Bionac 25mg Injection: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Unusual bruising or bleeding
- Severe skin rash with blisters or peeling
If experiencing severe symptoms, call emergency services immediately.
What is bionac 25mg injection used for?
This medicine is a diclofenac injection used for short-term relief of moderate to severe pain and inflammation. It is given by a healthcare professional into a muscle, usually once or twice daily, and works within 10 to 20 minutes. It should not be used in people with stomach ulcers, severe kidney or liver disease, or aspirin-sensitive asthma.
- Generic Name: Diclofenac
- Manufacturer: Ultramark Healthcare Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 bionac 25mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा डाइक्लोफेनाक का इंजेक्शन है, जिसका उपयोग मध्यम से गंभीर दर्द और सूजन को कम करने के लिए किया जाता है। यह ऑपरेशन के बाद के दर्द, चोट, गुर्दे की पथरी के दर्द, गठिया के दर्द और अन्य तीव्र दर्द में दी जाती है। यह इंजेक्शन डॉक्टर या नर्स द्वारा मांसपेशी में लगाया जाता है और लगभग 10 से 20 मिनट में असर दिखाने लगता है। यह दवा केवल थोड़े समय के लिए दी जाती है और इसे डॉक्टर की सलाह के बिना खुद नहीं लगवाना चाहिए।
साइड इफेक्ट्स: आम दुष्प्रभावों में इंजेक्शन लगाने की जगह पर दर्द, लालिमा या सूजन, जी मिचलाना, उल्टी, पेट में गड़बड़ी, सिरदर्द, चक्कर आना और नींद आना शामिल हैं। गंभीर दुष्प्रभाव कम होते हैं, लेकिन पेट में ब्लीडिंग, किडनी की समस्या, दिल की समस्या, सांस लेने में तकलीफ, चेहरे या गले में सूजन, आंखों या त्वचा का पीला पड़ना जैसे लक्षण दिखें तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: यह दवा केवल डॉक्टर या नर्स द्वारा ही लगाई जानी चाहिए। खुद से इंजेक्शन न लगाएं। अपने डॉक्टर को अपनी सभी बीमारियों और दवाओं के बारे में बताएं, खासकर पेट के अल्सर, किडनी या लिवर की बीमारी, दिल की बीमारी, अस्थमा और खून पतला करने वाली दवाओं के बारे में। इलाज के दौरान शराब न पिएं। सबसे कम असरदार खुराक सबसे कम समय के लिए लें। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर से सलाह लें।
💊 bionac 25mg injection Uses & Benefits
[{"condition":"Acute postoperative pain","description":"Provides rapid relief of moderate to severe pain after surgery when oral intake is not possible or when fast onset is needed.","evidence":"Well-established"},{"condition":"Acute musculoskeletal injury","description":"Reduces pain and inflammation in sprains, strains, and sports injuries.","evidence":"Well-established"},{"condition":"Renal colic","description":"Relieves severe flank pain caused by kidney stones while awaiting definitive treatment.","evidence":"Well-established"},{"condition":"Acute gout flare","description":"Helps control severe joint pain and swelling during an acute attack.","evidence":"Well-established"},{"condition":"Acute exacerbation of osteoarthritis or rheumatoid arthritis","description":"Used short-term for severe flare-ups when oral NSAIDs are not enough or not tolerated.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Prevention of heterotopic ossification after hip surgery","description":"Sometimes used off-label, though other NSAIDs are more commonly studied for this purpose.","evidence":"Limited"},{"condition":"Acute migraine attack","description":"May be used off-label for severe migraine pain in some emergency settings.","evidence":"Limited"}]
Primary treatment for: Acute moderate to severe pain and inflammation
Also treats: Postoperative pain, Musculoskeletal injuries, Renal colic, Acute gout, Arthritis flare-ups
📋 Drug Information
| Generic Name(s) | Diclofenac |
| Brand Name | Adiflam 50mg Tablet |
| Manufacturer | Ultramark Healthcare Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | NSAID's- Non-Selective COX 1&2 Inhibitors (acetic acid) |
| Route of Administration | Parenteral (intramuscular injection) |
| Storage | Store below 30°C in a dry place, protected from light. Do not freeze. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture, or as printed on the pack. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by reversibly inhibiting both cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) enzymes. This inhibition blocks the conversion of arachidonic acid into prostaglandin H2, which is the precursor for prostaglandins, prostacyclin, and thromboxane. The reduced production of prostaglandins leads to decreased pain signaling, less inflammation, and reduced fever. Because COX-1 is also involved in protecting the stomach lining and in platelet function, its inhibition explains some of the gastrointestinal and bleeding risks associated with this medicine.
