artacil 10mg/ml injection: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Sudden difficulty in breathing or wheezing after receiving this medicine
- Severe low blood pressure or fainting
- Swelling of the face, lips, or throat
- Persistent muscle weakness or inability to move limbs after the procedure
- Signs of seizure-like activity such as unusual movements or confusion
- Chest pain or irregular heartbeat
- Decreased urine output or signs of kidney problems
If experiencing severe symptoms, call emergency services immediately.
What is artacil 10mg/ml injection used for?
This medicine is a hospital-only intravenous muscle relaxant used by anesthesiologists to facilitate intubation, provide muscle relaxation during surgery, and support mechanical ventilation in intensive care. It works by blocking acetylcholine at the neuromuscular junction and must always be given with appropriate anesthesia or sedation.
- Generic Name: Atracurium besilate
- Manufacturer: Neon Laboratories Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 artacil 10mg/ml injection के बारे में (Hindi Summary)
उपयोग: यह दवा अस्पताल में विशेषज्ञों द्वारा दी जाने वाली इंजेक्शन है जिसका उपयोग सर्जरी के दौरान मांसपेशियों को ढीला करने, सांस की नली डालने और वेंटिलेटर पर रखे मरीजों की मदद के लिए किया जाता है। यह दवा मांसपेशियों को पूरी तरह से आराम देती है ताकि डॉक्टर ऑपरेशन आसानी से कर सकें। इसे केवल एनेस्थीसियोलॉजिस्ट या गहन चिकित्सा विशेषज्ञ ही दे सकते हैं। मरीज को इस दवा के साथ बेहोशी की दवा भी दी जाती है ताकि उसे दर्द या जागरूकता महसूस न हो।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में चेहरे पर गर्मी लगना, रक्तचाप में हल्की गिरावट, हृदय गति में मामूली वृद्धि और त्वचा पर चकत्ते शामिल हैं। कभी-कभी सांस लेने में कठिनाई, घरघराहट या एलर्जी की प्रतिक्रिया हो सकती है। लंबे समय तक इंफ्यूजन देने पर मांसपेशियों में कमजोरी महसूस हो सकती है। सभी दुष्प्रभावों की निगरानी अस्पताल में डॉक्टरों द्वारा की जाती है।
सुरक्षा सलाह: यह दवा केवल अस्पताल में डॉक्टर की देखरेख में दी जाती है, इसे घर पर कभी न लें। इससे पहले कि आपको यह दवा दी जाए, अपने डॉक्टर को अपनी सभी बीमारियों, दवाओं और एलर्जी के बारे में बताएं। सर्जरी से पहले खाने-पीने की सलाह का पालन करें। दवा देने के बाद जब तक आपकी सांस और मांसपेशियों की ताकत सामान्य न हो जाए, तब तक निगरानी में रहें। अस्पताल से छुट्टी के बाद अगर सांस लेने में तकलीफ, सूजन या चकत्ते दिखें तो तुरंत डॉक्टर से संपर्क करें।
💊 artacil 10mg/ml injection Uses & Benefits
[{"condition":"Endotracheal intubation during general anesthesia","description":"This medicine relaxes the jaw, vocal cords, and throat muscles so that a breathing tube can be placed safely and smoothly.","evidence":"Well-established"},{"condition":"Skeletal muscle relaxation during surgery","description":"It provides controlled muscle relaxation for abdominal, orthopedic, cardiac, and neurosurgical procedures, improving surgical access and reducing the risk of movement.","evidence":"Well-established"},{"condition":"Mechanical ventilation in intensive care","description":"It is used as a continuous infusion in critically ill patients who need deep sedation and paralysis to allow effective lung ventilation and to reduce oxygen demand.","evidence":"Well-established"},{"condition":"Facilitation of diagnostic and therapeutic procedures","description":"It helps during procedures such as endoscopy, bronchoscopy, and reduction of joint dislocations where brief muscle relaxation is required.","evidence":"Well-established"},{"condition":"Control of muscle spasms in tetanus and other spastic conditions","description":"It may be used in selected patients with severe muscle spasms when other measures are inadequate, under close monitoring.","evidence":"Limited"}]
Off-label uses: [{"condition":"Rapid sequence intubation in emergency departments","description":"Sometimes used off-label when a fast-onset neuromuscular blocker is needed, although other agents are often preferred.","evidence":"Limited"},{"condition":"Adjunct in therapeutic hypothermia protocols","description":"Occasionally used to prevent shivering in patients undergoing targeted temperature management, under specialist supervision.","evidence":"Limited"}]
Primary treatment for: Surgical muscle relaxation and intubation
Also treats: Mechanical ventilation in intensive care, Tetanus with severe muscle spasms, Diagnostic procedures requiring muscle relaxation
📋 Drug Information
| Generic Name(s) | Atracurium besilate |
| Brand Name | Atracurium Besilate Injection |
