af 400 tablet - Fluconazole (400mg) medicine

AF 400 Tablet (Fluconazole 400 mg): Complete Medicine Guide

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Fluconazole (400mg)
🏭 Systopic Laboratories Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 22, 2026
⚠️ Hepatotoxicity Risk 🤰 Pregnancy Category This medicine should be used during pregnancy only when clearly needed and after discussing risks and benefits with a specialist. Observational data have raised concerns about a possible small increase in certain birth defects with high-dose or long-term use, so it is generally avoided in pregnancy unless the infection is serious and no safer alternative is suitable. 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Well-established for approved indications.
Reviewed by
SaathiMed Expert Panel | Sep 22, 2026

When to Call Your Doctor IMMEDIATELY

  • Yellowing of the skin or eyes, or dark urine
  • Severe skin rash with blisters or peeling
  • Palpitations, fainting, or irregular heartbeat
  • Swelling of the face, lips, or throat, or difficulty breathing
  • Severe abdominal pain or persistent vomiting
  • Unusual bruising or bleeding
  • Confusion, extreme tiredness, or seizures

If experiencing severe symptoms, call emergency services immediately.

What is af 400 tablet used for?

This medicine contains fluconazole 400 mg, an antifungal used to treat serious fungal infections such as invasive candidiasis and cryptococcal meningitis. It works by breaking down the fungal cell membrane. Take it exactly as prescribed, avoid alcohol, and report any rash, yellowing of eyes, or palpitations immediately.

  • Generic Name: Fluconazole
  • Manufacturer: Systopic Laboratories Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 af 400 tablet के बारे में (Hindi Summary)

उपयोग: यह दवा फ्लुकोनाज़ोल 400 मिलीग्राम की एक एंटीफंगल गोली है, जिसका उपयोग गंभीर फंगल संक्रमणों जैसे कैंडिडा संक्रमण, क्रिप्टोकोकल मेनिनजाइटिस और म्यूकोसल कैंडिडिआसिस के इलाज के लिए किया जाता है। यह फंगस की कोशिका झिल्ली को कमजोर करके उसे बढ़ने से रोकती है। यह दवा डॉक्टर के निर्देशानुसार ही लेनी चाहिए और कोर्स पूरा करना बहुत जरूरी है।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में सिरदर्द, जी मिचलाना, पेट में असहजता, दस्त और चक्कर आना शामिल हैं। कभी-कभी त्वचा पर दाने, खुजली या स्वाद में बदलाव हो सकता है। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन लीवर की समस्या, गंभीर त्वचा प्रतिक्रिया या दिल की धड़कन में गड़बड़ी हो सकती है। कोई भी असामान्य लक्षण दिखने पर तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें और बेहतर महसूस होने पर भी कोर्स बीच में न छोड़ें। दवा लेते समय शराब न पिएं। अपने डॉक्टर को अपनी सभी दवाओं, सप्लीमेंट्स और हर्बल उत्पादों के बारे में बताएं। अगर आप गर्भवती हैं या गर्भधारण की योजना बना रही हैं, तो डॉक्टर से सलाह लें। आंखों या त्वचा का पीलापन, गहरे रंग का पेशाब, सीने में धड़कन या गंभीर दाने दिखने पर तुरंत इलाज कराएं।

💡 Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

💊 af 400 tablet Uses & Benefits

[{"condition":"Invasive candidiasis","description":"Used to treat serious Candida infections in the blood, deep tissues, or organs, especially in hospitalized or immunocompromised patients.","evidence":"Well-established"},{"condition":"Cryptococcal meningitis","description":"Used as part of treatment for cryptococcal infection of the brain and spinal cord, particularly in people with weakened immunity.","evidence":"Well-established"},{"condition":"Esophageal candidiasis","description":"Treats fungal infection of the food pipe, which causes pain or difficulty swallowing, especially in immunocompromised patients.","evidence":"Well-established"},{"condition":"Oropharyngeal candidiasis","description":"Treats oral thrush, causing white patches and soreness in the mouth and throat.","evidence":"Well-established"},{"condition":"Vaginal candidiasis","description":"Treats vaginal yeast infection, though a single 150 mg dose is more commonly used for uncomplicated cases.","evidence":"Well-established"},{"condition":"Disseminated fungal infections","description":"May be used for other serious systemic fungal infections when the clinician determines it is appropriate.","evidence":"Moderate"}]

