aldactone 100 tablet - Spironolactone (100mg) medicine

aldactone 100 tablet

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🏭 RPG Life Sciences Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 23, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Reviewed by
SaathiMed Expert Panel | Sep 23, 2026

What is aldactone 100 tablet used for?

This medicine contains Spironolactone (100mg) and is used to treat CARDIAC. Competitive antagonist of aldosterone at mineralocorticoid receptors in distal renal tubules, increa. Always consult your doctor before use.

  • Generic Name: Spironolactone
  • Manufacturer: RPG Life Sciences Ltd
  • Form: Allopathy
  • Pregnancy Category: Category C
  • Prescription Required: Yes
💡 Did You Know? The Indian pharmaceutical market is expected to reach $130 billion by 2030.

💊 aldactone 100 tablet Uses & Benefits

Hypertension, heart failure (NYHA class III-IV), edema (cirrhosis, nephrotic syndrome), primary hyperaldosteronism, hypokalemia

Off-label uses: Acne vulgaris (due to antiandrogen effects), hirsutism, polycystic ovary syndrome

📋 Drug Information

Generic Name(s)Spironolactone
Brand NameAldactone
ManufacturerRPG Life Sciences Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassCARDIAC
Action ClassPotassium- sparing Diuretics
Route of AdministrationOral
StorageStore at 20-25°C (68-77°F), protect from light and moisture
Shelf LifeAs per manufacturer

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionWell absorbed orally, approximately 90%
DistributionExtensively bound to plasma proteins (98%)
Protein Binding98%
MetabolismHepatic, primarily to active metabolites (canrenone, 7α-thiomethylspironolactone)
Half-Life1.4 hours (spironolactone); 13-24 hours (metabolites)
ExcretionUrine (50-60% as metabolites), feces (40-50%)
Bioavailability90%
Onset of Action24-48 hours for diuretic effect
Peak Plasma Time2-4 hours (spironolactone); 3-4 hours (canrenone)
Duration of Action2-3 days after discontinuation

How It Works

Competitive antagonist of aldosterone at mineralocorticoid receptors in distal renal tubules, increasing sodium and water excretion while retaining potassium.

Mechanism Steps

1Spironolactone binds to mineralocorticoid receptors in the distal convoluted tubule and collecting duct.
2Competitively inhibits aldosterone binding, reducing sodium reabsorption and potassium excretion.
3Increases sodium and water excretion, leading to diuresis and decreased blood volume.
4Retains potassium, which can cause hyperkalemia.
5At higher doses, blocks androgen receptors, producing antiandrogenic effects.

💡 How to Take aldactone 100 tablet

Follow your doctor's prescription exactly.

⚠️ Side Effects of aldactone 100 tablet

✅ Common Side Effects

Hyperkalemia
Gynecomastia
Menstrual irregularities
Nausea
Dizziness

🚨 Serious Side Effects

Severe hyperkalemia
Arrhythmias
Acute renal failure
Stevens-Johnson syndrome

⚠️ Rare Side Effects

Agranulocytosis
Hepatotoxicity
Breast cancer (possible association)

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
ACE inhibitors Major Increased risk of hyperkalemia
Potassium supplements Major Severe hyperkalemia
Digoxin Moderate Increased digoxin toxicity risk
NSAIDs Moderate Reduced diuretic effect, increased nephrotoxicity
Warfarin Moderate Decreased anticoagulant effect
Lithium Moderate Increased lithium toxicity

🚨 Major Interactions

  • ACE inhibitors
  • Angiotensin II receptor blockers
  • Potassium supplements
  • Potassium-sparing diuretics
  • Cyclosporine
  • Tacrolimus

⚡ Moderate Interactions

  • Digoxin
  • Lithium
  • NSAIDs
  • Warfarin
  • Heparin

🍷 Alcohol Interaction

May enhance orthostatic hypotension

🛡️ Safety & Warnings

🚫 Contraindications

Anuria, acute renal insufficiency, hyperkalemia, Addison's disease, concomitant use with eplerenone

🤱 Lactation Safety

Excreted in breast milk; avoid or use with caution

💊 Overdose Management

Induce emesis or gastric lavage; monitor electrolytes; treat hyperkalemia with IV calcium gluconate, insulin/glucose, sodium bicarbonate, or dialysis

⏰ Missed Dose

Take as soon as remembered unless near next dose; do not double dose

🔄 Substitutes for aldactone 100 tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

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