Theophylline + Pyridoxine 400mg/25mg Tablet: Complete Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe nausea or vomiting that prevents keeping the medicine down
- Fast, irregular, or pounding heartbeat
- Seizures or convulsions
- Severe headache with visual changes
- Swelling of face, lips, or throat
- Difficulty breathing or chest pain
- Black or bloody stools
If experiencing severe symptoms, call emergency services immediately.
What is wirespo t 400mg/25mg tablet used for?
This medicine is a combination of theophylline, a bronchodilator, and pyridoxine (vitamin B6). It is used to treat asthma and other chronic lung conditions by relaxing the airways and making breathing easier. It is taken orally and requires regular monitoring of blood levels.
- Generic Name: Theophylline (400mg) + Vitamin B6 (Pyridoxine) (25mg)
- Manufacturer: Windlas Biotech Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 wirespo t 400mg/25mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा थियोफिलिन और विटामिन बी6 (पाइरिडोक्सिन) का संयोजन है। इसका उपयोग अस्थमा और क्रोनिक ऑब्सट्रक्टिव पल्मोनरी डिजीज (सीओपीडी) जैसी सांस की बीमारियों के इलाज में किया जाता है। यह वायुमार्ग की मांसपेशियों को आराम देकर सांस लेने में आसानी प्रदान करती है। विटामिन बी6 थियोफिलिन के कारण होने वाले तंत्रिका संबंधी दुष्प्रभावों को कम करने में मदद करता है। यह दवा मुंह से ली जाती है और इसका सेवन डॉक्टर के निर्देशानुसार ही करना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट में परेशानी, सिरदर्द, बेचैनी और नींद न आना शामिल हैं। गंभीर दुष्प्रभावों में दिल की धड़कन तेज या अनियमित होना, दौरे पड़ना और गंभीर एलर्जी प्रतिक्रिया शामिल हैं। यदि आपको कोई भी असामान्य लक्षण महसूस हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे पानी के साथ निगलें, चबाएं नहीं। इसे हर दिन एक ही समय पर लें। शराब का सेवन न करें। बिना डॉक्टर की सलाह के कोई अन्य दवा शुरू या बंद न करें। नियमित रूप से रक्त परीक्षण कराएं ताकि थियोफिलिन का स्तर जांचा जा सके। यदि आपको दिल की धड़कन तेज, गंभीर मतली या दौरे पड़ें, तो तुरंत चिकित्सा सहायता लें।
💊 wirespo t 400mg/25mg tablet Uses & Benefits
[{"condition":"Asthma (maintenance therapy)","description":"Used to prevent and control bronchospasm in patients with chronic asthma, reducing the frequency and severity of attacks.","evidence":"Well-established"},{"condition":"Chronic obstructive pulmonary disease (COPD)","description":"Helps relax airway smooth muscle and improve airflow in patients with COPD, though it is not a first-line treatment.","evidence":"Established"},{"condition":"Bronchospasm associated with chronic bronchitis","description":"Provides bronchodilation and may improve symptoms in patients with chronic bronchitis and reversible airway obstruction.","evidence":"Established"},{"condition":"Apnea of prematurity (neonatal)","description":"Theophylline has been used in premature infants to stimulate breathing, but this use requires specialized neonatal care and is not applicable to this oral adult formulation.","evidence":"Established in neonatal settings"}]
Off-label uses: [{"condition":"Athletic performance enhancement","description":"Theophylline has been misused for its stimulant effects, but this is not a medical use and is banned by many sports authorities.","evidence":"Not recommended"},{"condition":"Weight loss","description":"Some methylxanthines have been explored for weight loss, but theophylline is not approved for this purpose and carries significant risks.","evidence":"Limited and not recommended"}]
Primary treatment for: Asthma
Also treats: Chronic obstructive pulmonary disease (COPD), Chronic bronchitis, Bronchospasm
📋 Drug Information
| Generic Name(s) | Theophylline (400mg) + Vitamin B6 (Pyridoxine) (25mg) |
| Brand Name | wirespo t 400mg/25mg tablet |
| Manufacturer | Windlas Biotech Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | RESPIRATORY |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Keep away from moisture, heat, and direct sunlight. Do not refrigerate unless specifically instructed. |
| Shelf Life | Typically 24 months from the date of manufacture, but check the expiry date on the packaging. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Theophylline works by inhibiting phosphodiesterase enzymes, which increases cyclic AMP levels in airway smooth muscle cells and leads to relaxation and bronchodilation. It also blocks adenosine receptors, which contributes to both bronchodilation and central nervous system stimulation. Additionally, theophylline may improve diaphragmatic contractility and mucociliary clearance. Pyridoxine is a water-soluble vitamin that is converted to pyridoxal phosphate, a coenzyme involved in many metabolic reactions, including the synthesis of neurotransmitters. It is added to this combination to help prevent or reduce theophylline-related neurological side effects such as peripheral neuropathy.