Off-label uses: [{"condition":"Refractory skin fungal infections","description":"Sometimes used for difficult-to-treat dermatophyte infections when topical or other oral treatments are not suitable.","evidence":"Limited"},{"condition":"Fungal infections in immunocompromised patients","description":"May be used in selected patients for prophylaxis or treatment based on specialist judgment.","evidence":"Limited"}]

Primary treatment for: Serious fungal infections caused by Candida and Cryptococcus species.

Also treats: Esophageal candidiasis, Oropharyngeal candidiasis, Vaginal candidiasis, Cryptococcal meningitis, Disseminated candidiasis

📋 Drug Information

Generic Name(s)Fluconazole
Brand NameAF 150 Tablet DT
ManufacturerSystopic Laboratories Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassANTI INFECTIVES
Action ClassFungal ergosterol synthesis inhibitor
Route of AdministrationOral
StorageStore at room temperature between 15°C and 30°C in a dry place, away from direct sunlight and moisture.
Shelf LifeTypically 24 to 36 months from the date of manufacture, depending on the manufacturer. Check the expiry date on the pack.
WHO GuidelineFluconazole is included in the World Health Organization Essential Medicines List for the treatment of certain fungal infections. Specific recommendations depend on the infection and patient population.
ICMR GuidelineIndian Council of Medical Research guidelines recommend fluconazole for the treatment of candidiasis and cryptococcosis in appropriate clinical settings, with dose and duration based on the site and severity of infection.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine at the same time each day to maintain steady levels in your body.
2
Complete the full course even if you feel better, because stopping early can cause the infection to return.
3
Tell your doctor about all other medicines, especially blood thinners, diabetes medicines, and heart medicines.
4
Avoid alcohol during treatment to reduce the risk of liver problems and dizziness.
5
Report any rash, yellowing of eyes or skin, dark urine, or palpitations immediately.
6
Use effective contraception during treatment and for a period after, as advised by your doctor.
7
Keep follow-up appointments for blood tests to monitor liver and kidney function if treatment is prolonged.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Painful swallowing or white patches in mouth
This medicine is commonly prescribed for esophageal or oral candidiasis.
Likely Use
✅
Fever with severe headache and neck stiffness
May be used for cryptococcal meningitis, but requires urgent medical evaluation.
Likely Use
✅
Vaginal itching and discharge
May be used, but a single lower dose is more common for uncomplicated cases.
Likely Use
❌
Common cold or flu
This medicine does not treat viral infections.
Not Primary
❌
Bacterial skin infection
This medicine is not an antibiotic.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionThis medicine is well absorbed after oral administration, and absorption is not significantly affected by food.
DistributionThis medicine distributes widely into body tissues and fluids, including cerebrospinal fluid, saliva, sputum, and vaginal fluids. It has a large volume of distribution.
Protein BindingApproximately 11 to 12 percent bound to plasma proteins.
MetabolismThis medicine is mainly eliminated unchanged by the kidneys, with only a small amount metabolized in the liver.
Half-LifeThe elimination half-life is approximately 30 hours in adults with normal kidney function, but it is longer in people with kidney impairment.
ExcretionAbout 80 percent of the dose is excreted unchanged in the urine, with a small amount excreted in feces.
BioavailabilityOral bioavailability is high, approximately 90 percent or more.
Onset of ActionAntifungal effects begin within hours, but noticeable clinical improvement may take several days depending on the infection.
Peak Plasma TimePeak plasma levels are reached about 1 to 2 hours after oral administration.
Duration of ActionBecause of its long half-life, this medicine continues to work for more than 24 hours after a dose, allowing once-daily dosing for many indications.

How It Works

This medicine works by selectively inhibiting the fungal enzyme lanosterol 14-alpha-demethylase, which is needed to convert lanosterol into ergosterol. Ergosterol is an essential component of the fungal cell membrane. When ergosterol production is blocked, the fungal cell membrane becomes weak and leaky, and the fungus cannot grow or divide properly. Because this medicine targets a fungal enzyme that is different from similar human enzymes, it is relatively selective for fungi, although it can still affect human liver enzymes and cause interactions with other medicines.

