wekcium-plus soft gel capsule - Calcitriol (0.25mcg) + Calcium Carbonate (1250mg) medicine

K to 7 Softgel Capsule: Complete Medicine Guide

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🏭 Meckley Life Sciences Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 23, 2026
⚠️ Nephrotoxicity Risk 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Well-established for approved indications.
Reviewed by
SaathiMed Expert Panel | Sep 23, 2026

When to Call Your Doctor IMMEDIATELY

  • Severe nausea, vomiting, or abdominal pain
  • Confusion, drowsiness, or extreme weakness
  • Irregular heartbeat or palpitations
  • Blood in urine or severe flank pain
  • Swelling of face, lips, or throat
  • Difficulty breathing or chest tightness
  • Decreased urine output or swelling in legs

If experiencing severe symptoms, call emergency services immediately.

What is wekcium-plus soft gel capsule used for?

This medicine is a combination of calcitriol and calcium carbonate used to treat and prevent calcium and vitamin D deficiency, support bone health, and manage conditions like osteoporosis and hypoparathyroidism. It works by increasing calcium absorption and promoting bone mineralisation.

  • Generic Name: Calcitriol (0.25mcg) + Calcium Carbonate (1250mg)
  • Manufacturer: Meckley Life Sciences Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 wekcium-plus soft gel capsule के बारे में (Hindi Summary)

उपयोग: यह दवा कैल्सिट्रियोल और कैल्शियम कार्बोनेट का संयोजन है, जिसका उपयोग कैल्शियम और विटामिन डी की कमी को पूरा करने, हड्डियों को मजबूत बनाने और ऑस्टियोपोरोसिस, रिकेट्स, हाइपोपैराथायरायडिज्म जैसी स्थितियों के इलाज में किया जाता है। यह दवा शरीर में कैल्शियम के अवशोषण को बढ़ाती है और हड्डियों के स्वास्थ्य को बनाए रखने में मदद करती है।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में जी मिचलाना, कब्ज, मुँह सूखना और प्यास लगना शामिल हैं। गंभीर दुष्प्रभावों में कैल्शियम का स्तर बढ़ना, किडनी में पथरी और एलर्जी प्रतिक्रिया हो सकती है। अगर आपको भ्रम, कमजोरी, धड़कन अनियमित लगे या सांस लेने में तकलीफ हो, तो तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे भोजन के साथ लें ताकि पेट की परेशानी कम हो और अवशोषण बेहतर हो। अपने आप कैल्शियम या विटामिन डी की अतिरिक्त खुराक न लें। किडनी की बीमारी, हृदय रोग या गर्भावस्था में डॉक्टर को जरूर बताएं। नियमित रूप से कैल्शियम और किडनी की जांच कराते रहें।

💡 Did You Know? Over 80% of the antiretroviral drugs used globally to combat AIDS are supplied by Indian pharmaceutical companies.

💊 wekcium-plus soft gel capsule Uses & Benefits

[{"condition":"Osteoporosis","description":"Helps maintain bone mineral density and reduces fracture risk when calcium and vitamin D levels are inadequate.","evidence":"Well-established"},{"condition":"Osteomalacia and rickets","description":"Corrects defective bone mineralisation caused by vitamin D deficiency or impaired calcitriol production.","evidence":"Well-established"},{"condition":"Hypoparathyroidism","description":"Supports calcium balance when parathyroid hormone is low or absent.","evidence":"Well-established"},{"condition":"Chronic kidney disease mineral bone disorder","description":"Used under specialist supervision to manage low calcium and high parathyroid hormone levels.","evidence":"Well-established"},{"condition":"Calcium and vitamin D deficiency","description":"Treats or prevents deficiency states in people with poor dietary intake or malabsorption.","evidence":"Well-established"},{"condition":"Prevention of steroid-induced bone loss","description":"Supports bone health in patients on long-term glucocorticoid therapy.","evidence":"Moderate"}]