Mechanism Steps
💡 How to Take bionac 25mg injection
Strength: 25 mg per 1 mL sterile injection
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 25 mg to 75 mg given by deep intramuscular injection into the upper outer quadrant of the buttock, once or twice daily depending on the severity of pain. The maximum daily dose is generally 150 mg. Treatment should be short-term, usually not more than 2 days, and should be switched to oral therapy as soon as possible. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and response to treatment. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients are at higher risk of stomach bleeding, kidney problems, and heart effects. Use the lowest effective dose for the shortest duration. Monitor kidney function and blood pressure closely. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Use with caution in patients with kidney impairment. Avoid in severe kidney disease. Dose reduction may be needed in moderate impairment. Monitor kidney function closely. Dose must be individualized by a qualified clinician. |
| Hepatic Impairment | Use with caution in patients with liver impairment. Avoid in severe liver disease. Dose reduction may be needed in mild to moderate impairment. Monitor liver function tests. Dose must be individualized by a qualified clinician. |
| Maximum Daily Dose | 150 mg per day by intramuscular injection, for short-term use only. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of bionac 25mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Methotrexate | Major | |
| Aspirin | Major | |
| Corticosteroids | Major | |
| ACE inhibitors | Major | |
| Diuretics | Moderate | |
| Lithium | Moderate | |
| SSRIs | Moderate | |
| Cyclosporine | Moderate | |
| Digoxin | Moderate |
🚨 Major Interactions
- Warfarin and other anticoagulants
- Methotrexate
- Other NSAIDs including aspirin
- Corticosteroids
- ACE inhibitors and angiotensin receptor blockers
⚡ Moderate Interactions
- Diuretics such as furosemide
- Lithium
- Selective serotonin reuptake inhibitors (SSRIs)
- Cyclosporine
- Digoxin
🍷 Alcohol Interaction
Avoid alcohol while receiving this medicine. Alcohol increases the risk of gastrointestinal bleeding, ulcers, and liver problems. It can also worsen dizziness and drowsiness.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Active peptic ulcer or gastrointestinal bleeding","Severe kidney disease or dialysis","Severe liver disease","History of asthma, urticaria, or allergic reaction to aspirin or other NSAIDs","Coronary artery bypass graft surgery (perioperative period)","Severe heart failure","Third trimester of pregnancy","Known allergy to diclofenac or any component of the injection"]
⚠️ Warnings & Precautions
["Use the lowest effective dose for the shortest possible time.","Avoid in patients with a history of stomach ulcers or bleeding.","Monitor kidney and liver function during treatment.","Use with caution in elderly patients and those with heart disease.","Do not use together with other NSAIDs.","Avoid alcohol during treatment.","Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding.","Stop the medicine and seek help if you develop signs of an allergic reaction.","Do not drive or operate machinery if you feel dizzy or drowsy.","Tell your doctor about all other medicines you are taking."]
🤱 Lactation Safety
Diclofenac passes into breast milk in small amounts. Short-term use of the injection is generally considered acceptable, but consult your doctor to weigh the benefits and risks. Monitor the baby for any unusual symptoms.
💊 Overdose Management
Overdose of this medicine can cause severe stomach pain, vomiting, bleeding, kidney failure, liver damage, and central nervous system effects such as headache, dizziness, and seizures. There is no specific antidote. Treatment is supportive and may include activated charcoal if given early, stomach lavage, and management of complications. Seek immediate medical attention if you suspect an overdose.
⏰ Missed Dose
This medicine is usually given as a single dose or a short course by a healthcare professional. If you miss a scheduled dose, contact your doctor or nurse for advice. Do not try to self-administer an extra dose.
Additional Safety Advice
This medicine must be given only by a healthcare professional. Do not self-administer. Inform your doctor about all your medical conditions, especially stomach ulcers, kidney or liver problems, heart disease, high blood pressure, asthma, or bleeding disorders. Tell your doctor about all medicines you take, including blood thinners, steroids, antidepressants, diuretics, and blood pressure medicines. Avoid alcohol during treatment because it increases the risk of stomach bleeding. Use the lowest effective dose for the shortest possible time. Do not use this medicine for more than a few days unless your doctor specifically advises. If you are pregnant, planning pregnancy, or breastfeeding, discuss the risks and benefits with your doctor before receiving this medicine. Keep all follow-up appointments and report any unusual symptoms promptly.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of stomach bleeding, kidney problems, and heart effects. Use the lowest effective dose for the shortest duration. Monitor kidney function, blood pressure, and signs of bleeding. Avoid long-term use.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, discuss with your doctor before using this medicine. NSAIDs like diclofenac may affect ovulation and are best avoided around conception and during pregnancy, especially in the third trimester.
