ulcitab d 40 mg/10 mg tablet - Domperidone (40mg) + Pantoprazole (10mg) medicine

Ulcitab D 40 mg/10 mg Tablet: Complete Guide

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🏭 Themis Medicare Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 21, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Moderate for combination use in GERD and dyspepsia.
Reviewed by
SaathiMed Expert Panel | Oct 21, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Irregular heartbeat or palpitations
  • Severe allergic reaction (swelling of face, lips, throat, difficulty breathing)
  • Unusual muscle movements or tremors
  • Severe abdominal pain or blood in vomit/stool
  • Signs of liver problems (yellowing of eyes or skin, dark urine)
  • Severe diarrhea with dehydration

If experiencing severe symptoms, call emergency services immediately.

What is ulcitab d 40 mg/10 mg tablet used for?

This medicine is a combination of Domperidone and Pantoprazole used to treat acid reflux, heartburn, and nausea by reducing stomach acid and improving gastric emptying.

  • Generic Name: Domperidone (40mg) + Pantoprazole (10mg)
  • Manufacturer: Themis Medicare Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 ulcitab d 40 mg/10 mg tablet के बारे में (Hindi Summary)

उपयोग: यह दवा डोम्पेरिडोन और पैंटोप्राजोल का संयोजन है, जिसका उपयोग एसिड रिफ्लक्स, सीने में जलन, मतली और पेट की समस्याओं के इलाज के लिए किया जाता है। यह पेट में एसिड को कम करती है और पेट खाली होने की गति को बढ़ाती है।

साइड इफेक्ट्स: आम दुष्प्रभावों में सिरदर्द, दस्त, मतली, पेट दर्द और मुंह सूखना शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इसमें अनियमित दिल की धड़कन, स्तन में बदलाव और एलर्जी प्रतिक्रियाएं हो सकती हैं।

सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। इसे खाली पेट, भोजन से 30-60 मिनट पहले लें। शराब का सेवन न करें। गाड़ी चलाने या मशीन चलाने से बचें जब तक कि आपको इसका असर पता न चल जाए। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर से सलाह लें।

💡 Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

💊 ulcitab d 40 mg/10 mg tablet Uses & Benefits

[{"condition":"Gastroesophageal reflux disease (GERD)","description":"Relieves heartburn, acid regurgitation, and associated nausea by reducing acid production and improving gastric emptying.","evidence":"Well-established"},{"condition":"Functional dyspepsia","description":"Helps reduce symptoms of bloating, early satiety, and upper abdominal discomfort by enhancing gastric motility and reducing acid.","evidence":"Moderate"},{"condition":"Gastroparesis","description":"Improves gastric emptying and reduces nausea and vomiting in patients with delayed stomach emptying.","evidence":"Moderate"},{"condition":"Nausea and vomiting associated with acid-related disorders","description":"Domperidone component provides antiemetic effect while pantoprazole treats underlying acid condition.","evidence":"Moderate"}]

Off-label uses: [{"condition":"Prevention of NSAID-induced ulcers","description":"Pantoprazole component may be used to prevent ulcers in patients on chronic NSAIDs, but combination with domperidone is not standard for this indication.","evidence":"Limited"},{"condition":"Diabetic gastroparesis","description":"Domperidone may be used off-label to improve gastric emptying in diabetic patients, but combination with pantoprazole is not specifically approved for this.","evidence":"Limited"}]

Primary treatment for: Gastroesophageal reflux disease (GERD)