Off-label uses: [{"condition":"Psoriasis","description":"Topical calcitriol is used for plaque psoriasis, but oral use for this purpose is not standard.","evidence":"Limited"},{"condition":"Secondary hyperparathyroidism in early kidney disease","description":"Sometimes used before dialysis, but only under specialist care.","evidence":"Moderate"}]

Primary treatment for: Calcium and vitamin D deficiency

Also treats: Osteoporosis, Osteomalacia, Rickets, Hypoparathyroidism, Chronic kidney disease mineral bone disorder

📋 Drug Information

Generic Name(s)Calcitriol (0.25mcg) + Calcium Carbonate (1250mg)
Brand Namewekcium-plus soft gel capsule
ManufacturerMeckley Life Sciences Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassVITAMINS MINERALS NUTRIENTS
Action Class
Route of AdministrationOral
StorageStore at room temperature between 15°C and 30°C in a dry place, away from direct sunlight and moisture. Keep in the original container.
Shelf Life24 months from the date of manufacture, or as printed on the pack.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Always take this medicine with food to enhance absorption and reduce stomach upset.
2
Do not take extra calcium or vitamin D supplements without your doctor's approval.
3
Drink plenty of water throughout the day to help prevent kidney stones.
4
Attend regular blood tests to monitor calcium and kidney function.
5
Inform your doctor if you experience confusion, muscle weakness, or irregular heartbeat.
6
Avoid taking antacids containing aluminium or magnesium at the same time.
7
Separate this medicine from iron, tetracycline, or fluoroquinolone antibiotics by at least 2 hours.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

Bone pain and muscle cramps
This medicine is commonly prescribed for calcium and vitamin D deficiency.
Likely Use
Fever
This medicine is not a fever reducer.
Not Primary
Frequent fractures
It may be used as part of osteoporosis management.
Likely Use

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionCalcitriol is rapidly absorbed from the intestine after oral administration. Calcium carbonate requires stomach acid to dissolve and release calcium ions; absorption of calcium occurs mainly in the small intestine and is enhanced by calcitriol.
DistributionCalcitriol is distributed widely in the body and is transported in the blood bound to vitamin D-binding protein. Calcium is distributed mainly in bone, with smaller amounts in extracellular fluid and soft tissues.
Protein BindingCalcitriol is approximately 99.9% bound to vitamin D-binding protein and albumin in the blood. Calcium is about 40% bound to plasma proteins, mainly albumin.
MetabolismCalcitriol is metabolised in the liver and intestine to less active metabolites, including calcitroic acid. Calcium is not metabolised; it is regulated by hormones such as parathyroid hormone and calcitonin.
Half-LifeThe elimination half-life of calcitriol is approximately 5 to 8 hours. Calcium is eliminated from the body with a biological half-life of several weeks, depending on bone turnover.
ExcretionCalcitriol metabolites are excreted mainly in bile and faeces, with a small amount in urine. Excess calcium is excreted primarily in urine and faeces.
BioavailabilityThe oral bioavailability of calcitriol is approximately 70% to 80%. Calcium absorption from calcium carbonate is about 30% to 40% under normal conditions and depends on stomach acid and vitamin D status.
Onset of ActionCalcitriol begins to increase intestinal calcium absorption within a few hours, but measurable changes in serum calcium and clinical benefits on bone may take several days to weeks.
Peak Plasma TimePeak plasma concentration of calcitriol occurs about 3 to 6 hours after oral administration. Calcium levels peak around 2 to 4 hours after intake.
Duration of ActionThe effect of a single dose of calcitriol on calcium absorption lasts about 24 to 48 hours. The beneficial effects on bone are seen only after weeks of consistent use.

