Atrelax 10mg/ml Injection: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Sudden severe allergic reaction with swelling of face, lips, or throat
- Difficulty breathing or wheezing
- Severe drop in blood pressure or fainting
- Chest pain or irregular heartbeat
- Prolonged muscle weakness or paralysis after the procedure
- Seizures or unusual neurological symptoms
- Signs of injection site infection like redness, swelling, or pus
If experiencing severe symptoms, call emergency services immediately.
What is kabitran injection used for?
This medicine is a non-depolarizing neuromuscular blocker used during surgery to relax muscles and assist with intubation and mechanical ventilation. It is given intravenously by anesthesia professionals and requires careful monitoring.
- Generic Name: Atracurium (10mg/ml)
- Manufacturer: Fresenius Kabi India Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 kabitran injection के बारे में (Hindi Summary)
उपयोग: यह दवा एट्राक्यूरियम बेसिलेट का इंजेक्शन है, जिसका उपयोग सर्जरी के दौरान मांसपेशियों को शिथिल करने, इंटुबैशन में मदद करने और आईसीयू में मशीन से सांस देने के लिए किया जाता है। यह केवल अस्पताल में प्रशिक्षित डॉक्टरों द्वारा नस में दी जाती है। यह दर्द निवारक या एंटीबायोटिक नहीं है। इसका उपयोग बहुत सावधानी से किया जाता है क्योंकि यह सांस की मांसपेशियों को भी शिथिल कर सकती है।
साइड इफेक्ट्स: आम दुष्प्रभावों में चेहरे पर लालिमा, हल्का रक्तचाप कम होना, और दिल की धड़कन बढ़ना शामिल हैं। गंभीर दुष्प्रभावों में एलर्जी, सांस लेने में कठिनाई, और लंबे समय तक पक्षाघात हो सकता है। किसी भी असामान्य लक्षण को तुरंत डॉक्टर को बताएं।
सुरक्षा सलाह: यह दवा केवल अस्पताल में डॉक्टर की देखरेख में दी जाती है। इससे पहले अपनी सभी बीमारियों और दवाओं के बारे में डॉक्टर को बताएं। इस दवा के प्रभाव में रहते हुए वाहन न चलाएं। गर्भवती महिलाएं डॉक्टर से सलाह लें।
💊 kabitran injection Uses & Benefits
[{"condition":"Surgical muscle relaxation","description":"Used to provide skeletal muscle relaxation during general anesthesia for surgical procedures, including abdominal, orthopedic, and cardiac surgeries.","evidence":"Well-established"},{"condition":"Endotracheal intubation","description":"Facilitates intubation by relaxing the vocal cords and jaw muscles, allowing for safe placement of an endotracheal tube.","evidence":"Well-established"},{"condition":"Mechanical ventilation in ICU","description":"Used in intensive care units to facilitate mechanical ventilation in critically ill patients who require prolonged paralysis, such as those with acute respiratory distress syndrome.","evidence":"Well-established"},{"condition":"Electroconvulsive therapy","description":"Administered to prevent fractures and muscle injuries during electroconvulsive therapy by inducing brief muscle relaxation.","evidence":"Well-established"},{"condition":"Diagnostic procedures","description":"Used to provide muscle relaxation during certain diagnostic procedures like endoscopy or bronchoscopy when general anesthesia is required.","evidence":"Established"}]
Off-label uses: [{"condition":"Treatment of tetanus","description":"May be used off-label to control muscle spasms in severe tetanus when other treatments are ineffective.","evidence":"Limited"},{"condition":"Management of status epilepticus","description":"Rarely used off-label to reduce muscle activity during prolonged seizures, but not as a primary anticonvulsant.","evidence":"Limited"}]
Primary treatment for: Surgical procedures requiring muscle relaxation
Also treats: Mechanical ventilation in critical care, Electroconvulsive therapy, Endotracheal intubation
📋 Drug Information
| Generic Name(s) | Atracurium (10mg/ml) |
| Brand Name | kabitran injection |
| Manufacturer | Fresenius Kabi India Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | Skeletal muscle relaxant- Peripherally acting |
| Route of Administration | Parenteral (intravenous) |
| Storage | This medicine should be stored refrigerated at 2°C to 8°C (36°F to 46°F). It should not be frozen. Once removed from refrigeration, it should be used within a specified time as per the manufacturer's instructions. Protect from light. Do not use if the solution is discolored or contains particulate matter. |
| Shelf Life | The shelf life is typically 24 months from the date of manufacture when stored under recommended conditions. Once opened or diluted, the stability may vary; refer to the product insert for specific guidelines. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine is a non-depolarizing neuromuscular blocker that competitively antagonizes acetylcholine at nicotinic receptors on the motor endplate of skeletal muscle. By binding to these receptors, it prevents depolarization and subsequent muscle contraction, leading to flaccid paralysis. Its action is reversed by acetylcholinesterase inhibitors such as neostigmine, which increase acetylcholine levels at the neuromuscular junction. Atracurium is unique among neuromuscular blockers because it undergoes spontaneous degradation in the plasma via Hofmann elimination, independent of liver and kidney function, making it suitable for patients with organ impairment.
