Diclofenac 25mg Injection: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Unusual bruising or bleeding
If experiencing severe symptoms, call emergency services immediately.
What is nac 25mg injection used for?
This medicine is a diclofenac injection used for short-term relief of moderate to severe acute pain, such as after surgery or kidney stones. It works by reducing inflammation and pain. It is given by a healthcare professional and is not for self-administration.
- Generic Name: Diclofenac (25mg/1ml)
- Manufacturer: Systopic Laboratories Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 nac 25mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा डाइक्लोफेनाक इंजेक्शन के रूप में उपलब्ध है और मध्यम से गंभीर दर्द के इलाज के लिए दी जाती है। यह सूजन और दर्द को कम करने में मदद करती है। इसका उपयोग आमतौर पर सर्जरी के बाद, गुर्दे की पथरी, और जोड़ों के दर्द में किया जाता है। यह दवा केवल डॉक्टर या नर्स द्वारा ही दी जाती है, खुद से नहीं लगाई जाती।
साइड इफेक्ट्स: आम दुष्प्रभावों में इंजेक्शन लगाने की जगह पर दर्द, मतली, उल्टी, सिरदर्द, चक्कर आना और नींद आना शामिल हैं। गंभीर दुष्प्रभावों में पेट में रक्तस्राव, दिल का दौरा, गुर्दे की समस्या, और एलर्जी प्रतिक्रिया हो सकती है। अगर आपको काला मल, खून की उल्टी, सीने में दर्द, या सांस लेने में तकलीफ हो तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: यह दवा केवल डॉक्टर की देखरेख में ही दी जानी चाहिए। खुद से इंजेक्शन न लगाएं। अगर आपको पेट की बीमारी, दिल की बीमारी, गुर्दे या लिवर की समस्या, या दमा है तो डॉक्टर को बताएं। इस दवा के साथ शराब न लें। बिना डॉक्टर की सलाह के अन्य दर्द निवारक दवाएं न लें। सबसे कम प्रभावी खुराक सबसे कम समय के लिए लें।
💊 nac 25mg injection Uses & Benefits
[{"condition":"Acute postoperative pain","description":"Provides rapid relief of moderate to severe pain following surgical procedures when oral intake is not possible.","evidence":"Well-established"},{"condition":"Renal colic","description":"Effective in relieving pain associated with kidney stones due to its anti-inflammatory and analgesic properties.","evidence":"Well-established"},{"condition":"Acute exacerbation of osteoarthritis or rheumatoid arthritis","description":"Used for short-term management of severe joint pain and inflammation when oral therapy is inadequate.","evidence":"Well-established"},{"condition":"Acute musculoskeletal pain","description":"Relieves pain from injuries, strains, and sprains when rapid onset is desired.","evidence":"Well-established"},{"condition":"Biliary colic","description":"May be used to alleviate pain from gallstones.","evidence":"Limited"}]
Off-label uses: [{"condition":"Migraine headache","description":"Sometimes used off-label for acute migraine treatment, though not first-line.","evidence":"Limited"},{"condition":"Cancer pain","description":"May be used as an adjunct for cancer-related pain, but evidence is limited.","evidence":"Limited"}]
Primary treatment for: Acute moderate to severe pain
Also treats: Postoperative pain, Renal colic, Acute musculoskeletal pain, Osteoarthritis exacerbation, Rheumatoid arthritis exacerbation
📋 Drug Information
| Generic Name(s) | Diclofenac (25mg/1ml) |
| Brand Name | nac 25mg injection |
| Manufacturer | Systopic Laboratories Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | NSAID's- Non-Selective COX 1&2 Inhibitors (acetic acid) |
| Route of Administration | Parenteral (intramuscular or intravenous) |
| Storage | Store below 25°C, protected from light. Do not freeze. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by inhibiting the cyclooxygenase (COX) enzymes, specifically COX-1 and COX-2, which are responsible for converting arachidonic acid into prostaglandins and thromboxanes. Prostaglandins are mediators of pain, inflammation, and fever. By blocking their production, diclofenac reduces pain, swelling, and fever. The inhibition is reversible and non-selective, affecting both COX isoforms.
