Esogress-L Capsule SR: Complete Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Blood in vomit or black, tarry stools
- Severe abdominal pain or persistent vomiting
- Chest pain, palpitations, or difficulty breathing
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes (jaundice)
- Decreased urine output or swelling in legs
- Uncontrolled muscle movements or tremors
- Severe headache with visual changes
If experiencing severe symptoms, call emergency services immediately.
What is pilodom-el capsule used for?
This medicine is a combination of Levosulpiride 75 mg and Esomeprazole 40 mg used to treat acid reflux and improve gastric emptying. It works by reducing stomach acid and enhancing gastrointestinal motility. It is usually taken once daily before breakfast.
- Generic Name: Levosulpiride (75mg) + Esomeprazole (40mg)
- Manufacturer: HRD Supra Healthcare
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 pilodom-el capsule के बारे में (Hindi Summary)
उपयोग: यह दवा लेवोसल्पिराइड 75 मिलीग्राम और एसोमेप्राजोल 40 मिलीग्राम का संयोजन है, जिसका उपयोग एसिड रिफ्लक्स (जीईआरडी), अपच, पेट में जलन, और गैस्ट्रिक खाली होने में देरी से जुड़े लक्षणों के इलाज के लिए किया जाता है। यह पेट में एसिड को कम करती है और पाचन को बेहतर बनाती है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में सिरदर्द, मतली, दस्त, पेट दर्द, कब्ज, और मुँह सूखना शामिल हैं। कुछ रोगियों में नींद आना, चक्कर आना, या थकान महसूस हो सकती है। दुर्लभ मामलों में मांसपेशियों में अकड़न, कंपन, या एलर्जी प्रतिक्रिया हो सकती है। कोई भी असामान्य लक्षण होने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। कैप्सूल को चबाएं या तोड़ें नहीं, पूरा निगल लें। इसे सुबह नाश्ते से 30-60 मिनट पहले खाली पेट लें। दवा लेते समय शराब का सेवन न करें। गाड़ी चलाने या मशीन चलाने से बचें यदि आपको नींद या चक्कर आते हैं। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर से सलाह लें।
💊 pilodom-el capsule Uses & Benefits
[{"condition":"Gastroesophageal reflux disease (GERD) with delayed gastric emptying","description":"This medicine helps reduce acid reflux and improves gastric motility, relieving symptoms like heartburn and regurgitation.","evidence":"Well-established"},{"condition":"Functional dyspepsia","description":"It alleviates postprandial fullness, early satiety, and epigastric pain associated with impaired gastric emptying.","evidence":"Moderate"},{"condition":"Nausea and vomiting due to gastrointestinal motility disorders","description":"Levosulpiride component provides antiemetic and prokinetic effects, while Esomeprazole reduces acid-related irritation.","evidence":"Moderate"},{"condition":"Diabetic gastroparesis","description":"May be used to improve gastric emptying and reduce symptoms in diabetic patients with gastroparesis.","evidence":"Limited"}]
Off-label uses: [{"condition":"Refractory GERD not responding to PPI alone","description":"Sometimes prescribed off-label when standard PPI therapy fails to control symptoms, based on the rationale of adding a prokinetic agent.","evidence":"Limited"},{"condition":"Functional vomiting","description":"May be used off-label for chronic functional vomiting after other causes are ruled out.","evidence":"Limited"}]
Primary treatment for: Gastroesophageal reflux disease (GERD) with delayed gastric emptying
Also treats: Functional dyspepsia, Diabetic gastroparesis, Nausea and vomiting due to motility disorders
📋 Drug Information
| Generic Name(s) | Levosulpiride (75mg) + Esomeprazole (40mg) |
| Brand Name | pilodom-el capsule |
| Manufacturer | HRD Supra Healthcare |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary mechanisms. Levosulpiride is a substituted benzamide that acts as a selective dopamine D2 receptor antagonist in the gastrointestinal tract. By blocking D2 receptors in the chemoreceptor trigger zone and the gastrointestinal smooth muscle, it enhances gastric motility, accelerates gastric emptying, and exerts antiemetic effects. Esomeprazole is a proton pump inhibitor that irreversibly inhibits the H+/K+-ATPase enzyme in gastric parietal cells, thereby suppressing both basal and stimulated gastric acid secretion. Together, they reduce acid exposure to the esophagus and improve gastric emptying, providing relief from reflux and dyspepsia symptoms.