Mechanism Steps
💡 How to Take wirespo t 400mg/25mg tablet
Strength: Each immediate-release tablet contains theophylline 400 mg and vitamin B6 (pyridoxine) 25 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet taken orally once or twice daily, depending on the prescribed regimen. However, the exact dose and frequency must be individualized by a qualified clinician based on the patient's condition, response to therapy, and serum theophylline levels. Do not adjust the dose without medical advice. The maximum daily dose should not exceed the limit set by your doctor, and regular monitoring is required to avoid toxicity. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician for appropriate dosing in children. |
| Elderly Dosage | Elderly patients may have reduced theophylline clearance and are more sensitive to its effects. Dose adjustment and close monitoring are recommended. Start with a lower dose and titrate slowly based on serum levels and clinical response. |
| Renal Impairment | Patients with renal impairment may require dose adjustment. Monitor theophylline levels and renal function regularly. Consult your doctor for individualized dosing. |
| Hepatic Impairment | Patients with hepatic impairment may have reduced theophylline metabolism and require lower doses. Close monitoring of serum levels is essential. Consult your doctor for individualized dosing. |
| Maximum Daily Dose | The maximum daily dose must be determined by a qualified clinician based on serum theophylline levels and clinical response. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of wirespo t 400mg/25mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Ciprofloxacin | Major | |
| Erythromycin | Major | |
| Propranolol | Major | |
| Phenytoin | Major | |
| Cimetidine | Moderate | |
| Oral contraceptives | Moderate | |
| Rifampin | Moderate | |
| Adenosine | Minor | |
| Benzodiazepines | Minor | |
| Caffeine | Minor |
🚨 Major Interactions
- Ciprofloxacin
- Erythromycin
- Propranolol
- Phenytoin
⚡ Moderate Interactions
- Cimetidine
- Oral contraceptives
- Rifampin
🍷 Alcohol Interaction
Alcohol may increase the risk of gastrointestinal side effects and can affect theophylline metabolism. It is best to avoid alcohol while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to theophylline, pyridoxine, or any component of the formulation","Active peptic ulcer disease","Uncontrolled seizure disorder","Severe cardiac arrhythmias","Acute asthma attack requiring rapid bronchodilation"]
⚠️ Warnings & Precautions
["Theophylline has a narrow therapeutic index; blood level monitoring is essential.","Avoid concurrent use with drugs that inhibit or induce CYP1A2 and CYP3A4 without dose adjustment.","Use with caution in patients with heart failure, liver disease, or renal impairment.","Do not crush or chew extended-release formulations; this is an immediate-release tablet, but follow your doctor's instructions.","Pyridoxine may interfere with certain laboratory tests; inform your doctor if you are scheduled for testing.","Avoid excessive caffeine intake while taking this medicine."]
🤱 Lactation Safety
Theophylline is excreted in breast milk and may cause irritability or insomnia in the nursing infant. Pyridoxine is also excreted in breast milk and is considered safe. Consult your doctor before breastfeeding while taking this medicine.