| Manufacturer | Neon Laboratories Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | Skeletal muscle relaxant- Peripherally acting |
| Route of Administration | Intravenous |
| Storage | Store this medicine in its original container at a controlled room temperature between 2°C and 8°C for the unopened vial, unless the manufacturer specifies otherwise. Once diluted for infusion, use the solution within the time specified by the hospital pharmacy. Protect the vial from light and do not freeze. Keep out of reach of children. |
| Shelf Life | The shelf life of this medicine is typically 24 months from the date of manufacture when stored as directed. Once the vial is opened or diluted, it should be used within the period recommended by the manufacturer or hospital pharmacy guidelines. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine is a non-depolarizing neuromuscular blocking agent. It competes with acetylcholine for binding sites on the nicotinic acetylcholine receptors located on the motor endplate of skeletal muscle. By occupying these receptors without activating them, it prevents acetylcholine from opening the ion channels that normally trigger muscle contraction. The result is a flaccid paralysis of skeletal muscles, including the muscles of respiration. Because the block is competitive, its effect can be partially reversed by increasing the amount of acetylcholine at the junction, for example with neostigmine, or by using a specific reversal agent such as sugammadex in appropriate settings. The medicine has no effect on smooth muscle or cardiac muscle at usual clinical doses, and it does not produce analgesia or loss of consciousness.
Mechanism Steps
💡 How to Take artacil 10mg/ml injection
Strength: This medicine is supplied as a 10 mg/ml intravenous injection solution. The strength is 10 mg per ml, and the total amount per vial depends on the pack size.
Dosage Information
| Adult Dosage | The dose of this medicine is individualized by a qualified clinician based on the patient's weight, age, medical condition, and the procedure being performed. A typical intubating dose for adults is in the range of 0.4 to 0.5 mg per kg given as an intravenous bolus, but this may be adjusted by the anesthesiologist. For continuous infusion during surgery or intensive care, the rate is titrated according to neuromuscular monitoring. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician or pediatric anesthesiologist for appropriate use in children. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine and may require lower doses. The anesthesiologist will adjust the dose based on age, general health, and neuromuscular monitoring. |
| Renal Impairment | This medicine can be used in patients with renal impairment because its breakdown does not depend on kidney function. However, during prolonged infusions, the metabolite laudanosine can accumulate, so the infusion duration and dose should be carefully monitored. Dose adjustment is usually not required for single bolus doses. |
| Hepatic Impairment | This medicine can be used in patients with liver disease because its metabolism is independent of liver enzymes. No specific dose adjustment is usually required, but the patient should be monitored closely for prolonged block. |
| Maximum Daily Dose | The maximum daily dose of this medicine is not fixed and depends on the clinical situation. It is determined by the treating clinician based on neuromuscular monitoring and the patient's response. Doses should not exceed what is necessary to achieve the desired level of muscle relaxation. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of artacil 10mg/ml injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Inhaled anesthetics | Major | |
| Aminoglycoside antibiotics | Major | |
| Magnesium sulfate | Major | |
| Local anesthetics | Major | |
| Loop diuretics | Moderate | |
| Corticosteroids | Moderate | |
| Lithium | Moderate | |
| Calcium channel blockers | Moderate | |
| Antiepileptic drugs | Minor | |
| Theophylline | Minor |
🚨 Major Interactions
- Inhaled anesthetics (isoflurane, sevoflurane, desflurane)
- Aminoglycoside antibiotics (gentamicin, amikacin, tobramycin)
- Magnesium sulfate
- Local anesthetics (lidocaine, bupivacaine)
⚡ Moderate Interactions
- Loop diuretics (furosemide)
- Corticosteroids
- Lithium
- Calcium channel blockers (verapamil, diltiazem)
🍷 Alcohol Interaction
