Andulfa 100mg Injection (Anidulafungin): Complete Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or shortness of breath during or after infusion
- Swelling of the face, lips, tongue, or throat
- Severe rash, blistering, or peeling skin
- Yellowing of the skin or eyes, dark urine, or severe abdominal pain
- Chest pain or irregular heartbeat
- Severe dizziness or fainting
- Unusual bleeding or bruising
- Persistent vomiting or inability to keep fluids down
If experiencing severe symptoms, call emergency services immediately.
What is anidulan injection used for?
This medicine is an intravenous antifungal used to treat serious fungal infections such as candidemia and invasive candidiasis. It works by breaking down the fungal cell wall, leading to fungal cell death. It is given by a healthcare professional, usually once daily after an initial loading dose.
- Generic Name: Anidulafungin
- Manufacturer: Mylan Pharmaceuticals Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 anidulan injection के बारे में (Hindi Summary)
उपयोग: यह दवा एक एंटीफंगल इंजेक्शन है जिसका इस्तेमाल गंभीर फंगल संक्रमणों के इलाज के लिए किया जाता है, खासकर कैंडिडेमिया और इनवेसिव कैंडिडियासिस में। यह फंगस की कोशिका की दीवार को तोड़कर उसे मार देती है। यह दवा केवल अस्पताल में डॉक्टर या नर्स द्वारा नस के माध्यम से दी जाती है। इसे घर पर खुद से नहीं लगाया जा सकता।
साइड इफेक्ट्स: इस दवा के आम दुष्प्रभावों में दस्त, जी मिचलाना, उल्टी, सिरदर्द, बुखार और पोटैशियम की कमी शामिल हैं। कुछ मरीजों में चकत्ते, खुजली या इंजेक्शन की जगह पर लालिमा भी हो सकती है। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन अगर सांस लेने में तकलीफ, चेहरे या गले में सूजन, पीलिया या गंभीर पेट दर्द हो तो तुरंत डॉक्टर को बताएं।
सुरक्षा सलाह: यह दवा केवल अस्पताल में प्रशिक्षित स्वास्थ्यकर्मी द्वारा ही दी जानी चाहिए। इसे घर पर खुद से न लगाएं। इलाज से पहले अपने डॉक्टर को अपनी सभी बीमारियों, दवाओं और एलर्जी के बारे में बताएं। इलाज के दौरान लिवर, किडनी और खून की जांच करवाते रहें। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर से सलाह लें। कोई भी नया लक्षण दिखने पर तुरंत डॉक्टर को सूचित करें।
💊 anidulan injection Uses & Benefits
[{"condition":"Candidemia and other forms of invasive candidiasis","description":"This medicine is used to treat serious bloodstream and deep-tissue infections caused by Candida species in adults and in some children.","evidence":"Well-established"},{"condition":"Esophageal candidiasis","description":"It may be used as an alternative treatment for Candida infection of the esophagus when other antifungals are not suitable.","evidence":"Established"},{"condition":"Intra-abdominal candidiasis","description":"It is used in some patients with Candida infection inside the abdomen, often as part of a broader treatment plan.","evidence":"Established"},{"condition":"Empirical antifungal therapy in febrile neutropenia","description":"In selected high-risk patients with persistent fever and low white blood cell counts, this medicine may be used when a fungal infection is suspected.","evidence":"Limited"}]
Off-label uses: [{"condition":"Aspergillus infections in patients who cannot tolerate other antifungals","description":"Sometimes used off-label for invasive aspergillosis when first-line treatments are not effective or not tolerated.","evidence":"Limited"},{"condition":"Prophylaxis in high-risk transplant patients","description":"Occasionally considered off-label to prevent fungal infections in certain very high-risk patients, but this is not a standard approved use.","evidence":"Limited"}]
Primary treatment for: Invasive candidiasis and candidemia
Also treats: Esophageal candidiasis, Intra-abdominal candidiasis, Empirical antifungal therapy in febrile neutropenia
📋 Drug Information
| Generic Name(s) | Anidulafungin |
| Brand Name | Andulfa 100mg Injection |
| Manufacturer | Mylan Pharmaceuticals Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Fungal cell wall synthesis inhibitor (Echiocandins) |
| Route of Administration | Intravenous (IV) infusion only. This medicine must be prepared and administered by a qualified healthcare professional |
| Storage | Store unopened vials in the refrigerator at 2°C to 8°C (36°F to 46°F). Do not freeze. The reconstituted solution should be used immediately, but if not used immediately, it may be stored at room temperature for up to 24 hours. Protect from light. |
| Shelf Life | The shelf life of the unopened vial is typically 24 to 36 months from the date of manufacture. Check the expiry date on the vial before use. Once reconstituted, use within the time specified by the manufacturer. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine belongs to the echinocandin class of antifungals. It works by non-competitively inhibiting the enzyme beta-1,3-D-glucan synthase, which is responsible for making beta-1,3-D-glucan, an essential building block of the fungal cell wall. When this building block is missing, the fungal cell wall becomes weak and unstable, leading to loss of cell integrity, leakage of cell contents, and ultimately fungal cell death. Because human cells do not have a cell wall or beta-1,3-D-glucan, this medicine is selectively toxic to susceptible fungi such as Candida species, including many strains that are resistant to azole antifungals.
