Adrim 10mg Injection (Doxorubicin): Complete Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Chest pain, shortness of breath, or swelling of the legs
- Fast or irregular heartbeat
- Fever above 100.4°F with chills or sore throat
- Unusual bleeding or bruising
- Severe mouth sores that prevent eating or drinking
- Burning or pain at the injection site during infusion
- Decreased urine output or confusion
- Yellowing of the skin or eyes
- Severe allergic reaction with rash, itching, or swelling of the face or throat
If experiencing severe symptoms, call emergency services immediately.
What is adrim 10mg injection used for?
This medicine is a prescription-only intravenous chemotherapy medicine containing doxorubicin (plain) 10mg. It is used to treat several types of cancer by blocking cancer cell growth and division. It must only be given by a trained healthcare professional in a hospital or cancer center.
- Generic Name: Doxorubicin
- Manufacturer: Fresenius Kabi India Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 adrim 10mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा एक प्रिस्क्रिप्शन-आधारित इंट्रावेनस इंजेक्शन है जिसमें डॉक्सोरूबिसिन (प्लेन) 10mg सक्रिय घटक के रूप में मौजूद है। यह एंथ्रासाइक्लिन वर्ग की कीमोथेरेपी दवा है और स्तन कैंसर, अंडाशय कैंसर, मूत्राशय कैंसर, फेफड़े के कैंसर, लिम्फोमा और ल्यूकेमिया जैसे कई प्रकार के कैंसर के इलाज में उपयोग की जाती है। यह दवा कैंसर कोशिकाओं के डीएनए को नुकसान पहुंचाकर उनकी वृद्धि और विभाजन को रोकती है। यह दवा केवल अस्पताल या कैंसर केंद्र में प्रशिक्षित डॉक्टर या नर्स द्वारा ही दी जानी चाहिए। मरीज को इसे घर पर स्वयं नहीं लगाना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, भूख न लगना, मुंह में छाले, बालों का झड़ना, थकान और पेशाब का रंग लाल-नारंगी होना शामिल हैं। कुछ मरीजों में रक्त कोशिकाओं की संख्या कम हो सकती है, जिससे संक्रमण, एनीमिया और रक्तस्राव का खतरा बढ़ जाता है। गंभीर दुष्प्रभावों में हृदय की क्षति, गंभीर अस्थि मज्जा दमन और ट्यूमर लिसिस सिंड्रोम शामिल हैं। अगर आपको सीने में दर्द, सांस लेने में कठिनाई, पैरों में सूजन, तेज धड़कन, बुखार या असामान्य रक्तस्राव हो तो तुरंत डॉक्टर को बताएं।
सुरक्षा सलाह: यह दवा केवल अस्पताल या कैंसर केंद्र में प्रशिक्षित स्वास्थ्यकर्मी द्वारा ही दी जानी चाहिए। इसे घर पर स्वयं न लगाएं। हर खुराक से पहले डॉक्टर आपके रक्त, लीवर, किडनी और हृदय की जांच करेंगे। अगर आपको हृदय, लीवर या किडनी की कोई बीमारी है तो डॉक्टर को बताएं। संक्रमण से बचने के लिए भीड़-भाड़ वाली जगहों से बचें और हाथ धोते रहें। नरम टूथब्रश और इलेक्ट्रिक रेजर का उपयोग करें। खूब पानी पिएं। इलाज के दौरान लाइव वैक्सीन न लगवाएं। गर्भधारण से बचने के लिए प्रभावी गर्भनिरोधक उपाय अपनाएं।
💊 adrim 10mg injection Uses & Benefits
[{"condition":"Breast cancer","description":"Used as part of combination chemotherapy regimens for early-stage and advanced breast cancer.","evidence":"Well-established"},{"condition":"Ovarian cancer","description":"Prescribed in combination with other anticancer medicines for ovarian cancer.","evidence":"Well-established"},{"condition":"Bladder cancer","description":"Given intravenously as part of systemic chemotherapy for bladder cancer.","evidence":"Well-established"},{"condition":"Lung cancer","description":"Used in combination regimens for small cell and non-small cell lung cancer.","evidence":"Well-established"},{"condition":"Hodgkin and non-Hodgkin lymphoma","description":"Included in multi-drug chemotherapy protocols for lymphomas.","evidence":"Well-established"},{"condition":"Acute lymphoblastic leukemia","description":"Used in induction and consolidation phases of leukemia treatment.","evidence":"Well-established"},{"condition":"Thyroid cancer","description":"Prescribed for advanced or refractory thyroid cancer in selected patients.","evidence":"Moderate"},{"condition":"Soft tissue sarcoma","description":"Used as part of combination chemotherapy for certain sarcomas.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Multiple myeloma","description":"Sometimes included in combination regimens for multiple myeloma.","evidence":"Limited"},{"condition":"Gestational trophoblastic disease","description":"Occasionally used in resistant cases under specialist care.","evidence":"Limited"}]
Primary treatment for: Cancer
Also treats: Breast cancer, Ovarian cancer, Bladder cancer, Lung cancer, Lymphoma, Leukemia, Thyroid cancer, Soft tissue sarcoma
📋 Drug Information
| Generic Name(s) | Doxorubicin |
| Brand Name | Adriamycin |
