ambact 1.5gm injection - Uses, Price, Side Effects & Substitutes
What is ambact 1.5gm injection used for?
Ampitrust 1.5gm Injection (Ampicillin + Sulbactam) is used to treat ANTI INFECTIVES. It contains Ampicillin (1000mg) + Sulbactam (500mg), which Ampicillin inhibits bacterial cell wall synthesis by binding to penicillin-bindi. Always consult your doctor before use. Take as prescribed.
- Generic Name: Ampicillin + Sulbactam
- Manufacturer: Ancalima Lifesciences Ltd
- Form: Allopathy
- Pregnancy Category: B
- Prescription Required: Yes
๐ ambact 1.5gm injection Uses & Benefits
Respiratory tract infections, urinary tract infections, intra-abdominal infections, skin and soft tissue infections, septicemia, pelvic inflammatory disease.
Off-label uses: Prophylaxis in surgery, Lyme disease, Anthrax
๐ Drug Information
| Generic Name(s) | Ampicillin + Sulbactam |
| Brand Name | Ampitrust 1.5gm Injection |
| Manufacturer | Ancalima Lifesciences Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Penicillin antibiotic with beta-lactamase inhibitor |
| Route of Administration | Intramuscular, Intravenous |
| Storage | Store at 20-25ยฐC; reconstituted solution stable for 1 hour at room temperature. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Ampicillin inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs); Sulbactam irreversibly inhibits beta-lactamases, protecting ampicillin from degradation.
Mechanism Steps
๐ก How to Take ambact 1.5gm injection
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of ambact 1.5gm injection
โ Common Side Effects
- Diarrhea
- Nausea
- Vomiting
- Rash
- Injection site pain
๐จ Serious Side Effects
- Anaphylaxis
- Stevens-Johnson syndrome
- Clostridioides difficile colitis
- Seizures
โ ๏ธ Rare Side Effects
- Hemolytic anemia
- Agranulocytosis
- Interstitial nephritis
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Methotrexate | Major | Increased methotrexate toxicity |
| Warfarin | Major | Increased bleeding risk |
| Oral contraceptives | Major | Reduced contraceptive efficacy |
| Allopurinol | Moderate | Increased risk of skin rash |
| Probenecid | Moderate | Decreased renal excretion of ampicillin/sulbactam |
| Aminoglycosides | Moderate | Physical incompatibility; synergistic effect |
| Chloramphenicol | Minor | Antagonistic effect |
| Tetracyclines | Minor | Antagonistic effect |
๐จ Major Interactions
- Methotrexate
- Warfarin
- Oral contraceptives
โก Moderate Interactions
- Allopurinol
- Probenecid
- Aminoglycosides
โน๏ธ Minor Interactions
- Chloramphenicol
- Tetracyclines
๐ฝ๏ธ Food Interactions
No significant food interactions (injection)
๐ท Alcohol Interaction
Avoid alcohol; may increase risk of disulfiram-like reaction (rare)
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to penicillins or beta-lactam antibiotics; history of cholestatic jaundice/hepatic dysfunction with sulbactam/ampicillin.
๐ Monitoring Parameters
Renal function, hepatic function, CBC, signs of hypersensitivity, superinfection.
๐คฑ Lactation Safety
Excreted in breast milk in low amounts; generally considered compatible with breastfeeding.
๐ Overdose Management
Supportive care; hemodialysis may enhance elimination.
โฐ Missed Dose
Administer as soon as remembered; skip if almost time for next dose; do not double dose.