Sucrafil D Tablet: Complete Guide to Uses, Side Effects, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in vomit or black, tarry stools
- Severe abdominal pain or cramping
- Chest pain, palpitations, or difficulty breathing
- Swelling of face, lips, or throat
- Yellowing of skin or eyes (jaundice)
- Decreased urine output or swelling in legs
- Uncontrollable muscle spasms or tremors
If experiencing severe symptoms, call emergency services immediately.
What is sucrafil d tablet used for?
This medicine is a combination of sucralfate and domperidone used to treat acid reflux, gastritis, and peptic ulcers. It protects the stomach lining and improves gastric emptying.
- Generic Name: Sucralfate (500mg) + Domperidone (10mg)
- Manufacturer: Fourrts India Laboratories Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 sucrafil d tablet के बारे में (Hindi Summary)
उपयोग: यह दवा सुक्राल्फेट और डोम्पेरिडोन का संयोजन है, जिसका उपयोग एसिड रिफ्लक्स, गैस्ट्रिटिस, और पेप्टिक अल्सर के इलाज के लिए किया जाता है। यह पेट की परत की रक्षा करती है और पेट खाली होने में मदद करती है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मुँह सूखना, कब्ज, दस्त, सिरदर्द, और पेट में असुविधा शामिल हो सकते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन एलर्जी, अनियमित दिल की धड़कन, या मांसपेशियों में अकड़न हो सकती है। किसी भी गंभीर लक्षण पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। इसे खाली पेट, भोजन से कम से कम 1 घंटा पहले लें। एंटासिड के साथ इसका सेवन न करें; दोनों के बीच 2 घंटे का अंतराल रखें। अगर आपको किडनी या दिल की समस्या है तो डॉक्टर को बताएं। धूम्रपान और शराब से बचें।
💊 sucrafil d tablet Uses & Benefits
[{"condition":"Gastroesophageal reflux disease (GERD)","description":"Helps reduce acid reflux symptoms by protecting the esophageal mucosa and improving gastric emptying.","evidence":"Well-established"},{"condition":"Peptic ulcer disease","description":"Sucralfate forms a protective barrier over ulcers, while domperidone aids in gastric motility.","evidence":"Well-established"},{"condition":"Gastritis","description":"Provides symptomatic relief by coating the inflamed stomach lining and reducing nausea.","evidence":"Moderate"},{"condition":"Functional dyspepsia","description":"May improve symptoms of bloating, early satiety, and upper abdominal discomfort.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Prevention of stress ulcers in critically ill patients","description":"Sometimes used off-label for stress ulcer prophylaxis, but evidence is limited.","evidence":"Limited"},{"condition":"Chemotherapy-induced nausea and vomiting","description":"Domperidone component may help, but not a first-line option.","evidence":"Limited"}]
Primary treatment for: Gastroesophageal reflux disease (GERD)
Also treats: Peptic ulcer disease, Gastritis, Functional dyspepsia
📋 Drug Information
| Generic Name(s) | Sucralfate (500mg) + Domperidone (10mg) |
| Brand Name | sucrafil d tablet |
| Manufacturer | Fourrts India Laboratories Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary mechanisms. Sucralfate is a complex of aluminum hydroxide and sulfated sucrose that polymerizes in the acidic environment of the stomach to form a viscous, adhesive paste. This paste selectively binds to damaged mucosa and ulcer craters, creating a physical barrier against acid, pepsin, and bile salts. It also inhibits pepsin activity and may stimulate local prostaglandin synthesis, enhancing mucosal defense. Domperidone is a peripheral dopamine D2 receptor antagonist that blocks dopamine receptors in the chemoreceptor trigger zone and gastrointestinal tract. This action enhances gastric motility, accelerates gastric emptying, and increases lower esophageal sphincter tone, thereby reducing nausea, vomiting, and reflux.
