Macralfate-O Suspension Sugar Free: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in vomit or black, tarry stools
- Severe abdominal pain that does not go away
- Difficulty breathing or swelling of face, lips, or throat
- Confusion, muscle weakness, or seizures (signs of aluminum toxicity)
- Signs of an allergic reaction such as rash, itching, or hives
- Yellowing of skin or eyes (jaundice)
If experiencing severe symptoms, call emergency services immediately.
What is sucraraff-o oral suspension used for?
This medicine is a sugar-free suspension containing sucralfate and oxetacaine. It is used to treat peptic ulcers, GERD, and gastritis by forming a protective barrier over the stomach lining and providing local pain relief. It is taken orally, usually four times a day on an empty stomach.
- Generic Name: Sucralfate (500mg) + Oxetacaine (10mg)
- Manufacturer: Raffles Pharmaceuticals
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 sucraraff-o oral suspension के बारे में (Hindi Summary)
उपयोग: यह दवा सुक्राल्फेट और ऑक्सेटाकेन का संयोजन है, जिसका उपयोग पेट के अल्सर, गैस्ट्रोएसोफेजियल रिफ्लक्स डिजीज (GERD), और गैस्ट्राइटिस के इलाज के लिए किया जाता है। यह पेट की परत पर एक सुरक्षात्मक परत बनाती है और दर्द को कम करने के लिए स्थानीय एनेस्थेटिक प्रभाव देती है। यह शुगर-फ्री सस्पेंशन है, इसलिए मधुमेह रोगी भी इसका उपयोग कर सकते हैं।
साइड इफेक्ट्स: आम दुष्प्रभावों में कब्ज, मुँह सूखना और हल्का चक्कर आना शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन एलर्जी प्रतिक्रिया, सूजन, या सांस लेने में कठिनाई हो सकती है। किडनी की बीमारी वाले लोगों में एल्यूमीनियम विषाक्तता का खतरा हो सकता है।
सुरक्षा सलाह: इस दवा को लेने से पहले अपने डॉक्टर को अपनी किडनी की स्थिति, गर्भावस्था, या स्तनपान के बारे में बताएं। अन्य दवाओं के साथ इस दवा को लेने से पहले कम से कम 2 घंटे का अंतराल रखें। शराब और दर्द निवारक दवाओं से बचें। दवा को खाली पेट लें और निर्धारित खुराक से अधिक न लें।
💊 sucraraff-o oral suspension Uses & Benefits
[{"condition":"Peptic ulcer disease","description":"Helps heal gastric and duodenal ulcers by forming a protective barrier and reducing pain.","evidence":"Well-established"},{"condition":"Gastroesophageal reflux disease (GERD)","description":"Provides symptomatic relief from heartburn and acid regurgitation by protecting the esophageal mucosa.","evidence":"Well-established"},{"condition":"Gastritis","description":"Soothes inflamed stomach lining and reduces associated pain and discomfort.","evidence":"Well-established"},{"condition":"Esophagitis","description":"Used off-label to relieve pain and promote healing in inflammation of the esophagus.","evidence":"Limited"}]
Off-label uses: [{"condition":"Mucositis due to chemotherapy or radiation","description":"Sometimes used to alleviate oral and gastrointestinal mucositis pain.","evidence":"Limited"},{"condition":"Stress ulcer prophylaxis","description":"Occasionally used in critically ill patients to prevent stress-related mucosal bleeding.","evidence":"Limited"}]
Primary treatment for: Peptic ulcer disease
Also treats: Gastroesophageal reflux disease (GERD), Gastritis, Esophagitis
📋 Drug Information
| Generic Name(s) | Sucralfate (500mg) + Oxetacaine (10mg) |
| Brand Name | sucraraff-o oral suspension |
| Manufacturer | Raffles Pharmaceuticals |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight. Do not freeze. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients. Sucralfate is a complex of aluminum hydroxide and sulfated sucrose that polymerizes in the acidic environment of the stomach to form a viscous, adhesive paste. This paste selectively binds to damaged mucosa and ulcer craters, creating a physical barrier against acid, pepsin, and bile salts. It also inhibits pepsin activity and adsorbs bile acids. Oxetacaine is a local anesthetic that blocks sodium channels in nerve endings, providing rapid relief from pain and discomfort in the gastrointestinal tract.
Mechanism Steps
💡 How to Take sucraraff-o oral suspension
Strength: Each 5 mL contains sucralfate 500 mg and oxetacaine 10 mg.
