Domne 40mg Capsule CR (Domperidone) - Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Palpitations, irregular heartbeat, or fainting
- Severe dizziness or lightheadedness
- Swelling of the face, lips, or throat
- Difficulty breathing or rash
- Uncontrollable muscle movements or tremors
- Yellowing of the skin or eyes
- Severe abdominal pain or blood in vomit/stool
- Decreased urine output
If experiencing severe symptoms, call emergency services immediately.
What is domne 40mg capsule cr used for?
This medicine contains Domperidone 40mg, a prokinetic and antiemetic agent used to treat nausea, vomiting, and delayed gastric emptying. It works by blocking dopamine receptors in the brain and gut. It is available as a controlled-release capsule and should be taken as prescribed by a doctor.
- Generic Name: Domperidone (40mg)
- Manufacturer: Raptakos Brett & Co Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 domne 40mg capsule cr के बारे में (Hindi Summary)
उपयोग: यह दवा डोमपेरिडोन 40 मिलीग्राम कैप्सूल के रूप में उपलब्ध है और मुख्य रूप से मतली, उल्टी और पेट की गड़बड़ी के इलाज के लिए इस्तेमाल की जाती है। यह पेट की खाली होने की गति को बढ़ाती है और उल्टी को रोकने में मदद करती है। यह दवा गैस्ट्रोपेरेसिस, अपच और पेट फूलने जैसी समस्याओं में भी फायदेमंद होती है। इसे डॉक्टर के निर्देशानुसार ही लें।
साइड इफेक्ट्स: इस दवा के आम दुष्प्रभावों में मुँह सूखना, सिरदर्द, पेट में ऐंठन, दस्त या कब्ज शामिल हैं। कुछ लोगों में स्तन में दर्द या सूजन, या दूध का स्राव भी हो सकता है। दुर्लभ मामलों में यह दिल की धड़कन में गड़बड़ी पैदा कर सकती है। अगर आपको कोई गंभीर दुष्प्रभाव महसूस हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को लेने से पहले अपने डॉक्टर को अपनी सभी स्वास्थ्य समस्याओं और दवाओं के बारे में बताएं। गर्भावस्था या स्तनपान के दौरान इसका सेवन न करें। शराब का सेवन न करें। दवा लेने के बाद चक्कर आ सकते हैं, इसलिए वाहन चलाने से बचें। दवा को डॉक्टर के बताए अनुसार ही लें, अधिक मात्रा में न लें।
💊 domne 40mg capsule cr Uses & Benefits
[{"condition":"Nausea and vomiting","description":"This medicine is used to relieve nausea and vomiting of various causes, including that associated with gastrointestinal disorders, chemotherapy, or radiotherapy.","evidence":"Well-established"},{"condition":"Gastroparesis","description":"It helps to improve gastric emptying in patients with delayed stomach emptying, reducing symptoms such as bloating, nausea, and early satiety.","evidence":"Well-established"},{"condition":"Functional dyspepsia","description":"This medicine may be used to relieve symptoms of functional dyspepsia, such as upper abdominal discomfort, bloating, and fullness after meals.","evidence":"Moderate"},{"condition":"Gastro-oesophageal reflux disease (GERD)","description":"It can help reduce reflux by improving gastric motility and reducing nausea, but it is not a first-line treatment for GERD.","evidence":"Limited"}]
Off-label uses: [{"condition":"Lactation enhancement","description":"Domperidone is sometimes used off-label to increase breast milk production, but this use is not recommended due to safety concerns.","evidence":"Limited"},{"condition":"Parkinson's disease-related nausea","description":"It may be used to treat nausea in patients with Parkinson's disease, but caution is needed as it can worsen Parkinsonian symptoms.","evidence":"Limited"}]
Primary treatment for: Nausea and vomiting
Also treats: Gastroparesis, Functional dyspepsia, Gastro-oesophageal reflux disease
📋 Drug Information
| Generic Name(s) | Domperidone (40mg) |
| Brand Name | domne 40mg capsule cr |
| Manufacturer | Raptakos Brett & Co Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | Dopamine (D2) receptor antagonist-Prokinetic agent |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by blocking dopamine D2 receptors in the chemoreceptor trigger zone (CTZ) located in the area postrema of the brain, which is outside the blood-brain barrier. This action helps to suppress nausea and vomiting. Additionally, it blocks dopamine receptors in the gastrointestinal tract, leading to increased gastric motility and accelerated gastric emptying. It also increases the tone of the lower oesophageal sphincter and enhances peristalsis in the upper intestine. Unlike some other prokinetic agents, domperidone does not readily cross the blood-brain barrier, which reduces the likelihood of central nervous system side effects such as sedation and extrapyramidal symptoms.