| Manufacturer | Fresenius Kabi India Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | Alkaloids-cytotoxic agents |
| Route of Administration | Intravenous |
| Storage | Store this medicine in a refrigerator at 2°C to 8°C. Do not freeze. Protect from light. Keep in the original container. Once diluted for infusion, use as directed by the pharmacy and follow stability guidelines. |
| Shelf Life | The shelf life of this medicine is typically 24 to 36 months from the date of manufacture when stored properly. Check the expiry date on the vial before use. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by intercalating between the base pairs of DNA, which prevents the DNA strands from separating and blocks the enzymes needed for DNA replication and RNA transcription. It also inhibits topoisomerase II, an enzyme that helps relieve tension in DNA during replication, leading to permanent DNA breaks and cell death. In addition, this medicine generates free radicals that damage cell membranes, proteins, and DNA. Because cancer cells divide more rapidly than most normal cells, they are more sensitive to these effects. However, normal tissues that also divide quickly, such as bone marrow, hair follicles, and the lining of the mouth and gut, can also be affected, which explains many of the side effects.
Mechanism Steps
💡 How to Take adrim 10mg injection
Strength: This medicine is supplied as a 10mg intravenous injection.
Dosage Information
| Adult Dosage | The dose of this medicine is determined by your oncologist based on the type of cancer, your body surface area, your blood counts, liver function, kidney function, and heart function. It is usually given as a slow intravenous infusion over 15 to 30 minutes, often once every 3 to 4 weeks as part of a chemotherapy cycle. The dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Never attempt to calculate or adjust your own dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatric oncologist. |
| Elderly Dosage | Elderly patients may be more sensitive to the side effects of this medicine, especially heart damage and bone marrow suppression. Dose reduction or closer monitoring may be needed. The dose must be individualized by a qualified clinician based on age, heart function, liver function, kidney function, and overall health. |
| Renal Impairment | Dose adjustment may be needed in patients with kidney impairment. Your doctor will monitor your kidney function and adjust the dose accordingly. The dose must be individualized by a qualified clinician. |
| Hepatic Impairment | Dose reduction is often needed in patients with liver impairment because this medicine is mainly metabolized and excreted by the liver. Your doctor will check your liver function tests and adjust the dose accordingly. The dose must be individualized by a qualified clinician. |
| Maximum Daily Dose | The maximum lifetime cumulative dose of this medicine is generally limited to 550 mg per square meter of body surface area to reduce the risk of heart damage. Lower limits may apply if you have risk factors for heart disease or have received chest radiation. Your oncologist will track your total lifetime dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of adrim 10mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Trastuzumab | Major | |
| Paclitaxel | Major | |
| Cyclophosphamide | Major | |
| Live vaccines | Major | |
| Cimetidine | Moderate | |
| Phenytoin | Moderate | |
| Phenobarbital | Moderate | |
| Hepatotoxic medicines | Moderate | |
| Nephrotoxic medicines | Moderate | |
| Grapefruit juice | Minor |
🚨 Major Interactions
- Other anthracyclines or anthracenediones
- Trastuzumab
- Paclitaxel
- Live vaccines
- Cyclophosphamide
⚡ Moderate Interactions
- Cimetidine
- Phenytoin
- Phenobarbital
- Hepatotoxic medicines
- Nephrotoxic medicines
🍷 Alcohol Interaction
Alcohol should be avoided while receiving this medicine because it can increase the risk of liver damage and worsen nausea, vomiting, and mouth sores. Alcohol may also add to fatigue and dizziness.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Severe heart disease or recent heart attack","Severe bone marrow suppression","Active serious infection","Previous treatment with maximum lifetime doses of anthracyclines","Severe liver impairment","Known allergy to doxorubicin or other anthracyclines","Pregnancy unless the benefit clearly outweighs the risk"]
