Axostat 100mg Injection (Tranexamic Acid): Comprehensive Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Sudden shortness of breath or chest pain
- Swelling, pain, or redness in an arm or leg
- Severe headache with vision changes
- Seizures or convulsions
- Signs of allergic reaction: rash, itching, swelling of face or throat
- Decreased urine output
- Unusual bleeding or bruising
If experiencing severe symptoms, call emergency services immediately.
What is Tranarest 100mg Injection used for?
Tranexamic acid injection is an antifibrinolytic medicine used to control excessive bleeding during surgery, trauma, or in certain medical conditions. It works by preventing the breakdown of blood clots.
- Generic Name: Tranexamic Acid (100mg)
- Manufacturer: Cadila Pharmaceuticals Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 Tranarest 100mg Injection के बारे में (Hindi Summary)
उपयोग: यह दवा ट्रैनेक्सैमिक एसिड का इंजेक्शन है, जिसका उपयोग अत्यधिक रक्तस्राव को नियंत्रित करने के लिए किया जाता है। यह सर्जरी, आघात, या कुछ चिकित्सीय स्थितियों में रक्तस्राव को कम करने में मदद करती है। यह रक्त के थक्के को बनने से नहीं रोकती, बल्कि थक्के को टूटने से बचाती है। यह दवा केवल अस्पताल में डॉक्टर या नर्स द्वारा दी जाती है। इसे स्वयं न लें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, दस्त, पेट दर्द, सिरदर्द, चक्कर आना और इंजेक्शन की जगह पर दर्द शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन रक्त के थक्के बनने, एलर्जी प्रतिक्रिया, दौरे और दृष्टि में बदलाव हो सकते हैं। यदि आपको सांस लेने में कठिनाई, सीने में दर्द, या पैर में सूजन हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: यह दवा केवल योग्य स्वास्थ्य पेशेवर द्वारा ही दी जानी चाहिए। इसे स्वयं न लें। इस दवा को लेने से पहले अपने डॉक्टर को अपनी सभी दवाओं, एलर्जी और चिकित्सीय स्थितियों के बारे में बताएं। यदि आपको रक्त के थक्के बनने का इतिहास है, गुर्दे की बीमारी है, या आप गर्भवती हैं, तो डॉक्टर को सूचित करें। इलाज के दौरान रक्त के थक्के के लक्षणों पर नजर रखें।
💊 Tranarest 100mg Injection Uses & Benefits
[{"condition":"Excessive bleeding during surgery","description":"This medicine is used to reduce blood loss and the need for transfusions in various surgical procedures, including cardiac, orthopedic, and prostate surgery.","evidence":"Well-established"},{"condition":"Trauma-related bleeding","description":"It is administered to patients with severe trauma to control bleeding and improve survival outcomes.","evidence":"Well-established"},{"condition":"Heavy menstrual bleeding (menorrhagia)","description":"Although oral forms are more common, the injectable form may be used in acute settings to control heavy uterine bleeding.","evidence":"Established"},{"condition":"Hemophilia and other bleeding disorders","description":"Used to prevent or control bleeding in patients with hemophilia undergoing dental or surgical procedures.","evidence":"Established"},{"condition":"Epistaxis (nosebleeds)","description":"May be used in severe or recurrent nosebleeds that do not respond to other measures.","evidence":"Limited"}]
Off-label uses: [{"condition":"Melasma","description":"Oral tranexamic acid is sometimes used off-label for skin pigmentation, but the injectable form is not typically used for this purpose.","evidence":"Limited"},{"condition":"Angioedema","description":"There is some evidence for use in hereditary angioedema, but this is not a standard indication for the injectable form.","evidence":"Limited"}]
Primary treatment for: Excessive bleeding
Also treats: Menorrhagia, Hemophilia, Epistaxis
📋 Drug Information
| Generic Name(s) | Tranexamic Acid (100mg) |
| Brand Name | Tranarest 100mg Injection |
| Manufacturer | Cadila Pharmaceuticals Ltd |
| Packaging / Form | vial of 1 Injection (Allopathy) |
| Therapeutic Class | |
| Action Class | |
| Route of Administration | Parenteral (intravenous or intramuscular injection) |
| Storage | Store at room temperature (15-30°C). Protect from light. Do not freeze. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | WHO recommends tranexamic acid for the treatment of postpartum hemorrhage and for trauma patients with significant bleeding. It is included in the WHO Model List of Essential Medicines. |
| ICMR Guideline | ICMR guidelines may recommend tranexamic acid for similar indications. Consult local guidelines. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Tranexamic acid is a synthetic lysine analog that reversibly binds to the lysine-binding sites on plasminogen and plasmin. This prevents the binding of plasminogen to fibrin, thereby inhibiting fibrinolysis and stabilizing blood clots. By blocking the breakdown of fibrin, it helps to reduce bleeding. The effect is specific to the fibrinolytic system and does not promote clot formation in the absence of a pre-existing clot.
