junto cold plus 100mg/5mg/5mg tablet - Nimesulide (100mg) + Phenylephrine (5mg) medicine

Drunim Cold 100mg/5mg/5mg Tablet: Complete Medicine Guide

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🏭 Ridhima Biocare 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 25, 2026
⚠️ Hepatotoxicity Risk ⚠️ Nephrotoxicity Risk 🤰 Pregnancy Category Not recommended. Nimesulide is contraindicated in the third trimester and should be avoided throughout pregnancy unless clearly needed. Phenylephrine may reduce placental blood flow. Consult your doctor for safer alternatives. 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Moderate for short-term symptomatic relief of cold and sinus congestion.
Reviewed by
SaathiMed Expert Panel | Sep 25, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
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When to Call Your Doctor IMMEDIATELY

  • Blood in stool or vomit
  • Severe abdominal pain
  • Chest pain or difficulty breathing
  • Severe headache with visual changes
  • Sudden swelling of face, lips, or throat
  • Yellowing of skin or eyes
  • Decreased urine output
  • Unusual bruising or bleeding

If experiencing severe symptoms, call emergency services immediately.

What is junto cold plus 100mg/5mg/5mg tablet used for?

This medicine is a combination of nimesulide (an NSAID) and phenylephrine (a decongestant) used for short-term relief of pain, inflammation, and nasal congestion associated with colds, sinusitis, and allergies. It is taken orally with food, usually 1-2 times daily for up to 5-7 days.

  • Generic Name: Nimesulide (100mg) + Phenylephrine (5mg)
  • Manufacturer: Ridhima Biocare
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 junto cold plus 100mg/5mg/5mg tablet के बारे में (Hindi Summary)

उपयोग: यह दवा नाइमेसुलाइड और फेनाइलएफ्रिन का संयोजन है, जिसका उपयोग सर्दी, साइनसाइटिस और एलर्जी से होने वाली नाक की भीड़, दर्द और सूजन के अल्पकालिक उपचार के लिए किया जाता है। यह दर्द और सूजन को कम करने के साथ-साथ नाक की भीड़ को भी कम करती है। इसे भोजन के साथ लेना चाहिए और 5-7 दिनों से अधिक नहीं लेना चाहिए।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट दर्द, सिरदर्द, चक्कर आना और रक्तचाप में वृद्धि शामिल हैं। गंभीर दुष्प्रभावों में पेट में रक्तस्राव, लीवर की क्षति, गुर्दे की समस्या और एलर्जी प्रतिक्रिया शामिल हो सकती है। यदि आपको कोई गंभीर लक्षण दिखाई दे तो तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को भोजन के साथ लें ताकि पेट में जलन न हो। शराब का सेवन न करें क्योंकि इससे पेट में रक्तस्राव का खतरा बढ़ सकता है। यदि आपको पेट के अल्सर, हृदय रोग, उच्च रक्तचाप, लीवर या गुर्दे की बीमारी है तो डॉक्टर को बताएं। गर्भवती और स्तनपान कराने वाली महिलाएं इस दवा का सेवन न करें। बच्चों को यह दवा न दें।

💡 Did You Know? The Indian pharmaceutical market is expected to reach $130 billion by 2030.

💊 junto cold plus 100mg/5mg/5mg tablet Uses & Benefits

[{"condition":"Common cold with nasal congestion","description":"Provides relief from pain, fever, and nasal stuffiness associated with the common cold.","evidence":"Well-established for short-term symptomatic relief"},{"condition":"Sinusitis","description":"Helps reduce facial pain, headache, and nasal congestion in sinusitis.","evidence":"Well-established for short-term use"},{"condition":"Allergic rhinitis","description":"Reduces nasal congestion and associated discomfort.","evidence":"Well-established for short-term use"},{"condition":"Pharyngitis","description":"Relieves sore throat pain and inflammation.","evidence":"Well-established for short-term use"}]

Off-label uses: [{"condition":"Acute otitis media","description":"Sometimes used for pain relief in ear infections, but not a standard treatment.","evidence":"Limited"},{"condition":"Dysmenorrhea","description":"Nimesulide component may relieve menstrual cramps, but phenylephrine is not indicated.","evidence":"Limited"}]

