Avonza Tablet: Complete Guide to Uses, Side Effects, and Safety
When to Call Your Doctor IMMEDIATELY
- Rapid breathing, extreme tiredness, or muscle pain that may indicate lactic acidosis.
- Yellowing of the skin or eyes, dark urine, or severe abdominal pain suggesting liver problems.
- Decreased urination, swelling in the legs, or bone pain indicating kidney issues.
- Severe upper abdominal pain radiating to the back, with nausea and vomiting, suggesting pancreatitis.
- Rash with blisters, peeling skin, or sores in the mouth, which may be a severe allergic reaction.
- New or worsening symptoms of infection such as fever, cough, or difficulty breathing.
- Sudden weight loss or persistent diarrhea.
If experiencing severe symptoms, call emergency services immediately.
What is avonza tablet used for?
This medicine is a combination of lamivudine and tenofovir disoproxil fumarate used to treat HIV-1 infection in adults. It works by blocking the virus from multiplying. It is taken once daily by mouth and must be used with other antiretroviral drugs. Regular monitoring of kidney and liver function is important.
- Generic Name: Lamivudine + Tenofovir disoproxil fumarate
- Manufacturer: Mylan Pharmaceuticals Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 avonza tablet के बारे में (Hindi Summary)
उपयोग: यह दवा लैमिवुडीन और टेनोफोविर डाइसोप्रोक्सिल फ्यूमरेट का संयोजन है, जिसका उपयोग एचआईवी-1 संक्रमण के इलाज के लिए किया जाता है। यह वायरस को शरीर में बढ़ने से रोकती है और प्रतिरक्षा प्रणाली को मजबूत बनाने में मदद करती है। यह दवा अन्य एंटीरेट्रोवायरल दवाओं के साथ मिलकर काम करती है और इसे रोज एक बार मुँह से लिया जाता है। यह दवा एचआईवी का इलाज नहीं है, लेकिन इसे नियमित रूप से लेने से वायरस नियंत्रण में रहता है और जीवन की गुणवत्ता बेहतर होती है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में सिरदर्द, जी मिचलाना, दस्त, पेट में परेशानी, थकान और नींद न आना शामिल हैं। ये आमतौर पर शुरुआती कुछ हफ्तों में ठीक हो जाते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन इनमें गुर्दे की समस्या, लैक्टिक एसिडोसिस, यकृत की समस्या और हड्डियों में दर्द शामिल हो सकते हैं। यदि आपको सांस लेने में तकलीफ, अत्यधिक थकान, पेशाब कम आना, आँखों या त्वचा का पीला पड़ना, या पेट में तेज दर्द हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को अपने डॉक्टर के बताए अनुसार ही लें, रोज एक ही समय पर, खाने के साथ या बिना। कोई भी खुराक न छोड़ें और न ही अधिक मात्रा में लें। नियमित रूप से खून की जांच कराते रहें ताकि गुर्दे और यकृत की कार्यप्रणाली की निगरानी हो सके। शराब से बचें क्योंकि इससे यकृत की समस्या बढ़ सकती है। यह दवा किसी और के साथ साझा न करें। यदि आप गर्भवती हैं या स्तनपान करा रही हैं, तो डॉक्टर से सलाह लें। एचआईवी को दूसरों तक फैलने से रोकने के लिए सुरक्षित यौन संबंध बनाएं।
💊 avonza tablet Uses & Benefits
[{"condition":"Human immunodeficiency virus type 1 infection","description":"Used as part of combination antiretroviral therapy to suppress viral replication, increase CD4 cell counts, and reduce the risk of AIDS-related illnesses.","evidence":"Well-established"},{"condition":"Chronic hepatitis B infection","description":"Lamivudine and tenofovir disoproxil fumarate both have activity against hepatitis B virus, and this combination may be used in certain patients with HIV and hepatitis B coinfection.","evidence":"Well-established for coinfection; specialist use only"}]
Off-label uses: [{"condition":"HIV pre-exposure prophylaxis","description":"Sometimes used off-label as part of a prevention strategy in high-risk individuals, but only under specialist supervision and never as a sole agent.","evidence":"Limited"}]
Primary treatment for: Human immunodeficiency virus type 1 infection
Also treats: Chronic hepatitis B infection
📋 Drug Information
| Generic Name(s) | Lamivudine + Tenofovir disoproxil fumarate |
| Brand Name | Avonza Tablet |
| Manufacturer | Mylan Pharmaceuticals Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Nucleoside Reverse Transcriptase Inhibitors (NRTIs) |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Keep in the original container tightly closed. Protect from moisture and heat. Do not refrigerate. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | The World Health Organization recommends tenofovir disoproxil fumarate plus lamivudine as part of first-line antiretroviral therapy for adults and adolescents living with HIV. This combination is included in the WHO 2021 consolidated guidelines on HIV prevention, testing, treatment, service delivery and monitoring. |
| ICMR Guideline | The Indian Council of Medical Research guidelines for HIV care recommend tenofovir disoproxil fumarate plus lamivudine as a preferred nucleoside reverse transcriptase inhibitor backbone in combination with an integrase inhibitor or efavirenz for first-line antiretroviral therapy in adults. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two antiretroviral drugs that inhibit the reverse transcriptase enzyme of HIV. Lamivudine is a nucleoside analogue that is phosphorylated inside cells to its active triphosphate form, which competes with natural nucleotides and causes chain termination during viral DNA synthesis. Tenofovir disoproxil fumarate is a prodrug that is converted to tenofovir, a nucleotide analogue that also inhibits reverse transcriptase and acts as a chain terminator. Together they reduce viral replication and lower the viral load.