Mechanism Steps
💡 How to Take kabitran injection
Strength: Injection: 10 mg/ml (as atracurium besylate) in single-use vials.
Dosage Information
| Adult Dosage | The dosage of this medicine must be individualized by a qualified clinician based on the patient's weight, age, renal and hepatic function, and the desired depth and duration of neuromuscular blockade. For endotracheal intubation, a common initial dose is 0.4 to 0.5 mg/kg intravenously, which provides muscle relaxation within 2 to 3 minutes and lasts approximately 20 to 35 minutes. For maintenance, smaller doses of 0.08 to 0.1 mg/kg may be administered as needed, or a continuous infusion may be used. In obese patients, dosing should be based on ideal body weight. The dose must be titrated to effect using a peripheral nerve stimulator. This information is for educational purposes only and does not replace clinical judgment. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician or pediatric anesthesiologist for appropriate dosing in children. |
| Elderly Dosage | Elderly patients may have increased sensitivity to the effects of this medicine and may require lower doses. The dose should be individualized based on the patient's overall health, renal and hepatic function, and response to therapy. Monitoring with a peripheral nerve stimulator is recommended. |
| Renal Impairment | Dose adjustment is generally not required for patients with renal impairment because atracurium undergoes Hofmann elimination, which is independent of renal function. However, the metabolite laudanosine can accumulate in renal failure and may cause seizures. Prolonged use in renal impairment should be monitored closely. |
| Hepatic Impairment | Dose adjustment is generally not required for patients with hepatic impairment because atracurium's metabolism is independent of liver function. However, patients with hepatic disease may have altered volume of distribution and sensitivity, so careful monitoring and titration are advised. |
| Maximum Daily Dose | The maximum daily dose is not fixed and depends on the clinical situation. It must be determined by a qualified clinician based on the patient's response and the duration of the procedure or ventilation. Continuous infusions should be titrated to the lowest effective dose. |
Dosage Timeline
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of kabitran injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Isoflurane | Major | |
| Gentamicin | Major | |
| Magnesium sulfate | Major | |
| Lidocaine | Moderate | |
| Furosemide | Moderate | |
| Propranolol | Moderate | |
| Verapamil | Moderate | |
| Corticosteroids | Minor | |
| Azathioprine | Minor | |
| Phenytoin | Moderate |
🚨 Major Interactions
- Inhalational anesthetics (e.g., isoflurane, sevoflurane)
- Aminoglycoside antibiotics (e.g., gentamicin, tobramycin)
- Magnesium sulfate
- Local anesthetics (e.g., lidocaine)
⚡ Moderate Interactions
- Loop diuretics (e.g., furosemide)
- Beta-blockers
- Calcium channel blockers
🍷 Alcohol Interaction
Alcohol may enhance the central nervous system depressant effects of anesthesia and could potentiate the neuromuscular blocking effects of this medicine. Patients should avoid alcohol before surgery and during recovery as advised by their healthcare provider.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to atracurium or any component of the formulation","Known allergy to other neuromuscular blocking agents","Use in patients with severe cardiovascular disease where histamine release could be dangerous","Use in patients with asthma or severe respiratory disease where bronchospasm could be life-threatening","Concurrent use with certain antibiotics that enhance neuromuscular blockade (relative contraindication)"]
⚠️ Warnings & Precautions
["This medicine should only be administered by experienced healthcare professionals in a setting with immediate access to resuscitation equipment.","It causes complete muscle paralysis, including respiratory muscles; patients require ventilatory support.","It has no sedative or analgesic properties; adequate anesthesia must be ensured.","Use with caution in patients with cardiovascular disease, asthma, or a history of allergic reactions.","Prolonged use in intensive care units may lead to tolerance and prolonged recovery.","Laudanosine, a metabolite, can accumulate in renal failure and cause seizures.","The dose must be individualized based on the patient's condition, age, and concomitant medications.","Reversal agents such as neostigmine should be readily available.","This medicine should not be mixed with alkaline solutions (e.g., barbiturates) as it may precipitate."]