Primary treatment for: Common cold with nasal congestion

Also treats: Sinusitis, Allergic rhinitis, Pharyngitis

📋 Drug Information

Generic Name(s)Nimesulide (100mg) + Phenylephrine (5mg)
Brand Namejunto cold plus 100mg/5mg/5mg tablet
ManufacturerRidhima Biocare
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassRESPIRATORY
Action Class
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a dry place, away from direct sunlight. Keep in the original container.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine with food or milk to reduce stomach upset.
2
Do not use this medicine for more than 5-7 days without consulting your doctor.
3
Avoid alcohol while taking this medicine to prevent stomach bleeding.
4
Monitor your blood pressure if you have hypertension.
5
Stay well hydrated throughout the day to help thin nasal secretions.
6
Do not take other NSAIDs or cold medicines concurrently without medical advice.
7
If you experience dizziness, avoid driving or operating heavy machinery.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Nasal congestion
This medicine is commonly prescribed for this.
Likely Use
✅
Sinus pressure
This medicine helps relieve sinus pressure.
Likely Use
✅
Fever
Nimesulide component reduces fever.
Likely Use
✅
Sore throat
This medicine can relieve sore throat pain.
Likely Use
❌
Chest pain
This medicine is not for chest pain; seek immediate medical attention.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionNimesulide is rapidly absorbed from the gastrointestinal tract after oral administration. Phenylephrine is also absorbed orally but undergoes extensive first-pass metabolism. Food may delay absorption of nimesulide but does not significantly affect the extent of absorption.
DistributionNimesulide is highly protein-bound and distributes widely into body tissues, including synovial fluid. Phenylephrine distribution is not well characterized but is expected to distribute into extracellular fluids.
Protein BindingNimesulide is approximately 99% bound to plasma proteins, primarily albumin. Phenylephrine protein binding is not established from the available information.
MetabolismNimesulide is extensively metabolized in the liver, primarily by CYP2C9, to several metabolites, including 4-hydroxynimesulide, which is pharmacologically active. Phenylephrine is metabolized in the liver and gut wall by monoamine oxidase and sulfotransferases.
Half-LifeThe elimination half-life of nimesulide is approximately 2-5 hours. The half-life of phenylephrine is approximately 2.5-3 hours.
ExcretionNimesulide metabolites are excreted primarily in urine (about 70%) and feces (about 20%). Phenylephrine and its metabolites are excreted mainly in urine.
BioavailabilityThe oral bioavailability of nimesulide is approximately 80-90%. The oral bioavailability of phenylephrine is low and variable, approximately 38% due to first-pass metabolism.
Onset of ActionNimesulide onset of action is typically within 30-60 minutes. Phenylephrine onset of decongestant effect is within 15-30 minutes.
Peak Plasma TimeNimesulide peak plasma concentration occurs approximately 1.5-3 hours after oral administration. Phenylephrine peak plasma concentration occurs within 1-2 hours.
Duration of ActionNimesulide duration of action is approximately 6-8 hours. Phenylephrine duration of decongestant effect is approximately 4-6 hours.

How It Works

This medicine combines two active ingredients. Nimesulide is a non-steroidal anti-inflammatory drug that selectively inhibits the cyclooxygenase-2 (COX-2) enzyme, reducing the production of prostaglandins, which are mediators of pain, inflammation, and fever. Phenylephrine is a selective alpha-1 adrenergic receptor agonist that causes vasoconstriction of blood vessels in the nasal mucosa, leading to decreased nasal congestion. The combination provides both analgesic/anti-inflammatory and decongestant effects.

Mechanism Steps

1
COX-2 inhibition by nimesulide: Nimesulide selectively binds to and inhibits the COX-2 enzyme, reducing prostaglandin synthesis.
2
Reduced prostaglandin production: Decreased prostaglandins lead to less pain, inflammation, and fever.
3
Alpha-1 receptor activation by phenylephrine: Phenylephrine stimulates alpha-1 adrenergic receptors on nasal blood vessels.
4
Vasoconstriction and decongestion: Stimulation of alpha-1 receptors causes blood vessels to narrow, reducing nasal swelling and congestion.

💡 How to Take junto cold plus 100mg/5mg/5mg tablet

Strength: Each tablet contains Nimesulide 100 mg and Phenylephrine 5 mg.

1Take the tablet with a full glass of water.
2Take it with food or milk to reduce stomach upset.
3Swallow the tablet whole; do not crush or chew.
4Take at the same time each day to maintain consistent levels.
5Do not lie down immediately after taking the tablet; stay upright for 30 minutes.

Dosage Information

Adult DosageThe usual adult dose is one tablet taken orally 1-2 times daily, preferably with food. The maximum recommended duration is 5-7 days. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the prescribed dose.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients (above 65 years) may be more sensitive to the side effects of this medicine. Use the lowest effective dose for the shortest duration. Dose must be individualized by a qualified clinician based on renal and hepatic function.
Renal ImpairmentUse with caution in patients with renal impairment. Avoid in severe renal impairment (eGFR <30 mL/min). Dose adjustment may be required. Consult your doctor.
Hepatic ImpairmentContraindicated in severe hepatic impairment. Use with caution in mild to moderate hepatic impairment. Dose adjustment may be required. Consult your doctor.
Maximum Daily DoseThe maximum recommended daily dose is 2 tablets (200 mg nimesulide and 10 mg phenylephrine). Do not exceed this dose.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset.
Grapefruit
Avoid
May increase drug levels.
Alcohol
Avoid
Increases risk of GI bleeding and liver damage.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of junto cold plus 100mg/5mg/5mg tablet

