Biominic Syrup: Complete Medicine Guide for Cold and Allergy Relief
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Sudden severe headache or worst headache of your life.
- Weakness or numbness on one side of the body, or difficulty speaking.
- Chest pain, palpitations, or shortness of breath.
- Swelling of the face, lips, tongue, or throat.
- Difficulty passing urine or severe lower abdominal pain.
- Confusion, hallucinations, or unusual behavior.
- Yellowing of the skin or eyes, or dark urine.
- Seizures or loss of consciousness.
If experiencing severe symptoms, call emergency services immediately.
What is Triotic Syrup used for?
This medicine is a combination syrup containing chlorpheniramine maleate, an antihistamine, and phenylpropanolamine, a decongestant. It is used for short-term relief of runny nose, sneezing, and nasal congestion due to colds or allergies. It can cause drowsiness and may raise blood pressure. Phenylpropanolamine has been linked to an increased risk of stroke and is withdrawn in several countries, so this medicine should only be used if legally available and specifically recommended by a doctor.
- Generic Name: Chlorpheniramine Maleate (2mg) + Phenylpropanolamine (12.5mg)
- Manufacturer: Bindlysh Biotec Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 Triotic Syrup के बारे में (Hindi Summary)
उपयोग: यह दवा क्लोरफेनिरामाइन मेलिएट और फेनिलप्रोपेनॉलामाइन का संयोजन है, जिसका उपयोग सर्दी-जुकाम और एलर्जी से होने वाली नाक बहने, छींक आने और नाक बंद होने में राहत के लिए किया जाता है। क्लोरफेनिरामाइन एलर्जी के लक्षणों को कम करता है, जबकि फेनिलप्रोपेनॉलामाइन नाक की भीड़ को कम करता है। यह दवा नींद और सुस्ती ला सकती है, इसलिए गाड़ी चलाने या मशीन चलाने से बचें। फेनिलप्रोपेनॉलामाइन से स्ट्रोक का खतरा बढ़ सकता है, इसलिए इसे केवल डॉक्टर की सलाह पर ही लें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में नींद आना, मुँह सूखना, चक्कर आना, धुंधला दिखना और पेट खराब होना शामिल हैं। कुछ लोगों को बेचैनी, घबराहट या अनिद्रा हो सकती है। दुर्लभ मामलों में दिल की धड़कन अनियमित हो सकती है, रक्तचाप बढ़ सकता है या स्ट्रोक का खतरा हो सकता है। अचानक तेज सिरदर्द, कमजोरी, बोलने में कठिनाई, सीने में दर्द या सांस लेने में तकलीफ हो तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा का उपयोग केवल डॉक्टर की सलाह पर और कम समय के लिए करें। यह दवा नींद ला सकती है, इसलिए गाड़ी चलाने या मशीन चलाने से बचें। शराब और अन्य नींद लाने वाली दवाओं के साथ इसका सेवन न करें। यदि आपको उच्च रक्तचाप, हृदय रोग, थायरॉइड की समस्या, ग्लूकोमा या पेशाब करने में कठिनाई है तो इस दवा को लेने से पहले डॉक्टर से सलाह लें। बच्चों को यह दवा बिना डॉक्टर की सलाह के न दें। अचानक तेज सिरदर्द, कमजोरी, सीने में दर्द या सांस लेने में तकलीफ हो तो तुरंत मेडिकल मदद लें।
💊 Triotic Syrup Uses & Benefits
[{"condition":"Allergic rhinitis","description":"This medicine can reduce sneezing, runny nose, itchy eyes, and nasal congestion associated with seasonal or perennial allergies.","evidence":"Established for the antihistamine component; decongestant component effective for nasal stuffiness but safety concerns limit modern use."},{"condition":"Common cold with nasal congestion","description":"This medicine provides temporary relief of runny nose, sneezing, and blocked nose during uncomplicated viral upper respiratory infections.","evidence":"Symptomatic benefit is established, but combination cold products are not recommended for young children."},{"condition":"Vasomotor rhinitis","description":"This medicine may help reduce nasal stuffiness and watery discharge in non-allergic rhinitis, though it is not a first-line treatment.","evidence":"Limited evidence; use is based on the known effects of the individual components."}]
Off-label uses: [{"condition":"Itching associated with urticaria","description":"The antihistamine component may relieve itching in mild hives, but this combination is not a preferred treatment because of the decongestant.","evidence":"Limited; safer antihistamines are usually preferred."},{"condition":"Motion sickness","description":"Chlorpheniramine has some anti-motion-sickness effect, but this combination is not designed for that purpose and the decongestant adds unnecessary risk.","evidence":"Limited; not recommended as a routine option."}]
Primary treatment for: Allergic rhinitis and common cold with nasal congestion
Also treats: Vasomotor rhinitis, Sinusitis with congestion, Upper respiratory allergy
📋 Drug Information
| Generic Name(s) | Chlorpheniramine Maleate (2mg) + Phenylpropanolamine (12.5mg) |
| Brand Name | Triotic Syrup |
| Manufacturer | Bindlysh Biotec Ltd |
| Packaging / Form | bottle of 60 ml Syrup (Allopathy) |
