Hepamerz Injection 10ml: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or swallowing
- Swelling of face, lips, tongue, or throat
- Severe rash or itching
- Chest pain or palpitations
- Severe abdominal pain or vomiting blood
- Decreased urine output
- Confusion or worsening neurological symptoms
If experiencing severe symptoms, call emergency services immediately.
What is Rejuve Infusion used for?
This medicine is an injection containing L-Ornithine L-Aspartate (5gm) used to treat hepatic encephalopathy by lowering blood ammonia levels. It is administered intravenously under medical supervision.
- Generic Name: L-Ornithine L-Aspartate (5gm)
- Manufacturer: Ancalima Lifesciences Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 Rejuve Infusion के बारे में (Hindi Summary)
उपयोग: यह दवा लीवर से जुड़ी एक गंभीर समस्या, हेपेटिक एन्सेफेलोपैथी, के इलाज में इस्तेमाल की जाती है। इसमें मरीज को भ्रम, बेचैनी और होश खोने जैसी समस्याएं होती हैं, जो खून में अमोनिया बढ़ने के कारण होती हैं। यह दवा अमोनिया को यूरिया में बदलकर शरीर से बाहर निकालने में मदद करती है। यह इंजेक्शन के रूप में डॉक्टर या नर्स द्वारा दी जाती है। इसे घर पर खुद से नहीं लगाना चाहिए। यह दवा लीवर की बीमारी का इलाज नहीं है, बल्कि इसके लक्षणों को कम करने में मदद करती है।
साइड इफेक्ट्स: इस दवा के आम दुष्प्रभावों में जी मिचलाना, उल्टी, पेट दर्द और दस्त शामिल हैं। ये आमतौर पर हल्के होते हैं और अपने आप ठीक हो जाते हैं। इंजेक्शन लगाने की जगह पर दर्द, लालिमा या सूजन हो सकती है। कभी-कभी गंभीर एलर्जी प्रतिक्रिया हो सकती है, जैसे चकत्ते, खुजली, चेहरे, होंठ या गले में सूजन, और सांस लेने में कठिनाई। ऐसा होने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: यह दवा केवल डॉक्टर या नर्स द्वारा ही दी जानी चाहिए। खुद से न लगाएं। अगर आप गर्भवती हैं, गर्भधारण की योजना बना रही हैं या स्तनपान करा रही हैं, तो डॉक्टर को बताएं। अपनी सभी दवाओं के बारे में डॉक्टर को जानकारी दें। इस दवा के साथ शराब न पिएं। इलाज के दौरान डॉक्टर खून में अमोनिया, लीवर और किडनी की जांच कर सकते हैं। एलर्जी के लक्षण दिखने पर तुरंत डॉक्टर को बताएं।
💊 Rejuve Infusion Uses & Benefits
[{"condition":"Hepatic encephalopathy","description":"Used to treat and prevent hepatic encephalopathy by lowering elevated blood ammonia levels.","evidence":"Well-established"},{"condition":"Hyperammonaemia in chronic liver disease","description":"Helps reduce ammonia levels in patients with chronic liver disease and portosystemic shunting.","evidence":"Well-established"},{"condition":"Acute liver failure with hyperammonaemia","description":"May be used as adjunctive therapy in acute liver failure to manage hyperammonaemia.","evidence":"Limited"}]
Off-label uses: [{"condition":"Hepatoprotection during chemotherapy","description":"Sometimes used off-label to protect liver function during hepatotoxic chemotherapy.","evidence":"Limited"},{"condition":"Chronic hepatitis","description":"May be used off-label as supportive therapy in chronic hepatitis to improve liver function.","evidence":"Limited"}]
Primary treatment for: Hepatic encephalopathy
Also treats: Chronic liver disease, Hyperammonaemia, Acute liver failure
📋 Drug Information
| Generic Name(s) | L-Ornithine L-Aspartate (5gm) |
| Brand Name | Rejuve Infusion |
| Manufacturer | Ancalima Lifesciences Ltd |
| Packaging / Form | vial of 10 ml Injection (Allopathy) |
| Therapeutic Class | |
| Action Class | |
| Route of Administration | Parenteral (intravenous) |
| Storage | Store at room temperature (15-30°C). Protect from light. Do not freeze. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by providing L-ornithine and L-aspartate, which are substrates for the urea cycle and glutamine synthesis. L-ornithine is a precursor for citrulline and subsequently arginine, facilitating the conversion of ammonia to urea in the liver. L-aspartate participates in the synthesis of glutamine from ammonia and glutamate in perivenous hepatocytes and skeletal muscle. This dual action helps reduce blood ammonia levels, which are neurotoxic and contribute to hepatic encephalopathy.