Mechanism Steps
💡 How to Take pilodom-el capsule
Strength: Sustained-release capsule containing Levosulpiride 75 mg and Esomeprazole 40 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one capsule of Levosulpiride 75 mg and Esomeprazole 40 mg taken orally once daily on an empty stomach, preferably 30 to 60 minutes before breakfast. However, the dose and duration must be individualized by a qualified clinician based on the indication, severity of symptoms, age, weight, renal and hepatic function, and response to therapy. Do not self-adjust the dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of Levosulpiride, especially extrapyramidal symptoms and drowsiness. Dose adjustment may be necessary based on renal and hepatic function. Use with caution and monitor closely. |
| Renal Impairment | Levosulpiride is excreted renally. In patients with renal impairment, dose reduction may be required. Esomeprazole does not require dose adjustment in mild to moderate renal impairment, but caution is advised in severe renal impairment. Consult your doctor for individualized dosing. |
| Hepatic Impairment | Esomeprazole is extensively metabolized in the liver. In patients with mild to moderate hepatic impairment, no dose adjustment is needed, but in severe hepatic impairment, the maximum dose should not exceed 20 mg of Esomeprazole daily. Levosulpiride should be used with caution. Consult your doctor for individualized dosing. |
| Maximum Daily Dose | The maximum recommended daily dose is one capsule containing Levosulpiride 75 mg and Esomeprazole 40 mg. Do not exceed this dose unless specifically instructed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of pilodom-el capsule
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Atazanavir | Major | |
| Clopidogrel | Major | |
| Methotrexate | Major | |
| Rifampicin | Major | |
| Diazepam | Moderate | |
| Phenytoin | Moderate | |
| Warfarin | Moderate | |
| Ketoconazole | Moderate | |
| Antacids | Minor | |
| Iron supplements | Minor |
🚨 Major Interactions
- Atazanavir, Nelfinavir
- Clopidogrel
- Methotrexate
- Rifampicin
⚡ Moderate Interactions
- Diazepam
- Phenytoin
- Warfarin
- Ketoconazole, Itraconazole
🍷 Alcohol Interaction
Alcohol may increase the sedative effects of Levosulpiride and worsen dizziness or drowsiness. It can also increase the risk of gastrointestinal irritation and bleeding. It is advisable to avoid alcohol while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to Levosulpiride, Esomeprazole, or any component of the formulation","Gastrointestinal bleeding or mechanical obstruction","Prolactin-dependent tumors (e.g., pituitary adenoma, breast cancer)","Severe hepatic impairment","Severe renal impairment (creatinine clearance < 20 mL/min)","Concomitant use with Atazanavir or Nelfinavir","Epilepsy or Parkinson's disease (Levosulpiride may worsen symptoms)"]
⚠️ Warnings & Precautions
["May cause drowsiness or dizziness; avoid driving or operating machinery until you know how it affects you.","Use with caution in elderly patients due to increased risk of extrapyramidal symptoms and falls.","Long-term use of Esomeprazole may increase the risk of bone fractures, especially in the elderly.","May increase the risk of Clostridium difficile-associated diarrhea; report persistent diarrhea.","Avoid in patients with a history of QT prolongation or on other QT-prolonging drugs.","Do not use in children unless prescribed by a pediatric gastroenterologist.","Inform your doctor if you have kidney or liver disease before taking this medicine."]
🤱 Lactation Safety
It is not known whether Levosulpiride or Esomeprazole are excreted in human breast milk. Consult your doctor before breastfeeding while taking this medicine.
💊 Overdose Management
Overdose may cause severe drowsiness, extrapyramidal symptoms, or cardiac arrhythmias. Seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote. Gastric lavage may be considered if ingestion is recent. Monitor vital signs and cardiac rhythm.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not crush, chew, or break the sustained-release capsule; swallow it whole with water. It is best taken on an empty stomach, at least 30 to 60 minutes before breakfast, unless your doctor advises otherwise. Avoid alcohol while taking this medicine as it may worsen drowsiness and increase stomach irritation. Do not drive or operate heavy machinery until you know how this medicine affects you, as it can cause dizziness or drowsiness. Inform your doctor if you have a history of heart rhythm problems, low magnesium levels, or kidney disease. Do not use this medicine for longer than recommended without medical supervision. If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before using this medicine. Keep out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of extrapyramidal symptoms, drowsiness, and falls due to Levosulpiride. They are also more susceptible to Esomeprazole-related bone fractures and hypomagnesemia. Dose adjustment and close monitoring are recommended.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. The safety of this combination in pregnancy is not well established. Your doctor may consider alternative treatments.
