Ampitrust 1.5gm Injection: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing, wheezing, or swelling of the face, lips, tongue, or throat.
- Severe diarrhea, abdominal cramps, or fever during or after treatment.
- Rash that spreads rapidly, blistering, or peeling skin.
- Seizures, confusion, or loss of consciousness.
- Unusual bleeding or bruising, such as nosebleeds, gum bleeding, or blood in urine or stool.
- Yellowing of the skin or eyes, dark urine, or severe abdominal pain.
- Decreased urine output, swelling in the legs, or flank pain.
If experiencing severe symptoms, call emergency services immediately.
What is ambact 1.5gm injection used for?
This medicine is a combination antibiotic given intravenously to treat serious bacterial infections. It contains ampicillin, which kills bacteria, and sulbactam, which protects ampicillin from being destroyed by bacterial enzymes. It is used in hospitals for infections like pneumonia, abdominal infections, and skin infections.
- Generic Name: Ampicillin + Sulbactam
- Manufacturer: Ancalima Lifesciences Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 ambact 1.5gm injection के बारे में (Hindi Summary)
उपयोग: यह दवा एक संयुक्त एंटीबायोटिक है जिसे नस के माध्यम से दिया जाता है। इसका उपयोग गंभीर बैक्टीरियल संक्रमणों जैसे निमोनिया, पेट के अंदर के संक्रमण, त्वचा और मांसपेशियों के संक्रमण, और स्त्री रोग संबंधी संक्रमणों के इलाज के लिए किया जाता है। इसमें एम्पीसिलिन और सल्बैक्टम दो सक्रिय तत्व होते हैं। एम्पीसिलिन बैक्टीरिया को मारता है और सल्बैक्टम एम्पीसिलिन को बैक्टीरिया द्वारा नष्ट होने से बचाता है। यह दवा केवल अस्पताल या क्लिनिक में डॉक्टर या नर्स द्वारा ही दी जानी चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में इंजेक्शन वाली जगह पर दर्द, लालिमा या सूजन, दस्त, जी मिचलाना, उल्टी, त्वचा पर चकत्ते और खुजली शामिल हैं। ये आमतौर पर हल्के और अस्थायी होते हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें तेज एलर्जी प्रतिक्रिया, सांस लेने में कठिनाई, चेहरे या गले में सूजन, गंभीर दस्त, खून की कमी, यकृत की समस्या, गुर्दे की समस्या और दौरे पड़ सकते हैं। यदि कोई गंभीर लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: यह दवा केवल डॉक्टर की देखरेख में ही दी जानी चाहिए। इससे पहले कि आपको यह दवा दी जाए, अपने डॉक्टर को अपनी सभी एलर्जी, खासकर पेनिसिलिन या सेफलोस्पोरिन से, और गुर्दे या यकृत की किसी भी समस्या के बारे में बताएं। यदि आप गर्भवती हैं, गर्भवती होने की योजना बना रही हैं, या स्तनपान करा रही हैं तो अपने डॉक्टर को बताएं। इलाज के दौरान गंभीर दस्त, त्वचा पर चकत्ते, सांस लेने में कठिनाई, या असामान्य रक्तस्राव होने पर तुरंत डॉक्टर को सूचित करें। अपने डॉक्टर द्वारा बताई गई पूरी दवा की खुराक पूरी करें, भले ही आप बेहतर महसूस करें।
💊 ambact 1.5gm injection Uses & Benefits
[{"condition":"Community-acquired pneumonia","description":"Used to treat pneumonia caused by susceptible bacteria, including Streptococcus pneumoniae and Haemophilus influenzae.","evidence":"Well-established"},{"condition":"Intra-abdominal infections","description":"Effective against mixed aerobic and anaerobic bacteria in conditions such as peritonitis and intra-abdominal abscesses.","evidence":"Well-established"},{"condition":"Skin and soft tissue infections","description":"Treats cellulitis, abscesses, and wound infections caused by susceptible organisms.","evidence":"Well-established"},{"condition":"Gynecological infections","description":"Used for pelvic inflammatory disease and postpartum endometritis caused by susceptible bacteria.","evidence":"Well-established"},{"condition":"Meningitis","description":"May be used for bacterial meningitis when caused by susceptible organisms, often in combination with other antibiotics.","evidence":"Established"},{"condition":"Bone and joint infections","description":"Used for osteomyelitis and septic arthritis caused by susceptible bacteria.","evidence":"Established"}]
Off-label uses: [{"condition":"Endocarditis","description":"Sometimes used as part of combination therapy for enterococcal endocarditis, though not a first-line agent.","evidence":"Limited"},{"condition":"Prophylaxis in surgery","description":"Occasionally used for surgical prophylaxis in patients with specific risk factors, but not standard.","evidence":"Limited"}]
Primary treatment for: Bacterial infections caused by susceptible organisms
Also treats: Pneumonia, Intra-abdominal infections, Skin and soft tissue infections, Gynecological infections, Meningitis, Bone and joint infections
📋 Drug Information
| Generic Name(s) | Ampicillin + Sulbactam |
| Brand Name | Ampitrust 1.5gm Injection |
| Manufacturer | Ancalima Lifesciences Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Penicillin antibiotic with beta-lactamase inhibitor |
| Route of Administration | Intravenous (IV) infusion or injection. It is administered by a healthcare professional over 15 to 30 minutes |
