actorab-ls capsule sr - Levosulpiride (75mg) + Rabeprazole (20mg) medicine

Cyra-LS Tablet SR: Complete Medicine Guide

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🏭 Fitwel Pharmaceuticals Private Limited 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 21, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Moderate to well-established for approved indications.
Reviewed by
SaathiMed Expert Panel | Sep 21, 2026

When to Call Your Doctor IMMEDIATELY

  • Blood in vomit or black, tarry stools
  • Severe abdominal pain or cramping
  • Chest pain, palpitations, or difficulty breathing
  • Severe headache with visual changes
  • Sudden swelling of face, lips, or throat
  • Yellowing of skin or eyes (jaundice)
  • Decreased urine output or swelling in legs
  • Uncontrollable muscle movements or tremors
  • High fever with muscle rigidity and confusion

If experiencing severe symptoms, call emergency services immediately.

What is actorab-ls capsule sr used for?

This medicine is a combination of Levosulpiride and Rabeprazole used to treat acid reflux, gastritis, and functional dyspepsia. It works by reducing stomach acid and improving stomach emptying. It is taken orally once daily before breakfast, usually for short-term treatment.

  • Generic Name: Levosulpiride + Rabeprazole
  • Manufacturer: Fitwel Pharmaceuticals Private Limited
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 actorab-ls capsule sr के बारे में (Hindi Summary)

उपयोग: यह दवा लेवोसल्पिराइड और रैबेप्राजोल का संयोजन है, जिसका उपयोग एसिड रिफ्लक्स, गैस्ट्र्रिटिस और अपच के इलाज के लिए किया जाता है। यह पेट में एसिड को कम करती है और पेट को खाली करने में मदद करती है। इसे सुबह नाश्ते से पहले खाली पेट लेना चाहिए।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में सिरदर्द, चक्कर आना, नींद आना, मतली, दस्त, पेट दर्द और मुँह सूखना शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन यदि आपको दिल की धड़कन में अनियमितता, मांसपेशियों में अकड़न, या सांस लेने में कठिनाई हो तो तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। इसे चबाएं या तोड़ें नहीं, पूरा निगल लें। इसे सुबह नाश्ते से पहले खाली पेट लें। इस दवा के साथ शराब न लें। यदि आप गर्भवती हैं या स्तनपान करा रही हैं तो डॉक्टर को बताएं। दवा बंद करने से पहले डॉक्टर से सलाह लें।

💡 Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

💊 actorab-ls capsule sr Uses & Benefits

[{"condition":"Gastroesophageal reflux disease (GERD)","description":"Reduces acid reflux and heartburn by suppressing gastric acid secretion and improving gastric emptying.","evidence":"Well-established"},{"condition":"Functional dyspepsia","description":"Helps relieve symptoms like bloating, early satiety, and upper abdominal discomfort by enhancing gastric motility and reducing acid.","evidence":"Moderate"},{"condition":"Gastritis","description":"Provides relief from inflammation of the stomach lining by reducing acid production and promoting gastric emptying.","evidence":"Moderate"},{"condition":"Peptic ulcer disease","description":"Used as part of combination therapy to heal ulcers and relieve symptoms by acid suppression and prokinetic action.","evidence":"Well-established"}]

Off-label uses: [{"condition":"Diabetic gastroparesis","description":"Sometimes prescribed off-label to improve gastric emptying in patients with diabetes.","evidence":"Limited"},{"condition":"Nausea and vomiting of various causes","description":"Levosulpiride component may help reduce nausea and vomiting, but this is not a primary approved indication.","evidence":"Limited"}]

Primary treatment for: Gastroesophageal reflux disease (GERD)

