Bactilam 250mg/62.5mg Tablet: Complete Guide to Uses, Side Effects, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or swelling of the face, lips, or throat
- Severe or persistent diarrhea, or blood in stool
- Yellowing of the skin or eyes (jaundice)
- Severe abdominal pain or cramping
- Unusual bleeding or bruising
- Decreased urine output or swelling in the legs
- Seizures or severe headache
If experiencing severe symptoms, call emergency services immediately.
What is Sayfurox CV 250mg/62.5mg Tablet used for?
This medicine is a combination antibiotic containing cefuroxime and clavulanic acid. It is used to treat bacterial infections of the respiratory tract, urinary tract, skin, and soft tissues. It works by killing bacteria and blocking their defense mechanisms. Take it with food twice daily as prescribed.
- Generic Name: Cefuroxime (250mg) + Clavulanic Acid (62.5mg)
- Manufacturer: Alobiote Healthcare
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 Sayfurox CV 250mg/62.5mg Tablet के बारे में (Hindi Summary)
उपयोग: यह दवा एक एंटीबायोटिक है जिसका उपयोग बैक्टीरियल संक्रमणों के इलाज के लिए किया जाता है। यह सेफ्यूरोक्सिम और क्लैवुलैनिक एसिड का संयोजन है। यह श्वसन तंत्र, मूत्र मार्ग, त्वचा और कोमल ऊतकों के संक्रमणों के इलाज में प्रभावी है। इसे भोजन के साथ दिन में दो बार लेना चाहिए। पूरा कोर्स पूरा करें, भले ही लक्षण ठीक हो जाएं।
साइड इफेक्ट्स: आम दुष्प्रभावों में दस्त, मतली, उल्टी, पेट दर्द, सिरदर्द और त्वचा पर चकत्ते शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन एलर्जी प्रतिक्रिया, गंभीर दस्त, और यकृत समस्याएं हो सकती हैं। यदि सांस लेने में कठिनाई, चेहरे या गले में सूजन, या गंभीर दस्त हो तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। इसे भोजन के साथ लें ताकि अवशोषण बेहतर हो और पेट की परेशानी कम हो। पूरा कोर्स पूरा करें। यदि खुराक भूल जाएं तो याद आते ही लें, लेकिन अगली खुराक का समय नजदीक हो तो छोड़ दें। डबल डोज न लें। शराब से बचें। गुर्दे या यकृत की समस्या हो तो डॉक्टर को बताएं।
💊 Sayfurox CV 250mg/62.5mg Tablet Uses & Benefits
[{"condition":"Respiratory tract infections","description":"Used to treat community-acquired pneumonia, acute bacterial exacerbations of chronic bronchitis, and sinusitis caused by susceptible bacteria.","evidence":"Well-established"},{"condition":"Urinary tract infections","description":"Effective against uncomplicated and complicated urinary tract infections caused by susceptible strains of Escherichia coli, Klebsiella species, and others.","evidence":"Well-established"},{"condition":"Skin and soft tissue infections","description":"Treats infections such as cellulitis, abscesses, and wound infections caused by susceptible gram-positive and gram-negative bacteria.","evidence":"Well-established"},{"condition":"Gonorrhea","description":"May be used as an alternative treatment for uncomplicated gonorrhea caused by Neisseria gonorrhoeae, though resistance patterns should be considered.","evidence":"Established but resistance may limit use"},{"condition":"Lyme disease","description":"Used in early stages of Lyme disease to prevent progression, particularly in patients allergic to doxycycline.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Prophylaxis in dental procedures","description":"Sometimes prescribed off-label to prevent endocarditis in high-risk patients undergoing dental work, though guidelines vary.","evidence":"Limited"},{"condition":"Traveler's diarrhea","description":"Occasionally used off-label for severe traveler's diarrhea caused by susceptible bacteria, but not first-line.","evidence":"Limited"}]
Primary treatment for: Bacterial infections
Also treats: Respiratory tract infections, Urinary tract infections, Skin and soft tissue infections, Gonorrhea, Lyme disease
📋 Drug Information
| Generic Name(s) | Cefuroxime (250mg) + Clavulanic Acid (62.5mg) |
| Brand Name | Sayfurox CV 250mg/62.5mg Tablet |
| Manufacturer | Alobiote Healthcare |
| Packaging / Form | strip of 6 tablets (Allopathy) |
| Therapeutic Class | |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Keep away from moisture and heat. Do not refrigerate unless specified by the manufacturer. |
| Shelf Life | Typically 24 months from the date of manufacture. Check the expiry date on the packaging. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients. Cefuroxime is a bactericidal antibiotic that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins, disrupting peptidoglycan cross-linking and leading to cell lysis. Clavulanic acid is a beta-lactamase inhibitor that irreversibly binds to and inactivates certain beta-lactamase enzymes produced by bacteria, protecting cefuroxime from degradation and extending its spectrum of activity against beta-lactamase-producing strains.
