Aprebion Kit: Complete Medicine Guide for Patients and Caregivers
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Swelling of the face, lips, tongue, or throat, or difficulty breathing
- Widespread rash, blistering, or peeling skin
- Yellowing of the eyes or skin, dark urine, or severe upper abdominal pain
- Persistent vomiting or signs of dehydration such as very little urine, dry mouth, or dizziness on standing
- Severe headache with confusion, weakness, or vision changes
- Chest pain, palpitations, or fainting
- Blood in vomit or black, tarry stools
If experiencing severe symptoms, call emergency services immediately.
What is opilo kit used for?
This medicine is an aprepitant kit used to prevent nausea and vomiting caused by chemotherapy or surgery. It works by blocking NK1 receptors in the brain and is taken by mouth as part of a combination antiemetic plan prescribed by a doctor.
- Generic Name: Aprepitant (125mg) + Aprepitant (80mg)
- Manufacturer: Abbott
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 opilo kit के बारे में (Hindi Summary)
उपयोग: यह दवा एप्रेपिटेंट किट है, जिसका उपयोग कीमोथेरेपी या सर्जरी के कारण होने वाली मतली और उल्टी को रोकने के लिए किया जाता है। यह मस्तिष्क में एनके1 रिसेप्टर को ब्लॉक करके काम करती है और इसे मुँह से लिया जाता है। यह अकेले नहीं, बल्कि ओंडानसेट्रॉन और डेक्सामेथासोन जैसी अन्य दवाओं के साथ मिलकर दी जाती है। डॉक्टर की सलाह के अनुसार ही इसका सेवन करें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में थकान, सिरदर्द, कब्ज, दस्त, पेट में गड़बड़ी, हिचकी और भूख कम लगना शामिल हैं। ये आमतौर पर हल्के होते हैं और अपने आप ठीक हो जाते हैं। कभी-कभी गंभीर एलर्जी, चेहरे या गले में सूजन, सांस लेने में कठिनाई, या लिवर से जुड़ी समस्या हो सकती है। ऐसे लक्षण दिखने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें, क्योंकि इसका समय और खुराक आपकी कीमोथेरेपी या सर्जरी की योजना के अनुसार तय होती है। कैप्सूल को पानी के साथ पूरा निगलें, चबाएं या तोड़ें नहीं। अपने डॉक्टर को अपनी सभी दवाओं के बारे में बताएं, खासकर खून पतला करने वाली दवाएं, गर्भनिरोधक गोलियां, और एचआईवी या फंगल इन्फेक्शन की दवाएं। इलाज के दौरान अंगूर और अंगूर का जूस न लें। शराब से बचें। अगर चक्कर या थकान महसूस हो तो गाड़ी न चलाएं।
💊 opilo kit Uses & Benefits
[{"condition":"Prevention of chemotherapy-induced nausea and vomiting (CINV)","description":"This medicine is used as part of a combination regimen to prevent acute and delayed nausea and vomiting in adults receiving highly emetogenic chemotherapy and in some patients receiving moderately emetogenic chemotherapy.","evidence":"Well-established"},{"condition":"Prevention of postoperative nausea and vomiting (PONV)","description":"Aprepitant is used in adults to reduce the risk of nausea and vomiting after surgery, often as part of a multimodal antiemetic plan.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Refractory chronic nausea and vomiting","description":"In some specialist settings, aprepitant has been tried for persistent nausea and vomiting not controlled by standard antiemetics, but this is not a standard approved use.","evidence":"Limited"},{"condition":"Cyclic vomiting syndrome","description":"Small reports describe benefit in selected patients, but evidence is not strong enough for routine use.","evidence":"Limited"}]
Primary treatment for: Chemotherapy-induced nausea and vomiting
Also treats: Postoperative nausea and vomiting
📋 Drug Information
| Generic Name(s) | Aprepitant (125mg) + Aprepitant (80mg) |
| Brand Name | opilo kit |
| Manufacturer | Abbott |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C, away from direct sunlight and moisture. Keep the capsules in their original packaging until it is time to take them. |
| Shelf Life | The shelf life is usually 24 months from the date of manufacture, but check the expiry date printed on the pack. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Aprepitant is a selective, high-affinity antagonist of the neurokinin-1 (NK1) receptor. Substance P is a natural peptide that binds to NK1 receptors in the central nervous system and in the gut, and it plays a key role in triggering nausea and vomiting. By blocking NK1 receptors, aprepitant prevents substance P from sending emetic signals, which reduces both the acute phase and the delayed phase of chemotherapy-induced nausea and vomiting. This action complements other antiemetics such as 5-HT3 receptor antagonists and corticosteroids, which work through different pathways.
Mechanism Steps
💡 How to Take opilo kit
Strength: This kit contains aprepitant 125 mg and aprepitant 80 mg immediate-release oral capsules.