Mechanism Steps
💡 How to Take Rejuve Infusion
Strength: Injection: 5gm/10ml
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 5g (one 10ml injection) administered intravenously, typically diluted in 500ml of infusion solution, over 4-6 hours. The frequency and duration depend on the severity of hyperammonaemia and the patient's clinical response. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may have reduced renal function; dose adjustment may be necessary. Use with caution and monitor renal function. |
| Renal Impairment | Use with caution in patients with renal impairment. Dose reduction may be required. Contraindicated in severe renal impairment (creatinine clearance < 30 mL/min). |
| Hepatic Impairment | No specific dose adjustment is recommended for hepatic impairment, as this medicine is used to treat hepatic conditions. However, monitor liver function closely. |
| Maximum Daily Dose | The maximum daily dose is not established from the available information. Dosing must be individualized by a clinician. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of Rejuve Infusion
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to L-Ornithine L-Aspartate or any component of the formulation","Severe renal impairment (creatinine clearance < 30 mL/min)","Severe hepatic encephalopathy with coma (unless under intensive care)"]
⚠️ Warnings & Precautions
["Administer under medical supervision only.","Use with caution in patients with renal impairment.","Monitor blood ammonia levels regularly.","Avoid alcohol consumption.","Do not use if solution is discoloured or contains particles.","Inform your doctor if you are pregnant or breastfeeding."]
🤱 Lactation Safety
It is not known whether L-Ornithine L-Aspartate is excreted in human breast milk. Consult your doctor before breastfeeding while on this medicine.
💊 Overdose Management
There is no specific antidote for overdose. In case of overdose, discontinue the medicine and provide supportive care. Monitor vital signs and blood ammonia levels. Contact a poison control centre or emergency department immediately.
⏰ Missed Dose
Since this medicine is administered by a healthcare professional, missed doses are unlikely. If a dose is missed, inform your doctor or nurse immediately. Do not attempt to self-administer a double dose.
Additional Safety Advice
This medicine must be administered by a qualified healthcare professional. Do not self-administer. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Inform your doctor about all other medicines you are taking, including prescription, over-the-counter, and herbal products. Avoid alcohol consumption while receiving this medicine, as it can worsen liver function. Your doctor may monitor your blood ammonia levels, liver function tests, and kidney function during treatment. Report any signs of allergic reaction immediately. Do not use this medicine if the solution is discoloured or contains particles. Follow your doctor's instructions regarding dosage and duration of treatment.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may have reduced renal function and are more susceptible to side effects. Use with caution and monitor renal function closely.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before receiving this medicine. Safety in pregnancy is not established.
🏥 Post-Surgery Considerations
This medicine may be used post-operatively in patients with liver disease and hyperammonaemia. Monitor ammonia levels and liver function closely.
🦷 Dental Procedures
Inform your dentist if you are receiving this medicine. No specific precautions are required, but maintain good oral hygiene.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise during acute illness. Light activity may be beneficial once stable, but consult your doctor before starting any exercise regimen.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is given in a hospital setting, so it may require hospitalization. After discharge, you may need to avoid driving or operating machinery if you feel dizzy or confused. Follow your doctor's advice regarding return to work.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. It is usually stopped when ammonia levels normalise and symptoms improve. Your doctor will determine the appropriate duration of treatment.
📅 Long-Term Use Effects
Long-term use of this medicine is generally not required, as it is used for acute management of hyperammonaemia. Prolonged use may be necessary in chronic liver disease with recurrent hepatic encephalopathy. Regular monitoring of blood ammonia, liver function, and renal function is recommended. The medicine is generally well-tolerated, but long-term safety data are limited.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Oral laxative that reduces ammonia absorption from the gut.
Evidence: Well-establishedOral antibiotic that reduces ammonia-producing bacteria in the gut.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions are known. However, patients with liver disease should receive appropriate vaccinations (e.g., hepatitis A and B) as advised by their doctor.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate or freeze
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Protect from light
❌ DON'T
Do not store in direct sunlight
✈️ Traveling with This Medicine
This medicine is administered in a hospital setting, so travel advice is limited. If you are prescribed this medicine during travel, carry it in its original packaging with the prescription. Store at room temperature (15-30°C) and protect from light. Do not freeze. Inform customs if carrying across borders. Since it is given intravenously, ensure a healthcare professional administers it. Plan for adequate supply if traveling for an extended period.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts reducing ammonia levels within 30 minutes to 1 hour, but clinical improvement may take several hours to days.
A: Safety in pregnancy is not established. Use only if clearly needed and prescribed by a doctor.
A: No, this medicine is formulated for intravenous administration only.
🤔 Common Patient Concerns
🔄 Substitutes for Rejuve Infusion
View AllAlternative brands with exact same active ingredient:
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liv cure 5gm injectionAncalima Lifesciences Ltd ₹134.30 24.6% CHEAPER
-
hepxure injectionNexure Lifesciences Pvt Ltd ₹167.81 5.8% CHEAPER
-
nitlor 5gm injectionBMW Pharmaco India Pvt. Ltd. ₹176.25 1.1% CHEAPER
-
hep-pep 5gm injectionZoic Lifesciences ₹182.81 2.6% COSTLIER
-
livor 5gm injectionZentis Drugs Pvt Ltd ₹185.63 4.2% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure liver cirrhosis.
Fact: This medicine helps manage hepatic encephalopathy by reducing ammonia levels, but it does not cure underlying liver disease. - Myth: This medicine can be taken orally.
Fact: This medicine is formulated for intravenous administration only. - Myth: This medicine is safe for everyone.
Fact: It is contraindicated in severe renal impairment and in those with known hypersensitivity.
🔄 Alternative Options
Generic Alternatives
- L-Ornithine L-Aspartate injection
Brand Alternatives
- Hepamerz injection 10ml