Also treats: Functional dyspepsia, Gastritis, Peptic ulcer disease

📋 Drug Information

Generic Name(s)Levosulpiride + Rabeprazole
Brand NameAcera-L Capsule SR
ManufacturerFitwel Pharmaceuticals Private Limited
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassGASTRO INTESTINAL
Action ClassProkinetic agent + Proton pump inhibitor
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a dry place, away from direct sunlight. Keep in the original container.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine on an empty stomach, preferably 30-60 minutes before breakfast, for best results.
2
Do not crush or chew the tablet; swallow it whole with water.
3
Avoid alcohol while taking this medicine as it can increase drowsiness and stomach irritation.
4
Do not drive or operate heavy machinery until you know how this medicine affects you.
5
If you experience persistent diarrhea, fever, or abdominal pain, contact your doctor immediately.
6
Do not stop taking this medicine abruptly without consulting your doctor.
7
Inform your doctor if you have heart rhythm problems or are taking other medications.
8
Long-term use may require monitoring of magnesium and vitamin B12 levels.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

Heartburn
This medicine is commonly prescribed for heartburn due to acid reflux.
Likely Use
Bloating
This medicine helps improve gastric emptying and reduces bloating.
Likely Use
Fever
This medicine is not a primary fever reducer.
Not Primary
Headache
This medicine is not used for headache; it may cause headache as a side effect.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionLevosulpiride is absorbed from the gastrointestinal tract, but specific bioavailability data are not established from the available information. Rabeprazole is rapidly absorbed, with peak plasma concentrations occurring about 2 to 5 hours after oral administration. Food may delay absorption of Rabeprazole but does not significantly affect the extent of absorption.
DistributionLevosulpiride distribution is not well characterized. Rabeprazole is approximately 96% bound to plasma proteins and distributes into gastric parietal cells. Specific volume of distribution data are not established from the available information.
Protein BindingRabeprazole is about 96% bound to plasma proteins. Protein binding of Levosulpiride is not established from the available information.
MetabolismLevosulpiride undergoes minimal hepatic metabolism and is primarily excreted unchanged in urine. Rabeprazole is extensively metabolized in the liver by cytochrome P450 enzymes, mainly CYP2C19 and CYP3A4.
Half-LifeThe elimination half-life of Levosulpiride is approximately 6 to 8 hours. Rabeprazole has a plasma elimination half-life of about 1 to 2 hours.
ExcretionLevosulpiride is mainly excreted unchanged in urine. Rabeprazole metabolites are excreted primarily in urine and feces.
BioavailabilityThe oral bioavailability of Rabeprazole is approximately 52%. Bioavailability of Levosulpiride is not established from the available information.
Onset of ActionRabeprazole begins to suppress acid secretion within 1 hour of oral administration, with maximum effect after 2 to 4 hours. Levosulpiride's prokinetic effect may start within 30 to 60 minutes.
Peak Plasma TimeRabeprazole reaches peak plasma concentration in about 2 to 5 hours. Levosulpiride peak plasma time is not established from the available information.
Duration of ActionRabeprazole's acid suppression lasts up to 24 hours. Levosulpiride's prokinetic effect lasts approximately 6 to 8 hours.

How It Works

This medicine combines two active ingredients with complementary actions. Levosulpiride is a selective dopamine D2 receptor antagonist that enhances gastric motility and accelerates gastric emptying. Rabeprazole is a proton pump inhibitor that irreversibly blocks the hydrogen-potassium ATPase enzyme in gastric parietal cells, thereby reducing both basal and stimulated acid secretion. Together, they provide symptomatic relief in conditions where both acid suppression and improved gastric motility are beneficial.

Mechanism Steps

1
Dopamine D2 receptor blockade by Levosulpiride: Levosulpiride blocks dopamine D2 receptors in the gastrointestinal tract, which enhances acetylcholine release and stimulates smooth muscle contractions, leading to accelerated gastric emptying.
2
Proton pump inhibition by Rabeprazole: Rabeprazole is activated in the acidic environment of gastric parietal cells and irreversibly binds to the H+/K+ ATPase enzyme, blocking the final step of acid secretion.
3
Combined effect on GERD symptoms: The prokinetic action reduces reflux by improving gastric emptying, while acid suppression reduces the acidity of any refluxate, leading to symptom relief and mucosal healing.

💡 How to Take actorab-ls capsule sr

Strength: Tablet containing Levosulpiride 75 mg and Rabeprazole 20 mg.

1Take the tablet at the same time each day, preferably before breakfast.
2Swallow the tablet whole with a glass of water. Do not crush, chew, or break it.
3If you have difficulty swallowing, consult your doctor.
4Follow your doctor's instructions regarding duration of treatment.
5Do not take more than the prescribed dose.