🤱 Lactation Safety
It is not known whether atracurium is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when this medicine is administered to a nursing woman. The amount of atracurium in breast milk is likely to be very low due to its rapid degradation and short half-life. However, breastfeeding should be avoided for at least 24 hours after administration to minimize infant exposure.
💊 Overdose Management
Overdose of this medicine results in prolonged neuromuscular blockade, leading to extended paralysis and respiratory depression. Management includes immediate discontinuation of the drug, maintenance of a patent airway, and assisted ventilation until spontaneous recovery occurs. Neuromuscular function should be monitored with a nerve stimulator. Reversal agents such as neostigmine or edrophonium may be administered, along with an anticholinergic like atropine or glycopyrrolate to counteract bradycardia. Supportive care, including cardiovascular monitoring and fluid management, is essential. There is no specific antidote for atracurium overdose, and recovery depends on its spontaneous degradation via Hofmann elimination.
⏰ Missed Dose
This medicine is administered by healthcare professionals in a controlled setting, so missed doses are not applicable to patients. If a scheduled dose is missed during a continuous infusion, the healthcare provider should follow the institutional protocol, which may involve administering the next dose as soon as possible or adjusting the infusion rate. Patients should not attempt to self-administer this medicine.
Additional Safety Advice
This medicine must only be administered by trained healthcare professionals in a hospital or surgical setting where continuous monitoring and resuscitation equipment are immediately available. Patients should inform their doctor about all medical conditions, especially kidney or liver disease, heart problems, asthma, or a history of allergic reactions to muscle relaxants. It is essential to disclose all medications, including over-the-counter drugs and herbal supplements, before receiving this medicine. Because this medicine causes muscle paralysis, patients will need breathing support and will not be able to move or speak until its effects wear off. Do not attempt to self-administer this medicine under any circumstances. After receiving this medicine, patients should not drive or operate machinery until fully recovered and cleared by their doctor. Pregnant women should discuss the risks and benefits with their healthcare provider before use. Always ensure that the healthcare team is aware of any allergies or previous adverse reactions to anesthetics.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the effects of this medicine and may experience a longer duration of action. Doses should be carefully titrated, and neuromuscular function should be monitored closely. Elderly patients may also have reduced renal or hepatic function, which can affect drug clearance, although atracurium's Hofmann elimination is largely independent of organ function. Close monitoring for side effects such as hypotension and prolonged paralysis is recommended.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, discuss with your doctor before receiving this medicine. It is classified as Pregnancy Category C, meaning potential risks exist. This medicine is typically used only when necessary during surgery, and the benefits should outweigh the risks. If you are pregnant and require surgery, your healthcare team will carefully consider the safest options for you and your baby.
🏥 Post-Surgery Considerations
After surgery, you will be monitored in a recovery area until the effects of this medicine wear off and you are fully awake. You may feel drowsy, weak, or have a sore throat from the breathing tube. Follow your doctor's instructions for pain management, activity, and diet. Report any difficulty breathing, muscle weakness, or signs of allergic reaction immediately.
