Dyrade M 200 mg/250 mg Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Seizures or convulsions
- Numbness or tingling in hands or feet
- Confusion or difficulty speaking
- Severe skin rash or blistering
- Yellowing of skin or eyes
If experiencing severe symptoms, call emergency services immediately.
What is kumagyl forte tablet used for?
This medicine is a combination of metronidazole and diloxanide used to treat intestinal amoebiasis. It works by killing the parasite Entamoeba histolytica in both tissues and the gut lumen. Take it with food and avoid alcohol completely during treatment.
- Generic Name: Metronidazole (200mg) + Diloxanide (250mg)
- Manufacturer: Kumayun Drugs Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 kumagyl forte tablet के बारे में (Hindi Summary)
उपयोग: यह दवा मेट्रोनिडाजोल और डाइलोक्सानाइड का संयोजन है, जिसका उपयोग आंतों के अमीबियासिस (अमीबिक पेचिश) के इलाज के लिए किया जाता है। यह आंतों में अमीबा परजीवी को मारती है और दस्त, पेट दर्द, और बुखार जैसे लक्षणों से राहत दिलाती है। इसे भोजन के साथ लें और शराब का सेवन बिल्कुल न करें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट में असहजता, मुँह में धातु जैसा स्वाद, सिरदर्द और भूख में कमी शामिल हैं। गंभीर दुष्प्रभावों में हाथ-पैरों में झुनझुनी, दौरे, और त्वचा पर गंभीर प्रतिक्रियाएँ हो सकती हैं। यदि कोई असामान्य लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को लेते समय और आखिरी खुराक के 48 घंटे बाद तक शराब का सेवन न करें, क्योंकि इससे गंभीर प्रतिक्रिया हो सकती है। दवा को भोजन के साथ लें। यदि आपको लीवर या किडनी की बीमारी है तो डॉक्टर को बताएं। पूरा कोर्स पूरा करें, चाहे लक्षण ठीक हो जाएं।
💊 kumagyl forte tablet Uses & Benefits
[{"condition":"Intestinal amoebiasis (amoebic dysentery)","description":"This medicine is used to treat acute amoebic dysentery caused by Entamoeba histolytica, relieving symptoms such as bloody diarrhea, abdominal pain, and fever.","evidence":"Well-established"},{"condition":"Amoebic liver abscess (as adjunct)","description":"Metronidazole component is effective against amoebic liver abscess, but diloxanide is not active in liver; combination may be used for intestinal carriage after abscess treatment.","evidence":"Established for metronidazole; diloxanide not for liver abscess"},{"condition":"Asymptomatic amoebic cyst passers","description":"Diloxanide is a luminal amoebicide that helps eliminate cysts from the intestine, reducing transmission.","evidence":"Well-established for diloxanide"}]
Off-label uses: [{"condition":"Giardiasis","description":"Metronidazole is effective against Giardia lamblia, but the combination with diloxanide is not standard; may be used off-label.","evidence":"Limited"},{"condition":"Trichomoniasis","description":"Metronidazole is the drug of choice, but diloxanide adds no benefit; combination not recommended.","evidence":"Limited"}]
Primary treatment for: Intestinal amoebiasis
Also treats: Amoebic dysentery, Amoebic colitis, Asymptomatic amoebic cyst carriage
📋 Drug Information
| Generic Name(s) | Metronidazole (200mg) + Diloxanide (250mg) |
| Brand Name | kumagyl forte tablet |
| Manufacturer | Kumayun Drugs Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C, away from direct sunlight and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two antiprotozoal agents with complementary mechanisms. Metronidazole is a nitroimidazole that enters susceptible protozoa and undergoes reductive activation of its nitro group, creating reactive intermediates that damage DNA and inhibit nucleic acid synthesis, leading to cell death. Diloxanide is a luminal amoebicide whose exact mechanism is not fully understood, but it is believed to interfere with parasite protein synthesis and energy metabolism, effectively eliminating Entamoeba histolytica cysts and trophozoites in the intestinal lumen.
