Levosulpiride + Rabeprazole Sustained-Release Capsule: Complete Guide
When to Call Your Doctor IMMEDIATELY
- Blood in vomit or black, tarry stools
- Severe abdominal pain or persistent vomiting
- Chest pain, palpitations, or difficulty breathing
- High fever with muscle rigidity, confusion, or irregular heartbeat
- Involuntary movements of the face, tongue, or limbs
- Swelling of the face, lips, or throat, or difficulty swallowing
- Yellowing of the skin or eyes, or dark urine
- Severe diarrhea with fever or blood
If experiencing severe symptoms, call emergency services immediately.
What is ropraz ls 75mg/20mg tablet used for?
This medicine is a combination of Levosulpiride and Rabeprazole used to treat acid reflux and functional dyspepsia. It works by reducing stomach acid and improving stomach emptying. It is usually taken once daily before breakfast.
- Generic Name: Levosulpiride (75mg) + Rabeprazole (20mg)
- Manufacturer: Sun Pharmaceutical Industries Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 ropraz ls 75mg/20mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा लेवोसल्पिराइड और रैबेप्राजोल का संयोजन है, जिसका उपयोग एसिड रिफ्लक्स, गैस्ट्रोएसोफेजियल रिफ्लक्स डिजीज (GERD) और कार्यात्मक अपच के इलाज के लिए किया जाता है। यह पेट में एसिड को कम करती है और पेट खाली होने की प्रक्रिया को तेज करती है, जिससे जलन, गैस, पेट भारी लगना और मतली जैसे लक्षणों में राहत मिलती है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में सिरदर्द, मतली, दस्त, पेट दर्द, मुंह सूखना और नींद आना शामिल हैं। कुछ लोगों को चक्कर आना या थकान महसूस हो सकती है। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन अगर आपको तेज बुखार, मांसपेशियों में अकड़न, दौरे, या सांस लेने में कठिनाई हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें, आमतौर पर सुबह नाश्ते से पहले। कैप्सूल को पूरा निगलें, चबाएं या तोड़ें नहीं। इस दवा के साथ शराब न लें क्योंकि इससे नींद और चक्कर बढ़ सकते हैं। जब तक आपको पता न चले कि यह दवा आप पर कैसा असर करती है, तब तक वाहन न चलाएं। अगर आप गर्भवती हैं या स्तनपान करा रही हैं, तो डॉक्टर से सलाह लें।
💊 ropraz ls 75mg/20mg tablet Uses & Benefits
[{"condition":"Gastroesophageal reflux disease (GERD)","description":"This medicine reduces acid reflux and improves stomach emptying, relieving heartburn and regurgitation.","evidence":"Well-established"},{"condition":"Functional dyspepsia","description":"Helps relieve post-meal fullness, upper abdominal bloating, and nausea by enhancing gastric motility and reducing acid.","evidence":"Well-established"},{"condition":"Non-ulcer dyspepsia","description":"Used when dyspeptic symptoms persist without an ulcer, combining prokinetic and acid-suppressive effects.","evidence":"Moderate"},{"condition":"Gastritis with delayed gastric emptying","description":"May be prescribed when inflammation of the stomach lining is accompanied by slow stomach emptying.","evidence":"Limited"}]
Off-label uses: [{"condition":"Diabetic gastroparesis","description":"Sometimes used off-label to improve gastric emptying in people with diabetes, but evidence is limited.","evidence":"Limited"},{"condition":"Nausea and vomiting of functional origin","description":"Levosulpiride component may help nausea not caused by organic disease, but this is not a standard approved use.","evidence":"Limited"}]
Primary treatment for: Gastroesophageal reflux disease (GERD)
Also treats: Functional dyspepsia, Non-ulcer dyspepsia, Gastritis, Delayed gastric emptying
📋 Drug Information
| Generic Name(s) | Levosulpiride (75mg) + Rabeprazole (20mg) |
| Brand Name | ropraz ls 75mg/20mg tablet |
| Manufacturer | Sun Pharmaceutical Industries Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary actions. Levosulpiride is a substituted benzamide that selectively blocks dopamine D2 receptors in the chemoreceptor trigger zone and the gastrointestinal tract. This blockade enhances gastric motility, accelerates gastric emptying, and increases lower esophageal sphincter tone, which reduces reflux and nausea. Rabeprazole is a proton pump inhibitor that irreversibly inhibits the hydrogen-potassium ATPase enzyme in gastric parietal cells. This enzyme is the final step in acid secretion, so its inhibition leads to a marked and prolonged reduction in both basal and stimulated gastric acid output. The combination addresses both acid reflux and poor stomach motility, which often coexist in functional gastrointestinal disorders.