Mechanism Steps

1
Entry into fungal cell: This medicine enters the fungal cell and reaches the enzyme target.
2
Inhibition of CYP51: It binds to and inhibits lanosterol 14-alpha-demethylase, blocking the conversion of lanosterol to ergosterol.
3
Ergosterol depletion: Without ergosterol, the fungal cell membrane becomes abnormal and cannot maintain normal function.
4
Fungal growth arrest: The fungus stops growing and multiplying, allowing the body's immune defenses to clear the infection.
5
Human CYP inhibition: This medicine also inhibits human CYP enzymes such as CYP2C9, CYP2C19, and CYP3A4, which can raise levels of other medicines and cause interactions.

💡 How to Take af 400 tablet

Strength: Fluconazole 400 mg immediate-release tablet for oral use.

1Take this medicine by mouth with a glass of water.
2Swallow the tablet whole; do not crush or chew unless your doctor says it is okay.
3You can take it with or without food.
4Take it at the same time each day to help you remember.
5Do not stop taking this medicine early, even if you feel better.
6If you miss a dose, follow the missed dose instructions.
7Keep all follow-up appointments and blood tests.

Dosage Information

Adult DosageThe dose of this medicine depends on the type and severity of the fungal infection, your kidney function, and other medicines you take. For serious infections such as invasive candidiasis or cryptococcal meningitis, a loading dose may be given on the first day followed by a lower daily dose. For mucosal infections, shorter courses are often used. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Never change the dose without medical advice.
Pediatric DosagePediatric dosing is not established from available information for this specific 400 mg tablet. Consult a pediatrician for appropriate dosing in children.
Elderly DosageOlder adults may need a lower dose if kidney function is reduced. Kidney function should be checked before and during treatment, and the dose adjusted by a clinician.
Renal ImpairmentIn people with kidney impairment, the dose of this medicine must be reduced. After the usual loading dose, the maintenance dose is typically adjusted based on creatinine clearance. Your doctor will determine the correct dose for you.
Hepatic ImpairmentNo specific dose adjustment is usually required for mild to moderate liver disease, but this medicine should be used with caution in severe liver disease because of the risk of liver injury. Monitoring may be needed.
Maximum Daily DoseThe maximum daily dose depends on the indication and is determined by your clinician. Do not exceed the prescribed dose.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With or without food
Can be taken with or without food
Food does not significantly affect absorption.
Alcohol
Avoid
Increases risk of liver problems and dizziness.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of af 400 tablet

✅ Common Side Effects

Headache (Common (1-10%))
Usually settles on its own. Ask your doctor if it persists or is severe.
Nausea (Common (1-10%))
Take with food and drink plenty of water. Tell your doctor if it continues.
Abdominal discomfort (Common (1-10%))
Take with meals. Contact your doctor if pain is severe or persistent.
Diarrhea (Common (1-10%))
Stay hydrated. Seek advice if diarrhea is severe or bloody.
Dizziness (Uncommon (0.1-1%))
Avoid driving or operating machinery until you know how this medicine affects you.
Rash (Uncommon (0.1-1%))
Stop the medicine and contact your doctor promptly, especially if the rash spreads or you feel unwell.

🚨 Serious Side Effects

Severe skin reactions such as Stevens-Johnson syndrome (Rare (<0.1%))
Seek emergency care if you develop a painful spreading rash, blisters, or peeling skin.
Liver injury (Rare (<0.1%))
Seek urgent care if you notice yellowing of eyes or skin, dark urine, or severe tiredness.
QT prolongation and dangerous heart rhythms (Rare (<0.1%))
Seek emergency help for palpitations, fainting, or unexplained dizziness.
Severe allergic reaction (anaphylaxis) (Rare (<0.1%))
Call emergency services for swelling of face, lips, or throat, or difficulty breathing.
Blood disorders such as low white cell or platelet counts (Rare (<0.1%))
Report unusual bruising, bleeding, or repeated infections to your doctor.