Dosage Information

Adult DosageThe usual adult dose is one tablet of Levosulpiride 75 mg and Rabeprazole 20 mg taken orally once daily before breakfast on an empty stomach. However, the dose and duration must be individualized by a qualified clinician based on the indication, age, weight, renal and hepatic function. Do not self-adjust the dose.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may be more sensitive to the side effects of Levosulpiride, especially extrapyramidal symptoms and drowsiness. Dose adjustment may be necessary. Consult a doctor for appropriate dosing.
Renal ImpairmentLevosulpiride is primarily excreted by the kidneys. Dose reduction may be required in patients with renal impairment. Rabeprazole does not require dose adjustment in mild to moderate renal impairment. Consult a doctor for individualized dosing.
Hepatic ImpairmentNo specific dose adjustment is established for Rabeprazole in hepatic impairment, but caution is advised in severe liver disease. Levosulpiride should be used with caution in patients with hepatic impairment. Consult a doctor for individualized dosing.
Maximum Daily DoseThe maximum recommended daily dose is one tablet containing Levosulpiride 75 mg and Rabeprazole 20 mg. Do not exceed this dose unless directed by a doctor.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take on an empty stomach
Rabeprazole is best absorbed on an empty stomach.
Grapefruit juice
Avoid
May increase Rabeprazole levels and side effects.
High-fat meals
Avoid taking with medicine
May delay absorption of Rabeprazole.

⏰ What to Do If You Miss a Dose

📌 Less than 12 hours have passed since the missed dose
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than 12 hours have passed since the missed dose
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of actorab-ls capsule sr

✅ Common Side Effects

Headache (Common (5-10%))
Usually resolves on its own. Consult doctor if persistent or severe.
Dizziness (Common (5-10%))
Avoid driving or operating machinery until you know how it affects you. Consult doctor if it persists.
Drowsiness (Common (5-10%))
Avoid alcohol and activities requiring alertness. Consult doctor if it interferes with daily activities.
Nausea (Common (5-10%))
Take with food if advised. Consult doctor if it continues.
Diarrhea (Common (5-10%))
Stay hydrated. Consult doctor if it becomes severe or persistent.
Abdominal pain (Common (5-10%))
Usually mild. Consult doctor if severe or persistent.
Dry mouth (Common (5-10%))
Sip water frequently. Consult doctor if it bothers you.

🚨 Serious Side Effects

Abnormal heart rhythms (QT prolongation) (Rare (<0.1%))
Seek immediate medical attention if you experience palpitations, fainting, or shortness of breath.
Extrapyramidal symptoms (tremors, muscle stiffness, difficulty speaking) (Rare (<0.1%))
Contact your doctor immediately if you notice unusual muscle movements or stiffness.
Severe allergic reactions (rash, swelling, difficulty breathing) (Rare (<0.1%))
Seek emergency medical help if you experience swelling of face, lips, or throat, or difficulty breathing.
Clostridium difficile-associated diarrhea (Rare (<0.1%))
Report persistent diarrhea, abdominal pain, or fever to your doctor.
Hypomagnesemia (low magnesium levels) (Rare (<0.1%))
Report muscle cramps, seizures, or abnormal heart rhythms to your doctor.

⚠️ Rare Side Effects

Neuroleptic malignant syndrome
Seek emergency care for high fever, muscle rigidity, confusion, or irregular pulse.
Tardive dyskinesia
Report involuntary repetitive movements to your doctor immediately.
Interstitial nephritis
Report decreased urine output, swelling, or fatigue to your doctor.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major
Ketoconazole Major
Atazanavir Major
Methotrexate Major
Diazepam Moderate
Phenytoin Moderate
Levodopa Moderate
Anticholinergics Moderate
Antacids Minor
Sucralfate Minor

🚨 Major Interactions

  • Warfarin
  • Ketoconazole, Itraconazole
  • Atazanavir, Nelfinavir
  • Methotrexate

