Nise Tablet (Nimesulide 100mg): Complete Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Unexplained weight gain or swelling in legs
If experiencing severe symptoms, call emergency services immediately.
What is nulide 100mg tablet used for?
This medicine contains Nimesulide 100mg, an NSAID used for short-term relief of acute pain, inflammation, and fever in adults. It works by selectively inhibiting COX-2 enzymes. It is not recommended for children under 12, pregnant women, or those with stomach ulcers, kidney, or liver disease.
- Generic Name: Nimesulide (100mg)
- Manufacturer: Neon Laboratories Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 nulide 100mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा निमेसुलाइड 100 मिलीग्राम युक्त एक दर्द निवारक और सूजन कम करने वाली दवा है। इसका उपयोग अल्पकालिक दर्द, सूजन और बुखार के इलाज के लिए किया जाता है। यह जोड़ों के दर्द, दांत दर्द, मांसपेशियों के दर्द और मासिक धर्म के दर्द में राहत देती है। यह दवा केवल 15 दिनों तक ही लेनी चाहिए। इसे भोजन के साथ लें। बच्चों, गर्भवती महिलाओं और स्तनपान कराने वाली महिलाओं को यह दवा नहीं लेनी चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट दर्द, दस्त और चक्कर आना शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें पेट में रक्तस्राव, लिवर की क्षति, गुर्दे की समस्या और त्वचा पर गंभीर एलर्जी शामिल हो सकती है। यदि आपको काला मल, खून की उल्टी, पेट में तेज दर्द, आंखों या त्वचा का पीलापन, या पेशाब कम आना जैसे लक्षण दिखें तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। खुराक या अवधि से अधिक न लें। इसे भोजन के साथ लें ताकि पेट की जलन कम हो। इस दवा के साथ शराब न लें। अन्य दर्द निवारक दवाओं के साथ इसका सेवन न करें। यदि आपको पेट अल्सर, गुर्दे या लिवर की बीमारी, हृदय रोग या अस्थमा है तो डॉक्टर को बताएं। गर्भावस्था और स्तनपान के दौरान इसका सेवन न करें। बच्चों की पहुंच से दूर रखें।
💊 nulide 100mg tablet Uses & Benefits
[{"condition":"Acute pain","description":"This medicine is used for short-term relief of acute pain such as musculoskeletal pain, dental pain, and post-operative pain.","evidence":"Well-established"},{"condition":"Osteoarthritis","description":"It helps reduce pain and inflammation in osteoarthritis, improving joint mobility.","evidence":"Well-established"},{"condition":"Fever","description":"This medicine is effective in reducing fever, but it is not a first-line choice for this purpose.","evidence":"Established"},{"condition":"Dysmenorrhea","description":"It can relieve menstrual cramps and associated pain.","evidence":"Established"}]
Off-label uses: [{"condition":"Migraine","description":"Sometimes used off-label for acute migraine attacks, but evidence is limited.","evidence":"Limited"},{"condition":"Soft tissue injuries","description":"May be used for pain and swelling in sprains and strains, though not a standard first-line option.","evidence":"Limited"}]
Primary treatment for: Acute pain and inflammation
Also treats: Osteoarthritis, Dysmenorrhea, Fever
📋 Drug Information
| Generic Name(s) | Nimesulide (100mg) |
| Brand Name | nulide 100mg tablet |
| Manufacturer | Neon Laboratories Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | NSAID's-Non-Selective COX 1&2 Inhibitors (Others) |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by selectively inhibiting the cyclooxygenase-2 (COX-2) enzyme, which is responsible for producing prostaglandins that mediate pain, inflammation, and fever. By blocking COX-2, it reduces the synthesis of these prostaglandins, thereby alleviating pain and swelling. It has less effect on COX-1, which is why it may have a lower risk of gastrointestinal side effects compared to non-selective NSAIDs, although this risk is not eliminated.
