Golbi SR 450 Tablet: Complete Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Yellowing of skin or eyes (jaundice)
- Dark urine or pale stools
- Severe abdominal pain, especially in the upper right quadrant
- Persistent nausea and vomiting
- Signs of allergic reaction such as rash, itching, swelling of face or throat, difficulty breathing
- Unusual tiredness or weakness
- Increased frequency of bowel movements or severe diarrhea
If experiencing severe symptoms, call emergency services immediately.
What is ursocol sr 450 tablet used for?
This medicine contains Ursodeoxycholic Acid 450 mg, used to dissolve cholesterol gallstones and treat primary biliary cholangitis. It works by reducing cholesterol in bile and protecting liver cells. Take it exactly as prescribed, usually once daily, and do not stop without medical advice.
- Generic Name: Ursodeoxycholic Acid (450mg)
- Manufacturer: Sun Pharmaceutical Industries Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 ursocol sr 450 tablet के बारे में (Hindi Summary)
उपयोग: यह दवा अर्सोडीऑक्सीकोलिक एसिड 450 मिलीग्राम युक्त एक सस्टेन्ड-रिलीज़ टैबलेट है, जिसका उपयोग मुख्य रूप से पित्ताशय की पथरी को घोलने, प्राइमरी बिलियरी कोलैंगाइटिस (एक दीर्घकालिक यकृत रोग) के इलाज और गर्भावस्था या सिस्टिक फाइब्रोसिस से जुड़े यकृत विकारों में किया जाता है। यह दवा यकृत में कोलेस्ट्रॉल के उत्पादन को कम करती है और पित्त के प्रवाह को बेहतर बनाती है, जिससे कोलेस्ट्रॉल वाली पथरी धीरे-धीरे घुल जाती है। यह पित्त रोग के कारण होने वाली खुजली को भी कम करती है।
साइड इफेक्ट्स: आमतौर पर यह दवा अच्छी तरह सहन की जाती है, लेकिन कुछ लोगों को मतली, उल्टी, दस्त, कब्ज, या धातु जैसा स्वाद महसूस हो सकता है। ये दुष्प्रभाव आमतौर पर हल्के और अस्थायी होते हैं। दुर्लभ मामलों में यकृत रोग बिगड़ सकता है, जिसके लक्षण हैं आंखों या त्वचा का पीला पड़ना, गहरे रंग का मूत्र, या लगातार थकान। यदि आपको कोई गंभीर या असामान्य लक्षण दिखे, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को अपने डॉक्टर के निर्देशानुसार ही लें। खुराक को बदलें या दवा बंद करने से पहले डॉक्टर से सलाह लें। टैबलेट को पानी के साथ पूरा निगलें, चबाएं या तोड़ें नहीं। इसे भोजन के साथ या बिना भोजन के ले सकते हैं, लेकिन भोजन के साथ लेने से पेट की परेशानी कम हो सकती है। यदि आप एक खुराक भूल जाते हैं, तो याद आते ही ले लें, लेकिन यदि अगली खुराक का समय नजदीक है, तो भूली हुई खुराक छोड़ दें और सामान्य अनुसूची जारी रखें। दोहरी खुराक न लें। अपने सभी चिकित्सा परीक्षण और प्रयोगशाला जांच समय पर कराएं, क्योंकि डॉक्टर को आपके यकृत की कार्यप्रणाली और पथरी की स्थिति की निगरानी करनी होती है। यदि आप गर्भवती हैं, गर्भवती होने की योजना बना रही हैं, या स्तनपान करा रही हैं, तो अपने डॉक्टर को बताएं। इस दवा के साथ शराब का सेवन न करें, क्योंकि इससे यकृत की समस्या का खतरा बढ़ सकता है। इस दवा को कमरे के तापमान पर, नमी और सीधी धूप से दूर रखें। बच्चों की पहुंच से दूर रखें।
💊 ursocol sr 450 tablet Uses & Benefits
[{"condition":"Cholesterol gallstones","description":"Used to dissolve small, non-calcified cholesterol gallstones in patients who cannot undergo surgery or who have a high surgical risk.","evidence":"Well-established"},{"condition":"Primary biliary cholangitis","description":"First-line therapy to slow disease progression and improve liver biochemistry in adults with primary biliary cholangitis.","evidence":"Well-established"},{"condition":"Intrahepatic cholestasis of pregnancy","description":"Used to relieve itching and improve liver function in pregnant women with this condition.","evidence":"Moderate"},{"condition":"Cystic fibrosis-related liver disease","description":"May be used to improve bile flow and liver function in patients with cystic fibrosis.","evidence":"Limited"},{"condition":"Cholestatic liver disease","description":"Helps reduce cholestasis and associated symptoms in various chronic liver diseases.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Non-alcoholic steatohepatitis","description":"Sometimes prescribed off-label to improve liver enzymes, but evidence of benefit is limited.","evidence":"Limited"},{"condition":"Biliary dyskinesia","description":"Occasionally used to relieve symptoms of biliary pain, though evidence is not robust.","evidence":"Limited"}]
Primary treatment for: Cholesterol gallstones
Also treats: Primary biliary cholangitis, Intrahepatic cholestasis of pregnancy, Cystic fibrosis-related liver disease, Cholestatic liver disease
📋 Drug Information
| Generic Name(s) | Ursodeoxycholic Acid (450mg) |
| Brand Name | ursocol sr 450 tablet |
| Manufacturer | Sun Pharmaceutical Industries Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | Hepatoprotectives |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from moisture and direct sunlight. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by replacing hydrophobic, detergent-like bile acids in the bile acid pool with the more hydrophilic ursodeoxycholic acid. This reduces cholesterol absorption from the intestine and decreases cholesterol secretion into bile, which helps dissolve cholesterol gallstones. It also stabilizes liver cell membranes, protects against bile acid-induced injury, and stimulates bile flow, which helps relieve cholestasis.