🦷 Dental Procedures
If you are scheduled for a dental procedure that requires general anesthesia or sedation, inform your dentist and anesthesiologist about any previous use of this medicine or other muscle relaxants. This medicine is not typically used in routine dental procedures, but it may be relevant if you have a history of adverse reactions to anesthetics.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
After receiving this medicine, you may experience muscle weakness for some time. Avoid strenuous exercise or heavy lifting until your doctor confirms full recovery. Start with gentle activities and gradually increase intensity as tolerated. Physical therapy may be recommended to help regain strength.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is used during surgery or in the ICU, so its direct impact on work life is limited to the recovery period. Patients should not drive or operate machinery for at least 24 hours after receiving anesthesia. Depending on the type of surgery, you may need to take time off work to recover. Follow your doctor's advice regarding when to resume normal activities.
🛑 When to Stop This Medicine
This medicine is stopped by the healthcare provider once the surgical procedure is completed or when neuromuscular blockade is no longer needed. Patients should not make decisions about stopping this medicine themselves. If prolonged use is required in the ICU, the medical team will regularly assess the need and discontinue as soon as possible to minimize complications.
📅 Long-Term Use Effects
Long-term use of this medicine is typically limited to critically ill patients in intensive care units. Prolonged infusion can lead to tolerance, requiring higher doses, and may cause prolonged muscle weakness after discontinuation. Accumulation of the metabolite laudanosine can occur in patients with renal failure and may lead to seizures. Regular monitoring of neuromuscular function and renal status is essential during prolonged use. Recovery may take longer after extended infusions, and physical therapy may be needed to regain muscle strength.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
A similar neuromuscular blocker with less histamine release, often used as an alternative.
Evidence: Well-establishedAn alternative non-depolarizing neuromuscular blocker with minimal cardiovascular effects.
Evidence: Well-establishedA rapid-onset neuromuscular blocker used for intubation, with a longer duration of action.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are scheduled for vaccination, inform your doctor about your recent anesthesia and any medications you are taking. Vaccination can usually be administered once you have fully recovered from surgery, as advised by your healthcare provider.
📦 Storage Guide
✅ DO
Store refrigerated at 2°C to 8°C (36°F to 46°F).
❌ DON'T
Do not freeze.
✅ DO
Keep in the original carton to protect from light.
❌ DON'T
Do not use if the solution is discolored or contains particles.
✅ DO
Use within the specified time after opening or diluting.
❌ DON'T
Do not store at room temperature for prolonged periods.
✈️ Traveling with This Medicine
This medicine is administered only in a hospital setting and is not for self-administration. Patients do not need to carry it during travel. If you are traveling after a procedure that required this medicine, carry a copy of your medical records and discharge summary. Inform your travel companions about your recent anesthesia. Avoid driving or operating machinery until fully recovered. If you experience any unusual symptoms during travel, seek medical attention immediately.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working within 2 to 3 minutes after intravenous administration.
A: This medicine only paralyzes muscles; it does not provide sedation or pain relief. You will receive anesthesia to ensure you are asleep and comfortable.
A: No, this medicine causes temporary paralysis of all muscles, including those used for breathing. You will need a ventilator to help you breathe until the effect wears off.
A: The effect can be reversed with medications like neostigmine, which increase acetylcholine at the neuromuscular junction. Your doctor will monitor your recovery closely.
🤔 Common Patient Concerns
🔄 Substitutes for kabitran injection
View AllAlternative brands with exact same active ingredient:
-
atrelax 10mg/ml injectionRaman Weil Pvt Ltd ₹111.82 31.6% CHEAPER
-
artacil 10mg/ml injectionNeon Laboratories Ltd ₹121.27 25.8% CHEAPER
-
acris 10mg/ml injectionGland Pharma Limited ₹129.00 21.1% CHEAPER
-
atcuron 10mg/ml injectionSun Pharmaceutical Industries Ltd ₹131.00 19.9% CHEAPER
-
troycurium injectionTroikaa Pharmaceuticals Ltd ₹132.06 19.2% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Atracurium is a painkiller.
Fact: Atracurium is a muscle relaxant and has no pain-relieving properties. It is used only in anesthesia. - Myth: Atracurium can be taken at home.
Fact: Atracurium is a hospital-only medicine given intravenously under strict supervision. - Myth: Atracurium is safe for everyone.
Fact: Atracurium is contraindicated in certain conditions and must be used with caution in others.
🔄 Alternative Options
Generic Alternatives
- Atracurium besylate
Brand Alternatives
- Atrelax
- Tracrium