Mechanism Steps
💡 How to Take domne 40mg capsule cr
Strength: Capsule, 40 mg controlled-release.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 10-20 mg taken 3 to 4 times daily, but the exact dose and frequency depend on the condition being treated and the patient's response. For the controlled-release 40mg capsule, it is typically taken once daily or as directed by the physician. The maximum daily dose should not exceed 40 mg for the controlled-release formulation. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the side effects of this medicine, especially cardiac effects. Use with caution and consider dose reduction. Dose must be individualized by a qualified clinician. |
| Renal Impairment | In patients with severe renal impairment, the elimination half-life of this medicine is prolonged. Dose reduction may be necessary. Since the medicine is not significantly removed by dialysis, no supplemental dose is needed after dialysis. Dose must be individualized by a qualified clinician. |
| Hepatic Impairment | This medicine is contraindicated in patients with moderate to severe hepatic impairment. In patients with mild hepatic impairment, use with caution and consider dose reduction. Dose must be individualized by a qualified clinician. |
| Maximum Daily Dose | The maximum recommended daily dose for the controlled-release formulation is 40 mg. For immediate-release formulations, the maximum daily dose is 80 mg, but higher doses increase the risk of cardiac side effects. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of domne 40mg capsule cr
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Ketoconazole | Major | |
| Clarithromycin | Major | |
| Amiodarone | Major | |
| Haloperidol | Major | |
| Citalopram | Major | |
| Ritonavir | Moderate | |
| Diltiazem | Moderate | |
| Atropine | Moderate | |
| Morphine | Moderate | |
| Antacids | Minor |
🚨 Major Interactions
- Ketoconazole, itraconazole, fluconazole, voriconazole
- Clarithromycin, erythromycin, telithromycin
- Amiodarone, sotalol, quinidine, procainamide
- Haloperidol, chlorpromazine, thioridazine
- Citalopram, escitalopram
⚡ Moderate Interactions
- Protease inhibitors (e.g., ritonavir, saquinavir)
- Calcium channel blockers (e.g., diltiazem, verapamil)
- Anticholinergic drugs (e.g., atropine, benztropine)
- Opioid analgesics (e.g., morphine, codeine)
🍷 Alcohol Interaction
Alcohol may increase the risk of dizziness, drowsiness, and other central nervous system side effects when taken with this medicine. It is advisable to avoid alcohol while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to domperidone or any component of the formulation","Prolactin-releasing pituitary tumour (prolactinoma)","Moderate to severe hepatic impairment","Known existing prolongation of cardiac conduction intervals, particularly QTc","Concomitant use with QT-prolonging drugs or potent CYP3A4 inhibitors","Severe renal impairment","Gastrointestinal obstruction, perforation, or haemorrhage","Breastfeeding"]
⚠️ Warnings & Precautions
["This medicine should be used with caution in patients with underlying heart disease or electrolyte disturbances.","Avoid concomitant use with drugs that prolong QT interval or inhibit CYP3A4.","Use the lowest effective dose for the shortest duration possible.","Caution in patients with mild liver impairment; dose adjustment may be needed.","Caution in patients with renal impairment; dose adjustment may be needed.","May cause drowsiness or dizziness; avoid driving or operating machinery until you know how it affects you.","Do not exceed the recommended dose.","Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding."]
🤱 Lactation Safety
This medicine is excreted in breast milk. It is not recommended during breastfeeding due to potential risks to the infant, including effects on the heart and central nervous system. Consult your doctor for alternative treatments.