Mechanism Steps
💡 How to Take nulide 100mg tablet
Strength: Immediate-release tablet, 100 mg
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 100 mg taken twice daily, preferably after meals. The maximum recommended duration of treatment is 15 days. For acute pain, the lowest effective dose should be used for the shortest duration. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. This medicine is not recommended for children under 12 years of age. Consult a pediatrician for appropriate pain relief in children. |
| Elderly Dosage | Elderly patients (above 65 years) are at increased risk of gastrointestinal bleeding, kidney impairment, and cardiovascular events. Use with caution, at the lowest effective dose, and for the shortest duration. Monitor renal and liver function closely. |
| Renal Impairment | Use with caution in patients with mild to moderate renal impairment. This medicine is contraindicated in severe renal impairment (eGFR <30 mL/min). Dose adjustment may be necessary; consult a nephrologist or clinician. |
| Hepatic Impairment | This medicine is contraindicated in patients with severe hepatic impairment or active liver disease. In mild to moderate hepatic impairment, use with caution and monitor liver function. Dose reduction may be required; consult a hepatologist or clinician. |
| Maximum Daily Dose | 200 mg per day (100 mg twice daily). |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of nulide 100mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Other NSAIDs | Major | |
| Corticosteroids | Major | |
| Lithium | Major | |
| Methotrexate | Major | |
| ACE inhibitors | Moderate | |
| Diuretics | Moderate | |
| Beta-blockers | Moderate | |
| Cyclosporine | Moderate | |
| Digoxin | Moderate |
🚨 Major Interactions
- Warfarin
- Other NSAIDs (e.g., ibuprofen, aspirin)
- Corticosteroids
- Anticoagulants (e.g., heparin, clopidogrel)
- Lithium
- Methotrexate
⚡ Moderate Interactions
- ACE inhibitors
- Diuretics
- Beta-blockers
- Cyclosporine
- Digoxin
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol can increase the risk of stomach bleeding, ulcers, and liver damage. It may also worsen dizziness and drowsiness.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to nimesulide or any component of the formulation.","Active or history of peptic ulcer or gastrointestinal bleeding.","Severe liver impairment or active liver disease.","Severe kidney impairment (eGFR
⚠️ Warnings & Precautions
["Use the lowest effective dose for the shortest possible duration to minimize risks.","Avoid concomitant use with other NSAIDs or anticoagulants.","Caution in elderly patients due to increased risk of GI bleeding and renal impairment.","Monitor for signs of gastrointestinal bleeding, especially in patients with a history of ulcers.","Discontinue immediately if signs of liver injury (jaundice, dark urine, fatigue) occur.","Use with caution in patients with cardiovascular risk factors; monitor blood pressure.","Avoid in patients with dehydration or hypovolemia due to risk of renal impairment.","Do not use for pain relief before or after coronary artery bypass graft surgery."]
🤱 Lactation Safety
Not recommended. It is not known if this medicine passes into breast milk. Due to potential risks to the infant, breastfeeding is not advised while taking this medicine. Consult your doctor for alternative pain relief.
💊 Overdose Management
Overdose of this medicine may cause nausea, vomiting, abdominal pain, drowsiness, and in severe cases, gastrointestinal bleeding, liver damage, and kidney failure. There is no specific antidote. Treatment is supportive and symptomatic. If overdose is suspected, seek immediate medical attention. Activated charcoal may be administered if the patient presents within 1-2 hours of ingestion. Monitor vital signs, liver and kidney function, and provide supportive care.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose or duration of treatment. Take it with food or milk to reduce stomach upset. Avoid alcohol while taking this medicine as it can increase the risk of stomach bleeding. Do not take other NSAIDs or pain relievers without consulting your doctor. Inform your doctor if you have a history of stomach ulcers, kidney or liver disease, heart problems, or asthma. This medicine is not recommended during pregnancy, especially in the third trimester, and should be avoided while breastfeeding. Keep out of reach of children. Store at room temperature away from moisture and heat. If you miss a dose, take it as soon as you remember, but skip it if it's almost time for the next dose. Do not double the dose.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of gastrointestinal bleeding, kidney impairment, and cardiovascular events. Use the lowest effective dose for the shortest duration. Monitor renal and liver function regularly. Avoid concomitant use with other NSAIDs or anticoagulants.