| Storage | Store the unreconstituted powder at room temperature (20°C to 25°C). After reconstitution, the solution should be used immediately or stored as per the manufacturer's instructions, typically refrigerated (2°C to 8°C) and used within 24 hours. Protect from light and moisture. |
| Shelf Life | The shelf life of the unreconstituted powder is typically 24 months from the date of manufacture. After reconstitution, the stability depends on the diluent and storage conditions; refer to the product labeling for specific details. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines ampicillin, a semisynthetic penicillin antibiotic, with sulbactam, a beta-lactamase inhibitor. Ampicillin kills bacteria by binding to penicillin-binding proteins (PBPs) on the bacterial cell wall, inhibiting the final transpeptidation step of peptidoglycan synthesis, which leads to cell lysis and death. However, many bacteria produce beta-lactamase enzymes that hydrolyze ampicillin, rendering it ineffective. Sulbactam is a beta-lactam compound that irreversibly binds to and inhibits these beta-lactamase enzymes, thereby protecting ampicillin from degradation and extending its spectrum of activity against beta-lactamase-producing bacteria. This combination is bactericidal.
Mechanism Steps
💡 How to Take ambact 1.5gm injection
Strength: This medicine is available as a sterile powder for injection containing ampicillin sodium 1000 mg and sulbactam sodium 500 mg per vial, which is reconstituted for intravenous administration.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 1.5 g to 3 g (ampicillin 1 g to 2 g plus sulbactam 0.5 g to 1 g) administered intravenously every 6 to 8 hours. For severe infections, the dose may be increased to a maximum of 12 g per day (ampicillin 8 g plus sulbactam 4 g). The exact dose and duration depend on the type and severity of the infection, the patient's renal function, and clinical response. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. In general, for children, the dose is based on body weight and is typically 150 to 300 mg/kg/day (ampicillin component) divided every 6 hours. However, this must be determined by a pediatrician. |
| Elderly Dosage | Elderly patients may have reduced renal function, which can affect the elimination of ampicillin and sulbactam. Dose adjustment may be necessary based on creatinine clearance. Monitor renal function closely. No specific dose adjustments are recommended solely based on age, but individualization is essential. |
| Renal Impairment | In patients with renal impairment, the dosing interval should be adjusted based on creatinine clearance (CrCl). For CrCl 15-29 mL/min, the usual dose is given every 12 hours. For CrCl 5-14 mL/min, the dose is given every 24 hours. For patients on hemodialysis, a dose should be given after each dialysis session. Dose must be individualized by a qualified clinician based on renal function. |
| Hepatic Impairment | No specific dosage adjustment is recommended for patients with hepatic impairment alone. However, caution is advised, and monitoring of liver function is recommended. Dose must be individualized by a qualified clinician based on hepatic function. |
| Maximum Daily Dose | The maximum recommended daily dose is 12 g (ampicillin 8 g plus sulbactam 4 g) for adults with normal renal function. Doses should be adjusted in renal impairment. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of ambact 1.5gm injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Methotrexate | Major | |
| Allopurinol | Moderate | |
| Probenecid | Moderate | |
| Oral contraceptives | Moderate | |
| Aminoglycosides | Moderate | |
| Tetracyclines | Moderate | |
| Chloramphenicol | Moderate |
🚨 Major Interactions
- Warfarin
- Methotrexate
- Allopurinol
- Probenecid
⚡ Moderate Interactions
- Oral contraceptives
- Aminoglycosides (e.g., gentamicin)
- Tetracyclines
- Chloramphenicol
🍷 Alcohol Interaction
Alcohol does not directly interact with this medicine, but consuming alcohol while you have a serious bacterial infection may worsen your condition, impair your immune response, and increase the risk of liver problems. It is advisable to avoid alcohol during treatment and until you have fully recovered.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known severe hypersensitivity to ampicillin, sulbactam, or any other penicillin or beta-lactam antibiotic.","History of anaphylaxis or serious allergic reaction to penicillins or cephalosporins.","Previous history of cholestatic jaundice or hepatic dysfunction associated with ampicillin-sulbactam.","Infectious mononucleosis (increased risk of rash)."]