How It Works

Calcitriol is the active form of vitamin D3. It binds to vitamin D receptors inside cells, especially in the intestine, bone, kidney, and parathyroid glands. This binding increases the production of calcium-binding proteins in the intestine, which enhances calcium absorption from food. In bone, calcitriol works with parathyroid hormone to regulate calcium release and deposition. It also reduces parathyroid hormone secretion when calcium levels are low. Calcium carbonate provides elemental calcium, which is essential for bone mineralisation, muscle contraction, nerve signalling, and blood clotting. Together, the two ingredients correct calcium and vitamin D deficiency and support healthy bone turnover.

Mechanism Steps

1
Calcitriol binds to vitamin D receptors: Calcitriol enters target cells and binds to vitamin D receptors, which are present in the intestine, bone, kidney, and parathyroid glands.
2
Increased intestinal calcium absorption: Activation of vitamin D receptors increases the production of calcium transport proteins in the intestine, leading to greater absorption of dietary calcium.
3
Calcium carbonate dissolves and releases calcium: Calcium carbonate dissolves in the stomach acid and releases elemental calcium, which is then available for absorption in the small intestine.
4
Bone mineralisation is supported: The absorbed calcium and the action of calcitriol together support the deposition of calcium and phosphate into bone, maintaining bone strength.
5
Parathyroid hormone suppression: Rising calcium levels and direct vitamin D receptor activation reduce parathyroid hormone secretion, helping to balance calcium homeostasis.

💡 How to Take wekcium-plus soft gel capsule

Strength: Softgel capsule containing calcitriol 0.25 mcg and calcium carbonate 1250 mg.

1Take the capsule with a full glass of water.
2Take it with food to improve absorption and reduce stomach upset.
3Swallow the capsule whole; do not crush or chew it.
4Take it at the same time each day to maintain consistent levels.
5Do not take extra calcium or vitamin D supplements unless prescribed.
6Follow your doctor's instructions about diet and other medicines.

Dosage Information

Adult DosageThe usual adult dose is one softgel capsule once daily or as prescribed by your doctor. The exact dose depends on the indication, your calcium and vitamin D levels, kidney function, and other medicines you take. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not change the dose without medical advice.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageOlder adults may need lower doses and more frequent monitoring of calcium and kidney function. Dose must be individualized by a qualified clinician.
Renal ImpairmentIn kidney disease, the dose must be carefully adjusted and calcium levels monitored frequently. Specialist supervision is recommended.
Hepatic ImpairmentIn severe liver disease, dose adjustment may be needed. Consult your doctor for individualised dosing.
Maximum Daily DoseThe maximum daily dose should not exceed the prescribed amount. Do not take more than one capsule daily unless your doctor specifically advises otherwise.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With meals
Take with food
Improves absorption and reduces stomach upset.
High-fibre foods
Separate by 2 hours
Fibre can bind calcium and reduce absorption.
Spinach and rhubarb
Limit close to dose
Oxalates bind calcium and reduce absorption.
Caffeine
Moderate intake
High caffeine can increase calcium loss.

⏰ What to Do If You Miss a Dose

📌 Less than 12 hours have passed since the missed dose
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than 12 hours have passed since the missed dose
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of wekcium-plus soft gel capsule

✅ Common Side Effects

Nausea (Common (5-10%))
Take with food and drink plenty of water. If nausea persists, consult your doctor.
Constipation (Common (5-10%))
Increase fibre and fluid intake. Consult your doctor if constipation is severe or lasts more than a few days.
Dry mouth (Common (5-10%))
Sip water regularly. If it continues, inform your doctor.
Increased thirst (Common (5-10%))
Drink water as needed. Report persistent thirst to your doctor.
Stomach upset (Common (5-10%))
Take with meals. If it worsens, consult your doctor.

🚨 Serious Side Effects

Hypercalcaemia (Uncommon (0.1-1%))
Seek medical attention if you experience confusion, drowsiness, muscle weakness, or irregular heartbeat.
Kidney stones (Rare (<0.1%))
Report severe flank pain, blood in urine, or painful urination to your doctor immediately.
Severe allergic reaction (Rare (<0.1%))
Stop the medicine and seek emergency care if you develop rash, swelling of face or throat, or difficulty breathing.