Dosage Information
| Adult Dosage | The dose and schedule of this medicine are set by your doctor based on the reason it is being used, your chemotherapy or surgery plan, your age, weight, liver function, and other medicines you take. For chemotherapy-induced nausea and vomiting, a common adult schedule is 125 mg on day 1 before chemotherapy, followed by 80 mg once daily on days 2 and 3, always as part of a combination regimen with other antiemetics. For postoperative nausea and vomiting, a single 40 mg dose is sometimes used, but this kit is not designed for that strength. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | No specific dose adjustment is usually needed for older adults based on age alone. However, older patients may be more sensitive to side effects and are more likely to have liver or kidney problems or to take other medicines, so the doctor will individualize the dose and monitor closely. |
| Renal Impairment | No dose adjustment is usually needed for mild to moderate kidney problems. In severe kidney disease, use with caution because data are limited. Dose must be individualized by a qualified clinician. |
| Hepatic Impairment | For mild to moderate liver disease, no dose adjustment is usually needed. In severe liver disease, aprepitant should be used with caution and under specialist supervision because its metabolism may be reduced. Dose must be individualized by a qualified clinician. |
| Maximum Daily Dose | The maximum daily dose depends on the indication and the schedule prescribed by your doctor. For chemotherapy-induced nausea and vomiting, the usual maximum is 125 mg on day 1 and 80 mg once daily on subsequent days. Do not exceed the dose prescribed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of opilo kit
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Pimozide | Major | |
| Warfarin | Major | |
| Oral contraceptives | Major | |
| Rifampicin | Major | |
| St John's wort | Major | |
| Dexamethasone | Moderate | |
| Midazolam | Moderate | |
| Ketoconazole | Moderate | |
| Carbamazepine | Moderate | |
| Paracetamol | Minor |
🚨 Major Interactions
- Pimozide
- Warfarin
- Oral contraceptives
- Rifampicin
- St John's wort
⚡ Moderate Interactions
- Dexamethasone
- Methylprednisolone
- Midazolam
- Some HIV medicines (for example, ritonavir)
- Some antifungal medicines (for example, ketoconazole, itraconazole)
- Some seizure medicines (for example, carbamazepine, phenytoin)
🍷 Alcohol Interaction
Alcohol may increase dizziness, drowsiness, and stomach upset while taking this medicine. It is best to avoid alcohol during treatment, especially if you are also receiving chemotherapy or recovering from surgery.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy or hypersensitivity to aprepitant or any component of the kit","Concurrent use with pimozide","Severe liver disease without specialist supervision","Use in children without specialist guidance"]
⚠️ Warnings & Precautions
["Tell your doctor about all medicines you take, especially blood thinners, oral contraceptives, and medicines for HIV, fungal infections, or seizures.","Use an additional non-hormonal contraceptive method during treatment and for one month after the last dose.","Avoid grapefruit and grapefruit juice during treatment.","Do not drive or operate machinery if you feel dizzy or tired.","Report signs of liver problems such as yellowing of the eyes or skin, dark urine, or upper abdominal pain.","Seek emergency care for swelling of the face, lips, or throat, or difficulty breathing.","Do not crush or chew the capsules; swallow them whole with water.","Follow the exact schedule given by your doctor for chemotherapy or surgery."]
🤱 Lactation Safety
It is not known whether aprepitant passes into breast milk in significant amounts. Because of limited data, breastfeeding is not recommended during treatment unless your doctor advises otherwise. Discuss infant feeding options with your healthcare team.
💊 Overdose Management
There is no specific antidote for aprepitant overdose. If you suspect an overdose, contact your doctor or a poison control centre immediately. Treatment is supportive, with monitoring of vital signs, liver function, and any symptoms. Do not try to make yourself vomit unless a healthcare professional tells you to.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember, unless it is almost time for the next dose. Do not take two doses at the same time to make up for a missed dose. Follow the schedule your doctor gave you, and ask your care team if you are unsure.
Additional Safety Advice
Take this medicine exactly as your doctor prescribes, because the dose and timing are planned around your chemotherapy or surgery schedule. Swallow the capsules whole with water; do not crush or chew them. This medicine is usually taken with other anti-nausea medicines, so follow the full regimen your doctor gives you. Tell your doctor about all other medicines you take, especially blood thinners such as warfarin, oral contraceptives, some HIV medicines, some antifungal medicines, and seizure medicines, because aprepitant can change how these drugs work. Avoid grapefruit and grapefruit juice during treatment. Do not drive or operate heavy machinery if you feel dizzy or tired. Do not start or stop any medicine without asking your doctor. If you miss a dose, follow your doctor's instructions rather than doubling the dose. Keep all appointments for blood tests if your doctor advises monitoring.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Older adults may be more sensitive to tiredness, dizziness, and interactions with other medicines. The doctor will consider liver and kidney function and other medicines when prescribing. Report any new symptoms promptly.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, discuss this with your doctor before starting treatment. Aprepitant is not recommended for routine use in pregnancy unless clearly needed. Use effective contraception during treatment and for one month after the last dose, and remember that aprepitant may reduce the effectiveness of hormonal contraceptives.