⚠️ Rare Side Effects

Seizures
Seek emergency medical attention.
Severe liver failure
Go to the nearest emergency department if you develop confusion, bleeding, or yellowing of the skin.
Torsades de pointes
Call emergency services for fainting or a racing irregular heartbeat.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major
Amiodarone Major
Tacrolimus Major
Simvastatin Major
Glipizide Major
Phenytoin Moderate
Rifampicin Moderate
Midazolam Moderate
Nifedipine Moderate
Oral contraceptives Moderate

🚨 Major Interactions

  • Warfarin
  • QT-prolonging medicines such as amiodarone, sotalol, or haloperidol
  • Tacrolimus, sirolimus, or cyclosporine
  • Statins such as simvastatin or atorvastatin
  • Sulfonylureas such as glipizide or glyburide

⚡ Moderate Interactions

  • Phenytoin
  • Rifampicin
  • Benzodiazepines such as midazolam or triazolam
  • Calcium channel blockers such as nifedipine
  • Oral contraceptives

🍷 Alcohol Interaction

Alcohol should be avoided while taking this medicine because both alcohol and this medicine can stress the liver, and alcohol may worsen dizziness or stomach upset. If you drink alcohol regularly, discuss this with your doctor before starting treatment.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known allergy to fluconazole or other azole antifungals","Concurrent use of medicines that can cause dangerous QT prolongation, such as certain antiarrhythmics","Concurrent use of cisapride, pimozide, or quinidine","Pregnancy, unless clearly needed and advised by a specialist","Severe liver disease, unless benefits outweigh risks","Breastfeeding, unless advised by a doctor"]

⚠️ Warnings & Precautions

["Tell your doctor about all medicines you take, including over-the-counter and herbal products.","Avoid alcohol during treatment.","Use effective contraception during treatment and for a period after, as advised.","Report any rash, yellowing of eyes or skin, dark urine, or severe tiredness immediately.","Report palpitations, fainting, or dizziness.","Dose adjustment is needed in kidney disease.","Use with caution in people with heart rhythm problems or electrolyte imbalances.","Do not share this medicine with others.","Keep out of reach of children."]

🤱 Lactation Safety

This medicine passes into breast milk in small amounts. It is generally considered acceptable during breastfeeding when prescribed by a doctor, but the infant should be monitored for feeding problems, rash, or diarrhea. Discuss with your doctor if you are breastfeeding.

💊 Overdose Management

If you suspect an overdose, seek emergency medical care immediately. There is no specific antidote for this medicine. Treatment is supportive, including monitoring of vital signs, ECG, and electrolytes. In severe cases, hemodialysis may help remove the medicine from the blood.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember if less than half the dosing interval has passed. If more than half the interval has passed, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed and do not stop early even if you feel better, because stopping too soon can allow the fungal infection to return. Swallow the tablet whole with a glass of water. Tell your doctor about all other medicines, supplements, and herbal products you use, especially blood thinners, diabetes medicines, and heart rhythm medicines. Avoid alcohol while taking this medicine because it can increase the risk of liver problems. Use effective contraception during treatment and for a period after treatment if you are a woman of childbearing age, unless your doctor advises otherwise. Keep all follow-up appointments and blood tests. Seek immediate medical help if you develop yellowing of the skin or eyes, dark urine, severe stomach pain, palpitations, fainting, or a severe skin rash.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Older adults may have reduced kidney function and may need a lower dose. Kidney function should be checked before and during treatment.

🤰 Pregnancy Planning (TTC)

If you are planning pregnancy, discuss this medicine with your doctor before conception. Use effective contraception during treatment and for a period after, as advised.

🏥 Post-Surgery Considerations

If you are scheduled for surgery, inform your surgeon and anesthesiologist that you are taking this medicine, as it can interact with other medicines used during surgery.

🦷 Dental Procedures

Inform your dentist that you are taking this medicine, especially if you are having a procedure that may involve bleeding or sedation.

💚 Lifestyle Tips for Better Results

🏃
Maintain good hygiene to prevent fungal infections.
🥗
Keep your blood sugar well controlled if you have diabetes.
😴
Eat a balanced diet to support your immune system.
💧
Get adequate sleep and manage stress.
🧘
Avoid sharing personal items like towels or razors.
🌞
Follow your doctor's advice on follow-up visits and tests.