| Therapeutic Class | |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C, away from direct sunlight and moisture. Keep the bottle tightly closed and do not freeze. Keep out of reach of children. |
| Shelf Life | Not established from the available information. Refer to the expiry date printed on the product label. |
| WHO Guideline | Not established from the available information. The World Health Organization does not currently recommend phenylpropanolamine-containing products for routine use because of safety concerns. |
| ICMR Guideline | Not established from the available information. Consult current Indian Council of Medical Research guidance or a qualified clinician for appropriate treatment of cold and allergy symptoms. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works through two complementary actions. Chlorpheniramine maleate is a first-generation antihistamine that competitively blocks histamine H1 receptors, reducing sneezing, itching, runny nose, and watery eyes. Phenylpropanolamine is a sympathomimetic amine that stimulates alpha-adrenergic receptors on nasal blood vessels, causing vasoconstriction and temporarily reducing nasal congestion. The antihistamine also has anticholinergic effects that dry respiratory secretions, while the decongestant can increase heart rate and blood pressure through its adrenergic activity.
Mechanism Steps
💡 How to Take Triotic Syrup
Strength: Each 5 mL of syrup contains chlorpheniramine maleate 2 mg and phenylpropanolamine 12.5 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 5 mL to 10 mL taken every 4 to 6 hours as needed for symptoms, not to exceed the maximum daily dose on the label. Because this combination contains phenylpropanolamine, which has safety concerns, it should only be used if legally available and specifically recommended by a qualified clinician. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and other medicines being taken. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. This medicine should not be given to newborns, premature infants, or young children unless specifically prescribed by a pediatrician. |
| Elderly Dosage | Older adults are more sensitive to the sedative, anticholinergic, and sympathomimetic effects of this medicine. Use with caution and at the lowest effective dose. Dose must be individualized by a qualified clinician based on renal and hepatic function and other medical conditions. |
| Renal Impairment | Dose adjustment may be needed in patients with severe kidney impairment because phenylpropanolamine is excreted by the kidneys. Consult a qualified clinician for individualized dosing. |
| Hepatic Impairment | Chlorpheniramine is metabolized by the liver, so dose adjustment may be needed in patients with severe liver disease. Consult a qualified clinician for individualized dosing. |
| Maximum Daily Dose | The maximum daily dose is not established from the available information for this specific product. Do not exceed the dose recommended on the product label or by your clinician. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of Triotic Syrup
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| MAOIs | Major | |
| Other decongestants or stimulants | Major | |
| Antihypertensives | Major | |
| Alcohol and sedatives | Major | |
| Tricyclic antidepressants | Moderate | |
| Beta-blockers | Moderate | |
| CYP2D6 inhibitors | Moderate | |
| Anticholinergics | Moderate | |
| Caffeine | Minor | |
| Antacids | Minor |
🚨 Major Interactions
- Monoamine oxidase inhibitors (MAOIs)
- Other sympathomimetic decongestants or stimulants
- Antihypertensive medicines
- Alcohol and other central nervous system depressants
⚡ Moderate Interactions
- Tricyclic antidepressants
- Beta-blockers
- CYP2D6 inhibitors such as fluoxetine, paroxetine, and quinidine
- Anticholinergic medicines such as oxybutynin and benztropine
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine because it increases drowsiness, dizziness, and impaired coordination. The combination can also increase the risk of falls and accidents. If you drink alcohol regularly, discuss safer alternatives with your doctor.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to chlorpheniramine maleate, phenylpropanolamine, or any component of this medicine.","Uncontrolled high blood pressure or severe coronary artery disease.","Use within 14 days of taking a monoamine oxidase inhibitor.","Hyperthyroidism.","Narrow-angle glaucoma.","Urinary retention or prostatic enlargement with difficulty passing urine.","Newborns, premature infants, and children below the age recommended by a clinician.","Severe liver or kidney disease unless specifically approved by a doctor."]