Mechanism Steps
💡 How to Take nac 25mg injection
Strength: 25 mg/1 mL injection
Dosage Information
| Adult Dosage | The usual adult dose is 25 mg to 75 mg administered intramuscularly or intravenously, depending on the severity of pain and the patient's condition. The dose may be repeated every 6 to 8 hours, but the total daily dose should not exceed 150 mg. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and concomitant medications. For intravenous administration, the dose should be diluted and infused slowly over 30 minutes to reduce the risk of adverse effects. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients are at increased risk of adverse effects, especially gastrointestinal bleeding and renal impairment. Use the lowest effective dose for the shortest duration. Monitor renal function and for signs of bleeding. |
| Renal Impairment | Use with caution in patients with renal impairment. For patients with eGFR 30-59 mL/min, dose reduction may be necessary. Avoid use in patients with eGFR <30 mL/min. Consult a nephrologist for guidance. |
| Hepatic Impairment | Use with caution in patients with hepatic impairment. For mild to moderate impairment, no dose adjustment is typically needed, but monitor liver function. Avoid use in severe hepatic impairment. |
| Maximum Daily Dose | 150 mg per day |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of nac 25mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Aspirin | Major | |
| Methotrexate | Major | |
| Lithium | Major | |
| ACE inhibitors | Major | |
| Diuretics | Moderate | |
| Corticosteroids | Moderate | |
| SSRIs | Moderate | |
| Cyclosporine | Moderate | |
| Alcohol | Moderate |
🚨 Major Interactions
- Warfarin
- Aspirin
- Methotrexate
- Lithium
- ACE inhibitors and ARBs
⚡ Moderate Interactions
- Diuretics
- Corticosteroids
- SSRIs
- Cyclosporine
🍷 Alcohol Interaction
Alcohol should be avoided while receiving this medicine as it can increase the risk of gastrointestinal bleeding, ulceration, and liver toxicity. It may also enhance central nervous system side effects such as dizziness and drowsiness.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to diclofenac or other NSAIDs","Active gastrointestinal bleeding or peptic ulcer","Severe renal impairment (eGFR
⚠️ Warnings & Precautions
["Cardiovascular risk: NSAIDs increase the risk of serious cardiovascular thrombotic events. Use with caution in patients with cardiovascular risk factors.","Gastrointestinal risk: NSAIDs increase the risk of GI bleeding, ulceration, and perforation. Use with caution in the elderly and those with a history of peptic ulcer disease.","Renal risk: NSAIDs can cause renal impairment. Monitor renal function in at-risk patients.","Hepatic risk: Monitor liver function in patients with liver disease.","Hypersensitivity: Severe allergic reactions can occur. Discontinue if any signs of hypersensitivity develop.","Skin reactions: Serious skin reactions have been reported. Discontinue at first sign of rash or mucosal lesions.","Hematologic: May increase bleeding time. Use with caution in patients with bleeding disorders."]
🤱 Lactation Safety
Diclofenac is excreted in breast milk in small amounts. It is generally considered compatible with breastfeeding, but caution is advised. Consult your doctor before use.
💊 Overdose Management
Overdose with diclofenac may cause nausea, vomiting, abdominal pain, gastrointestinal bleeding, lethargy, drowsiness, and in severe cases, acute renal failure and convulsions. Management is supportive and symptomatic. There is no specific antidote. Activated charcoal may be administered if the patient presents within 1-2 hours of ingestion. Monitor vital signs, renal function, and electrolytes. Hemodialysis is not effective in removing diclofenac due to high protein binding.
⏰ Missed Dose
This medicine is administered by a healthcare professional, so missed doses are unlikely. If a dose is missed, contact your healthcare provider for guidance. Do not attempt to self-administer an extra dose.