Also treats: Functional dyspepsia, Gastroparesis, Nausea and vomiting

📋 Drug Information

Generic Name(s)Domperidone (40mg) + Pantoprazole (10mg)
Brand Nameulcitab d 40 mg/10 mg tablet
ManufacturerThemis Medicare Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassGASTRO INTESTINAL
Action Class
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a dry place, away from direct sunlight. Keep in the original container.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine on an empty stomach, at least 30-60 minutes before breakfast, for best results.
2
Do not crush or chew the tablet; swallow it whole with water.
3
Avoid alcohol while taking this medicine as it can worsen side effects.
4
If you experience palpitations or unusual muscle movements, contact your doctor immediately.
5
Long-term use should be reviewed periodically by your doctor to assess need and monitor for side effects.
6
Inform your doctor if you are taking other medications, especially blood thinners or antifungals.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Heartburn
This medicine is commonly prescribed for this.
Likely Use
✅
Nausea
Domperidone component helps relieve nausea.
Likely Use
❌
Fever
This medicine is not a primary fever reducer.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionDomperidone is rapidly absorbed from the gastrointestinal tract, but its bioavailability is low (about 15%) due to extensive first-pass metabolism. Pantoprazole is also rapidly absorbed, with a bioavailability of about 77%. Food may delay the absorption of pantoprazole, so it is best taken on an empty stomach.
DistributionDomperidone is widely distributed in the body, but it does not readily cross the blood-brain barrier. It is highly protein-bound (about 91-93%). Pantoprazole is also highly protein-bound (about 98%) and distributes into gastric parietal cells.
Protein BindingDomperidone: approximately 91-93%; Pantoprazole: approximately 98%.
MetabolismDomperidone undergoes extensive hepatic metabolism via CYP3A4 and CYP1A2 enzymes. Pantoprazole is metabolized in the liver by CYP2C19 and CYP3A4 enzymes.
Half-LifeDomperidone: approximately 7-9 hours; Pantoprazole: approximately 1-2 hours.
ExcretionDomperidone is excreted mainly in feces (about 66%) and urine (about 33%). Pantoprazole is excreted primarily as metabolites in urine (about 80%) and feces (about 20%).
BioavailabilityDomperidone: about 15%; Pantoprazole: about 77%.
Onset of ActionDomperidone: within 30-60 minutes; Pantoprazole: within 1-2 hours for acid suppression.
Peak Plasma TimeDomperidone: 1-2 hours; Pantoprazole: 2-4 hours.
Duration of ActionDomperidone: 6-8 hours; Pantoprazole: up to 24 hours for acid suppression.

How It Works

This medicine combines two active ingredients with complementary mechanisms. Domperidone is a peripheral dopamine D2 receptor antagonist that acts on the chemoreceptor trigger zone and the gastrointestinal tract. By blocking dopamine receptors, it enhances gastric motility and accelerates gastric emptying without crossing the blood-brain barrier significantly, thus reducing nausea and vomiting. Pantoprazole is a proton pump inhibitor that irreversibly inhibits the H+/K+-ATPase enzyme in the gastric parietal cells. This enzyme is responsible for the final step of acid secretion. By inhibiting this pump, pantoprazole reduces both basal and stimulated gastric acid secretion. Together, these actions provide relief from acid-related symptoms and improve gastric motility.

Mechanism Steps

1
Domperidone blocks dopamine D2 receptors: Domperidone antagonizes dopamine D2 receptors in the chemoreceptor trigger zone and the gastrointestinal tract, which leads to increased gastric motility and reduced nausea.
2
Enhanced gastric emptying: By blocking D2 receptors, domperidone promotes peristalsis and accelerates the movement of food from the stomach to the small intestine.
3
Pantoprazole inhibits proton pumps: Pantoprazole irreversibly binds to the H+/K+-ATPase enzyme in gastric parietal cells, blocking the final step of acid secretion.
4
Reduced gastric acid secretion: This inhibition decreases both basal and stimulated acid production, lowering stomach acidity and reducing reflux symptoms.
5
Combined symptomatic relief: The prokinetic effect of domperidone and the antisecretory effect of pantoprazole work together to alleviate symptoms of GERD, dyspepsia, and gastroparesis.

💡 How to Take ulcitab d 40 mg/10 mg tablet

Strength: Tablet containing Domperidone 40 mg and Pantoprazole 10 mg.

1Take the tablet at least 30-60 minutes before a meal, preferably breakfast.
2Swallow the tablet whole with a glass of water.
3Do not crush, chew, or break the tablet.
4If you miss a dose, follow the missed dose instructions.
5Do not take more than the prescribed dose.