⚠️ Rare Side Effects

Nephrocalcinosis
Regular kidney function tests are advised. Report any decrease in urine output.
Arrhythmias due to high calcium
Seek immediate medical attention if you feel palpitations or chest discomfort.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Thiazide diuretics Major
Digoxin Major
Vitamin D analogues Major
Corticosteroids Moderate
Aluminium antacids Moderate
Iron supplements Moderate
Tetracyclines Minor
Fluoroquinolones Minor
Levothyroxine Moderate
Bisphosphonates Moderate

🚨 Major Interactions

  • Thiazide diuretics
  • Digoxin
  • Vitamin D analogues

⚡ Moderate Interactions

  • Corticosteroids
  • Aluminium-containing antacids
  • Iron supplements

🍷 Alcohol Interaction

Drinking large amounts of alcohol can reduce calcium absorption and weaken bones. It is best to limit or avoid alcohol while taking this medicine, especially if you have osteoporosis or liver disease.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Hypercalcaemia (high blood calcium)","Hypercalciuria (high urine calcium)","Known allergy to calcitriol, calcium carbonate, or any ingredient","Severe kidney failure without specialist supervision","Active kidney stones","Sarcoidosis or other granulomatous diseases"]

⚠️ Warnings & Precautions

["Do not exceed the prescribed dose.","Monitor calcium levels regularly.","Avoid additional calcium or vitamin D supplements unless advised.","Use with caution in kidney disease.","Use with caution in heart disease and in patients on digoxin.","Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding.","Keep out of reach of children."]

🤱 Lactation Safety

Calcitriol and calcium are excreted in small amounts in breast milk. This medicine is generally considered compatible with breastfeeding when used at prescribed doses. Consult your doctor to ensure the dose is appropriate for you and your baby.

💊 Overdose Management

Overdose can cause high calcium levels with symptoms such as nausea, vomiting, confusion, weakness, and irregular heartbeat. If you suspect an overdose, stop the medicine and seek immediate medical attention. Treatment may include stopping the medicine, intravenous fluids, and medications to lower calcium levels.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed and do not increase the dose on your own. Always take it with food to improve absorption and reduce stomach upset. Drink plenty of water throughout the day unless your doctor has restricted fluids. Avoid taking extra calcium supplements or high-dose vitamin D without medical advice, because the combination can raise blood calcium to unsafe levels. Tell your doctor if you have a history of kidney stones, kidney disease, heart disease, or sarcoidosis. Do not start or stop this medicine without consulting your doctor, especially if you are pregnant, planning pregnancy, or breastfeeding. Keep all follow-up appointments for blood tests, because monitoring calcium and kidney function is essential for safe long-term use. Store this medicine in its original container, away from heat, light, and moisture, and keep it out of reach of children.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Older adults are more prone to hypercalcaemia and kidney problems. Lower doses and regular monitoring of calcium and kidney function are recommended.

🤰 Pregnancy Planning (TTC)

If you are planning pregnancy, consult your doctor before starting or continuing this medicine. Adequate calcium and vitamin D are important for both mother and baby, but doses must be individualised.

🏥 Post-Surgery Considerations

After surgery, continue this medicine as advised by your doctor. It may be important for bone healing, but your dose may need adjustment based on your condition and other medications.

🦷 Dental Procedures

Inform your dentist that you are taking this medicine. It is generally safe for dental procedures, but your dentist may need to know about your calcium levels.

💚 Lifestyle Tips for Better Results

🏃
Maintain a balanced diet rich in calcium and vitamin D.
🥗
Get regular weight-bearing exercise like walking or light weights.
😴
Avoid smoking and limit alcohol intake.
💧
Stay hydrated to help prevent kidney stones.
🧘
Get adequate sunlight exposure for natural vitamin D synthesis.
🌞
Follow up regularly with your doctor for monitoring.