Mechanism Steps
💡 How to Take anidulan injection
Strength: Each vial contains 100 mg of anidulafungin as a sterile lyophilized powder for intravenous infusion.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is a single 200 mg loading dose on day 1, followed by 100 mg once daily starting on day 2. The dose is given as a slow intravenous infusion over at least 1.5 to 3 hours. The duration of treatment depends on the type and severity of the infection and the patient's clinical response. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | No dose adjustment is required for elderly patients based on age alone. However, elderly patients may have reduced liver or kidney function, so dose must be individualized by a qualified clinician based on clinical status and organ function. |
| Renal Impairment | No dose adjustment is required for patients with mild to severe renal impairment, including those on dialysis. However, dose must be individualized by a qualified clinician based on the patient's overall condition. |
| Hepatic Impairment | No dose adjustment is required for patients with mild to moderate hepatic impairment. For patients with severe hepatic impairment, use with caution and monitor closely. Dose must be individualized by a qualified clinician. |
| Maximum Daily Dose | The maximum recommended daily dose is 100 mg after the initial 200 mg loading dose on day 1. Do not exceed the dose prescribed by your doctor. |
Dosage Timeline
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of anidulan injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Cyclosporine | Moderate | |
| Tacrolimus | Moderate | |
| Amphotericin B | Minor | |
| Voriconazole | Minor |
🚨 Major Interactions
- Other echinocandin antifungals
⚡ Moderate Interactions
- Cyclosporine
- Tacrolimus
🍷 Alcohol Interaction
There is no known direct interaction between this medicine and alcohol. However, because this medicine is used for serious infections and is given in a hospital setting, alcohol should be avoided during treatment unless your doctor says it is safe.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known serious hypersensitivity to anidulafungin or any other echinocandin antifungal","Known serious allergic reaction to any component of this medicine"]
⚠️ Warnings & Precautions
["This medicine must be administered only by a healthcare professional.","Serious allergic reactions, including anaphylaxis, have been reported. Stop the infusion and seek immediate medical help if a reaction occurs.","Abnormal liver function tests have been reported. Monitor liver enzymes in patients with liver disease.","Infusion-related reactions may occur; monitor vital signs during infusion.","Use with caution in patients with kidney disease.","Safety and effectiveness in children have not been fully established for all indications; consult a pediatrician.","Tell your doctor about all other medicines you are taking, including over-the-counter and herbal products."]
🤱 Lactation Safety
It is not known whether this medicine passes into human breast milk. Because many medicines are excreted in breast milk, breastfeeding should be discontinued or the medicine should be stopped, taking into account the importance of the medicine to the mother. Consult your doctor for guidance.
💊 Overdose Management
There is limited information on overdose with this medicine. In case of suspected overdose, stop the infusion and provide supportive care. Contact a poison control center or emergency department immediately. Because this medicine is given in a hospital setting, overdose is unlikely, but if it occurs, the patient should be monitored closely for any adverse effects.
⏰ Missed Dose
This medicine is given by a healthcare professional, so a missed dose is unlikely. If a dose is missed, contact your doctor or nurse as soon as possible. Do not try to take an extra dose to make up for the missed one. Your healthcare team will adjust the schedule as needed.