🤰 Pregnancy Planning (TTC)
This medicine is not recommended for women planning pregnancy or those who are pregnant. It may interfere with ovulation and increase the risk of miscarriage. Consult your doctor for safer alternatives for pain relief.
🏥 Post-Surgery Considerations
This medicine may be used for post-operative pain, but it should be avoided before or after coronary artery bypass graft surgery due to increased cardiovascular risk. Consult your surgeon before taking this medicine after any surgery.
🦷 Dental Procedures
This medicine can be used for dental pain, but inform your dentist if you are taking it, especially before any dental surgery, as it may increase bleeding risk. Do not take it without consulting your dentist or doctor.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While taking this medicine, you may experience dizziness or fatigue. Avoid strenuous exercise or activities that require alertness until you know how the medicine affects you. If you have joint pain, gentle stretching and low-impact exercises are recommended.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It is generally safe to continue desk work, but take regular breaks and maintain good posture.
🛑 When to Stop This Medicine
Stop taking this medicine and consult your doctor immediately if you experience any signs of liver injury (yellowing of eyes or skin, dark urine, severe fatigue), gastrointestinal bleeding (black or bloody stools, vomiting blood), severe abdominal pain, or allergic reactions (rash, swelling, difficulty breathing). Do not stop abruptly without consulting your doctor if you have been on long-term therapy.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended due to the risk of serious side effects, including liver damage, kidney impairment, gastrointestinal bleeding, and cardiovascular events. If prolonged use is necessary, regular monitoring of liver and kidney function is advised. Always consult your doctor before extending the duration of treatment.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain and improve joint function.
Evidence: Well-establishedMay help reduce pain and inflammation in localized areas.
Evidence: ModerateSome evidence for pain relief in chronic conditions.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are scheduled for vaccination, inform your healthcare provider about all medications you are taking.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging along with a copy of your prescription. Store it in a cool, dry place away from direct sunlight. If crossing time zones, continue taking it as prescribed, but adjust timing gradually. Check customs regulations for carrying prescription medicines. Always keep it in your carry-on luggage.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine typically starts relieving pain within 30 to 60 minutes after taking it orally.
A: It is best taken with food or milk to reduce the risk of stomach upset.
A: No, it is only approved for short-term use, usually not exceeding 15 days, due to risks of liver, kidney, and gastrointestinal side effects.
A: Do not take it with other NSAIDs or painkillers without consulting your doctor, as it may increase the risk of side effects.
🤔 Common Patient Concerns
🔄 Substitutes for nulide 100mg tablet
View AllAlternative brands with exact same active ingredient:
-
nimley 100mg tabletMedley Pharmaceuticals ₹2.23 3.7% COSTLIER
-
nimucon 100mg tabletConcept Pharmaceuticals Ltd ₹2.31 7.4% COSTLIER
-
genlide 100mg tabletCadila Pharmaceuticals Ltd ₹2.34 8.8% COSTLIER
-
nimopen 100mg tabletMorepen Laboratories Ltd ₹2.34 8.8% COSTLIER
-
nes tabletPCI Pharmaceuticals ₹2.93 36.3% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is completely safe for long-term use.
Fact: This medicine is only approved for short-term use (up to 15 days) due to risks of liver, kidney, and gastrointestinal side effects. - Myth: This medicine can be taken on an empty stomach.
Fact: It should be taken with food to reduce stomach upset and risk of ulcers. - Myth: This medicine is safe for children.
Fact: It is not recommended for children under 12 years of age.
🔄 Alternative Options
Generic Alternatives
- Nimesulide 100mg tablet
Brand Alternatives
- Nise
- Nimulid
- Nimesulide