🏋️ Exercise Considerations

Weight-bearing exercises are beneficial for bone health, but avoid high-impact activities if you have severe osteoporosis or joint pain. Consult your doctor before starting any new exercise programme.

🥗 Diet Recommendations

Include dairy products, leafy greens, and fortified foods.
Ensure adequate protein intake for bone health.
Limit excessive caffeine and alcohol.
Stay well hydrated.

💼 Impact on Daily Work & Life

This medicine is unlikely to affect your ability to work or drive. However, if you experience dizziness or drowsiness due to high calcium levels, avoid driving or operating machinery until you feel well.

🛑 When to Stop This Medicine

Do not stop this medicine without consulting your doctor. If you experience serious side effects such as severe hypercalcaemia or allergic reaction, stop and seek medical attention immediately.

📅 Long-Term Use Effects

Long-term use at prescribed doses is generally safe, but regular monitoring of calcium and kidney function is important. Prolonged high doses can lead to hypercalcaemia, kidney stones, and soft tissue calcification. Your doctor may adjust the dose based on blood test results.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Dietary calcium and vitamin D

Increasing intake of calcium-rich foods and safe sun exposure can help maintain levels.

Evidence: Well-established
Weight-bearing exercise

Regular exercise helps maintain bone density.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

There are no known interactions between this medicine and vaccines. Continue routine vaccinations as advised by your doctor.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of your prescription. Store it in a cool, dry place away from direct sunlight. If travelling across time zones, continue taking it at your usual time or adjust gradually as advised by your doctor. Keep it in your hand luggage to avoid loss or extreme temperatures.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 58-year-old postmenopausal woman with osteoporosis
She was prescribed this medicine along with a bisphosphonate. After 3 months, her calcium levels normalised and she reported fewer muscle cramps. She learned to take it with breakfast and to avoid taking it with her iron tablet.
💡 Lesson: Taking this medicine consistently with food and separating it from other supplements improves outcomes.
👤 A 45-year-old man with chronic kidney disease
He was started on this medicine under specialist care. Regular monitoring helped adjust the dose and prevent high calcium. He was advised to avoid aluminium-based antacids.
💡 Lesson: In kidney disease, close monitoring and dose adjustment are essential for safe use.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: It starts increasing calcium absorption within hours, but benefits on bone health may take several weeks to months.

Q: Can I take it on an empty stomach?

A: It is best taken with food to improve absorption and reduce stomach upset.

Q: What should I do if I miss a dose?

A: Take it as soon as you remember if less than 12 hours have passed. Otherwise, skip the missed dose and continue with your regular schedule.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I take it with other supplements?
  • What if I miss a dose?
  • Is it safe during pregnancy?
  • Does it interact with my blood pressure medicine?

🔄 Substitutes for wekcium-plus soft gel capsule

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can be taken without a prescription.
    Fact: This medicine should only be taken under medical supervision because it can affect calcium levels.
  • Myth: More calcium always means stronger bones.
    Fact: Excess calcium can be harmful and cause kidney stones or high blood calcium.
  • Myth: This medicine works immediately.
    Fact: It takes weeks to see benefits on bone health.

🔄 Alternative Options

Generic Alternatives

  • Calcitriol + Calcium Carbonate softgel capsules from other manufacturers

📊 Comparison with Similar Medicines

[{"medicine":"This medicine","composition":"Calcitriol 0.25 mcg + Calcium Carbonate 1250 mg","form":"Softgel capsule","route":"Oral"},{"medicine":"Calcitriol alone","composition":"Calcitriol 0.25 mcg","form":"Capsule","route":"Oral"},{"medicine":"Calcium carbonate alone","composition":"Calcium Carbonate 1250 mg","form":"Tablet","route":"Oral"}]

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