⚠️ Warnings & Precautions
["This medicine must only be given by a qualified healthcare professional in a controlled clinical setting.","Heart function must be monitored before and during treatment because of the risk of heart damage.","Blood counts must be checked regularly because of the risk of bone marrow suppression.","Liver and kidney function should be monitored, and dose adjustments may be needed.","This medicine can cause severe tissue damage if it leaks out of the vein, so the injection site must be watched closely.","Avoid live vaccines during treatment.","Use effective contraception during treatment and for several months afterward.","Do not breastfeed during treatment.","This medicine may cause a reddish-orange discoloration of urine, which is harmless.","Report any signs of infection, bleeding, or heart problems immediately."]
🤱 Lactation Safety
This medicine passes into breast milk and may harm a nursing baby. Breastfeeding should be stopped during treatment and for a period afterward as advised by your doctor.
💊 Overdose Management
Overdose of this medicine can cause severe bone marrow suppression, heart damage, and liver damage. There is no specific antidote. Treatment is supportive and may include blood transfusions, antibiotics, and heart support. Patients should be monitored closely in a hospital setting.
⏰ Missed Dose
This medicine is given by a healthcare professional in a clinic or hospital. If you miss a scheduled appointment for your dose, contact your cancer care team as soon as possible to reschedule. Do not try to catch up on your own.
Additional Safety Advice
This medicine must only be given by a qualified healthcare professional in a hospital or cancer treatment center. Do not attempt to handle or inject this medicine at home. Before each dose, your doctor will check your blood counts, liver function, kidney function, and heart function. Tell your doctor if you have any history of heart problems, liver disease, or kidney disease. Avoid contact with people who have active infections, and wash your hands frequently to reduce the risk of infection. Use a soft toothbrush and an electric razor to lower the risk of bleeding. Drink plenty of fluids unless your doctor tells you otherwise. Do not receive any live vaccines while on this medicine. Inform your dentist or any other doctor treating you that you are receiving this medicine. Use effective contraception during treatment and for several months afterward, as this medicine can harm an unborn baby.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the side effects of this medicine, especially heart damage and bone marrow suppression. Your doctor may reduce the dose or monitor you more closely. Tell your doctor about all your other medicines and health conditions.
🤰 Pregnancy Planning (TTC)
This medicine can harm an unborn baby. Women should use effective contraception during treatment and for several months afterward. Men should also use effective contraception during treatment and for several months afterward. Talk to your doctor if you are planning a pregnancy after treatment.
🏥 Post-Surgery Considerations
If you have surgery planned, tell your surgeon and oncologist that you are receiving this medicine. This medicine can affect wound healing and increase the risk of bleeding and infection. Your doctor will advise you on the best timing for surgery.
🦷 Dental Procedures
Tell your dentist that you are receiving this medicine before any dental work. This medicine can increase the risk of bleeding and infection. Your dentist may recommend delaying dental procedures until your blood counts recover. Practice good mouth care to prevent mouth sores.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Light exercise like short walks can help reduce fatigue, but avoid strenuous activity during treatment, especially when your blood counts are low. Avoid contact sports or activities that could cause bleeding or injury. Talk to your doctor before starting any exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause fatigue, nausea, and other side effects that can affect your ability to work. Many patients need to take time off during treatment. Talk to your employer about flexible work arrangements. Avoid driving or operating heavy machinery if you feel dizzy or tired. Ask your doctor for advice about when you can return to work.