💊 Overdose Management
Overdose of this medicine may cause symptoms such as drowsiness, confusion, extrapyramidal reactions, and QT prolongation. In case of overdose, seek immediate medical attention. Treatment is symptomatic and supportive, with continuous ECG monitoring for cardiac arrhythmias. There is no specific antidote. Activated charcoal may be considered if the overdose is recent. Dialysis is not effective in removing domperidone.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Before taking this medicine, inform your doctor if you have any heart problems, liver disease, kidney disease, or if you are taking any other medications, especially those that affect heart rhythm or are used to treat infections or depression. Do not take this medicine if you are pregnant or breastfeeding without consulting your doctor. Avoid alcohol while taking this medicine, as it may increase the risk of side effects. Do not drive or operate heavy machinery until you know how this medicine affects you, as it may cause dizziness. Take this medicine exactly as prescribed by your doctor. Do not take more than the recommended dose, as higher doses can increase the risk of serious heart rhythm problems. If you miss a dose, take it as soon as you remember, but if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose. Store this medicine at room temperature, away from moisture and direct sunlight. Keep it out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more susceptible to the cardiac side effects of this medicine, including QT prolongation and arrhythmias. Use with caution and consider dose reduction. Regular monitoring of heart rhythm may be advised.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended during pregnancy or when planning pregnancy. Consult your doctor for safer alternatives to manage nausea and vomiting.
🏥 Post-Surgery Considerations
This medicine may be used to treat post-operative nausea and vomiting. However, it should be used with caution in patients with underlying heart conditions. Inform your surgeon and anesthesiologist about all medicines you are taking.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine, as it may interact with certain medications used during dental procedures. It may also cause dry mouth, which can affect dental health.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine may cause dizziness or drowsiness. Avoid strenuous exercise or activities that require alertness until you know how the medicine affects you. Light exercise like walking may be beneficial for digestion.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness, which can affect your ability to drive or operate machinery. It is advisable to avoid these activities until you know how the medicine affects you. It may also cause dry mouth, which can be managed by drinking water. Overall, it can improve your quality of life by relieving nausea and vomiting.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience serious side effects such as heart palpitations, fainting, or allergic reactions, seek immediate medical attention. Your doctor may advise stopping the medicine if the risks outweigh the benefits.
📅 Long-Term Use Effects
Long-term use of this medicine may increase the risk of hyperprolactinaemia, which can lead to breast-related side effects. There is also a potential risk of cardiac arrhythmias with prolonged use, especially at high doses. Regular monitoring by a doctor is recommended. The lowest effective dose should be used for the shortest duration.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Eating small, frequent meals and avoiding trigger foods can help manage nausea and vomiting.
Evidence: Well-establishedAcupuncture at the P6 point may help reduce nausea and vomiting.
Evidence: ModerateGinger has antiemetic properties and may help reduce nausea.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are scheduled for vaccination, inform your healthcare provider about all medicines you are taking.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging along with a copy of your prescription. Store it at room temperature, away from direct sunlight and moisture. If crossing time zones, adjust the dosing schedule gradually to avoid missing doses. Check customs regulations for carrying prescription medicines. Always keep it in your carry-on luggage.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts working within 30 to 60 minutes after oral administration, but the controlled-release formulation may have a slightly delayed onset. Relief of nausea and vomiting may be noticed within hours.
A: This medicine can interact with several other medications, especially those that affect heart rhythm or are metabolized by the liver. Always inform your doctor about all medicines you are taking.
A: Long-term use should be under the supervision of a doctor. The lowest effective dose for the shortest duration is recommended to minimize the risk of side effects, especially cardiac effects.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
A: It is advisable to avoid alcohol while taking this medicine, as it may increase the risk of dizziness and drowsiness.
🤔 Common Patient Concerns
🔄 Substitutes for domne 40mg capsule cr
View AllAlternative brands with exact same active ingredient:
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is a painkiller.
Fact: This medicine is not a painkiller. It is used to treat nausea, vomiting, and gastric motility disorders. - Myth: This medicine can be taken for any stomach upset.
Fact: This medicine is specifically for nausea, vomiting, and delayed gastric emptying. It should not be used for general stomach upset without a doctor's advice. - Myth: Higher doses of this medicine work better.
Fact: Higher doses increase the risk of serious heart rhythm problems. Always take the dose prescribed by your doctor. - Myth: This medicine is safe to take during pregnancy.
Fact: This medicine is not recommended during pregnancy. Consult your doctor for safer alternatives.
🔄 Alternative Options
Generic Alternatives
- Domperidone 40mg controlled-release capsule
Brand Alternatives
- Domne 40mg capsule CR