Mechanism Steps
💡 How to Take avonza tablet
Strength: Tablet containing lamivudine 300 mg and tenofovir disoproxil fumarate 300 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet (lamivudine 300 mg and tenofovir disoproxil fumarate 300 mg) taken orally once daily, with or without food. This dose is for patients with normal kidney function. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. For patients with kidney problems, the dose or dosing interval may need adjustment. Do not change your dose without consulting your doctor. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may have reduced kidney function, so the dose should be adjusted based on creatinine clearance. Regular monitoring of kidney function is recommended. Dose must be individualized by a qualified clinician. |
| Renal Impairment | For patients with creatinine clearance 30-49 mL/min, the dose may be adjusted to one tablet every 48 hours. For creatinine clearance 15-29 mL/min, one tablet every 72 hours. For patients on hemodialysis, one tablet after each dialysis session. Dose must be individualized by a qualified clinician based on renal function. |
| Hepatic Impairment | No dose adjustment is required for mild to moderate hepatic impairment. However, caution is advised in patients with severe hepatic impairment. Monitor liver function closely. Dose must be individualized by a qualified clinician. |
| Maximum Daily Dose | One tablet (lamivudine 300 mg and tenofovir disoproxil fumarate 300 mg) once daily. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of avonza tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Adefovir | Major | |
| Didanosine | Major | |
| NSAIDs | Major | |
| Aminoglycosides | Major | |
| Amphotericin B | Major | |
| Ciclosporin | Major | |
| Tacrolimus | Major | |
| Trimethoprim-sulfamethoxazole | Moderate | |
| Ribavirin | Moderate | |
| Probenecid | Moderate |
🚨 Major Interactions
- Adefovir dipivoxil
- Didanosine
- Nephrotoxic drugs (e.g., aminoglycosides, amphotericin B, ciclosporin, tacrolimus, NSAIDs)
⚡ Moderate Interactions
- Trimethoprim-sulfamethoxazole
- Ribavirin
- Probenecid
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine because it can increase the risk of liver damage and may worsen side effects such as nausea and fatigue. If you have a history of alcohol abuse, discuss this with your doctor before starting treatment.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to lamivudine, tenofovir disoproxil fumarate, or any component of the formulation","Severe renal impairment (creatinine clearance less than 30 mL/min) not on dialysis","Use as monotherapy for HIV infection"]
⚠️ Warnings & Precautions
["Lactic acidosis and severe hepatomegaly with steatosis have been reported with nucleoside analogues, including this medicine. Fatal cases have occurred. Discontinue if lactic acidosis or hepatotoxicity is suspected.","Severe acute exacerbations of hepatitis B have been reported in patients coinfected with hepatitis B virus who have discontinued this medicine. Monitor liver function closely for several months after stopping.","New onset or worsening renal impairment, including Fanconi syndrome, has been reported. Avoid use with other nephrotoxic agents. Monitor renal function.","Bone loss and osteomalacia have been reported with tenofovir disoproxil fumarate. Consider monitoring bone mineral density in patients with a history of fractures or risk factors.","Immune reconstitution syndrome may occur, leading to inflammatory responses to opportunistic infections. Monitor and treat as needed.","Redistribution or accumulation of body fat has been observed in patients receiving antiretroviral therapy.","This medicine is not a cure for HIV and does not prevent transmission of HIV to others. Practice safer sex."]
🤱 Lactation Safety
Both lamivudine and tenofovir are excreted in breast milk. The World Health Organization recommends that women living with HIV in resource-limited settings continue antiretroviral therapy while breastfeeding to reduce the risk of transmission. In other settings, formula feeding may be recommended. Discuss with your doctor.
💊 Overdose Management
There is no specific antidote for overdose with this medicine. If an overdose occurs, seek immediate medical attention. Treatment should be symptomatic and supportive. Hemodialysis may be used to remove lamivudine and tenofovir from the blood, but its clinical benefit is uncertain.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose. If you are unsure, contact your doctor or pharmacist.