Alcohol is not directly relevant to this medicine because it is given in a hospital setting under medical supervision. However, patients who have consumed alcohol before surgery may have altered anesthetic requirements and a higher risk of complications. It is important to inform the anesthesiologist about recent alcohol intake so that the dose and choice of medicines can be adjusted safely.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to atracurium or any component of the formulation","Known allergy to benzyl alcohol if the formulation contains it","Use in patients who cannot be adequately ventilated","Use outside a setting with immediate access to resuscitation equipment","Use without appropriate anesthesia or sedation"]
⚠️ Warnings & Precautions
["This medicine must be administered only by trained healthcare professionals.","Ensure that facilities for intubation, artificial ventilation, and oxygen therapy are immediately available.","Use with caution in patients with myasthenia gravis or other neuromuscular disorders.","Use with caution in patients with severe electrolyte abnormalities.","Use with caution in patients with a history of anaphylaxis to neuromuscular blocking agents.","Prolonged infusion in intensive care may lead to delayed recovery of muscle strength.","Dose reduction may be needed in elderly patients and in those with hypothermia.","Avoid use in patients with known hypersensitivity to benzyl alcohol if a benzyl alcohol-containing formulation is used."]
🤱 Lactation Safety
This medicine is given as a single dose or short infusion during surgery, and the amount that reaches breast milk is expected to be very small. It is generally considered compatible with breastfeeding, but mothers should discuss the timing of feeding with their doctor after the procedure. If the mother is sedated or unwell, she may need to express and discard milk temporarily until she is fully alert.
💊 Overdose Management
Overdose of this medicine leads to prolonged muscle paralysis, including paralysis of the breathing muscles. The patient must remain on assisted ventilation with oxygen until normal muscle power returns. There is no specific antidote that works instantly, but reversal agents such as neostigmine or sugammadex may be used under specialist supervision. The medical team will monitor neuromuscular function continuously and provide supportive care until recovery. If you suspect an overdose, seek emergency medical help immediately.
⏰ Missed Dose
This medicine is given only in a hospital or clinic by a healthcare professional, so a missed dose is not applicable in the usual home setting. If a scheduled dose during a continuous infusion is delayed, the medical team will adjust the infusion rate according to the patient's needs. Patients should not attempt to self-administer this medicine under any circumstances.
Additional Safety Advice
This medicine is given only in a hospital or operation theatre by a qualified anesthesiologist or intensivist, so patients do not self-administer it at home. Before receiving this medicine, tell your doctor about all your medical conditions, especially myasthenia gravis, kidney or liver problems, heart disease, asthma, or any previous allergic reaction to anesthesia. Inform the team about all medicines you take, including antibiotics, seizure medicines, magnesium supplements, and herbal products, because some of these can prolong the muscle relaxation. Do not eat or drink before a planned surgery unless your doctor gives specific instructions, and follow the fasting advice exactly. After the procedure, you will remain under observation until your breathing and muscle power return to normal. Do not attempt to drive, operate machinery, or make important decisions on the same day, because residual sedation and muscle weakness can affect your alertness. If you notice any difficulty in breathing, swelling, or rash after discharge, seek emergency medical help immediately.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the effects of this medicine and may experience a longer duration of action. Lower doses and careful monitoring are recommended. The anesthesiologist will adjust the dose based on age and overall health.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy and have a condition that requires this medicine, discuss it with your doctor. This medicine is used during pregnancy only when clearly needed, and your doctor will weigh the benefits and risks.