🏥 Post-Surgery Considerations
After surgery, the use of this medicine should be discussed with your surgeon. It may affect gastric motility and acid secretion, which could impact postoperative recovery. Do not self-administer without medical advice.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine before any dental procedure. It may increase the risk of bleeding or interact with medications used during dental work. Your dentist may advise temporary discontinuation or adjustment.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Moderate exercise is generally safe, but avoid vigorous activities immediately after meals as they may worsen reflux. If you experience dizziness or drowsiness, avoid activities that require balance or coordination.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause drowsiness or dizziness in some people, which can affect your ability to drive or operate machinery. It is advisable to assess your response before engaging in such activities. Otherwise, it should not significantly impact your daily work life if taken as prescribed.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience severe side effects or your symptoms resolve, your doctor may gradually reduce the dose or switch to an alternative. Abrupt discontinuation of Esomeprazole can cause rebound acid hypersecretion.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to vitamin B12 deficiency, hypomagnesemia, and an increased risk of bone fractures due to Esomeprazole. Levosulpiride can cause tardive dyskinesia and hyperprolactinemia with prolonged use. Regular monitoring of magnesium, vitamin B12, and renal function is advised. Periodic reassessment of the need for continued therapy is recommended.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Avoiding trigger foods, eating smaller meals, and elevating the head of the bed can reduce reflux symptoms.
Evidence: Well-establishedDomperidone or Itopride may be used as alternatives to Levosulpiride, depending on patient tolerance.
Evidence: ModerateFor severe GERD unresponsive to medication, fundoplication may be considered.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are scheduled for any vaccination, inform your healthcare provider about all medications you are taking.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When traveling, carry your medicine in its original packaging along with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature and protect from extreme heat or moisture. If crossing time zones, consult your doctor about adjusting the timing of your dose. Do not pack it in checked baggage in case of delays.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling relief from symptoms within a few hours to a day, but full effects may take a few days to a week.
A: It is best taken on an empty stomach, 30-60 minutes before breakfast. Food may reduce its effectiveness.
A: If you remember within a few hours, take it. If it's almost time for your next dose, skip the missed dose and continue as usual. Do not double dose.
A: Avoid high-fat meals, alcohol, and excessive caffeine while taking this medicine.
A: Do not stop without consulting your doctor. Stopping abruptly may cause rebound acid secretion.
🤔 Common Patient Concerns
🔄 Substitutes for pilodom-el capsule
View AllAlternative brands with exact same active ingredient:
-
davaindia levosulpiride+esomeprazole 75mg/40mg capsule srDavaindia Generic Pharmacy ₹50.00 66.7% CHEAPER
-
stayhappi levosulpiride+esomeprazole 75mg/40mg capsuleSarvagunaushdhi Pvt Ltd ₹72.19 51.9% CHEAPER
-
esomez l 75mg/40mg capsule srAroma Healthcare ₹79.69 46.9% CHEAPER
-
gastro-sl capsuleSSK Pharma ₹103.13 31.2% CHEAPER
-
esjor-ls capsuleJaiwik Biotech ₹131.25 12.5% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken anytime regardless of meals.
Fact: It should be taken on an empty stomach, preferably 30-60 minutes before breakfast, for optimal absorption and effect. - Myth: It is safe to take this medicine indefinitely without monitoring.
Fact: Long-term use requires periodic monitoring of magnesium, vitamin B12, and kidney function. Consult your doctor regularly. - Myth: This medicine is a painkiller for stomach pain.
Fact: It is not a painkiller. It reduces acid and improves motility, which indirectly relieves pain due to reflux or dyspepsia.
🔄 Alternative Options
Generic Alternatives
- Levosulpiride + Esomeprazole sustained-release capsules (various manufacturers)
Brand Alternatives
- Esogress-L Capsule SR