Mechanism Steps
💡 How to Take Tranarest 100mg Injection
Strength: Injection: 100mg per vial (or as specified).
Dosage Information
| Adult Dosage | The dose of this medicine varies depending on the indication, patient's weight, and renal function. For example, in cardiac surgery, a common dose is 10-15 mg/kg before and after surgery. For trauma, a loading dose of 1g over 10 minutes followed by 1g infusion over 8 hours is used. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may have reduced renal function; dose adjustment may be necessary. Use with caution and monitor renal function. |
| Renal Impairment | In patients with renal impairment, the dose should be reduced. For serum creatinine 1.4-2.8 mg/dL, 10 mg/kg twice daily; for 2.8-5.7 mg/dL, 10 mg/kg once daily; for >5.7 mg/dL, 5 mg/kg once daily. Consult a nephrologist for precise dosing. |
| Hepatic Impairment | No specific dose adjustment is required for hepatic impairment, as tranexamic acid is not metabolized in the liver. |
| Maximum Daily Dose | The maximum daily dose varies by indication. For adults, up to 4g per day has been used in some settings. Dose must be individualized by a qualified clinician. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of Tranarest 100mg Injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Heparin | Major | |
| Alteplase | Major | |
| Factor IX complex | Moderate | |
| Anti-inhibitor coagulant complex | Moderate |
🚨 Major Interactions
- Anticoagulants (e.g., warfarin, heparin)
- Thrombolytic agents (e.g., alteplase)
⚡ Moderate Interactions
- Factor IX complex concentrates
- Anti-inhibitor coagulant complexes
🍷 Alcohol Interaction
Alcohol may increase the risk of gastrointestinal bleeding and should be avoided while receiving this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Active intravascular clotting","History of thrombosis or thromboembolism","Severe renal impairment (e.g., eGFR
⚠️ Warnings & Precautions
["Use with caution in patients with a history of thrombosis.","Dose adjustment required in renal impairment.","May cause seizures, especially in high doses or renal impairment.","Visual disturbances may occur with long-term use; periodic eye exams recommended.","Not for intrathecal or intraventricular administration.","Should not be used in patients with disseminated intravascular coagulation (DIC) unless there is predominant fibrinolysis."]
🤱 Lactation Safety
Tranexamic acid is excreted in breast milk at low concentrations. It is generally considered safe during breastfeeding, but consult your doctor.
💊 Overdose Management
Overdose may lead to increased risk of thrombosis. Treatment is supportive and symptomatic. There is no specific antidote. In case of overdose, discontinue the medicine and monitor for signs of thrombosis. Hemodialysis may be considered to remove tranexamic acid from the bloodstream.
⏰ Missed Dose
Since this medicine is administered by a healthcare professional, missed doses are unlikely. If you miss a scheduled dose, contact your doctor or nurse for instructions. Do not attempt to self-administer.