Mechanism Steps
💡 How to Take ropraz ls 75mg/20mg tablet
Strength: Sustained-release capsule containing Levosulpiride 75 mg and Rabeprazole 20 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one capsule once daily, preferably before breakfast. However, the exact dose and duration must be individualized by a qualified clinician based on the indication, severity of symptoms, age, weight, renal function, and hepatic function. Do not self-adjust the dose. Follow your doctor's instructions exactly. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the side effects of this medicine, especially drowsiness, dizziness, and extrapyramidal symptoms. Dose adjustment may be necessary based on renal and hepatic function. Use with caution and monitor closely. |
| Renal Impairment | Levosulpiride is primarily excreted by the kidneys. In patients with mild to moderate renal impairment, dose reduction may be considered. This medicine is contraindicated in severe renal impairment (creatinine clearance < 30 mL/min). Consult your doctor for dose adjustment. |
| Hepatic Impairment | Rabeprazole is metabolized in the liver. In patients with mild to moderate hepatic impairment, no dose adjustment is typically required, but caution is advised. This medicine is contraindicated in severe hepatic impairment. Consult your doctor. |
| Maximum Daily Dose | The maximum recommended daily dose is one capsule (Levosulpiride 75 mg + Rabeprazole 20 mg) per day. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of ropraz ls 75mg/20mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Anticholinergics | Major | |
| Dopamine agonists | Major | |
| QT-prolonging drugs | Major | |
| Methotrexate | Major | |
| Atazanavir | Major | |
| Ketoconazole | Moderate | |
| Digoxin | Moderate | |
| Warfarin | Moderate | |
| Clopidogrel | Moderate | |
| Antacids | Minor |
🚨 Major Interactions
- Anticholinergic drugs (e.g., atropine, dicyclomine)
- Dopamine agonists (e.g., levodopa, pramipexole)
- QT-prolonging drugs (e.g., amiodarone, haloperidol)
- Methotrexate
- Atazanavir, nelfinavir
⚡ Moderate Interactions
- Ketoconazole, itraconazole
- Digoxin
- Warfarin
- Clopidogrel
- Diuretics (e.g., furosemide)
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine. It can increase stomach acid production, worsening the condition being treated, and may enhance the sedative effects of Levosulpiride, leading to increased drowsiness and dizziness. Alcohol also increases the risk of gastrointestinal bleeding and can interfere with the healing of the esophagus and stomach lining.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to Levosulpiride, Rabeprazole, or any component of the formulation","Suspected or confirmed pheochromocytoma","Epilepsy or history of seizures","Severe renal impairment (creatinine clearance < 30 mL/min)","Severe hepatic impairment","Concurrent use with dopamine agonists (e.g., levodopa)","Concurrent use with QT-prolonging drugs","Pregnancy and breastfeeding unless clearly needed","Children and adolescents below 18 years of age"]
⚠️ Warnings & Precautions
["May cause drowsiness or dizziness; avoid driving or operating machinery until you know how it affects you.","Use with caution in patients with cardiovascular disease or electrolyte imbalances due to QT prolongation risk.","Long-term use of Rabeprazole may increase the risk of bone fractures, especially in the elderly.","May increase the risk of Clostridium difficile-associated diarrhea; report severe or bloody diarrhea.","Do not crush, chew, or open the sustained-release capsule; swallow it whole.","Avoid alcohol while taking this medicine.","Inform your doctor if you have kidney or liver disease before starting this medicine.","Do not use for longer than prescribed without medical supervision."]
🤱 Lactation Safety
It is not known whether Levosulpiride or Rabeprazole are excreted in human breast milk. Because many drugs are excreted in human milk, caution should be exercised when this medicine is administered to a breastfeeding woman. Consult your doctor before use.