⚠️ Warnings & Precautions
["Serious and occasionally fatal hypersensitivity reactions (anaphylaxis) can occur. Before starting therapy, inquire about previous hypersensitivity to penicillins, cephalosporins, or other allergens.","Clostridioides difficile-associated diarrhea may occur. If diarrhea develops, evaluate for this condition and do not treat with antiperistaltic agents.","Use with caution in patients with renal impairment; dose adjustment is required.","Prolonged use may result in overgrowth of non-susceptible organisms, including fungi. Monitor for superinfections.","Hematologic effects (e.g., thrombocytopenia, leukopenia) have been reported; monitor blood counts during prolonged therapy.","Seizures may occur in patients with renal impairment or those receiving high doses; adjust dose accordingly.","This medicine contains sodium; consider sodium intake in patients on a sodium-restricted diet."]
🤱 Lactation Safety
Ampicillin and sulbactam are excreted in human breast milk in low concentrations. Caution should be exercised when administered to a nursing woman. Monitor the infant for diarrhea, thrush, or rash. Consult your doctor before breastfeeding while receiving this medicine.
💊 Overdose Management
Overdose with this medicine is unlikely due to its intravenous route of administration in a controlled healthcare setting. In case of accidental overdose, treatment should be symptomatic and supportive. Ampicillin and sulbactam can be removed from the blood by hemodialysis. Monitor vital signs, renal function, and neurological status. Contact a poison control center for guidance.
⏰ Missed Dose
This medicine is administered by a healthcare professional, so missed doses are unlikely. If a dose is missed, it should be given as soon as possible. However, if it is almost time for the next dose, the missed dose should be skipped, and the regular dosing schedule should be resumed. Do not double the dose to catch up. Consult your healthcare provider for specific instructions.
Additional Safety Advice
This medicine must only be given by a healthcare professional in a setting where emergency equipment is available. Before receiving this medicine, tell your doctor about all your allergies, especially to penicillins or cephalosporins, and about any kidney or liver problems. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Do not attempt to self-administer this injection. While receiving this medicine, report any new symptoms such as severe diarrhea, rash, difficulty breathing, or unusual bleeding or bruising immediately. Your doctor may monitor your kidney function, liver function, and blood counts during treatment. Complete the full course as prescribed, even if you feel better, to prevent resistance. Do not share this medicine with anyone else.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more likely to have reduced kidney function, which can lead to higher blood levels of ampicillin and sulbactam and an increased risk of side effects, including seizures. Dose adjustment based on creatinine clearance is essential. Monitor renal function closely and watch for signs of neurotoxicity. Elderly patients may also be more susceptible to C. difficile infection.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, discuss with your doctor before starting this medicine. It is classified as Pregnancy Category B, meaning animal studies show no risk, but human data are limited. Use only if clearly needed. If you become pregnant while on this medicine, inform your doctor immediately.
🏥 Post-Surgery Considerations
This medicine may be used to treat or prevent surgical site infections. If you have recently had surgery and are prescribed this medicine, follow your surgeon's instructions carefully. Monitor the surgical wound for signs of infection, such as increased redness, swelling, or discharge. Report any fever or chills.
🦷 Dental Procedures
If you are scheduled for a dental procedure while receiving this medicine, inform your dentist. No specific precautions are typically needed, but maintaining good oral hygiene is important. If you have a history of infective endocarditis, your dentist may recommend prophylactic antibiotics for certain dental procedures, but this medicine is not usually used for that purpose.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While receiving this medicine, you may feel tired or weak due to the infection. Avoid strenuous exercise until you have fully recovered. Light activity such as walking is generally fine if you feel up to it. Consult your doctor before resuming intense workouts.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is given in a healthcare setting, so you may need to take time off work or arrange for transportation to and from appointments. The infection itself may cause fatigue, fever, and discomfort, which can affect your ability to work. Driving may be unsafe if you feel dizzy or weak. Discuss with your doctor when you can safely resume work and driving.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. The full course must be completed as prescribed, even if you feel better, to ensure the infection is fully treated and to prevent resistance. If you experience serious side effects, your doctor may decide to stop the medicine and switch to an alternative. Always consult your healthcare provider before discontinuing treatment.