Additional Safety Advice
Take this medicine exactly as your doctor prescribes, at the same time each day, with or without food. Do not skip doses and do not take more than the prescribed amount. Keep all laboratory appointments because regular blood tests are needed to check kidney function, liver enzymes, and viral load. Tell your doctor if you have kidney disease, liver disease, hepatitis B, or bone problems before starting this medicine. Avoid alcohol because it can increase the risk of liver problems. Do not share this medicine with anyone else, even if they have similar symptoms. If you are pregnant, planning pregnancy, or breastfeeding, talk to your doctor about the best treatment options. Use condoms during sex to prevent passing HIV to others and to protect yourself from other infections. Store this medicine at room temperature away from moisture and heat. If you miss a dose, take it as soon as you remember unless it is almost time for the next dose; never double the dose.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may have reduced kidney function, so the dose should be adjusted based on creatinine clearance. Regular monitoring of kidney function is recommended. Elderly patients may also be more susceptible to bone loss and should have bone health assessed.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, discuss your treatment with your doctor. This medicine is considered safe during pregnancy, but your regimen may need to be adjusted. Continue taking your medicine unless your doctor advises otherwise. Effective treatment reduces the risk of passing HIV to your baby.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine before any surgery. Continue taking it as prescribed unless told otherwise. Monitor for any signs of infection or delayed healing after surgery.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. Maintain good oral hygiene to prevent infections. If you have bleeding gums or mouth sores, consult your dentist.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Moderate exercise is generally safe and beneficial while taking this medicine. However, if you experience bone pain, muscle weakness, or fatigue, consult your doctor before starting a new exercise regimen. Avoid high-impact activities if you have bone loss.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause fatigue, headache, or nausea, especially when starting treatment. These effects usually improve over time. If you feel dizzy or unusually tired, avoid driving or operating heavy machinery until you know how the medicine affects you. Most people can continue their normal daily activities.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. Stopping suddenly can cause the virus to become resistant and lead to treatment failure. If you experience severe side effects, contact your doctor immediately; they may adjust your treatment. If you have hepatitis B, stopping this medicine can cause a severe flare of hepatitis.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to kidney problems, decreased bone mineral density, and changes in body fat distribution. Regular monitoring of kidney function, bone health, and viral load is essential. Some patients may experience persistent fatigue or gastrointestinal symptoms. The benefits of continued viral suppression generally outweigh these risks. Your doctor will adjust your treatment if needed.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
An alternative dual NRTI backbone with potentially less kidney and bone toxicity.
Evidence: Well-establishedAn alternative for patients with kidney problems, but requires HLA-B*5701 testing before use.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Patients taking this medicine should receive routine vaccinations as recommended, including influenza, pneumococcal, and hepatitis B vaccines. Live vaccines should be avoided if you have severe immunosuppression. Discuss with your doctor before receiving any vaccine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C).
❌ DON'T
Do not refrigerate.
✅ DO
Keep in the original container tightly closed.
❌ DON'T
Do not transfer to unmarked containers.
✅ DO
Keep away from direct sunlight and moisture.
❌ DON'T
Do not store in the bathroom.
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Carry enough supply to last your entire trip, plus extra in case of delays. Store at room temperature and protect from extreme heat or moisture. If crossing time zones, continue taking your dose at the same time each day according to your home schedule, or adjust gradually with your doctor's advice. Check customs regulations for carrying prescription medicines into your destination country.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts reducing the virus within days, but a significant drop in viral load is usually seen within 2 to 4 weeks. Maximum suppression may take several months.
A: Yes, you can take this medicine with or without food. Food does not significantly affect its absorption.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: This medicine is considered safe during pregnancy when prescribed by a doctor. The benefits of treating HIV generally outweigh the risks. However, it should only be used under specialist care.
A: No, you must not stop taking this medicine without consulting your doctor. Stopping can cause the virus to rebound and become resistant, and if you have hepatitis B, it can cause a severe flare.
🤔 Common Patient Concerns
🔄 Substitutes for avonza tablet
View AllAlternative brands with exact same active ingredient:
-
Tavin LN KitEmcure Pharmaceuticals Ltd ₹68.00 97% CHEAPER
-
tenolam-ar kitHetero Drugs Ltd ₹140.63 93.7% CHEAPER
-
virofovir 300 mg/300 mg tabletSun Pharmaceutical Industries Ltd ₹781.25 65% CHEAPER
-
viro 4 kitEmcure Pharmaceuticals Ltd ₹828.50 62.9% CHEAPER
-
Ricovir L Tablet 300mg/300mgMylan Pharmaceuticals Pvt Ltd ₹1,172.81 47.5% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure HIV.
Fact: This medicine cannot cure HIV. It controls the virus and helps the immune system recover, but treatment must be continued lifelong. - Myth: I can stop taking this medicine once my viral load is undetectable.
Fact: Stopping this medicine can cause the virus to rebound and become resistant. You must continue treatment as prescribed. - Myth: This medicine can be taken alone to treat HIV.
Fact: This medicine must be used as part of a combination regimen with at least one other antiretroviral drug from a different class.
🔄 Alternative Options
Generic Alternatives
- Lamivudine 300 mg + Tenofovir disoproxil fumarate 300 mg tablet
Brand Alternatives
- Avonza Tablet