Enphene 50mg/50mg Tablet: A Comprehensive Guide to Uses, Side Effects, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blurred vision, double vision, or any visual disturbances
- Severe abdominal pain, bloating, or rapid weight gain
- Difficulty breathing or shortness of breath
- Swelling, pain, or redness in one leg
- Chest pain or palpitations
- Yellowing of skin or eyes, dark urine
- Severe allergic reaction (rash, itching, swelling of face or throat)
- Heavy vaginal bleeding
If experiencing severe symptoms, call emergency services immediately.
What is qucophene 50 tablet used for?
This medicine is a combination of Clomiphene 50 mg and Coenzyme Q10 50 mg used to induce ovulation in women with anovulatory infertility. It works by stimulating the release of hormones that trigger egg release from the ovaries. Coenzyme Q10 supports egg quality. It is taken orally for 5 days starting early in the menstrual cycle, under medical supervision.
- Generic Name: Clomiphene (50mg) + Coenzyme Q10 (50mg)
- Manufacturer: Cheminnova Life Sciences
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 qucophene 50 tablet के बारे में (Hindi Summary)
उपयोग: यह दवा क्लोमिफीन 50 मिलीग्राम और कोएंजाइम क्यू10 50 मिलीग्राम का संयोजन है, जिसका उपयोग महिलाओं में ओव्यूलेशन (अंडोत्सर्ग) को प्रेरित करने के लिए किया जाता है। यह उन महिलाओं के लिए है जो नियमित रूप से ओव्यूलेट नहीं करती हैं और गर्भधारण करने में कठिनाई का सामना कर रही हैं। क्लोमिफीन मस्तिष्क में एस्ट्रोजन रिसेप्टर्स को अवरुद्ध करता है, जिससे पिट्यूटरी ग्रंथि से एफएसएच और एलएच हार्मोन अधिक मात्रा में निकलते हैं, जो अंडाशय को उत्तेजित करते हैं। कोएंजाइम क्यू10 एक एंटीऑक्सिडेंट है जो अंडे की गुणवत्ता में सुधार करने में मदद कर सकता है। यह दवा आमतौर पर मासिक धर्म चक्र के दूसरे, तीसरे, चौथे या पांचवें दिन से 5 दिनों तक ली जाती है। इसे डॉक्टर की सलाह के बिना न लें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में गर्म लहरें (हॉट फ्लैश), मूड स्विंग, स्तन में कोमलता, मतली, पेट फूलना और सिरदर्द शामिल हैं। ये आमतौर पर हल्के और अस्थायी होते हैं। गंभीर दुष्प्रभावों में दृष्टि में बदलाव (धुंधला दिखना), ओवेरियन हाइपरस्टिमुलेशन सिंड्रोम (ओएचएसएस) जैसे पेट दर्द, तेजी से वजन बढ़ना और सांस लेने में कठिनाई शामिल हो सकते हैं। यदि आपको कोई भी गंभीर या लगातार दुष्प्रभाव महसूस हो, तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को लेने से पहले अपने डॉक्टर को अपनी सभी चिकित्सीय स्थितियों के बारे में बताएं, विशेष रूप से यकृत रोग, गुर्दे की बीमारी, या रक्त के थक्के की समस्या। यदि आप गर्भवती हैं या गर्भवती होने की संभावना है तो यह दवा न लें। यदि आप गर्भधारण नहीं करना चाहती हैं तो प्रभावी गर्भनिरोधक का उपयोग करें। इस दवा को लेते समय शराब और धूम्रपान से बचें। दवा को बिल्कुल वैसे ही लें जैसे डॉक्टर ने बताया है, आमतौर पर मासिक धर्म चक्र के 2, 3, 4, या 5 दिन से 5 दिनों तक। डॉक्टर की सलाह के बिना खुराक न बढ़ाएं या कम न करें। नियमित अल्ट्रासाउंड और रक्त परीक्षण की आवश्यकता हो सकती है। यदि आपको दृष्टि में कोई बदलाव दिखे, तो दवा बंद करें और तुरंत चिकित्सा सहायता लें।
💊 qucophene 50 tablet Uses & Benefits
[{"condition":"Ovulation induction in anovulatory infertility","description":"This medicine is used to stimulate ovulation in women who do not ovulate regularly, such as those with polycystic ovary syndrome (PCOS).","evidence":"Well-established"},{"condition":"Unexplained infertility","description":"Sometimes used to increase the number of eggs released, improving chances of conception in couples with unexplained infertility.","evidence":"Moderate"},{"condition":"Luteal phase defect","description":"May be used to improve luteal phase progesterone levels by inducing better ovulation.","evidence":"Limited"}]
Off-label uses: [{"condition":"Male hypogonadism","description":"Clomiphene alone is sometimes used off-label to boost testosterone levels in men with low testosterone, but the combination with Coenzyme Q10 is not standard for this purpose.","evidence":"Limited"},{"condition":"Gynecomastia","description":"Rarely, clomiphene may be used off-label to treat breast enlargement in men, but this combination is not typical.","evidence":"Limited"}]