📅 Long-Term Use Effects
Long-term use of this medicine is not common, as it is typically used for short courses to treat acute infections. Prolonged use may lead to overgrowth of non-susceptible organisms, including fungi, and increase the risk of antibiotic resistance. Rarely, blood dyscrasias, liver enzyme elevations, or kidney problems may occur with extended therapy. Monitoring of blood counts, liver function, and kidney function is recommended during prolonged treatment. If you require long-term therapy, your doctor will regularly assess the benefits and risks.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Depending on the infection and susceptibility, other antibiotics such as cephalosporins, fluoroquinolones, or carbapenems may be used.
Evidence: Well-establishedRest, hydration, and fever control can complement antibiotic therapy.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are scheduled to receive a live vaccine, inform your doctor, as antibiotics may affect the immune response to some vaccines. In general, inactivated vaccines can be given safely.
📦 Storage Guide
✅ DO
Store the unreconstituted powder at room temperature (20°C to 25°C).
❌ DON'T
Do not freeze the powder.
✅ DO
After reconstitution, store as per the manufacturer's instructions, typically refrigerated (2°C to 8°C) and use within 24 hours.
❌ DON'T
Do not use the reconstituted solution if it is cloudy or contains particles.
✅ DO
Keep the vial in its original carton to protect from light.
❌ DON'T
Do not store in the bathroom or near a sink.
✅ DO
Keep out of reach of children.
❌ DON'T
Do not use after the expiry date.
✈️ Traveling with This Medicine
This medicine is administered intravenously in a healthcare setting, so it is not typically self-administered during travel. If you are traveling and need to continue treatment, ensure you have a copy of your prescription and a letter from your doctor explaining the need for the medicine. Carry it in its original packaging with the pharmacy label. Check the laws of your destination country regarding carrying prescription injectable antibiotics. Store the unreconstituted powder at room temperature and protect it from light and moisture. If reconstituted, follow the storage instructions provided by your pharmacist. Plan ahead for time zone changes and arrange for administration by a healthcare professional at your destination.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling better within 24 to 48 hours after starting treatment, but it may take several days for the infection to fully resolve. It is important to complete the full course as prescribed.
A: No, this medicine is given intravenously and must be administered by a healthcare professional in a hospital or clinic setting.
A: Report any side effects to your doctor or nurse immediately. Mild side effects like nausea or injection site pain are common, but serious reactions require urgent medical attention.
A: This medicine is classified as Pregnancy Category B. It should be used during pregnancy only if clearly needed, as determined by your doctor.
A: Yes, it can interact with drugs like warfarin, methotrexate, and allopurinol. Inform your doctor about all medications you are taking.
🤔 Common Patient Concerns
🔄 Substitutes for ambact 1.5gm injection
View AllAlternative brands with exact same active ingredient:
-
astreak 1000 mg/500 mg injectionChandra Bhagat Pharma Pvt Ltd ₹44.76 59.3% CHEAPER
-
osocillin-s 1000mg/500mg injectionOsper Formulations Pvt Ltd ₹45.00 59.1% CHEAPER
-
sulbact 1000 mg/500 mg injectionBiochem Pharmaceutical Industries ₹66.30 39.7% CHEAPER
-
ampitum 1000 mg/500 mg injectionFDC Ltd ₹96.00 12.7% CHEAPER
-
ambac 1000mg/500mg injectionSerene Lifeworld Pvt Ltd ₹124.00 12.7% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure any infection.
Fact: This medicine only works against susceptible bacteria. It is not effective against viruses, fungi, or bacteria that are resistant to it. - Myth: You can stop this medicine once you feel better.
Fact: You must complete the full course as prescribed to prevent the infection from returning and to avoid antibiotic resistance. - Myth: This medicine is safe to take without a prescription.
Fact: This is a prescription-only injectable antibiotic and must only be given by a healthcare professional. - Myth: This medicine is the same as oral ampicillin.
Fact: This medicine contains both ampicillin and sulbactam and is given intravenously, providing a broader spectrum and faster action than oral ampicillin alone.
🔄 Alternative Options
Generic Alternatives
- Ampicillin + Sulbactam generic injections
Brand Alternatives
- Ampitrust 1.5gm injection