actorab-d capsule sr - Domperidone (30mg) + Rabeprazole (20mg) medicine

Domperidone 30mg + Rabeprazole 20mg: Comprehensive Medical Guide

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🏭 Fitwel Pharmaceuticals Private Limited 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 21, 2026
⚠️ Hepatotoxicity Risk 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: B
Reviewed by
SaathiMed Expert Panel | Sep 21, 2026

What is actorab-d capsule sr used for?

Domperidone 30mg + Rabeprazole 20mg is a combination medicine used to treat gastroesophageal reflux disease (GERD). Domperidone improves stomach motility and prevents reflux, while rabeprazole reduces stomach acid. It is taken once daily before breakfast. Common side effects include dry mouth, headache, and diarrhea. It may cause QT prolongation; use with caution in patients with heart conditions.

  • Generic Name: Domperidone + Rabeprazole
  • Manufacturer: Fitwel Pharmaceuticals Private Limited
  • Form: Allopathy
  • Pregnancy Category: Category C
  • Prescription Required: Yes
💡 Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

💊 actorab-d capsule sr Uses & Benefits

  • This combination is primarily used for the management of gastroesophageal reflux disease (GERD) with associated dysmotility symptoms, such as heartburn, regurgitation, and nausea.
  • It is also indicated for the treatment of functional dyspepsia, where both acid suppression and prokinetic effects are beneficial.
  • Additionally, it may be used in the management of gastroparesis, particularly in diabetic patients, to improve gastric emptying and reduce symptoms like early satiety, bloating, and vomiting.

Off-label uses: Off-label uses include the treatment of chronic hiccups, cyclic vomiting syndrome, and as an adjunct in the management of refractory nausea and vomiting in palliative care. However, evidence for these uses is limited and should be considered only under specialist guidance.

Primary treatment for: Gastroesophageal reflux disease (GERD)

Also treats: Functional dyspepsia, Gastroparesis

📋 Drug Information

Generic Name(s)Domperidone + Rabeprazole
Brand NameAcera-D Capsule SR
ManufacturerFitwel Pharmaceuticals Private Limited
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassGastrointestinal agents
Action ClassProkinetic agent + Proton pump inhibitor
Route of AdministrationOral
StorageStore at room temperature (20-25°C), protected from light and moisture. Keep out of reach of children.
Shelf Life2 years
WHO GuidelineWHO Model List of Essential Medicines: Rabeprazole is not listed; Domperidone is listed as an antiemetic.
ICMR GuidelineICMR guidelines for GERD management recommend PPI plus prokinetic in selected cases.

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionDomperidone is rapidly absorbed after oral administration, with peak plasma concentrations occurring within 30-60 minutes. Rabeprazole is also rapidly absorbed, with peak plasma levels reached in 2-5 hours. Food delays absorption of both drugs.
DistributionDomperidone is widely distributed in tissues but has poor penetration into the central nervous system due to P-glycoprotein efflux. Rabeprazole is extensively distributed with a volume of distribution of about 0.34 L/kg.
Protein BindingDomperidone: 91-93% bound to plasma proteins; Rabeprazole: 96% bound to plasma proteins.
MetabolismDomperidone undergoes extensive hepatic metabolism via CYP3A4 and CYP2D6 to inactive metabolites. Rabeprazole is metabolized primarily by CYP2C19 and CYP3A4 to inactive metabolites.
Half-LifeDomperidone: 7-9 hours; Rabeprazole: 1-2 hours.
ExcretionDomperidone is excreted mainly in feces (66%) and urine (32%). Rabeprazole is excreted primarily in urine (90%) as metabolites, with the remainder in feces.
BioavailabilityDomperidone: 13-17% (oral); Rabeprazole: 52% (oral).
Onset of ActionDomperidone: 30-60 minutes; Rabeprazole: 1-2 hours (maximal effect after 2-4 days).
Peak Plasma TimeDomperidone: 0.5-1 hour; Rabeprazole: 2-5 hours.
Duration of ActionDomperidone: 8-12 hours; Rabeprazole: 24 hours (acid suppression).

How It Works

Domperidone is a peripheral dopamine D2 receptor antagonist that increases gastrointestinal motility by blocking inhibitory dopamine receptors in the gut. It enhances lower esophageal sphincter pressure, improves gastric emptying, and coordinates antral and duodenal contractions. Rabeprazole is a proton pump inhibitor that accumulates in the acidic environment of gastric parietal cells, where it is activated and irreversibly binds to the H+/K+ ATPase enzyme, inhibiting acid secretion. This dual action provides both symptomatic relief and healing of erosive esophagitis.

Mechanism Steps

1Domperidone blocks dopamine D2 receptors in the gastrointestinal tract, increasing peristalsis and lower esophageal sphincter tone.
2Rabeprazole is absorbed and concentrated in gastric parietal cells, where it is protonated and converted to its active form.
3Active rabeprazole binds covalently to the H+/K+ ATPase enzyme, irreversibly inhibiting acid secretion.