Primary treatment for: Anovulatory infertility
Also treats: Polycystic ovary syndrome (PCOS), Unexplained infertility, Luteal phase defect
📋 Drug Information
| Generic Name(s) | Clomiphene (50mg) + Coenzyme Q10 (50mg) |
| Brand Name | qucophene 50 tablet |
| Manufacturer | Cheminnova Life Sciences |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GYNAECOLOGICAL |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep in the original container, tightly closed. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Clomiphene acts as a selective estrogen receptor modulator (SERM). It binds to estrogen receptors in the hypothalamus and pituitary gland, blocking the negative feedback of estrogen. This leads to increased secretion of gonadotropin-releasing hormone (GnRH), which in turn stimulates the pituitary to release more follicle-stimulating hormone (FSH) and luteinizing hormone (LH). These hormones then act on the ovaries to promote follicular growth and ovulation. Coenzyme Q10 is a fat-soluble antioxidant that plays a key role in mitochondrial energy production. In the context of fertility, it helps protect ovarian follicles from oxidative damage and may improve egg quality and ovarian response.
Mechanism Steps
💡 How to Take qucophene 50 tablet
Strength: Each tablet contains Clomiphene 50 mg and Coenzyme Q10 50 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet (Clomiphene 50 mg + Coenzyme Q10 50 mg) taken orally once daily for 5 days, starting on day 2, 3, 4, or 5 of the menstrual cycle, unless otherwise prescribed by your doctor. If ovulation does not occur, your doctor may increase the dose to 100 mg (two tablets) daily for 5 days in the next cycle. The maximum recommended dose is 100 mg per day for 5 days. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and response to treatment. |
| Pediatric Dosage | Pediatric dosing is not established from available information. This medicine is not indicated for use in children. Consult a pediatrician for any concerns. |
| Elderly Dosage | This medicine is not intended for use in elderly women beyond reproductive age. Safety and efficacy have not been established in this population. |
| Renal Impairment | No specific dose adjustment is provided for renal impairment. However, caution is advised, and the dose should be individualized by a clinician based on renal function. |
| Hepatic Impairment | This medicine is contraindicated in patients with liver disease. No specific dose adjustment is available. Use with caution and under close monitoring in patients with mild hepatic impairment. |
| Maximum Daily Dose | 100 mg of clomiphene (two tablets) per day for 5 days per cycle. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of qucophene 50 tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Tamoxifen | Major | |
| Fluoxetine | Moderate | |
| Paroxetine | Moderate | |
| Rifampin | Moderate | |
| Carbamazepine | Moderate | |
| Antacids | Minor | |
| Statins | Minor |
🚨 Major Interactions
- Warfarin
- Tamoxifen
⚡ Moderate Interactions
- CYP2D6 inhibitors (e.g., fluoxetine, paroxetine)
- CYP2D6 inducers (e.g., rifampin, carbamazepine)
🍷 Alcohol Interaction
Alcohol may worsen liver toxicity and increase the risk of side effects such as dizziness and mood changes. It is advisable to avoid alcohol while taking this medicine, especially if you are trying to conceive.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Pregnancy or suspected pregnancy","Known hypersensitivity to clomiphene, Coenzyme Q10, or any component of the formulation","Liver disease or abnormal liver function tests","Undiagnosed abnormal vaginal bleeding","Ovarian cysts (except those due to polycystic ovary syndrome)","History of thromboembolic disorders (blood clots)","Breastfeeding"]
⚠️ Warnings & Precautions