Mechanism Steps
💡 How to Take kumagyl forte tablet
Strength: Tablet containing Metronidazole 200 mg and Diloxanide 250 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet taken orally two to three times daily, depending on the severity of the infection and your doctor's prescription. The exact dose and duration must be individualized by a qualified clinician based on the indication, age, weight, renal and hepatic function. Do not self-medicate. Always follow your doctor's instructions. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician for appropriate dosing in children. |
| Elderly Dosage | Elderly patients may be more sensitive to the side effects of this medicine, especially neurological effects. Dose adjustment may be needed based on liver and kidney function. Consult your doctor for personalized dosing. |
| Renal Impairment | In patients with severe renal impairment, dose adjustment may be necessary. Metronidazole and its metabolites are excreted in urine. Consult your doctor for appropriate dosing. |
| Hepatic Impairment | In patients with severe hepatic impairment, dose reduction may be required due to reduced metabolism of metronidazole. Consult your doctor for personalized dosing. |
| Maximum Daily Dose | The maximum daily dose should not exceed the prescribed amount. Typically, the maximum adult dose is 600 mg of metronidazole and 750 mg of diloxanide per day, but this must be confirmed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of kumagyl forte tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Alcohol | Major | |
| Lithium | Major | |
| Phenytoin | Moderate | |
| Carbamazepine | Moderate | |
| Cimetidine | Moderate | |
| Antacids | Minor | |
| Food | Minor |
🚨 Major Interactions
- Warfarin
- Alcohol
- Lithium
⚡ Moderate Interactions
- Phenytoin
- Carbamazepine
- Cimetidine
🍷 Alcohol Interaction
Alcohol must be strictly avoided while taking this medicine and for at least 48 hours after the last dose. Combining alcohol with metronidazole can cause a disulfiram-like reaction characterized by severe nausea, vomiting, flushing, headache, and rapid heartbeat. This reaction can be dangerous and requires immediate medical attention if it occurs.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to metronidazole, diloxanide, or other nitroimidazole derivatives","First trimester of pregnancy","Active neurological disorders or history of seizures","Severe liver disease","Alcohol consumption during treatment and for 48 hours after"]
⚠️ Warnings & Precautions
["Avoid alcohol completely during treatment and for 48 hours after the last dose.","May cause dizziness or confusion; avoid driving or operating machinery until you know how it affects you.","Inform your doctor if you have liver disease, kidney disease, or blood disorders.","Do not use for longer than prescribed without medical supervision.","May interfere with certain laboratory tests; inform your doctor before any tests.","Complete the full course even if symptoms improve to prevent relapse."]
🤱 Lactation Safety
Metronidazole is excreted in breast milk and may affect the nursing infant. It is generally recommended to avoid this medicine during breastfeeding, especially in high doses. If treatment is essential, your doctor may advise temporarily stopping breastfeeding or pumping and discarding milk during treatment and for 24-48 hours after the last dose. Consult your doctor for personalized advice.
💊 Overdose Management
Overdose of this medicine may cause nausea, vomiting, abdominal pain, dizziness, headache, and in severe cases, seizures or peripheral neuropathy. If you suspect an overdose, seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote. Gastric lavage may be considered if ingestion is recent. Monitor vital signs and neurological status.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Do not consume alcohol while taking this medicine and for at least 48 hours after finishing the course, as it can cause a disulfiram-like reaction with severe nausea, vomiting, flushing, and rapid heartbeat. Take this medicine with food to reduce stomach upset. Inform your doctor if you have liver disease, kidney disease, or a history of blood disorders. Avoid driving or operating heavy machinery if you feel dizzy or confused. Complete the full prescribed course even if symptoms improve. Do not share this medicine with others. Keep out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more susceptible to neurological side effects. Use with caution and monitor closely.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. It is not recommended during the first trimester.
🏥 Post-Surgery Considerations
Inform your surgeon if you are taking this medicine before any surgery. It may interact with anesthetics and other medications.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine, as it may interact with certain antibiotics or anesthetics used during dental procedures.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise if you feel weak or dizzy. Light activity is fine if you feel up to it. Consult your doctor before resuming intense workouts.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or confusion in some people. Avoid driving or operating heavy machinery until you know how it affects you. Most people can continue their daily activities with caution.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Complete the full prescribed course even if symptoms improve. If you experience serious side effects, contact your doctor immediately.
📅 Long-Term Use Effects
Long-term use of this medicine may increase the risk of peripheral neuropathy and other neurological effects. It should only be used for the prescribed duration. Regular monitoring of liver function and neurological status is advised for prolonged therapy.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
A longer-acting nitroimidazole that may be used as an alternative for amoebiasis.
Evidence: Well-establishedA luminal amoebicide used for asymptomatic cyst passers.
Evidence: Established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions are known. However, inform your doctor if you are due for any vaccinations.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from moisture. If traveling across time zones, adjust dosing times gradually to maintain even intervals. Check customs regulations for carrying prescription medicines. Always carry enough supply for your entire trip.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling better within 1-2 days, but it is important to complete the full course as prescribed.
A: No, you must complete the full course to prevent relapse and resistance.
A: Take it as soon as you remember, but if it's almost time for your next dose, skip the missed dose. Do not double dose.
🤔 Common Patient Concerns
🔄 Substitutes for kumagyl forte tablet
View AllAlternative brands with exact same active ingredient:
-
qugyl ss 200mg/250mg tabletRPG Life Sciences Ltd ₹3.94 92.1% CHEAPER
-
a nil tabletPan Pharmaceuticals Ltd ₹6.30 87.4% CHEAPER
-
dyrade m 200 mg/250 mg tabletCipla Ltd ₹6.39 87.2% CHEAPER
-
ameebee 200mg/250mg tabletTOSC International Pvt Ltd ₹7.00 86% CHEAPER
-
Fremogyl 200 mg/250 mg TabletDales Pharmaceuticals Ltd ₹7.40 85.2% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be stopped as soon as symptoms improve.
Fact: You must complete the full prescribed course to prevent relapse and resistance. - Myth: It is safe to drink alcohol while taking this medicine.
Fact: Alcohol can cause a severe disulfiram-like reaction and must be avoided. - Myth: This medicine is safe to take during pregnancy.
Fact: It is not recommended during the first trimester and should only be used if prescribed by a doctor.
🔄 Alternative Options
Generic Alternatives
- Metronidazole 200 mg + Diloxanide 250 mg tablet (various manufacturers)
Brand Alternatives
- Dyrade M 200 mg/250 mg tablet