🏥 Post-Surgery Considerations
This medicine is often used for postoperative pain. It should be given under medical supervision. Monitor for bleeding, kidney function, and interactions with other postoperative medicines such as anticoagulants.
🦷 Dental Procedures
Inform your dentist if you have received this medicine recently, especially before any dental surgery, because it can increase bleeding risk. Your dentist may advise stopping it temporarily or taking precautions.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise or heavy lifting while you are in pain. Once the pain improves, start with gentle stretching and gradually increase activity. Do not push through severe pain. Consult a physiotherapist for a safe exercise plan.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness in some people. Do not drive or operate heavy machinery until you know how it affects you. You may need to take rest for a few hours after the injection. Most people can return to light duties the same day, but follow your doctor's advice.
🛑 When to Stop This Medicine
Stop this medicine and seek medical advice if you develop signs of an allergic reaction, severe stomach pain, black stools, vomiting blood, chest pain, difficulty breathing, or any other serious symptom. Do not stop or change the dose without consulting your doctor, especially if you are on a short course.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended. Prolonged use increases the risk of stomach ulcers and bleeding, kidney impairment, high blood pressure, heart attack, stroke, and liver damage. If long-term pain control is needed, your doctor will consider safer alternatives and monitor your kidney and liver function regularly.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain and improve function.
Evidence: Well-establishedHelp reduce pain and swelling in acute injuries.
Evidence: Well-establishedMay help some patients with chronic pain.
Evidence: LimitedCan be used for localized pain with fewer systemic side effects.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are unwell with a fever or infection, consult your doctor before receiving any vaccine.
📦 Storage Guide
✅ DO
Store below 30°C in a dry place
❌ DON'T
Do not freeze
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Protect from light
❌ DON'T
Do not store in direct sunlight
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
This medicine is given by a healthcare professional, so you do not need to carry it yourself. If you are prescribed a course, keep the prescription copy with you. Store the injection below 30°C, protected from light, and do not freeze. When traveling, carry it in its original packaging with the prescription. If you need a dose during travel, visit a clinic or hospital. Time zone changes do not usually affect a short course of injections, but follow your doctor's schedule.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts relieving pain within 10 to 20 minutes after the injection.
A: Pain relief typically lasts 4 to 6 hours after a single dose.
A: It should be used with caution or avoided in kidney disease. Your doctor will decide based on your kidney function.
A: It should be avoided, especially in the third trimester. Consult your doctor if you are pregnant or planning pregnancy.
A: No, alcohol increases the risk of stomach bleeding and liver problems.
A: Serious side effects include stomach bleeding, kidney injury, heart problems, and severe allergic reactions. Seek immediate help if you notice black stools, chest pain, or swelling of the face or throat.
🤔 Common Patient Concerns
🔄 Substitutes for bionac 25mg injection
View AllAlternative brands with exact same active ingredient:
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zodic 25mg injectionZodak Healthcare ₹4.31 38.4% CHEAPER
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TOPAC IM INJECTIONAbbott ₹7.99 14.1% COSTLIER
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diclasia 25mg injectionWillow Pharmaceuticals Pvt Ltd ₹8.48 21.1% COSTLIER
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Serofin-D 25mg InjectionGlobus Remedies Ltd ₹14.90 112.9% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be used for any type of pain.
Fact: This medicine is for moderate to severe pain and inflammation. It is not suitable for all types of pain and should be used only when prescribed. - Myth: Injections are always stronger and better than tablets.
Fact: Injections work faster but are not always better. They are used when oral medicines cannot be taken or when rapid effect is needed. They also carry the same risks as oral NSAIDs. - Myth: This medicine is safe to use for a long time.
Fact: This medicine is for short-term use only. Long-term use increases the risk of stomach bleeding, kidney problems, and heart effects. - Myth: You can take this medicine on an empty stomach without any problem.
Fact: This medicine is given by injection, so stomach issues are less immediate, but it still increases the risk of stomach ulcers and bleeding. Food does not directly affect the injection.
🔄 Alternative Options
Generic Alternatives
- Diclofenac sodium injection
Brand Alternatives
- Voveran
- Dynapar
- Zerodol