["This medicine should only be used under the supervision of a fertility specialist.","Visual disturbances may occur; if they do, stop the medicine and consult your doctor immediately.","Ovarian hyperstimulation syndrome (OHSS) is a rare but serious risk; report symptoms promptly.","Multiple pregnancies (twins, triplets) are more common with ovulation induction; discuss with your doctor.","Long-term use may increase the risk of ovarian cancer; use for the shortest duration necessary.","Do not take this medicine if you have uncontrolled thyroid or adrenal disorders.","Inform your doctor if you have a history of depression or mood disorders, as clomiphene may exacerbate them."]
🤱 Lactation Safety
It is not known whether clomiphene or Coenzyme Q10 are excreted in human breast milk. Because of the potential for serious adverse reactions in nursing infants, this medicine should not be used during breastfeeding. Consult your doctor for alternative options.
💊 Overdose Management
Overdose of this medicine may cause severe nausea, vomiting, abdominal pain, visual disturbances, and ovarian hyperstimulation. If you suspect an overdose, seek emergency medical attention immediately. Treatment is supportive and symptomatic. There is no specific antidote.
⏰ Missed Dose
If you miss a dose of this medicine, take it as soon as you remember, unless it is almost time for your next dose. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one. If you miss multiple doses, contact your doctor for advice.
Additional Safety Advice
Before taking this medicine, inform your doctor about all your medical conditions, especially liver disease, kidney disease, or a history of blood clots. Do not take this medicine if you are pregnant or suspect you might be pregnant. Use effective contraception if you are not trying to conceive. Avoid alcohol and smoking while on this medicine, as they can reduce fertility. Take this medicine exactly as prescribed, usually for 5 days starting on day 2, 3, 4, or 5 of your menstrual cycle, unless your doctor advises otherwise. Do not increase or decrease the dose without consulting your doctor. Regular monitoring with ultrasound and blood tests may be required to assess ovulation and rule out complications. If you experience vision changes, stop the medicine and seek immediate medical help. Keep this medicine out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
This medicine is not intended for use in elderly women beyond reproductive age. Safety and efficacy have not been established in this population.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, this medicine may be prescribed to induce ovulation. It is important to take it exactly as directed and monitor ovulation. If you become pregnant, stop the medicine immediately and consult your doctor. Ensure you are taking folic acid supplements before conception.
🏥 Post-Surgery Considerations
If you have recently undergone surgery, inform your doctor before taking this medicine. It may increase the risk of blood clots, especially after major surgery. Your doctor may advise delaying treatment until you have recovered.
🦷 Dental Procedures
No specific precautions are required for dental procedures while taking this medicine. However, inform your dentist about all medicines you are taking. If you experience any bleeding issues, consult your doctor before dental work.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Moderate exercise is generally safe while taking this medicine. However, if you experience ovarian hyperstimulation symptoms such as abdominal bloating or pain, avoid strenuous activities and consult your doctor. High-impact exercises may increase discomfort if ovaries are enlarged.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause visual disturbances, dizziness, or mood swings in some women, which could affect driving or operating machinery. If you experience these, avoid such activities until you feel normal. Otherwise, it generally does not interfere with daily work. Plan your doses around your schedule, especially if you have a busy routine.