Additional Safety Advice
This medicine should only be administered by a qualified healthcare professional in a hospital or clinic setting. Do not attempt to self-administer. Before receiving this medicine, inform your doctor if you have a history of blood clots, kidney disease, liver disease, or if you are pregnant or breastfeeding. It is important to provide a complete list of all medications you are taking, including over-the-counter drugs and herbal supplements, as interactions may occur. Avoid activities that increase the risk of bleeding or injury while receiving treatment. If you experience signs of a blood clot such as pain, swelling, redness in an arm or leg, chest pain, shortness of breath, or sudden severe headache, seek emergency medical help immediately. Regular monitoring of kidney function and blood tests may be required during treatment. Do not receive this medicine if you are allergic to tranexamic acid or any of its components.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may have reduced renal function, increasing the risk of accumulation and toxicity. Dose adjustment based on renal function is recommended. Monitor for signs of thrombosis and seizures.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before receiving this medicine. It should be used during pregnancy only if clearly needed. It crosses the placenta.
🏥 Post-Surgery Considerations
This medicine is often used during surgery to reduce bleeding. After surgery, monitor for signs of thrombosis and follow your surgeon's instructions.
🦷 Dental Procedures
This medicine may be used before dental procedures in patients with bleeding disorders to prevent excessive bleeding. Inform your dentist if you are receiving this medicine.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise or contact sports that could increase the risk of bleeding or injury while receiving this medicine.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or fatigue. Avoid driving or operating heavy machinery until you know how it affects you. It is usually administered in a hospital setting, so work impact is minimal.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. It is typically given for a short duration. If you experience any serious side effects, seek immediate medical attention.
📅 Long-Term Use Effects
Long-term use of tranexamic acid may increase the risk of thrombosis and visual disturbances. Periodic monitoring of renal function and eye examinations are recommended for prolonged therapy. The risk-benefit should be assessed regularly.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Another antifibrinolytic that can be used as an alternative.
Evidence: Well-establishedDirect surgical control of bleeding may be necessary in some cases.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific interactions with vaccines. However, consult your doctor before receiving any vaccine while on this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not freeze
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Protect from light
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
This medicine is administered in a healthcare setting, so travel advice is limited. If you are prescribed this medicine for self-administration (unlikely), carry it in its original packaging with a copy of your prescription. Store at room temperature and protect from light. Check customs regulations for injectable medicines before traveling. Inform security personnel about your medical condition and medication.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Following intravenous administration, it starts working immediately. For intramuscular injection, it may take 15-30 minutes.
A: No, this medicine must be administered by a healthcare professional in a hospital or clinic.
A: Since it is given by a healthcare professional, missed doses are unlikely. If you miss a scheduled dose, contact your doctor.
🤔 Common Patient Concerns
🔄 Substitutes for Tranarest 100mg Injection
View AllAlternative brands with exact same active ingredient:
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stayhappi tranexamic acid 100mg injectionSarvagunaushdhi Pvt Ltd ₹21.11 44.4% CHEAPER
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t syl 100mg injectionIndoco Remedies Ltd ₹27.57 27.4% CHEAPER
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Tonopan 100mg InjectionBiotavia Labs Pvt Ltd ₹32.00 15.8% CHEAPER
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clotawin-t injectionBestoChem Formulations India Ltd ₹37.25 2% CHEAPER
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Transy 100mg InjectionBiosys Medisciences ₹42.50 11.8% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Tranexamic acid is a blood thinner.
Fact: Tranexamic acid is not a blood thinner; it helps to stabilize blood clots and reduce bleeding. - Myth: Tranexamic acid can be used for any bleeding.
Fact: It is specific for bleeding due to excessive fibrinolysis and is not effective for all types of bleeding.
🔄 Alternative Options
Generic Alternatives
- Tranexamic acid injection (generic)
Brand Alternatives
- Axostat 100mg injection