🛑 When to Stop This Medicine
Do not stop this medicine on your own. Your oncologist will decide when to stop based on your response to treatment, side effects, and your overall health. If you experience serious side effects like heart problems or severe infections, your doctor may pause or stop treatment. Always consult your doctor before making any changes.
📅 Long-Term Use Effects
Long-term use of this medicine can increase the risk of heart damage, which may lead to heart failure years after treatment. The risk depends on the total lifetime dose, age, and other heart risk factors. Regular heart monitoring is important even after treatment ends. This medicine can also cause secondary cancers, such as leukemia, in rare cases. Long-term follow-up with your oncologist is recommended to monitor for these effects.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Medicines like epirubicin or daunorubicin may be used instead, depending on the type of cancer.
Evidence: Well-establishedFor some cancers, targeted medicines may be used alone or in combination with chemotherapy.
Evidence: Well-establishedFor some cancers, immunotherapy may be an option.
Evidence: Well-establishedMay be used instead of or in addition to chemotherapy for certain cancers.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Do not receive live vaccines while on this medicine because they can cause serious infections. Inactivated vaccines may be given, but they may not work as well. Talk to your doctor about which vaccines you need and when to get them.
📦 Storage Guide
✅ DO
Store in a refrigerator at 2°C to 8°C
❌ DON'T
Do not freeze
✅ DO
Keep in the original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Protect from light
❌ DON'T
Do not store in direct sunlight
✅ DO
Check the expiry date before use
❌ DON'T
Do not use if the solution is discolored or contains particles
✈️ Traveling with This Medicine
This medicine is given in a hospital or cancer center, so travel should be planned around your treatment schedule. If you need to travel, carry a copy of your prescription and a letter from your oncologist explaining your treatment. Keep the medicine in its original packaging and store it in a refrigerator at 2°C to 8°C during travel if you are carrying it. Check customs rules for carrying prescription medicines across borders. Avoid travel to areas with high risk of infections during your treatment. Discuss your travel plans with your oncologist before booking any trips.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine is given as a slow intravenous infusion by a trained healthcare professional in a hospital or cancer center. It is usually given over 15 to 30 minutes.
A: The schedule depends on your type of cancer and treatment plan. It is often given once every 3 to 4 weeks as part of a chemotherapy cycle.
A: Common side effects include nausea, vomiting, hair loss, mouth sores, fatigue, and a temporary drop in blood cell counts.
A: Yes, this medicine can cause heart damage. Your doctor will check your heart function before and during treatment to reduce this risk.
A: This medicine can harm an unborn baby. Use effective contraception during treatment and for several months afterward. Talk to your doctor if you are planning a pregnancy.
A: Contact your cancer care team as soon as possible to reschedule. Do not try to catch up on your own.
🤔 Common Patient Concerns
🔄 Substitutes for adrim 10mg injection
View AllAlternative brands with exact same active ingredient:
-
metodox 10mg injectionNeon Laboratories Ltd ₹69.04 67.8% CHEAPER
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doxorex 10mg injectionSamarth Life Sciences Pvt Ltd ₹128.86 39.9% CHEAPER
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doxotero 10mg injectionHetero Drugs Ltd ₹141.74 33.9% CHEAPER
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adrib 10mg injectionAdley Formulations ₹159.38 25.6% CHEAPER
-
cadria 10mg injectionCadila Pharmaceuticals Ltd ₹166.66 22.2% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken as a pill at home.
Fact: This medicine is given only as an intravenous injection by a trained healthcare professional in a hospital or cancer center. - Myth: Hair loss from this medicine is permanent.
Fact: Hair loss is usually temporary and hair often grows back after treatment ends. - Myth: This medicine is safe for everyone with cancer.
Fact: This medicine is not suitable for people with severe heart disease, severe bone marrow suppression, active serious infections, or severe liver disease. - Myth: You can stop this medicine whenever you feel better.
Fact: You must complete the full course as prescribed by your oncologist. Stopping early can allow the cancer to return.
🔄 Alternative Options
Generic Alternatives
- Doxorubicin (plain) generic injection
Brand Alternatives
- Adrim 10mg injection