⚠️ Warnings & Precautions
["This medicine may cause drowsiness. Do not drive or operate machinery until you know how it affects you.","Avoid alcohol and other sedating medicines while taking this product.","Phenylpropanolamine has been associated with an increased risk of hemorrhagic stroke. Use only if legally available and specifically recommended by a clinician.","Use with caution in older adults, who are more sensitive to anticholinergic and sympathomimetic effects.","Do not use for more than a few days without medical advice, as nasal congestion may worsen with prolonged decongestant use.","Check with your doctor before use if you have diabetes, thyroid disease, heart disease, or glaucoma.","Keep out of reach of children and never give to infants or premature babies.","Do not take additional cold or allergy products without checking for overlapping ingredients."]
🤱 Lactation Safety
Chlorpheniramine maleate passes into breast milk and may cause drowsiness or irritability in a breastfed infant. Phenylpropanolamine may reduce milk supply and is not recommended during breastfeeding. Consult your doctor for safer alternatives.
💊 Overdose Management
Overdose of this medicine can cause severe drowsiness, agitation, hallucinations, seizures, high blood pressure, irregular heartbeat, and difficulty breathing. If you suspect an overdose, seek emergency medical care immediately. Do not try to make yourself vomit unless instructed by a medical professional. Treatment is supportive and may include activated charcoal, blood pressure control, and management of seizures or arrhythmias. Carry the medicine container to the hospital so the medical team knows exactly what was taken.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember if less than half the dosing interval has passed. If more than half the interval has passed, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Use this medicine only for short-term relief of cold or allergy symptoms and only at the dose recommended by a qualified clinician. Do not drive or operate heavy machinery until you know how this medicine affects you, because it commonly causes drowsiness. Avoid alcohol and other sedating medicines while taking this product. Do not use this medicine if you have uncontrolled high blood pressure, severe heart disease, hyperthyroidism, narrow-angle glaucoma, or trouble emptying your bladder. Check with your doctor before use if you are pregnant, breastfeeding, or taking blood pressure medicines, antidepressants, or other cold remedies. Keep this medicine out of the reach of children and never give it to infants or premature babies. Stop the medicine and seek medical help immediately if you develop a sudden severe headache, weakness, chest pain, or difficulty breathing.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Older adults are more likely to experience drowsiness, confusion, dry mouth, constipation, urinary retention, and blood pressure changes from this medicine. The risk of falls and fractures is also higher. Use with caution, at the lowest effective dose, and consider safer alternatives such as non-sedating antihistamines or saline nasal sprays.
🤰 Pregnancy Planning (TTC)
If you are trying to conceive or are pregnant, avoid this medicine unless specifically advised by your doctor. Phenylpropanolamine has been linked to birth defects in some studies, and its safety during pregnancy is not well established. Discuss safer options for cold and allergy relief with your obstetrician.
🏥 Post-Surgery Considerations
This medicine can cause drowsiness and may interact with anesthesia and pain medicines. Inform your surgeon and anesthesiologist if you are taking this medicine. It is usually stopped before surgery, and you should not restart it without your doctor's approval.
🦷 Dental Procedures
This medicine can cause dry mouth, which may increase the risk of dental problems. Inform your dentist if you are taking this medicine, especially before any procedure that requires sedation or anesthesia. It may interact with sedatives used during dental procedures.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine can cause drowsiness, dizziness, and blurred vision, which may affect your coordination. Avoid strenuous exercise or activities that require balance until you know how the medicine affects you. If you feel dizzy or weak, stop exercising and rest.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine commonly causes drowsiness, which can reduce your alertness and reaction time. Avoid driving, operating heavy machinery, or performing tasks that require full concentration until you know how it affects you. It may also cause dry mouth and dizziness, which can be uncomfortable at work. Discuss with your doctor if you need a non-sedating alternative.
🛑 When to Stop This Medicine
Stop this medicine if your symptoms improve or after the short course recommended by your doctor. Stop immediately and seek medical help if you develop a sudden severe headache, weakness, chest pain, palpitations, difficulty breathing, or swelling of the face or throat. Do not stop other prescribed medicines without consulting your doctor.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended. Prolonged use of decongestants can cause rebound nasal congestion, and long-term antihistamine use may lead to tolerance and persistent drowsiness. Phenylpropanolamine has been linked to an increased risk of hemorrhagic stroke, especially with prolonged or high-dose use. Regular monitoring of blood pressure and review of the need for continued therapy are advised if long-term use is considered.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Rinsing the nasal passages with saline solution can help relieve congestion without medicine.