⚡ Moderate Interactions

  • Diazepam
  • Phenytoin
  • Levodopa
  • Anticholinergics

🍷 Alcohol Interaction

Alcohol may increase drowsiness and dizziness caused by Levosulpiride. It may also worsen stomach irritation. Avoid alcohol while taking this medicine.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known hypersensitivity to Levosulpiride, Rabeprazole, or any component of the formulation","Suspected or confirmed gastrointestinal obstruction, perforation, or bleeding","Prolactin-dependent tumors (e.g., pituitary adenoma, breast cancer)","Severe renal impairment (creatinine clearance < 20 mL/min)","Epilepsy or history of seizures","Concurrent use with levodopa","Pregnancy and breastfeeding unless clearly needed"]

⚠️ Warnings & Precautions

["May cause drowsiness; avoid driving or operating machinery until you know how it affects you.","Avoid alcohol while taking this medicine.","Use with caution in elderly patients due to increased risk of extrapyramidal symptoms.","May increase risk of bone fractures with long-term use.","May cause low magnesium levels with prolonged use; monitor if taking diuretics.","May increase risk of Clostridium difficile-associated diarrhea.","Do not use for more than 8 weeks without medical advice.","Inform your doctor if you have heart rhythm problems or are taking other medications that affect heart rhythm."]

🤱 Lactation Safety

It is not known whether Levosulpiride or Rabeprazole are excreted in human breast milk. Consult your doctor before breastfeeding while taking this medicine.

💊 Overdose Management

Overdose may cause severe drowsiness, extrapyramidal symptoms, or cardiac arrhythmias. Seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote. Gastric lavage may be considered if overdose is recent. Monitor vital signs and ECG.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not crush, chew, or break the tablet; swallow it whole with water. It is best taken before breakfast on an empty stomach, but follow your doctor's specific instructions. Avoid alcohol while taking this medicine as it may increase drowsiness and stomach irritation. Do not drive or operate heavy machinery until you know how this medicine affects you. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Do not stop taking this medicine abruptly without consulting your doctor. Keep out of reach of children.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are at higher risk of extrapyramidal symptoms, drowsiness, and fractures with long-term use. Dose adjustment may be necessary. Regular monitoring of renal function and magnesium levels is advised.

🤰 Pregnancy Planning (TTC)

Consult your doctor before planning pregnancy while taking this medicine. The safety of this combination during pregnancy is not well established. Your doctor may consider alternative treatments.

🏥 Post-Surgery Considerations

Inform your surgeon and anesthesiologist that you are taking this medicine before any surgery. It may interact with anesthetic agents and affect gastric motility. Your doctor may advise you to stop it temporarily before surgery.

🦷 Dental Procedures

Inform your dentist that you are taking this medicine before any dental procedure. It may cause dry mouth, which can affect dental health. Maintain good oral hygiene and stay hydrated.

💚 Lifestyle Tips for Better Results

🏃
Eat smaller, more frequent meals to reduce acid reflux.
🥗
Avoid lying down immediately after eating; wait at least 2-3 hours.
😴
Elevate the head of your bed by 6-8 inches to prevent nighttime reflux.
💧
Avoid trigger foods like spicy, fatty, and acidic foods.
🧘
Maintain a healthy weight to reduce abdominal pressure.
🌞
Quit smoking and limit alcohol consumption.
🚭
Practice stress-reducing techniques like yoga or meditation.

🏋️ Exercise Considerations

Avoid vigorous exercise immediately after taking this medicine, especially if you experience drowsiness or dizziness. Moderate exercise like walking is generally safe. Consult your doctor before starting any new exercise regimen.

🥗 Diet Recommendations

Include high-fiber foods like fruits, vegetables, and whole grains.
Avoid spicy, fatty, and fried foods.
Limit caffeine and carbonated drinks.
Stay well hydrated by drinking plenty of water.
Eat smaller, more frequent meals.
Avoid eating within 3 hours of bedtime.

💼 Impact on Daily Work & Life

This medicine may cause drowsiness and dizziness, which can affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. It may also cause fatigue, so plan your work schedule accordingly. Consult your doctor if side effects interfere with your daily activities.