Additional Safety Advice
This medicine must be administered only by a healthcare professional. Do not self-administer. Inform your doctor if you have a history of stomach ulcers, heart disease, kidney or liver problems, high blood pressure, or asthma. Avoid alcohol while receiving this medicine as it may increase the risk of gastrointestinal bleeding. Do not take other NSAIDs or blood thinners without consulting your doctor. Use the lowest effective dose for the shortest duration possible. Report any unusual symptoms such as black stools, vomiting blood, severe abdominal pain, chest pain, shortness of breath, decreased urine output, or yellowing of the skin or eyes immediately. This medicine is not recommended during pregnancy, especially in the third trimester, and should be used with caution during breastfeeding.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at increased risk of gastrointestinal bleeding, renal impairment, and cardiovascular events. Use the lowest effective dose for the shortest duration and monitor closely.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended during pregnancy planning or pregnancy, especially in the third trimester. Consult your doctor for alternative pain management options.
🏥 Post-Surgery Considerations
This medicine is often used for postoperative pain. It should be administered under medical supervision. Monitor for bleeding and renal function.
🦷 Dental Procedures
Inform your dentist if you are receiving this medicine, as it may increase bleeding risk during dental procedures. Your dentist may recommend stopping it temporarily.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise or activities that may increase pain or risk of injury while on this medicine. Gentle stretching and low-impact exercises are recommended. Consult your doctor before starting any exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness. Avoid driving or operating heavy machinery until you know how it affects you. It is administered by a healthcare professional, so work impact is mainly related to the underlying condition being treated.
🛑 When to Stop This Medicine
Stop this medicine and seek medical attention if you experience any serious side effects such as chest pain, difficulty breathing, severe abdominal pain, black stools, or signs of an allergic reaction. Do not stop prescribed therapy without consulting your doctor.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended due to increased risk of cardiovascular events, gastrointestinal bleeding, and renal impairment. If long-term therapy is necessary, regular monitoring of renal function, liver function, and blood counts is required. Use the lowest effective dose for the shortest duration.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain.
Evidence: Well-establishedMay help with certain types of pain.
Evidence: LimitedCan help reduce pain and inflammation.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific interactions with vaccines are established. However, if you are scheduled for vaccination, inform your healthcare provider about this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
This medicine is administered by a healthcare professional, so travel advice is limited. If you are prescribed this medicine during travel, carry it in its original packaging with a copy of your prescription. Store below 25°C and protect from light. Do not freeze. Check customs regulations for carrying injectable medications. If you need a dose while traveling, arrange for administration at a medical facility.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Pain relief typically begins within 10 to 20 minutes after intramuscular injection.
A: The analgesic effect lasts approximately 4 to 6 hours.
A: This medicine is generally avoided during pregnancy, especially in the third trimester. Consult your doctor.
A: Do not take other NSAIDs without consulting your doctor due to increased risk of side effects.
🤔 Common Patient Concerns
🔄 Substitutes for nac 25mg injection
View AllAlternative brands with exact same active ingredient:
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zodic 25mg injectionZodak Healthcare ₹4.31 46.1% CHEAPER
-
bionac 25mg injectionUltramark Healthcare Pvt Ltd ₹7.00 12.5% CHEAPER
-
TOPAC IM INJECTIONAbbott ₹7.99 0.1% CHEAPER
-
diclasia 25mg injectionWillow Pharmaceuticals Pvt Ltd ₹8.48 6% COSTLIER
-
Serofin-D 25mg InjectionGlobus Remedies Ltd ₹14.90 86.3% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Diclofenac injection is safe for everyone.
Fact: It is contraindicated in certain conditions such as severe kidney or liver disease, heart failure, and NSAID hypersensitivity. - Myth: Diclofenac injection can be self-administered.
Fact: It must be administered by a healthcare professional only. - Myth: Diclofenac injection is a permanent cure for arthritis.
Fact: It provides symptomatic relief but does not cure the underlying condition.
🔄 Alternative Options
Generic Alternatives
- Diclofenac sodium injection 25 mg/mL
Brand Alternatives
- Voveran
- Dynapar
- Diclonac