Mechanism Steps
💡 How to Take Sayfurox CV 250mg/62.5mg Tablet
Strength: Immediate-release tablet containing 250 mg cefuroxime and 62.5 mg clavulanic acid.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet (250 mg cefuroxime + 62.5 mg clavulanic acid) taken orally twice daily, approximately every 12 hours, with food. For more severe infections, your doctor may prescribe a higher dose or a different strength. The duration of treatment depends on the type and severity of infection, typically 5 to 10 days. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not self-adjust the dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information for this specific combination and strength. Consult a pediatrician for appropriate dosing in children. |
| Elderly Dosage | Elderly patients may have reduced renal function, which can affect drug elimination. Dose adjustment may be necessary based on renal function. Consult your doctor for appropriate dosing. |
| Renal Impairment | In patients with renal impairment, dose adjustment is required. For creatinine clearance between 10 and 30 mL/min, the usual dose may be reduced or the dosing interval extended. For creatinine clearance less than 10 mL/min, dosing may need further adjustment. Consult your doctor for specific guidance. |
| Hepatic Impairment | No specific dosage adjustment is established for hepatic impairment, but caution is advised. Monitor liver function if used in patients with liver disease. |
| Maximum Daily Dose | The maximum recommended daily dose is typically 500 mg cefuroxime and 125 mg clavulanic acid (two tablets per day). However, higher doses may be prescribed by a clinician for severe infections. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of Sayfurox CV 250mg/62.5mg Tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Probenecid | Major | |
| Oral contraceptives | Moderate | |
| Antacids | Moderate | |
| H2 blockers | Moderate | |
| Proton pump inhibitors | Moderate | |
| Loop diuretics | Minor | |
| Aminoglycosides | Minor |
🚨 Major Interactions
- Warfarin
- Probenecid
- Oral contraceptives
⚡ Moderate Interactions
- Antacids (e.g., aluminum/magnesium hydroxide)
- H2 blockers (e.g., ranitidine)
- Proton pump inhibitors (e.g., omeprazole)
🍷 Alcohol Interaction
Alcohol may worsen gastrointestinal side effects such as nausea, vomiting, and abdominal pain. It is advisable to avoid alcohol while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to cefuroxime, clavulanic acid, or any other cephalosporin or beta-lactam antibiotic","History of severe allergic reaction (e.g., anaphylaxis) to penicillins or cephalosporins","Use in patients with a history of Clostridioides difficile-associated diarrhea"]
⚠️ Warnings & Precautions
["Before starting this medicine, inform your doctor if you are allergic to penicillin or other antibiotics.","Use with caution in patients with renal impairment; dose adjustment may be required.","Prolonged use may lead to overgrowth of non-susceptible organisms, including fungi.","May cause dizziness; avoid driving or operating machinery until you know how it affects you.","Do not use this medicine to treat viral infections like the common cold.","If you develop a rash, hives, or difficulty breathing, stop the medicine and seek immediate medical attention.","Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.","Take with food to enhance absorption and reduce gastrointestinal side effects."]
🤱 Lactation Safety
Cefuroxime and clavulanic acid are excreted in small amounts in breast milk. This medicine is generally considered compatible with breastfeeding, but monitor the infant for diarrhea, thrush, or rash. Consult your doctor for guidance.