Additional Safety Advice
This medicine must only be given by a qualified healthcare professional through an intravenous line. Do not attempt to use it at home or adjust the dose yourself. Before treatment, tell your doctor about all your medical conditions, especially liver disease, heart problems, or any previous allergic reaction to antifungal medicines. Also inform your doctor about all other medicines, vitamins, and herbal supplements you take, because some medicines can interact with this product. While receiving this medicine, your doctor may order blood tests to check your liver, kidney, and blood cell counts. Report any new symptoms such as fever, chills, rash, swelling, difficulty breathing, or yellowing of the skin or eyes immediately. If you are pregnant, planning pregnancy, or breastfeeding, discuss the risks and benefits with your doctor before starting treatment. Keep all follow-up appointments and do not stop treatment early unless your doctor tells you to.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may have reduced liver or kidney function. No dose adjustment is required based on age alone, but your doctor will individualize the dose based on your overall health and organ function. Monitor for side effects closely.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, discuss with your doctor before starting this medicine. There are no adequate studies in pregnant women. Use effective contraception during treatment and consult your doctor if you become pregnant.
🏥 Post-Surgery Considerations
This medicine may be used after surgery if a fungal infection is suspected or confirmed. Your surgical team will coordinate with infectious disease specialists. Monitor for signs of infection and follow post-operative care instructions.
🦷 Dental Procedures
Inform your dentist that you are receiving this medicine before any dental procedure. There are no specific restrictions, but your dentist may consult your doctor if you have a serious infection.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While receiving this medicine, you may feel tired or weak. Avoid strenuous exercise until you have recovered from the infection. Light activity such as walking may be helpful, but consult your doctor before starting any exercise routine.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is given in a hospital or clinic, so you will need to take time off work during treatment. You may feel tired or unwell while recovering from a serious infection. Avoid driving or operating heavy machinery if you feel dizzy or weak. Discuss your return to work with your doctor.
🛑 When to Stop This Medicine
Do not stop this medicine without your doctor's advice. Your doctor will decide when to stop based on your clinical response and test results. If you experience serious side effects, your doctor may stop the medicine or change the treatment.
📅 Long-Term Use Effects
Long-term use of this medicine is generally not required for most patients, as treatment duration is based on the infection. Prolonged use may increase the risk of liver enzyme abnormalities and rare side effects. Your doctor will monitor your liver and kidney function during treatment. If you need long-term therapy, regular follow-up and blood tests are important.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Micafungin and caspofungin are alternatives in the same class.
Evidence: Well-establishedFluconazole or voriconazole may be used for some Candida infections, depending on susceptibility.
Evidence: Well-establishedAmphotericin B is an alternative for serious fungal infections but has more side effects.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, live vaccines should be avoided during treatment for serious infections. Consult your doctor about vaccination timing.
📦 Storage Guide
✅ DO
Store unopened vials in the refrigerator at 2°C to 8°C.
❌ DON'T
Do not freeze the vials.
✅ DO
Keep the vial in its original carton to protect from light.
❌ DON'T
Do not store at room temperature for long periods before reconstitution.
✅ DO
Use the reconstituted solution within the time specified by the manufacturer.
❌ DON'T
Do not use if the solution is cloudy or contains particles.
✈️ Traveling with This Medicine
This medicine is given in a hospital or clinic setting, so travel is usually not applicable during treatment. If you need to travel after completing treatment, carry a copy of your prescription and medical records. Store any remaining medicine as directed by your doctor. If you are traveling with this medicine, keep it in its original packaging and carry a doctor's letter explaining that it is for a serious medical condition. Check customs regulations for carrying prescription medicines across borders.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Clinical improvement usually begins within a few days, but the full course may last several weeks depending on the infection.
A: Yes, you can eat and drink normally unless your doctor advises otherwise. There are no known food interactions.
A: Yes, your doctor may order blood tests to monitor liver function, kidney function, and blood cell counts.
A: Pediatric dosing is not established from available information. Consult a pediatrician.
🤔 Common Patient Concerns
🔄 Substitutes for anidulan injection
View AllAlternative brands with exact same active ingredient:
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dulafix 100mg injectionAlniche Life Sciences Pvt Ltd ₹8,666.66 8.8% CHEAPER
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dulaedge 100mg injectionAbbott ₹9,257.13 2.6% CHEAPER
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canidula injectionGufic Bioscience Ltd ₹9,799.00 3.1% COSTLIER
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dulazar 100mg injectionFusion Healthcare Pvt Ltd ₹9,899.00 4.2% COSTLIER
-
dulavin injectionVinder Pharma ₹9,950.00 4.7% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken as a pill.
Fact: This medicine is only available as an intravenous infusion and must be given by a healthcare professional. - Myth: This medicine is safe for all fungal infections.
Fact: This medicine is specifically used for serious Candida infections and is not effective against all types of fungi. - Myth: You can stop treatment as soon as you feel better.
Fact: You must complete the full course prescribed by your doctor to prevent the infection from returning.