Mechanism Steps
💡 How to Take ursocol sr 450 tablet
Strength: Sustained-release tablet containing 450 mg of Ursodeoxycholic Acid.
Dosage Information
| Adult Dosage | The usual adult dose for gallstone dissolution is 8-10 mg/kg/day divided into 2-3 doses, but for this 450 mg sustained-release tablet, the typical dose is one tablet once daily or as directed by your doctor. For primary biliary cholangitis, the dose is 13-15 mg/kg/day divided into 2-4 doses. The exact dose and duration must be individualized by a qualified clinician based on the indication, age, weight, and liver function. Do not adjust the dose without medical advice. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | No specific dose adjustment is required for elderly patients, but caution is advised due to potential age-related decline in liver and kidney function. Dose should be individualized by a clinician. |
| Renal Impairment | No dose adjustment is required for renal impairment. However, use with caution in severe renal disease. |
| Hepatic Impairment | In patients with severe hepatic impairment, this medicine should be used with caution. Dose adjustment may be necessary based on liver function tests. Consult a hepatologist. |
| Maximum Daily Dose | The maximum recommended daily dose is 15 mg/kg/day, but for this 450 mg tablet, the maximum is usually one tablet per day unless otherwise prescribed. Do not exceed the dose prescribed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of ursocol sr 450 tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Aluminum-based antacids | Major | |
| Cholestyramine | Major | |
| Colestipol | Major | |
| Colesevelam | Major | |
| Oral contraceptives | Moderate | |
| Clofibrate | Moderate | |
| Cyclosporine | Moderate | |
| Ciprofloxacin | Moderate | |
| Nitrendipine | Moderate | |
| Dapsone | Moderate |
🚨 Major Interactions
- Aluminum-based antacids
- Cholestyramine, colestipol, colesevelam
- Oral contraceptives containing estrogen
- Clofibrate
- Cyclosporine
⚡ Moderate Interactions
- Ciprofloxacin
- Nitrendipine
- Dapsone
🍷 Alcohol Interaction
Alcohol may increase the risk of liver damage and can worsen the underlying liver condition. It is advisable to avoid alcohol while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Complete biliary obstruction","Acute cholecystitis or cholangitis","Calcified cholesterol gallstones","Gallstones larger than 15 mm in diameter","Severe hepatic impairment or hepatic encephalopathy","Hypersensitivity to ursodeoxycholic acid or any component of the formulation","Non-functioning gallbladder"]
⚠️ Warnings & Precautions
["Use with caution in patients with severe liver disease; monitor liver function regularly.","Patients with gallstones should be monitored with ultrasound to detect calcification or worsening.","This medicine may not be effective if gallstones are radiopaque or larger than 15 mm.","Avoid concurrent use with bile acid sequestrants; separate administration times.","Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.","Do not use this medicine for gallstone dissolution if you have a non-functioning gallbladder.","In patients with primary biliary cholangitis, monitor for response and consider alternative therapy if no improvement after 1 year."]
🤱 Lactation Safety
It is not known whether this medicine is excreted in human breast milk. It should be used with caution during breastfeeding, and only if the potential benefit justifies the potential risk to the infant.