Dosage Information

Adult DosageThe usual adult dose is one tablet taken orally once daily on an empty stomach, at least 30-60 minutes before breakfast. However, the dose may be adjusted by your doctor based on your condition and response. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may be more sensitive to the side effects of this medicine, especially cardiac effects and extrapyramidal symptoms. Dose adjustment may be needed. Consult your doctor.
Renal ImpairmentDose adjustment may be required in patients with severe renal impairment. Consult your doctor.
Hepatic ImpairmentContraindicated in severe hepatic impairment. Use with caution in mild to moderate impairment. Consult your doctor.
Maximum Daily DoseThe maximum recommended daily dose is one tablet (Domperidone 40 mg + Pantoprazole 10 mg). Do not exceed this dose.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take on an empty stomach
Food may delay absorption of pantoprazole.
Grapefruit
Avoid
May increase drug levels by affecting CYP3A4.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of ulcitab d 40 mg/10 mg tablet

✅ Common Side Effects

Headache (Common (5-10%))
Usually resolves on its own. Consult doctor if persistent.
Diarrhea (Common (5-10%))
Stay hydrated. Consult doctor if severe or persistent.
Nausea (Common (5-10%))
Take with food if tolerated. Consult doctor if worsening.
Abdominal pain (Common (5-10%))
Usually temporary. Consult doctor if severe.
Dry mouth (Common (5-10%))
Drink water, chew sugar-free gum. Consult doctor if bothersome.

🚨 Serious Side Effects

Irregular heartbeat (QT prolongation) (Rare (<0.1%))
Seek immediate medical attention if you experience palpitations, dizziness, or fainting.
Extrapyramidal symptoms (tremors, rigidity) (Rare (<0.1%))
Contact your doctor immediately if you notice unusual muscle movements.
Allergic reactions (rash, swelling, difficulty breathing) (Rare (<0.1%))
Seek emergency medical help if you experience swelling of face, lips, or throat, or difficulty breathing.
Severe diarrhea with dehydration (Rare (<0.1%))
Consult doctor if diarrhea is severe or accompanied by dehydration symptoms.

⚠️ Rare Side Effects

Galactorrhea (breast milk production)
Consult doctor if this occurs.
Gynecomastia (breast enlargement in men)
Consult doctor if this occurs.
Hypomagnesemia (low magnesium levels)
Regular monitoring may be needed for long-term use.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Ketoconazole Major
Clarithromycin Major
Warfarin Major
Antacids Moderate
Atazanavir Moderate
Methotrexate Moderate
Cimetidine Minor
Digoxin Minor

🚨 Major Interactions

  • Ketoconazole
  • Clarithromycin
  • Warfarin

⚡ Moderate Interactions

  • Antacids
  • Atazanavir
  • Methotrexate

🍷 Alcohol Interaction

Avoid alcohol while taking this medicine. Alcohol can increase stomach acid production, worsening your condition, and may increase the risk of drowsiness and dizziness from domperidone.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known allergy to domperidone or pantoprazole","Severe liver disease","Gastrointestinal bleeding, obstruction, or perforation","Prolactin-releasing pituitary tumor (prolactinoma)","Concurrent use with ketoconazole, clarithromycin, or other QT-prolonging drugs","Moderate to severe heart failure"]

⚠️ Warnings & Precautions

["May cause drowsiness; avoid driving or operating machinery until you know how it affects you.","Avoid alcohol while taking this medicine.","Use with caution in patients with kidney or liver disease.","Long-term use of pantoprazole may increase risk of bone fractures, low magnesium, and vitamin B12 deficiency.","Domperidone may cause breast changes; consult doctor if you notice any.","Do not use for more than 12 weeks without medical advice."]

🤱 Lactation Safety

Domperidone is excreted in breast milk and may cause side effects in the infant. Pantoprazole may also pass into breast milk. This medicine is not recommended during breastfeeding unless clearly needed and advised by a doctor.

💊 Overdose Management

Overdose may cause severe drowsiness, irregular heartbeat, and extrapyramidal symptoms. Seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not crush, chew, or break the tablet; swallow it whole with water. It is best taken on an empty stomach, at least 30-60 minutes before a meal, to maximize its effectiveness. Avoid alcohol while taking this medicine, as it can worsen stomach irritation and increase drowsiness. Do not drive or operate heavy machinery until you know how this medicine affects you, as it may cause dizziness. Inform your doctor if you have kidney or liver problems, heart conditions, or if you are pregnant or breastfeeding. Do not share this medicine with others, even if they have similar symptoms. Keep out of reach of children.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are at higher risk of cardiac side effects, extrapyramidal symptoms, and bone fractures. Use with caution and monitor regularly.