✅ Common Side Effects

Nausea (Common (5-10%))
Take with food to reduce nausea. If persistent, consult your doctor.
Stomach pain (Common (5-10%))
Take with food or milk. Avoid alcohol. If severe, contact your doctor.
Headache (Common (5-10%))
Usually resolves on its own. If severe or persistent, consult your doctor.
Dizziness (Common (5-10%))
Avoid driving or operating machinery until you know how it affects you.
Increased blood pressure (Common (5-10%))
Monitor your blood pressure. If it remains high, consult your doctor.

🚨 Serious Side Effects

Gastrointestinal bleeding (Rare (<0.1%))
Seek immediate medical attention if you notice black stool, vomiting blood, or severe abdominal pain.
Liver damage (Rare (<0.1%))
Report yellowing of skin or eyes, dark urine, or severe fatigue to your doctor immediately.
Kidney problems (Rare (<0.1%))
Seek medical attention if you experience decreased urine output or swelling in legs.
Severe allergic reaction (Rare (<0.1%))
Seek emergency help if you experience swelling of face, lips, throat, or difficulty breathing.
Increased heart rate (Rare (<0.1%))
Contact your doctor if you experience palpitations or chest pain.

⚠️ Rare Side Effects

Blood disorders (e.g., agranulocytosis, thrombocytopenia)
Report unusual bruising, bleeding, or signs of infection to your doctor immediately.
Severe skin reactions (e.g., Stevens-Johnson syndrome)
Seek immediate medical attention if you develop a rash with blisters or peeling skin.
Mood changes
Consult your doctor if you experience unusual mood swings or depression.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major
Other NSAIDs Major
MAOIs Major
Tricyclic antidepressants Major
ACE inhibitors Moderate
ARBs Moderate
Diuretics Moderate
Beta-blockers Moderate
Corticosteroids Moderate
Lithium Moderate

🚨 Major Interactions

  • Warfarin
  • Other NSAIDs (e.g., ibuprofen, aspirin)
  • Monoamine oxidase inhibitors (MAOIs)
  • Tricyclic antidepressants

⚡ Moderate Interactions

  • ACE inhibitors, ARBs, diuretics
  • Beta-blockers
  • Corticosteroids
  • Lithium

🍷 Alcohol Interaction

Avoid alcohol while taking this medicine. Alcohol increases the risk of gastrointestinal bleeding, ulcers, and liver damage. It may also worsen dizziness and drowsiness.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known hypersensitivity to nimesulide, phenylephrine, or any NSAID","Active or history of peptic ulcer or gastrointestinal bleeding","Severe liver impairment","Severe kidney impairment (eGFR

⚠️ Warnings & Precautions

["Take with food to reduce stomach upset.","Do not exceed the recommended dose or duration (maximum 5-7 days).","Avoid alcohol while taking this medicine.","Use with caution in elderly patients due to increased risk of side effects.","Monitor blood pressure in patients with hypertension.","May cause dizziness; avoid driving or operating machinery until you know how it affects you.","Do not use in patients with a history of asthma triggered by NSAIDs.","Consult your doctor if symptoms persist or worsen."]

🤱 Lactation Safety

Not recommended. Nimesulide and phenylephrine may pass into breast milk and could harm the infant. Consult your doctor for alternative treatments.

💊 Overdose Management

Overdose may cause severe nausea, vomiting, abdominal pain, drowsiness, and increased blood pressure. Seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote. Gastric lavage may be considered if within 1-2 hours of ingestion. Monitor vital signs and liver/kidney function.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.

Additional Safety Advice

General Safety

Take this medicine with food or milk to minimize stomach irritation. Do not exceed the recommended dose or duration of treatment. Avoid alcohol while taking this medicine as it can increase the risk of stomach bleeding. Inform your doctor if you have a history of stomach ulcers, heart disease, high blood pressure, liver or kidney disease, or asthma. Do not take this medicine if you are allergic to nimesulide, phenylephrine, or any other NSAIDs. This medicine may cause dizziness; avoid driving or operating heavy machinery until you know how it affects you. Do not use this medicine during pregnancy, especially in the third trimester, or while breastfeeding without consulting your doctor. Keep out of reach of children.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are at higher risk of gastrointestinal bleeding, kidney impairment, and cardiovascular events. Use the lowest effective dose for the shortest duration. Monitor blood pressure and kidney function regularly.

🤰 Pregnancy Planning (TTC)

This medicine is not recommended during pregnancy or when planning pregnancy. Consult your doctor for safer alternatives for cold and congestion relief.