Mechanism Steps
💡 How to Take sucrafil d tablet
Strength: Tablet containing sucralfate 500 mg and domperidone 10 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet taken orally on an empty stomach, typically 2-4 times daily, or as directed by your doctor. The exact dose and frequency depend on the condition being treated, your age, kidney and liver function, and other medications you are taking. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not self-adjust the dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may require lower doses due to reduced renal function and increased sensitivity to side effects. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Use with caution in renal impairment. Sucralfate may accumulate; dose reduction or avoidance may be necessary. Consult a doctor for individualized dosing. |
| Hepatic Impairment | Domperidone is metabolized in the liver; use with caution in hepatic impairment. Dose adjustment may be needed. Consult a doctor. |
| Maximum Daily Dose | The maximum recommended daily dose is 4 tablets (2000 mg sucralfate and 40 mg domperidone) per day, but this must be individualized by a clinician. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of sucrafil d tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Ketoconazole | Major | |
| Clarithromycin | Major | |
| Amiodarone | Major | |
| Warfarin | Moderate | |
| Digoxin | Moderate | |
| Levodopa | Moderate | |
| Antacids | Moderate | |
| Tetracycline | Minor | |
| Levothyroxine | Minor | |
| Fluoroquinolones | Minor |
🚨 Major Interactions
- Ketoconazole, itraconazole, clarithromycin, ritonavir
- QT-prolonging drugs (e.g., amiodarone, sotalol, haloperidol)
- Antacids and acid-suppressing agents
⚡ Moderate Interactions
- Levodopa
- Warfarin
- Digoxin
🍷 Alcohol Interaction
Alcohol may worsen gastrointestinal irritation and increase the risk of side effects such as dizziness and drowsiness. It is advisable to avoid alcohol while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to sucralfate or domperidone","Gastrointestinal obstruction, perforation, or bleeding","Prolactin-releasing pituitary tumor (prolactinoma)","Severe renal impairment (for sucralfate component)","Concomitant use with strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin)","QT prolongation or history of arrhythmias"]
⚠️ Warnings & Precautions
["Use with caution in patients with kidney disease; monitor for aluminum toxicity.","Avoid in patients with cardiac disease or electrolyte imbalances due to risk of arrhythmias.","May cause drowsiness; avoid driving or operating machinery until you know how it affects you.","Do not take antacids within 2 hours of this medicine.","Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding.","Elderly patients may be more sensitive to side effects; dose adjustment may be needed.","Long-term use should be periodically reviewed by a doctor."]
🤱 Lactation Safety
Domperidone is excreted in breast milk and may cause side effects in the infant. Sucralfate is minimally absorbed. Consult a doctor before use during breastfeeding.
💊 Overdose Management
Overdose may cause severe gastrointestinal symptoms, drowsiness, or extrapyramidal reactions. Seek immediate medical attention. Treatment is symptomatic and supportive. Activated charcoal may be considered if taken recently. Monitor ECG for arrhythmias.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not crush or chew the tablet; swallow it whole with a glass of water. It is best taken on an empty stomach, at least one hour before meals, to allow sucralfate to coat the stomach lining effectively. Avoid taking antacids within two hours of this medicine, as they can reduce its effectiveness. Inform your doctor if you have kidney problems, heart conditions, or a history of allergies. Do not drive or operate heavy machinery if you feel dizzy or drowsy after taking this medicine. Avoid alcohol consumption while on this medication, as it may worsen stomach irritation. Keep out of reach of children. Store at room temperature away from moisture and direct sunlight.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more prone to kidney impairment and cardiac arrhythmias. Dose adjustment may be necessary. Regular monitoring of renal function and ECG is advised.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before taking this medicine. The safety of this combination during pregnancy is not well established.
🏥 Post-Surgery Considerations
Use with caution after gastrointestinal surgery. Consult your surgeon before resuming this medicine.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine, as it may interact with certain medications used during dental procedures.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid vigorous exercise immediately after meals, as it may worsen reflux. Light walking after meals can aid digestion. Consult your doctor before starting any new exercise regimen.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause drowsiness or dizziness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It generally does not affect office work, but take precautions if you feel unwell.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience severe side effects or your symptoms resolve, your doctor may advise tapering or stopping. Abrupt discontinuation may lead to recurrence of symptoms.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to aluminum accumulation in patients with kidney disease, and domperidone may cause hyperprolactinemia or cardiac effects. Periodic monitoring of renal function and clinical review is recommended. Do not use for prolonged periods without medical supervision.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
May be used as an alternative for acid suppression.
Evidence: Well-establishedAnother class for reducing stomach acid.
Evidence: Well-establishedDietary changes and weight loss can complement or reduce need for medication.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions are known. However, consult your doctor before any vaccination while on this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from moisture. If traveling across time zones, adjust dosing times gradually as advised by your doctor. Check customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Sucralfate starts protecting the stomach within 30-60 minutes, while domperidone begins improving motility within 30-60 minutes. Symptom relief may take a few days.
A: It is best taken on an empty stomach, at least 1 hour before meals, to allow sucralfate to coat the stomach lining effectively.
A: Consult your doctor. The safety of this combination during pregnancy is not well established.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: This medicine can be taken with antacids.
Fact: Antacids can reduce the effectiveness of sucralfate. They should be taken at least 2 hours apart. - Myth: It is safe to take this medicine for long periods without monitoring.
Fact: Long-term use requires periodic review by a doctor, especially to monitor kidney function and domperidone side effects.
🔄 Alternative Options
Generic Alternatives
- Sucralfate + Domperidone combination generics available
Brand Alternatives
- Sucrafil D Tablet