💊 Overdose Management
Overdose may cause nausea, vomiting, abdominal pain, and diarrhea. In severe cases, seizures may occur, especially in patients with renal impairment. There is no specific antidote. Treatment is supportive and symptomatic. Hemodialysis may help remove cefuroxime from the blood in cases of severe overdose. Contact a poison control center or emergency department immediately if overdose is suspected.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not skip doses or stop early, even if you feel better. Take each dose with a meal to improve absorption and reduce stomach upset. Swallow the tablet whole with a glass of water; do not crush or chew. If you miss a dose, take it as soon as you remember, but if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose. Inform your doctor if you have kidney problems, liver disease, or a history of allergies to antibiotics. Avoid alcohol while taking this medicine as it may worsen side effects. This medicine may interact with blood thinners, antacids, and certain other drugs, so always tell your healthcare provider about all medications you are taking. Keep this medicine out of reach of children and store it at room temperature away from moisture and heat.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more likely to have reduced renal function, which can affect drug clearance. Dose adjustment may be necessary. Monitor for signs of toxicity and ensure adequate hydration.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. It is generally considered safe during pregnancy when clearly needed, but your doctor will assess the risks and benefits.
🏥 Post-Surgery Considerations
This medicine may be prescribed to prevent or treat surgical site infections. Follow your surgeon's instructions regarding dosing and duration. Inform your surgeon if you have any allergies.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine. It may interact with certain dental medications or affect healing. Your dentist may recommend postponing elective procedures until you complete the course.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While taking this medicine, you may experience dizziness or fatigue. Avoid strenuous exercise or activities requiring alertness until you know how the medicine affects you. Light activities like walking are generally safe.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or fatigue in some people. Avoid driving or operating heavy machinery until you know how it affects you. It is generally safe to continue normal daily activities, but listen to your body and rest when needed.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor, even if you feel better. Stopping early can lead to recurrence of infection and antibiotic resistance. If you experience severe side effects, contact your doctor immediately for guidance.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to overgrowth of non-susceptible organisms, including fungi, and may increase the risk of antibiotic resistance. Prolonged use may also rarely cause blood dyscrasias or liver enzyme abnormalities. Regular monitoring may be required if used for extended periods. Usually, this medicine is prescribed for short courses.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can help prevent antibiotic-associated diarrhea when taken alongside.
Evidence: ModerateHelps flush out bacteria in urinary tract infections.
Evidence: Supportive💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine may reduce the efficacy of live bacterial vaccines like typhoid vaccine. Avoid live vaccines during and shortly after treatment. Consult your doctor for vaccination timing.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging along with a copy of your prescription. Keep it in your carry-on luggage to avoid loss or temperature extremes. Store at room temperature and protect from moisture. If crossing time zones, adjust dosing times gradually to maintain even intervals. Check customs regulations for carrying prescription medications. Carry enough supply for your entire trip.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling better within 24 to 48 hours, but it is important to complete the full course as prescribed.
A: Yes, take it with food to improve absorption and reduce stomach upset.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
A: Consult your doctor. It is generally considered safe if clearly needed, but your doctor will weigh the benefits and risks.
A: It is advisable to avoid alcohol as it may worsen side effects like nausea and abdominal pain.
🤔 Common Patient Concerns
🔄 Substitutes for Sayfurox CV 250mg/62.5mg Tablet
View AllAlternative brands with exact same active ingredient:
-
meritum cv 250mg/62.5mg tabletMRG Biotech Pvt Ltd ₹70.00 61.1% CHEAPER
-
cefuxime-cv 250mg/62.5mg tabletNectar Biopharma Pvt Limited ₹118.13 34.4% CHEAPER
-
pulmocef-cv 250 tabletMicro Labs Ltd ₹121.88 32.3% CHEAPER
-
bactilam 250mg/62.5mg tabletEmcure Pharmaceuticals Ltd ₹128.81 28.4% CHEAPER
-
ocef cv 250 mg/62.5 mg tabletGujarat Terce Laboratories Ltd ₹141.56 21.4% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Antibiotics can cure viral infections like the flu.
Fact: This medicine is effective only against bacterial infections. It does not treat viral infections. - Myth: You can stop taking antibiotics once you feel better.
Fact: You must complete the full prescribed course to prevent recurrence and resistance. - Myth: Antibiotics can be shared with others.
Fact: Never share antibiotics; they are prescribed for a specific infection and person.
🔄 Alternative Options
Generic Alternatives
- Cefuroxime + Clavulanic Acid generic tablets
Brand Alternatives
- Bactilam 250mg/62.5mg tablet