine.
    Fact: Combining this medicine with erectile dysfunction drugs can cause a life-threatening drop in blood pressure and is contraindicated.
  • Myth: You can stop this medicine whenever you feel better.
    Fact: Stopping suddenly can worsen angina. Always consult your doctor before stopping.

🔄 Alternative Options

Generic Alternatives

  • Nitroglycerin 6.5 mg immediate-release capsule

Brand Alternatives

  • Angiplat 6.5 capsule tr

📊 Comparison with Similar Medicines

[{"medicine":"Nitroglycerin (this medicine)","class":"Nitrate","onset":"30-60 minutes","duration":"4-6 hours","main_use":"Angina prophylaxis"},{"medicine":"Isosorbide mononitrate","class":"Nitrate","onset":"30-60 minutes","duration":"12-24 hours","main_use":"Angina prophylaxis"}]

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