💡 How to Take actorab-d capsule sr

1Take the tablet whole with a glass of water, preferably before breakfast.
2Do not crush or chew the tablet.
3If you miss a dose, take it as soon as you remember unless it's almost time for the next dose.

Dosage Information

Adult DosageOne tablet (domperidone 30mg + rabeprazole 20mg) once daily, preferably before breakfast. Maximum duration: 4 weeks.
Pediatric DosageNot recommended for children under 12 years of age.
Elderly DosageSame as adult dosage, but monitor for adverse effects, especially QT prolongation and electrolyte disturbances.
Renal ImpairmentNo dose adjustment required for mild to moderate renal impairment. Use with caution in severe renal impairment.
Hepatic ImpairmentContraindicated in severe hepatic impairment. Use with caution in moderate impairment; consider dose reduction.
Maximum Daily DoseDomperidone: 30mg; Rabeprazole: 20mg (as per combination).

Dosage Timeline

🌅 Morning ✅ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

⚠️ Side Effects of actorab-d capsule sr

✅ Common Side Effects

Dry mouth
Headache
Diarrhea
Abdominal pain
Flatulence
Constipation
Dizziness
Asthenia
Rash

🚨 Serious Side Effects

QT prolongation
Ventricular arrhythmias
Clostridium difficile infection
Hypomagnesemia
Interstitial nephritis
Gynecomastia
Galactorrhea

⚠️ Rare Side Effects

Anaphylaxis
Angioedema
Stevens-Johnson syndrome
Toxic epidermal necrolysis
Hepatic enzyme elevation
Agranulocytosis
Thrombocytopenia

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Ketoconazole Major Increased risk of QT prolongation and arrhythmias
Clarithromycin Major Increased domperidone levels and QT prolongation risk
Warfarin Moderate Increased INR and bleeding risk (rabeprazole may potentiate warfarin)
Digoxin Moderate Increased digoxin levels due to pH changes (rabeprazole)
Sucralfate Minor Reduced absorption of rabeprazole; separate by 30 minutes

🚨 Major Interactions

  • Ketoconazole
  • Itraconazole
  • Clarithromycin
  • Erythromycin
  • Fluconazole
  • Ritonavir
  • Saquinavir
  • Amiodarone
  • Quinidine
  • Sotalol

⚡ Moderate Interactions

  • Cimetidine
  • Ranitidine
  • Digoxin
  • Warfarin
  • Diazepam
  • Phenytoin
  • Theophylline
  • Methotrexate
  • Cyclosporine
  • Tacrolimus

🍷 Alcohol Interaction

Alcohol may worsen GERD symptoms and increase the risk of gastrointestinal side effects. Avoid alcohol during treatment.

🛡️ Safety & Warnings

🚫 Contraindications

Contraindicated in patients with known hypersensitivity to domperidone, rabeprazole, or any excipients. Also contraindicated in patients with gastrointestinal hemorrhage, mechanical obstruction, or perforation. Domperidone is contraindicated in patients with prolonged QT interval, significant electrolyte disturbances, or concomitant use of QT-prolonging drugs. Rabeprazole is contraindicated in patients with severe hepatic impairment.

⚠️ Warnings & Precautions

Domperidone may cause QT prolongation and ventricular arrhythmias, especially at high doses or in patients with risk factors (e.g., electrolyte imbalance, bradycardia, concomitant QT-prolonging drugs). Use lowest effective dose and shortest duration. Rabeprazole may increase risk of Clostridium difficile infection, hypomagnesemia, and vitamin B12 deficiency with long-term use. Bone fracture risk may be increased with high-dose or prolonged PPI use. Monitor renal function and electrolytes periodically. Discontinue if signs of interstitial nephritis occur. Avoid abrupt discontinuation; taper if used long-term.

🤱 Lactation Safety

Domperidone is excreted in breast milk and may cause adverse effects in the infant. Rabeprazole is l

💊 Overdose Management

Overdose may cause extrapyramidal reactions (domperidone) and drowsiness, confusion, or blurred vision (rabeprazole). Treatment is symptomatic and supportive. Gastric lavage may be considered if ingestion is recent. Activated charcoal may reduce absorption. Monitor ECG for QT prolongation. Extrapyramidal symptoms may be treated with anticholinergic agents.

⏰ Missed Dose

Take the missed dose as soon as remembered. If it is almost time for the next dose, skip the missed dose and continue the regular schedule. Do not double the dose.

🔄 Substitutes for actorab-d capsule sr

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Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can be taken with any antacid.
    Fact: Antacids can reduce absorption of rabeprazole; separate by at least 30 minutes.
  • Myth: Domperidone is safe for all ages.
    Fact: Domperidone is not recommended for children under 12 due to risk of extrapyramidal effects and QT prolongation.

🔄 Alternative Options

Generic Alternatives

  • Domperidone + Rabeprazole
  • Domperidone + Pantoprazole
  • Domperidone + Omeprazole

Brand Alternatives

  • Rabeloc-D
  • Razo-D
  • Rabemac-D
  • Zoleri-D

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