🏥 Post-Surgery Considerations
After surgery, you will be monitored until your breathing and muscle power return to normal. You may feel drowsy or weak for a few hours. Follow your doctor's advice on when to resume eating, drinking, and normal activities.
🦷 Dental Procedures
This medicine is not typically used for dental procedures. If you are scheduled for dental work and have received this medicine recently, inform your dentist. You may need to postpone non-urgent dental procedures until you have fully recovered.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
After receiving this medicine, you may feel weak or drowsy for some time. Avoid strenuous exercise or heavy lifting until your doctor says it is safe. Start with light activities and gradually increase as your strength returns.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is given in a hospital setting, and its effects can last for a few hours. You should not drive, operate machinery, or make important decisions on the same day. Plan to have someone accompany you home and rest for the remainder of the day.
🛑 When to Stop This Medicine
This medicine is stopped by the medical team once the procedure is complete or when muscle relaxation is no longer needed. You should not attempt to stop or adjust the dose yourself. If you experience any unusual symptoms after discharge, contact your doctor.
📅 Long-Term Use Effects
This medicine is not intended for long-term home use. When used as a continuous infusion in intensive care for several days, it has been associated with prolonged muscle weakness and, rarely, critical illness polyneuropathy. Patients who receive prolonged infusions should be monitored for muscle strength and renal function. Recovery is usually gradual after the infusion is stopped.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Cisatracurium, vecuronium, or rocuronium may be used depending on the clinical situation.
Evidence: Well-establishedIn some cases, deep sedation alone may be sufficient, avoiding the need for neuromuscular blockade.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no specific vaccine interactions with this medicine. However, if you are scheduled for surgery, inform your doctor about recent vaccinations. Live vaccines should generally be avoided around the time of surgery as per standard guidelines.
📦 Storage Guide
✅ DO
Store in the refrigerator at 2-8°C
❌ DON'T
Do not freeze
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Protect from light
❌ DON'T
Do not use if the solution is discolored or contains particles
✈️ Traveling with This Medicine
This medicine is given only in a hospital setting, so travel advice is not applicable for patients. If you are a healthcare professional traveling with this medicine, carry it in its original packaging with a prescription copy and a letter explaining its medical purpose. Store it at the recommended temperature and avoid freezing. Check customs regulations for controlled or prescription medicines before traveling internationally.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working within 1 to 3 minutes after intravenous injection.
A: This medicine does not provide pain relief. You will receive separate anesthesia or sedation to ensure you do not feel pain.
A: Yes, this medicine can be used in kidney disease, but prolonged infusions require monitoring because a metabolite can accumulate.
A: It is used during pregnancy only when clearly needed, such as for emergency cesarean section, under the supervision of an anesthesiologist.
🤔 Common Patient Concerns
🔄 Substitutes for artacil 10mg/ml injection
View AllAlternative brands with exact same active ingredient:
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atrelax 10mg/ml injectionRaman Weil Pvt Ltd ₹111.82 7.8% CHEAPER
-
acris 10mg/ml injectionGland Pharma Limited ₹129.00 6.4% COSTLIER
-
atcuron 10mg/ml injectionSun Pharmaceutical Industries Ltd ₹131.00 8% COSTLIER
-
troycurium injectionTroikaa Pharmaceuticals Ltd ₹132.06 8.9% COSTLIER
-
kabitran injectionFresenius Kabi India Pvt Ltd ₹163.46 34.8% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be used as a painkiller.
Fact: This medicine is not a painkiller. It only relaxes muscles and has no analgesic effect. - Myth: This medicine can be taken at home for muscle spasms.
Fact: This medicine is given only in a hospital setting because it paralyses the breathing muscles and requires assisted ventilation. - Myth: This medicine makes you sleep.
Fact: This medicine does not cause sleep or loss of consciousness. It must be used with anesthesia or sedation.
🔄 Alternative Options
Generic Alternatives
- Atracurium besylate injection
Brand Alternatives
- artacil 10mg/ml injection