Evidence: Well-established for mild congestion.Medicines such as cetirizine or loratadine can treat allergy symptoms without causing much drowsiness.
Evidence: Well-established for allergic rhinitis.These sprays reduce inflammation in the nose and are effective for allergic rhinitis.
Evidence: Well-established for allergic rhinitis.Moist air can help loosen nasal secretions and ease breathing.
Evidence: Limited but commonly used.💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. If you are sick with a fever or severe cold, your doctor may advise delaying vaccination until you recover. Follow your doctor's advice regarding routine vaccinations.
📦 Storage Guide
✅ DO
Store at room temperature between 15°C and 30°C.
❌ DON'T
Do not refrigerate or freeze unless specified on the label.
✅ DO
Keep the bottle tightly closed and in its original carton.
❌ DON'T
Do not transfer to unmarked containers.
✅ DO
Keep away from direct sunlight and moisture.
❌ DON'T
Do not store in the bathroom cabinet.
✅ DO
Keep out of reach of children.
❌ DON'T
Do not use after the expiry date.
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription if it is a prescription medicine. Keep it in your hand luggage if you need it during the flight, but be aware that it can cause drowsiness. Check the laws of your destination country because phenylpropanolamine is banned or restricted in several countries. Store it at room temperature and protect it from extreme heat or cold during travel. If you are crossing time zones, continue your doses at the usual intervals and do not double up.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: The antihistamine effect usually begins within 30 to 60 minutes, and the decongestant effect may begin within 15 to 30 minutes. You may notice relief of runny nose and sneezing within an hour.
A: The effects usually last about 4 to 6 hours, so the medicine is often taken every 4 to 6 hours as needed.
A: Yes, but it may cause drowsiness, which can be helpful at night. However, some people experience restlessness or insomnia due to the decongestant. Follow your doctor's advice.
A: Yes, you can take it with or without food. Taking it with food may reduce stomach upset.
A: If you remember within half the dosing interval, take the missed dose. If more than half the interval has passed, skip it and continue with your regular schedule. Do not double dose.
A: The safety of phenylpropanolamine during pregnancy is not well established, and it may increase the risk of birth defects. Avoid this medicine unless specifically advised by your obstetrician.
A: Chlorpheniramine can pass into breast milk and may cause drowsiness in the baby. Phenylpropanolamine may reduce milk supply. Consult your doctor for safer alternatives.
A: Seek emergency care for sudden severe headache, weakness on one side of the body, difficulty speaking, chest pain, palpitations, difficulty breathing, or swelling of the face or throat.
🤔 Common Patient Concerns
🔄 Substitutes for Triotic Syrup
View AllAlternative brands with exact same active ingredient:
-
biominic syrupBilcare Ltd ₹23.44 0.4% COSTLIER
-
axn syrupEsquire Drug House ₹25.00 7.1% COSTLIER
-
anoril-d syrupStalwart Remedies Pvt Ltd ₹26.00 11.4% COSTLIER
-
cofset syrupOrison Pharma International ₹26.25 12.5% COSTLIER
-
coldina cough syrupHamax Pharmaceuticals ₹26.25 12.5% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure the common cold.
Fact: This medicine only relieves symptoms such as runny nose and congestion. It does not cure or shorten a cold. - Myth: It is safe to take this medicine for weeks.
Fact: This medicine is for short-term use only. Prolonged use of decongestants can worsen nasal congestion and increase side effects. - Myth: Since it is a syrup, it is safe for babies.
Fact: This medicine should not be given to newborns, premature infants, or young children unless specifically prescribed by a pediatrician. - Myth: It is fine to take this medicine with other cold remedies.
Fact: Many cold remedies contain the same or similar ingredients. Combining them can lead to overdose and serious side effects.
🔄 Alternative Options
Generic Alternatives
- Chlorpheniramine maleate syrup alone
- Phenylpropanolamine is not recommended as a standalone generic due to safety concerns
- Other antihistamine syrups such as cetirizine or loratadine, which are non-sedating
Brand Alternatives
- This medicine is marketed as biominic syrup by Bilcare Ltd. Other brands may exist, but many countries have withdrawn phenylpropanolamine-containing products.