adbone-k2 softgel capsule - Calcitriol (0.25mcg) + Calcium Carbonate (1250mg) medicine

Adbone-K2 Softgel Capsule - Uses, Price, Side Effects

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๐Ÿญ Adinex Healthcare ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Jun 30, 2026
๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
SaathiMed Expert Panel | Jun 30, 2026

What is adbone-k2 softgel capsule used for?

Adbone-K2 Softgel Capsule is used to prevent and treat osteoporosis and other bone disorders. It combines Calcitriol (active vitamin D) to enhance calcium absorption and Calcium Carbonate to provide essential calcium, strengthening bones and reducing fracture risk.

  • Generic Name: Calcitriol + Calcium Carbonate
  • Manufacturer: Adinex Healthcare
  • Form: Allopathy
  • Pregnancy Category: A
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

๐Ÿ’Š adbone-k2 softgel capsule Uses & Benefits

Osteoporosis, hypocalcemia, renal osteodystrophy, vitamin D deficiency, calcium deficiency.

Off-label uses: Psoriasis (topical calcitriol), prevention of corticosteroid-induced osteoporosis.

๐Ÿ“‹ Drug Information

Generic Name(s)Calcitriol + Calcium Carbonate
Brand NameAtibon-K27 Softgel Capsule
ManufacturerAdinex Healthcare
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassVITAMINS MINERALS NUTRIENTS
Action ClassVitamins and Minerals
Route of AdministrationOral
StorageStore at room temperature (20-25ยฐC), protect from light and moisture.
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionCalcitriol is rapidly absorbed from the gastrointestinal tract; calcium carbonate absorption is pH-dependent, enhanced by food.
DistributionCalcitriol is highly protein-bound (99.9%) and distributed to target tissues; calcium is distributed primarily in bones and teeth.
Protein BindingCalcitriol: >99.9% bound to vitamin D-binding protein; calcium: ~40% bound to albumin.
MetabolismCalcitriol is metabolized in the kidney and other tissues via hydroxylation; calcium is not metabolized.
Half-LifeCalcitriol: 5-8 hours; calcium: variable, depends on renal function.
ExcretionCalcitriol: excreted in bile and feces; calcium: primarily excreted in urine (with reabsorption) and feces.
BioavailabilityCalcitriol: ~70-80%; calcium carbonate: ~30-40% (increases with food).
Onset of ActionCalcitriol: 2-6 hours for serum calcium increase; calcium: immediate upon absorption.
Peak Plasma TimeCalcitriol: 3-6 hours; calcium: 2-4 hours.
Duration of ActionCalcitriol: 3-5 days; calcium: 6-8 hours.

How It Works

Calcitriol increases intestinal absorption of calcium and phosphate; calcium carbonate provides elemental calcium for bone mineralization and other physiological functions.

Mechanism Steps

1Calcitriol binds to vitamin D receptor (VDR) in intestinal cells.
2VDR complex translocates to nucleus and increases transcription of calcium-binding proteins.
3Increased calcium absorption from gut lumen into bloodstream.

๐Ÿ’ก How to Take adbone-k2 softgel capsule

Follow your doctor's prescription exactly.

Dosage Timeline

๐ŸŒ… Morning โœ… โ˜€๏ธ Afternoon โŒ ๐ŸŒ† Evening โœ… ๐ŸŒ™ Night โŒ

โš ๏ธ Side Effects of adbone-k2 softgel capsule

โœ… Common Side Effects

  • Nausea
  • Constipation
  • Hypercalcemia
  • Hypercalciuria

๐Ÿšจ Serious Side Effects

  • Nephrocalcinosis
  • Renal impairment
  • Cardiac arrhythmias

โš ๏ธ Rare Side Effects

  • Allergic reactions
  • Metastatic calcification

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
Thiazide diuretics Moderate Increased risk of hypercalcemia
Digitalis glycosides Major Increased risk of arrhythmias due to hypercalcemia
Corticosteroids Moderate Reduced calcium absorption

๐Ÿšจ Major Interactions

  • Digitalis glycosides
  • Thiazide diuretics
  • Vitamin D analogs

โšก Moderate Interactions

  • Corticosteroids
  • Cholestyramine
  • Orlistat

โ„น๏ธ Minor Interactions

  • Magnesium-containing antacids
  • Fluoroquinolones

๐Ÿฝ๏ธ Food Interactions

High-fiber foods, oxalates (spinach), phytates (whole grains) may reduce calcium absorption; vitamin D-rich foods enhance calcitriol effect.

๐Ÿท Alcohol Interaction

Chronic alcohol use may reduce calcium absorption and increase risk of osteoporosis.

๐Ÿ›ก๏ธ Safety & Warnings

Liver
Low
Kidney
Moderate
Heart
Low
Pregnancy
Category A

๐Ÿšซ Contraindications

Hypercalcemia, hypercalciuria, severe renal impairment, vitamin D toxicity, hypersensitivity to any component.

๐Ÿ“Š Monitoring Parameters

Serum calcium, phosphate, creatinine, 25-hydroxyvitamin D levels; urine calcium excretion.

๐Ÿคฑ Lactation Safety

Calcitriol and calcium are excreted in breast milk; use with caution.

๐Ÿ’Š Overdose Management

Discontinue medication, monitor serum calcium, treat hypercalcemia (hydration, loop diuretics, calcitonin, bisphosphonates if severe).

โฐ Missed Dose

Take as soon as remembered unless near next dose; do not double dose.

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Reviewed: Jun 30, 2026

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