🤰 Pregnancy Planning (TTC)

Consult your doctor if you are planning pregnancy or are pregnant. This medicine is not recommended unless clearly needed.

🏥 Post-Surgery Considerations

Consult your doctor before taking this medicine after surgery, especially if you have had gastrointestinal surgery.

🦷 Dental Procedures

Inform your dentist if you are taking this medicine, as it may affect bleeding risk or interact with anesthetics.

💚 Lifestyle Tips for Better Results

🏃
Eat smaller, more frequent meals to reduce acid reflux.
🥗
Avoid lying down immediately after eating.
😴
Elevate the head of your bed to prevent nighttime reflux.
💧
Maintain a healthy weight to reduce pressure on the stomach.
🧘
Avoid trigger foods like spicy, fatty, or acidic foods.
🌞
Quit smoking and limit alcohol consumption.

🏋️ Exercise Considerations

Avoid vigorous exercise immediately after taking this medicine, especially if you experience dizziness or drowsiness. Light to moderate exercise is generally safe.

🥗 Diet Recommendations

Include high-fiber foods like fruits and vegetables.
Avoid spicy, fatty, and acidic foods.
Stay well hydrated.
Eat smaller meals more frequently.

💼 Impact on Daily Work & Life

This medicine may cause drowsiness or dizziness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It is generally safe for office work.

🛑 When to Stop This Medicine

Do not stop taking this medicine without consulting your doctor. If you experience severe side effects, contact your doctor immediately. Your doctor will advise on tapering or stopping based on your condition.

📅 Long-Term Use Effects

Long-term use of this medicine may increase the risk of bone fractures, low magnesium levels, vitamin B12 deficiency, and certain infections. Domperidone may cause breast changes and cardiac effects. Regular monitoring by a doctor is recommended.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Lifestyle modifications

Diet changes, weight loss, and avoiding trigger foods can help manage GERD symptoms.

Evidence: Well-established
Other medications

H2 blockers or other proton pump inhibitors may be alternatives.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

No specific vaccine interactions are known. However, long-term use of pantoprazole may increase susceptibility to certain infections; ensure routine vaccinations are up to date.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

When traveling, carry this medicine in its original packaging along with a copy of your prescription. Store it at room temperature and protect it from direct sunlight. If crossing time zones, continue taking it at your usual time or adjust gradually as advised by your doctor. Check customs regulations for carrying prescription medicines.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 45-year-old man with chronic heartburn and nausea
He was prescribed this medicine for GERD. After taking it regularly before breakfast for two weeks, his heartburn and nausea significantly reduced. He noted that taking it on an empty stomach was key to its effectiveness.
💡 Lesson: Consistent timing on an empty stomach improves symptom relief.
👤 A 60-year-old woman with diabetic gastroparesis
She experienced bloating and early satiety. Her doctor added this medicine to her regimen. Over a month, her symptoms improved, and she could eat meals more comfortably. She was monitored for cardiac effects due to her age.
💡 Lesson: Regular monitoring is important, especially in elderly patients with other health conditions.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: Domperidone starts working within 30-60 minutes, while pantoprazole takes 1-2 hours for acid suppression. Full effects may take a few days.

Q: Can I take it with food?

A: It is best taken on an empty stomach, at least 30-60 minutes before a meal.

Q: Is it safe for long-term use?

A: Long-term use should be monitored by your doctor due to potential side effects like bone fractures and low magnesium.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my heart?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🛑 Myths vs. Facts

  • Myth: This medicine can be taken with food.
    Fact: It should be taken on an empty stomach for best effect.
  • Myth: It is safe to take indefinitely.
    Fact: Long-term use should be monitored by a doctor.

🔄 Alternative Options

Generic Alternatives

  • Domperidone + Pantoprazole combination generics

Brand Alternatives

  • Dompan
  • Pantop-D
  • Domperidone + Pantoprazole brands

📊 Comparison with Similar Medicines

[{"medicine":"Ulcitab D","composition":"Domperidone 40 mg + Pantoprazole 10 mg","release":"Immediate release","frequency":"Once daily"},{"medicine":"Pantoprazole + Domperidone SR","composition":"Pantoprazole 40 mg + Domperidone 30 mg SR","release":"Sustained release","frequency":"Once daily"}]

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