Dosage Information
| Adult Dosage | The usual adult dose is 10 mL (containing 500 mg sucralfate and 10 mg oxetacaine) taken four times daily, preferably on an empty stomach, one hour before meals and at bedtime. Dose may be adjusted by your doctor based on your condition. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may have reduced renal function; dose adjustment may be necessary. Consult your doctor. |
| Renal Impairment | Use with caution in renal impairment. Dose reduction may be required. Consult your doctor. |
| Hepatic Impairment | No specific dose adjustment is recommended for hepatic impairment. |
| Maximum Daily Dose | The maximum recommended daily dose is 40 mL (2000 mg sucralfate and 40 mg oxetacaine) in divided doses. Do not exceed without medical advice. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of sucraraff-o oral suspension
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Ciprofloxacin | Major | |
| Tetracycline | Major | |
| Levothyroxine | Major | |
| Digoxin | Moderate | |
| Warfarin | Moderate | |
| Ketoconazole | Moderate | |
| Antacids | Minor | |
| Phenytoin | Minor |
🚨 Major Interactions
- Fluoroquinolone antibiotics (e.g., ciprofloxacin, levofloxacin)
- Tetracycline antibiotics
- Levothyroxine
⚡ Moderate Interactions
- Digoxin
- Warfarin
- Ketoconazole
🍷 Alcohol Interaction
Alcohol can irritate the stomach lining and worsen your condition. It is advisable to avoid alcohol while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to sucralfate, oxetacaine, or any component of the formulation","Severe renal impairment (creatinine clearance
⚠️ Warnings & Precautions
["Use with caution in patients with renal impairment; risk of aluminum toxicity.","May interfere with absorption of other medications; separate administration by at least 2 hours.","Not recommended for long-term use without medical supervision.","Avoid in patients with delayed gastric emptying or bezoar risk.","Sugar-free formulation may contain sorbitol; caution in fructose intolerance."]
🤱 Lactation Safety
It is not known whether sucralfate or oxetacaine are excreted in breast milk. Consult your doctor before breastfeeding.
💊 Overdose Management
Overdose may cause gastrointestinal symptoms such as constipation, nausea, and vomiting. In severe cases, especially with renal impairment, aluminum toxicity may occur. Treatment is symptomatic and supportive. Contact a poison control center or emergency room immediately if overdose is suspected.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Additional Safety Advice
Before taking this medicine, inform your doctor if you have kidney disease, are pregnant, planning to become pregnant, or breastfeeding. Do not take this medicine within two hours of other medications, as sucralfate can reduce their absorption. Avoid alcohol and NSAIDs (like ibuprofen) as they can worsen your condition. Take this medicine exactly as prescribed, and do not exceed the recommended dose. If you miss a dose, take it as soon as you remember, but skip it if it's almost time for your next dose. Do not double the dose. Store this medicine at room temperature, away from direct sunlight and moisture. Keep out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may have reduced kidney function and are at higher risk of aluminum toxicity. Dose adjustment may be necessary. Consult your doctor.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. Sucralfate is generally considered safe, but oxetacaine's safety is not well established.
🏥 Post-Surgery Considerations
If you have recently had surgery, inform your surgeon and anesthesiologist that you are taking this medicine. It may need to be temporarily stopped before certain procedures.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine. It is generally safe for dental procedures, but your dentist may need to know for anesthesia considerations.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid vigorous exercise immediately after taking this medicine, especially if you experience dizziness. Light to moderate exercise is generally safe.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It is generally safe to continue your daily activities.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience severe side effects, contact your doctor immediately. Your doctor will advise you on when to stop based on your condition.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to aluminum accumulation, especially in patients with kidney disease. It is not recommended for prolonged use without medical supervision. Regular monitoring of renal function may be advised.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Avoiding trigger foods can help manage symptoms.
Evidence: Well-establishedStress can worsen acid-related conditions; relaxation techniques may help.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No known interactions with vaccines. Continue with your regular vaccination schedule.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Store it at room temperature and protect it from direct sunlight. If crossing time zones, adjust your dosing schedule to maintain even intervals, but consult your doctor for specific advice. Check customs regulations for carrying medications.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Oxetacaine provides pain relief within minutes, while sucralfate starts protecting the stomach lining immediately. Ulcer healing may take several weeks.
A: It is best taken on an empty stomach, at least 1 hour before meals or 2 hours after meals.
A: Yes, this sugar-free formulation is suitable for diabetics.
🤔 Common Patient Concerns
🔄 Substitutes for sucraraff-o oral suspension
View AllAlternative brands with exact same active ingredient:
-
nufate o 500mg/10mg suspensionNucleo Remedies ₹70.31 28.6% CHEAPER
-
sucranist o oral suspension sugar freeVenistro Biotech ₹90.56 8% CHEAPER
-
papancid s oral suspension sugar freePanm Labs India ₹103.13 4.8% COSTLIER
-
gelorich syrupRichfaith Pharmaceuticals ₹107.81 9.5% COSTLIER
-
megacid o oral suspensionTecnex Pharma ₹107.81 9.5% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken with food.
Fact: It should be taken on an empty stomach for best effect. - Myth: This medicine is safe for everyone.
Fact: It is not recommended for people with severe kidney disease. - Myth: You can stop taking this medicine as soon as you feel better.
Fact: Complete the full course as prescribed to prevent recurrence.
🔄 Alternative Options
Generic Alternatives
- Sucralfate + Oxetacaine suspension (various manufacturers)
Brand Alternatives
- Macralfate-O suspension sugar free