💊 Overdose Management
Overdose of theophylline can cause severe nausea, vomiting, cardiac arrhythmias, seizures, and potentially death. If you suspect an overdose, seek emergency medical attention immediately. Treatment may include activated charcoal, supportive care, and management of seizures and arrhythmias. Hemodialysis or hemoperfusion may be considered in severe cases. Pyridoxine overdose is generally not life-threatening but can cause nerve damage with chronic high doses.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not crush, chew, or split the tablet unless your doctor or pharmacist says it is safe to do so. Swallow it whole with a glass of water. Take it at the same times each day to keep blood levels steady. Avoid drinking alcohol while taking this medicine because it can increase the risk of side effects. Do not start or stop any other medicine, including over-the-counter products and herbal supplements, without checking with your doctor or pharmacist. Keep all scheduled blood tests to monitor theophylline levels and adjust your dose. If you miss a dose, follow your doctor's instructions; do not double the next dose. Store this medicine at room temperature, away from moisture and direct sunlight. Keep it out of reach of children. If you experience palpitations, severe nausea, or seizures, seek medical help immediately.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to the effects of theophylline and may have reduced clearance. Lower doses and close monitoring of serum levels are recommended. Watch for signs of toxicity such as confusion, palpitations, and nausea.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. Theophylline is Pregnancy Category C and should be used only if clearly needed. Your doctor may adjust your dose during pregnancy.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine. Theophylline can interact with certain anesthetics and may affect heart rhythm. Your doctor may adjust the dose before surgery.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine. It may interact with certain local anesthetics or medications used during dental procedures. Your dentist may need to consult your doctor before proceeding.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Exercise may increase your heart rate and breathing rate. If you have asthma or COPD, use your rescue inhaler as prescribed before exercise. Avoid strenuous activity in extreme temperatures or high pollution levels. Consult your doctor before starting a new exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness, restlessness, or insomnia in some people. Avoid driving or operating heavy machinery until you know how it affects you. It is usually safe to continue working, but inform your employer if your job involves safety-sensitive tasks.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience severe side effects or your condition worsens, contact your doctor immediately. Your doctor will decide if and when to stop or change the treatment.
📅 Long-Term Use Effects
Long-term use of this medicine requires regular monitoring of serum theophylline levels to avoid toxicity. Chronic use may lead to tolerance and reduced effectiveness. Pyridoxine in high doses over long periods can cause peripheral neuropathy. Regular follow-up with your doctor is essential to adjust the dose and monitor for side effects.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
First-line controller therapy for asthma, reducing airway inflammation.
Evidence: Well-establishedUsed in combination with inhaled corticosteroids for asthma and COPD.
Evidence: Well-establishedOral medications that reduce airway inflammation and bronchoconstriction.
Evidence: Established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Patients with chronic respiratory conditions should receive annual influenza and pneumococcal vaccinations as recommended by their doctor. These vaccines can help prevent respiratory infections that may worsen asthma or COPD.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store it at room temperature and protect it from extreme heat or moisture. If crossing time zones, consult your doctor about adjusting the dosing schedule. Check local customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts to relax the airways within 30 minutes to 1 hour after taking a dose, but its full benefits for chronic conditions may take several days to weeks.
A: Yes, you can take it with or without food. Taking it with food may help reduce stomach upset.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
A: Theophylline is Pregnancy Category C. It should be used during pregnancy only if the potential benefit justifies the potential risk. Consult your doctor.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: This medicine can be used to treat acute asthma attacks.
Fact: This medicine is for maintenance therapy and is not a rescue medication for acute attacks. - Myth: You can stop taking this medicine once you feel better.
Fact: You should not stop without consulting your doctor, as it may worsen your condition. - Myth: Pyridoxine in this medicine is just a filler.
Fact: Pyridoxine is added to help prevent neurological side effects associated with theophylline.
🔄 Alternative Options
Generic Alternatives
- Theophylline + Pyridoxine 400 mg/25 mg tablet (various manufacturers)