🛑 When to Stop This Medicine

Do not stop taking this medicine without consulting your doctor. If you experience severe side effects or your symptoms resolve, your doctor may advise you to stop gradually. Abrupt discontinuation may cause rebound acid hypersecretion.

📅 Long-Term Use Effects

Long-term use of this medicine may increase the risk of bone fractures, low magnesium levels, vitamin B12 deficiency, and Clostridium difficile-associated diarrhea. Prolonged use of Levosulpiride may cause tardive dyskinesia. Regular monitoring of magnesium, vitamin B12, and renal function is advised. Use the lowest effective dose for the shortest duration.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Lifestyle modifications

Dietary changes, weight loss, and elevating the head of the bed can help manage GERD symptoms.

Evidence: Well-established
Other proton pump inhibitors

Omeprazole, Pantoprazole, or Esomeprazole may be used as alternatives.

Evidence: Well-established
H2 receptor antagonists

Ranitidine or Famotidine may be used for milder symptoms.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

No specific vaccine interactions are established. However, long-term use of proton pump inhibitors may slightly reduce the immune response to certain vaccines. Consult your doctor for personalized advice.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✅ DO

Keep out of reach of children

❌ DON'T

Do not use after expiry date

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from direct sunlight. If traveling across time zones, consult your doctor about adjusting the dosing schedule. Keep enough supply for the entire trip. Check customs regulations for carrying prescription medicines.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 45-year-old man with chronic acid reflux and bloating
He was prescribed this medicine for GERD and functional dyspepsia. After taking it daily before breakfast for 4 weeks, his heartburn and bloating significantly reduced. He experienced mild drowsiness initially, which subsided after a few days. He was advised to avoid alcohol and to not drive until he knew how the medicine affected him.
💡 Lesson: Consistent use as prescribed and following safety precautions leads to good symptom control and tolerability.
👤 A 60-year-old woman with gastritis and early satiety
She started this medicine and noticed improvement in her appetite and reduction in stomach pain within 2 weeks. She was monitored for magnesium levels due to long-term use. She was advised to take calcium and vitamin D supplements to reduce fracture risk.
💡 Lesson: Regular monitoring and supplementation can prevent long-term complications of acid-suppressing therapy.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: Rabeprazole starts reducing acid within 1 hour, and Levosulpiride improves gastric motility within 30-60 minutes. Symptom relief may take a few days.

Q: Can I take this medicine with food?

A: It is best taken on an empty stomach, preferably 30-60 minutes before breakfast. Food may delay absorption.

Q: What should I do if I miss a dose?

A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.

Q: Can I stop taking this medicine suddenly?

A: Do not stop taking this medicine without consulting your doctor. Abrupt discontinuation may cause rebound acid hypersecretion.

Q: Is it safe to take during pregnancy?

A: Consult your doctor before taking this medicine during pregnancy. The safety profile is not well established.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?
  • Is it safe during pregnancy?
  • Can I take it with other antacids?

🔄 Substitutes for actorab-ls capsule sr

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can be taken indefinitely for acid reflux.
    Fact: This medicine is usually prescribed for short-term use. Long-term use should be under medical supervision due to potential side effects.
  • Myth: It is safe to take this medicine without a prescription.
    Fact: This is a prescription medicine. It should only be taken under a doctor's supervision.
  • Myth: This medicine can be taken with alcohol without any issues.
    Fact: Alcohol may increase drowsiness and dizziness. Avoid alcohol while taking this medicine.

🔄 Alternative Options

Generic Alternatives

  • Levosulpiride 75 mg + Rabeprazole 20 mg tablet

Brand Alternatives

  • Cyra-LS Tablet SR

📊 Comparison with Similar Medicines

[{"medicine":"This medicine","composition":"Levosulpiride 75 mg + Rabeprazole 20 mg","release_type":"Immediate release","usual_frequency":"Once daily"},{"medicine":"Levosulpiride + Pantoprazole","composition":"Levosulpiride 75 mg + Pantoprazole 40 mg","release_type":"Immediate release","usual_frequency":"Once daily"},{"medicine":"Rabeprazole + Domperidone","composition":"Rabeprazole 20 mg + Domperidone 30 mg","release_type":"Sustained release","usual_frequency":"Once daily"}]

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