💊 Overdose Management
Overdose with this medicine is unlikely to cause serious effects. In case of suspected overdose, seek immediate medical attention. Treatment is supportive and symptomatic. Diarrhea may occur and should be managed with hydration.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not change the dose or stop taking it without medical advice. Swallow the tablet whole with a glass of water; do not crush or chew it. You may take it with or without food, but taking it with meals may reduce stomach upset. If you miss a dose, take it as soon as you remember, but if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose. Keep all your medical appointments and laboratory tests, as your doctor will need to monitor your liver function and gallstone status. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Avoid alcohol while taking this medicine, as it can increase the risk of liver problems. Store this medicine at room temperature, away from moisture and direct sunlight. Keep it out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may have reduced liver function and should be monitored more closely. No specific dose adjustment is required, but individualization is advised.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before starting or continuing this medicine. It is considered safe for use in pregnancy when prescribed for intrahepatic cholestasis of pregnancy, but use only under medical supervision.
🏥 Post-Surgery Considerations
If you have undergone gallbladder removal surgery, this medicine is generally not needed for gallstone dissolution. However, it may be continued for other liver conditions as prescribed by your doctor.
🦷 Dental Procedures
No specific precautions are required for dental procedures. Inform your dentist about all medicines you are taking.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
No specific exercise restrictions are required while taking this medicine. However, if you have gallstone pain or liver disease, consult your doctor before starting any strenuous exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is unlikely to affect your ability to drive or operate machinery. However, if you experience dizziness or fatigue, avoid these activities until you know how the medicine affects you.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. For gallstone dissolution, treatment is usually continued for several months after the stones have dissolved to prevent recurrence. For primary biliary cholangitis, it is often a lifelong therapy. Your doctor will determine when it is safe to stop based on your condition and test results.
📅 Long-Term Use Effects
Long-term use of this medicine is generally safe and well-tolerated. It may be continued for months to years for gallstone dissolution or indefinitely for primary biliary cholangitis. Regular monitoring of liver function tests and gallstone status is recommended. In rare cases, gallstones may calcify and become resistant to dissolution. Long-term use has not been associated with significant toxicity, but periodic evaluation by your doctor is necessary.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Surgical removal of the gallbladder is the definitive treatment for symptomatic gallstones.
Evidence: Well-establishedNon-invasive procedure to break up gallstones using shock waves, suitable for selected patients.
Evidence: ModerateDiet and weight management can help prevent gallstone formation.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions are known. However, patients with chronic liver disease should receive hepatitis A and B vaccines as recommended by their doctor.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry your medicine in its original packaging along with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature and protect from extreme heat or moisture. If crossing time zones, continue taking your dose at the same local time as much as possible; consult your doctor if you need to adjust the timing. Check customs regulations for carrying prescription medicines to your destination.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: For gallstone dissolution, it may take several months to years depending on the size and number of stones. For relief of cholestatic itching, improvement may be seen within a few weeks.
A: Yes, you can take it with or without food, but taking it with meals may reduce stomach upset.
A: Take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
A: It is considered safe for use in pregnancy when prescribed for intrahepatic cholestasis of pregnancy. However, it should be used only under medical supervision.
A: It is advisable to avoid alcohol as it may increase the risk of liver damage.
🤔 Common Patient Concerns
🔄 Substitutes for ursocol sr 450 tablet
View AllAlternative brands with exact same active ingredient:
-
actibile 450 sr tabletZydus Cadila ₹316.00 63.5% CHEAPER
-
ursocad 450mg tablet srCadila Pharmaceuticals Ltd ₹427.00 50.7% CHEAPER
-
ursodox 450mg tablet srSignova Pharma Pvt Ltd ₹435.00 49.8% CHEAPER
-
ricobile 450mg tabletEnrico Pharmaceuticals ₹435.60 49.7% CHEAPER
-
adebile 450mg tabletAdelmo Healthcare ₹449.00 48.2% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can dissolve all types of gallstones.
Fact: It is only effective for cholesterol gallstones that are small and non-calcified. It does not work for pigment stones or calcified stones. - Myth: You can stop taking this medicine once you feel better.
Fact: Gallstone dissolution requires months of continuous therapy. Stopping early may cause stones to recur or not dissolve completely. - Myth: This medicine is a painkiller.
Fact: It is not a painkiller. It works by dissolving gallstones and improving liver function, which may indirectly reduce pain.
🔄 Alternative Options
Generic Alternatives
- Ursodeoxycholic Acid 450 mg sustained-release tablet
Brand Alternatives
- Golbi SR 450 Tablet
- Udiliv 450 Tablet
- Ursocol 450 Tablet
- Sorbidiol 450 Tablet