🏥 Post-Surgery Considerations
This medicine may be used to prevent nausea and vomiting after surgery. Follow your surgical team's instructions about when to take it, and tell them about all other medicines you take. Report any unusual symptoms such as severe pain, swelling, or difficulty breathing.
🦷 Dental Procedures
Tell your dentist and oral surgeon that you are taking this medicine, especially if you are also on blood thinners or have liver problems. No specific dental precautions are usually needed for a short course, but your dentist may want to coordinate with your doctor.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Light activity such as short walks may help you feel better, but avoid strenuous exercise if you feel tired, dizzy, or weak. Follow your doctor's advice about activity after surgery or during chemotherapy.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
You may feel tired or dizzy, so avoid driving or operating heavy machinery until you know how this medicine affects you. Most people can continue light daily activities, but plan rest breaks and ask your employer about flexible hours around chemotherapy or surgery days.
🛑 When to Stop This Medicine
Do not stop this medicine on your own if it was prescribed as part of a short course around chemotherapy or surgery. If you develop a serious side effect such as an allergic reaction, severe skin rash, or signs of liver problems, stop the medicine and seek medical help immediately. For any other reason, talk to your doctor before stopping.
📅 Long-Term Use Effects
This medicine is usually taken for a short period, such as a few days around chemotherapy or a single dose around surgery, so long-term effects are not common. If it is used repeatedly with chemotherapy cycles, liver function may be monitored. There is no evidence of dependence or serious long-term harm with short courses, but any new or persistent symptoms should be reviewed by your doctor.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
5-HT3 receptor antagonists such as ondansetron and corticosteroids such as dexamethasone are commonly used with or instead of aprepitant depending on the situation.
Evidence: Well-establishedRelaxation techniques, ginger, and acupressure may help some people with mild nausea, but they do not replace prescribed antiemetics for chemotherapy.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There is no known interaction between this medicine and vaccines. However, if you are receiving chemotherapy, your immune response to vaccines may be reduced, and live vaccines may not be safe. Discuss vaccination timing with your cancer care team.
📦 Storage Guide
✅ DO
Store at room temperature between 15°C and 30°C
❌ DON'T
Do not refrigerate unless the label says to
✅ DO
Keep the capsules in their original container
❌ DON'T
Do not transfer them to unmarked containers
✅ DO
Keep away from direct sunlight and moisture
❌ DON'T
Do not store in the bathroom cabinet
✅ DO
Check the expiry date before use
❌ DON'T
Do not use expired capsules
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with the prescription label visible. Keep a copy of your prescription and a letter from your doctor if you are travelling internationally, especially if you carry more than a personal supply. Store it at room temperature and protect it from heat, sunlight, and moisture during travel. If you are crossing time zones, ask your doctor how to adjust the timing of doses around your chemotherapy or surgery schedule. Check customs rules for your destination before you travel.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts blocking NK1 receptors within about an hour, and it helps prevent nausea and vomiting during the acute phase after chemotherapy or surgery.
A: Yes, it is usually used together with other antiemetics such as ondansetron and dexamethasone. Your doctor will plan the combination and doses for you.
A: It may reduce the effectiveness of hormonal contraceptives. Use an additional non-hormonal method during treatment and for one month after the last dose.
A: Take it as soon as you remember if it is not almost time for the next dose. Do not double the dose. Call your doctor if you are unsure.
A: It is best to avoid alcohol because it can increase dizziness, drowsiness, and stomach upset.
🤔 Common Patient Concerns
🔄 Substitutes for opilo kit
View AllAlternative brands with exact same active ingredient:
-
emvoid 125 mg/80 mg capsuleTorrent Pharmaceuticals Ltd ₹799.20 27.6% CHEAPER
-
apretero 125/80 kitHetero Drugs Ltd ₹1,218.00 10.3% COSTLIER
-
apricyt kitUnited Biotech Pvt Ltd ₹1,252.97 13.5% COSTLIER
-
apristar 125 mg/80 mg capsuleLupin Ltd ₹1,300.00 17.8% COSTLIER
-
empov 125mg/80mg capsuleDr Reddy's Laboratories Ltd ₹1,300.00 17.8% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken after vomiting has already started to stop it quickly.
Fact: This medicine is used mainly to prevent nausea and vomiting before chemotherapy or surgery. It is not a rescue medicine for vomiting that has already begun. - Myth: This medicine can replace all other anti-nausea medicines.
Fact: It is usually used together with other antiemetics such as ondansetron and dexamethasone for the best effect. - Myth: It is safe to take with any other medicine without checking.
Fact: Aprepitant can interact with several medicines, including warfarin, oral contraceptives, and some HIV or antifungal medicines, so always tell your doctor about everything you take.
🔄 Alternative Options
Generic Alternatives
- Aprepitant
Brand Alternatives
- Emend