💊 Overdose Management
Overdose of this medicine may cause severe drowsiness, extrapyramidal symptoms, hypotension, or cardiac arrhythmias. There is no specific antidote. Treatment should be symptomatic and supportive. If overdose is suspected, contact a poison control center or emergency room immediately. Gastric lavage may be considered if the patient presents early. Monitor vital signs, ECG, and electrolytes closely.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor, usually once daily before breakfast. Swallow the capsule whole with water; do not crush, chew, or open it because it is a sustained-release formulation. Avoid alcohol while taking this medicine as it can worsen drowsiness and stomach irritation. Do not drive or operate heavy machinery until you know how this medicine affects you. Inform your doctor if you have kidney or liver problems, heart rhythm disorders, or a history of seizures. Do not take antacids or other acid-suppressing medicines without consulting your doctor. If you are pregnant, planning pregnancy, or breastfeeding, talk to your doctor before using this medicine. Keep all follow-up appointments and report any new or worsening symptoms.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more prone to side effects such as drowsiness, dizziness, and extrapyramidal symptoms. They also have a higher risk of bone fractures and vitamin B12 deficiency with long-term Rabeprazole use. Dose adjustment may be needed based on renal and hepatic function. Regular monitoring is advised.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. The safety of this medicine during pregnancy is not well established. Your doctor may consider alternative treatments. Use effective contraception while on this medicine unless otherwise advised.
🏥 Post-Surgery Considerations
After surgery, consult your doctor before resuming this medicine. It may affect gastric motility and acid secretion, which could impact postoperative recovery. Your doctor will determine the appropriate timing and dose.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine before any dental procedure. It may increase the risk of bleeding or interact with medications used during dental work. Your dentist may advise temporary discontinuation or dose adjustment.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Moderate exercise is generally safe, but avoid vigorous activities immediately after meals as they can worsen reflux. If you experience dizziness or drowsiness, avoid activities that require balance or coordination. Consult your doctor before starting any new exercise regimen.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause drowsiness or dizziness, which can affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. It is advisable to take it in the morning to minimize interference with sleep. Most people can continue their normal work routine with caution.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience severe side effects such as involuntary movements, severe allergic reactions, or persistent diarrhea, stop the medicine and seek immediate medical attention. Your doctor will advise on the appropriate duration of treatment and whether to taper or stop.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to vitamin B12 deficiency, low magnesium levels, and an increased risk of bone fractures due to Rabeprazole. Levosulpiride can cause tardive dyskinesia and other extrapyramidal symptoms with prolonged use. Regular monitoring of blood levels, renal function, and symptoms is recommended. Do not use for longer than prescribed without medical supervision.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Dietary changes, weight loss, and elevating the head of the bed can reduce reflux symptoms.
Evidence: Well-establishedPantoprazole or esomeprazole may be used if Rabeprazole is not suitable.
Evidence: Well-establishedDomperidone or metoclopramide may be alternatives to Levosulpiride.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are scheduled for any vaccination, inform your healthcare provider about all medicines you are taking.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in the original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight and moisture
❌ DON'T
Do not store in the bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after the expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Store it in a cool, dry place away from direct sunlight. If crossing time zones, continue taking your dose at the same local time as much as possible; consult your doctor for specific advice. Keep enough supply for your entire trip and carry it in your hand luggage to avoid loss. Check customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling relief from symptoms within a few days, but maximum benefit may take 1 to 2 weeks of regular use.
A: It is best taken on an empty stomach, about 30 minutes before breakfast, unless your doctor advises otherwise.
A: If you remember within 12 hours, take it as soon as possible. If more than 12 hours have passed, skip the missed dose and continue with your regular schedule. Do not double dose.
A: Avoid high-fat meals, caffeine, and alcohol as they can worsen your symptoms and interfere with the medicine.
A: Do not stop without consulting your doctor. Stopping abruptly may cause symptoms to return. Your doctor will advise on the duration of treatment.
🤔 Common Patient Concerns
🔄 Substitutes for ropraz ls 75mg/20mg tablet
View AllAlternative brands with exact same active ingredient:
-
lavirabe ls 75mg/20mg capsuleLavish Biotech ₹17.81 51.3% CHEAPER
-
rabeyog tabletVotary Laboratories I Ltd ₹22.50 38.5% CHEAPER
-
davazole l 75mg/20mg capsule srDavaindia Generic Pharmacy ₹40.00 9.4% COSTLIER
-
raberide-ls capsule srZeelab Pharmacy Pvt Ltd ₹45.00 23.1% COSTLIER
-
ripro l 75mg/20mg capsule srVimac Healthcare ₹51.56 41% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken for any stomach problem.
Fact: This medicine is specifically for acid reflux and motility disorders. It is not for all stomach problems and should be used only as prescribed. - Myth: It is safe to take this medicine long-term without monitoring.
Fact: Long-term use requires monitoring for side effects such as vitamin B12 deficiency, bone fractures, and magnesium imbalance. - Myth: You can stop this medicine as soon as you feel better.
Fact: You should complete the prescribed course. Stopping early may cause symptoms to return. Consult your doctor before stopping.
🔄 Alternative Options
Generic Alternatives
- Levosulpiride + Rabeprazole combination generics