🏋️ Exercise Considerations

You can exercise as usual unless you feel dizzy or weak. If you experience dizziness, avoid strenuous exercise or driving until you feel better.

🥗 Diet Recommendations

Include plenty of fruits and vegetables.
Choose whole grains and lean proteins.
Stay well hydrated.
Limit sugary and processed foods.
Avoid alcohol during treatment.

💼 Impact on Daily Work & Life

Most people can continue their daily activities while taking this medicine. If you feel dizzy or unwell, avoid driving or operating heavy machinery until you know how the medicine affects you.

🛑 When to Stop This Medicine

Do not stop this medicine without consulting your doctor. Stopping early can allow the infection to return. Your doctor will tell you when it is safe to stop based on your response to treatment.

📅 Long-Term Use Effects

Long-term use of this medicine may increase the risk of liver injury, drug interactions, and the development of resistant fungi. Regular monitoring of liver and kidney function may be needed. Your doctor will decide the duration of treatment based on your infection and response.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Other antifungal medicines

Depending on the infection, other antifungals such as itraconazole or amphotericin B may be used.

Evidence: Well-established
Supportive care

Rest, hydration, and treatment of underlying conditions can help recovery.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

There are no specific vaccine interactions with this medicine. However, if you are immunocompromised, discuss your vaccination schedule with your doctor.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of your prescription. Keep it in your hand luggage to avoid loss or temperature extremes. Store at room temperature and avoid direct sunlight. If you are crossing time zones, ask your doctor how to adjust the timing of your doses. Check customs rules for carrying prescription medicines in your destination country.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 38-year-old man with HIV and cryptococcal meningitis
He was started on this medicine as part of his treatment. He initially felt dizzy and nauseated, but these effects settled after a few days. He completed the full course under specialist care and recovered well.
💡 Lesson: Serious fungal infections require complete treatment and close monitoring. Mild side effects often improve with time.
👤 A 52-year-old woman with esophageal candidiasis causing painful swallowing
She was prescribed this medicine and noticed improvement in swallowing within a week. She was advised to avoid alcohol and to report any rash. She completed the course and her symptoms resolved.
💡 Lesson: Taking the medicine as prescribed and following safety advice helps achieve the best outcome.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: You may start to feel better within a few days, but the full effect depends on the type and severity of the infection. Complete the full course as prescribed.

Q: Can I take this medicine with food?

A: Yes, you can take it with or without food. Food does not significantly affect how well it is absorbed.

Q: What should I do if I miss a dose?

A: If less than half the dosing interval has passed, take the missed dose as soon as you remember. If more than half has passed, skip it and continue with your regular schedule. Do not double dose.

Q: Is this medicine safe in pregnancy?

A: It should be used in pregnancy only when clearly needed and after discussing risks and benefits with a specialist.

Q: Can I drink alcohol while taking this medicine?

A: It is best to avoid alcohol because it can increase the risk of liver problems and dizziness.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?
  • Is it safe in pregnancy?
  • Does it affect my birth control pills?

🔄 Substitutes for af 400 tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can cure any infection.
    Fact: This medicine only treats fungal infections. It does not work against bacteria or viruses.
  • Myth: You can stop this medicine as soon as you feel better.
    Fact: Stopping early can allow the fungal infection to return. Complete the full course as prescribed.
  • Myth: This medicine is safe to take with all other medicines.
    Fact: This medicine interacts with many medicines, including blood thinners and heart medicines. Always tell your doctor about everything you take.

🔄 Alternative Options

Generic Alternatives

  • Fluconazole 400 mg tablet

Brand Alternatives

  • AF 400 Tablet

📊 Comparison with Similar Medicines

[{"medicine":"Fluconazole","class":"Triazole antifungal","route":"Oral","common_use":"Candidiasis, cryptococcosis"},{"medicine":"Itraconazole","class":"Triazole antifungal","route":"Oral","common_use":"Dermatophyte infections, aspergillosis"},{"medicine":"Voriconazole","class":"Triazole antifungal","route":"Oral, intravenous","common_use":"Invasive aspergillosis, candidemia"}]

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