🛑 When to Stop This Medicine
Stop taking this medicine and consult your doctor immediately if you experience visual disturbances, severe abdominal pain, rapid weight gain, difficulty breathing, or signs of an allergic reaction. Also stop if you become pregnant. Do not stop or change the dose without consulting your doctor, as it may affect your treatment plan.
📅 Long-Term Use Effects
Long-term use of clomiphene beyond 6 cycles may increase the risk of ovarian cancer, although the evidence is not conclusive. It is recommended to use the lowest effective dose for the shortest duration. Coenzyme Q10 is generally safe for long-term use. Regular monitoring of liver function and ovarian health is advised. If pregnancy does not occur after 3-6 cycles, alternative treatments should be considered.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Another oral ovulation induction agent that may be used as an alternative to clomiphene, especially in PCOS.
Evidence: Well-establishedInjectable hormones that directly stimulate the ovaries; used if oral agents fail.
Evidence: Well-establishedWeight loss, diet, and exercise can improve ovulation in overweight women with PCOS.
Evidence: Well-establishedComplementary therapy that may improve ovulation and fertility, but evidence is mixed.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are planning to conceive, ensure your vaccinations (e.g., rubella, varicella) are up to date before starting fertility treatment. Consult your doctor for personalized advice.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid temperature extremes. Store at room temperature, away from direct sunlight. If crossing time zones, continue taking the medicine at the same time each day as prescribed; you may need to adjust the timing gradually. Check customs regulations for carrying prescription medicines. Always carry enough supply for your entire trip.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Ovulation typically occurs 5 to 10 days after the last dose of this medicine. Your doctor may monitor with ultrasound or blood tests to confirm ovulation.
A: No, this is a prescription-only medicine and must be taken under the supervision of a fertility specialist due to potential serious side effects.
A: Stop taking this medicine immediately and contact your doctor right away. Visual disturbances may indicate ocular toxicity.
A: Yes, this medicine is intended to help you ovulate and conceive. However, if you become pregnant, stop the medicine immediately and inform your doctor.
A: Yes, ovulation induction medicines like clomiphene can increase the chance of multiple pregnancies (twins, triplets). Discuss with your doctor.
🤔 Common Patient Concerns
🔄 Substitutes for qucophene 50 tablet
View AllAlternative brands with exact same active ingredient:
-
clomien plus tabletDakshinamurti Pharma Pvt. Ltd. ₹132.70 41% CHEAPER
-
fertilix 50 tabletInnovcare Lifesciences Pvt Ltd ₹150.00 33.3% CHEAPER
-
clonin tabletBryson Pharmaceutical Llp ₹160.00 28.9% CHEAPER
-
clomeva q 50mg/50mg tabletVIVO Life Science ₹195.00 13.3% CHEAPER
-
roelet 50 mg/50 mg tabletBharat Serums & Vaccines Ltd ₹195.23 13.2% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Enphene guarantees pregnancy.
Fact: This medicine induces ovulation, but pregnancy depends on many factors including egg quality, sperm health, and fallopian tube patency. It does not guarantee pregnancy. - Myth: Enphene can be taken without doctor's supervision.
Fact: This medicine is a prescription drug and must only be taken under the supervision of a fertility specialist due to potential serious side effects. - Myth: Enphene is safe during pregnancy.
Fact: This medicine is contraindicated in pregnancy and may harm the fetus. Stop immediately if you suspect pregnancy. - Myth: Coenzyme Q10 in this medicine is just a supplement with no effect.
Fact: Coenzyme Q10 is an antioxidant that may improve egg quality and ovarian response, complementing Clomiphene's action.
🔄 Alternative Options
Generic Alternatives
- Clomiphene 50 mg + Coenzyme Q10 50 mg tablet (various manufacturers)
Brand Alternatives
- Enphene 50mg/50mg tablet (Xeno Pharmaceuticals Pvt Ltd)