🏥 Post-Surgery Considerations

Avoid this medicine after surgery unless specifically prescribed by your surgeon, as it may increase the risk of bleeding and interfere with healing. Consult your doctor for pain relief options.

🦷 Dental Procedures

Inform your dentist if you are taking this medicine before any dental procedure, as it may increase the risk of bleeding. Your dentist may advise you to stop it temporarily.

💚 Lifestyle Tips for Better Results

🏃
Stay well hydrated to help thin nasal secretions.
🥗
Use a humidifier to keep nasal passages moist.
😴
Get plenty of rest to support your immune system.
💧
Avoid exposure to allergens and irritants like smoke.
🧘
Practice good hand hygiene to prevent infections.
🌞
Use saline nasal sprays for additional congestion relief.

🏋️ Exercise Considerations

Avoid strenuous exercise while taking this medicine, especially if you experience dizziness or fatigue. Light activities like walking are generally safe. Consult your doctor before resuming intense workouts.

🥗 Diet Recommendations

Include warm fluids like soups and herbal teas.
Eat fruits rich in vitamin C to support immunity.
Avoid cold and processed foods that may worsen congestion.
Stay well hydrated.
Limit caffeine intake as it may increase stimulant effects.

💼 Impact on Daily Work & Life

This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It is advisable to take rest if symptoms are severe. Most people can continue light work activities.

🛑 When to Stop This Medicine

Stop taking this medicine if your symptoms resolve or after 5-7 days, whichever is earlier. If symptoms persist or worsen, consult your doctor. Do not stop abruptly if you have been on long-term therapy without medical advice.

📅 Long-Term Use Effects

Long-term use of this medicine is not recommended due to the risk of serious side effects, including liver damage, kidney impairment, and gastrointestinal bleeding. If long-term use is necessary, regular monitoring of liver and kidney function is required. Consult your doctor for alternative treatments if symptoms persist.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Saline nasal irrigation

Helps relieve nasal congestion without medication.

Evidence: Well-established
Steam inhalation

Can temporarily relieve nasal stuffiness.

Evidence: Limited
Rest and hydration

Supports the body's natural recovery from colds.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

This medicine does not interact with vaccines. However, if you have a fever or acute illness, consult your doctor before vaccination.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from direct sunlight. If traveling across time zones, adjust dosing times gradually. Check customs regulations for carrying prescription medicines. Do not leave in a hot car or checked luggage.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 35-year-old man with acute sinusitis
He was prescribed this medicine for sinus pressure and nasal congestion. He took it with food twice daily for 5 days. His symptoms improved significantly within 2 days. He reported mild stomach upset on the first day, which resolved when he took it with a fuller meal.
💡 Lesson: Taking this medicine with food reduces stomach upset and improves tolerability.
👤 A 50-year-old woman with common cold and body aches
She took this medicine for 3 days as prescribed. Her body aches and nasal congestion improved, but she experienced dizziness. She was advised to avoid driving until the dizziness resolved. She recovered fully after 5 days.
💡 Lesson: Dizziness is a possible side effect; avoid driving or operating machinery until you know how the medicine affects you.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine usually starts relieving symptoms within 30-60 minutes after taking it.

Q: Can I take it on an empty stomach?

A: It is best taken with food or milk to reduce the risk of stomach upset.

Q: Is it safe to take with other cold medicines?

A: Do not take with other NSAIDs or decongestants without consulting your doctor, as it may increase the risk of side effects.

Q: What should I do if I miss a dose?

A: Take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for junto cold plus 100mg/5mg/5mg tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can cure the common cold.
    Fact: This medicine only provides symptomatic relief; it does not cure the underlying viral infection.
  • Myth: It is safe to take this medicine for long periods.
    Fact: Prolonged use can cause serious liver, kidney, and gastrointestinal problems. It should be used for short-term relief only.
  • Myth: This medicine is safe for everyone.
    Fact: It is not safe for children, pregnant women, or people with certain medical conditions. Always consult a doctor.

🔄 Alternative Options

Generic Alternatives

  • Nimesulide + Phenylephrine generic tablets

Brand Alternatives

  • Drunim Cold 100mg/5mg/5mg Tablet

📊 Comparison with Similar Medicines

[{"medicine":"This medicine","composition":"Nimesulide 100mg + Phenylephrine 5mg","uses":"Cold, sinusitis, allergic rhinitis","onset":"30-60 minutes"},{"medicine":"Paracetamol + Phenylephrine","composition":"Paracetamol 500mg + Phenylephrine 5mg","uses":"Cold, fever, nasal congestion","onset":"30-60 minutes"},{"medicine":"Ibuprofen + Phenylephrine","composition":"Ibuprofen 200mg + Phenylephrine 5mg","uses":"Cold, pain, nasal congestion","onset":"30-60 minutes"}]

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