Advamab 400 Injection (Bevacizumab 400 mg): Comprehensive Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe bleeding, such as vomiting blood or blood in stool
- Chest pain or difficulty breathing
- Sudden weakness or numbness on one side of the body
- Severe abdominal pain with fever or vomiting
- Decreased urine output or swelling in the legs
- Severe headache with confusion or vision changes
- Sudden swelling of the face, lips, or throat
- Yellowing of the skin or eyes
If experiencing severe symptoms, call emergency services immediately.
What is ivzumab 400 solution for injection used for?
This medicine is a prescription injection containing bevacizumab 400 mg, used to treat several types of cancer by blocking the growth of new blood vessels that feed tumours. It is given by a healthcare professional as an intravenous infusion.
- Generic Name: Bevacizumab (400mg)
- Manufacturer: RPG Life Sciences Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 ivzumab 400 solution for injection के बारे में (Hindi Summary)
उपयोग: यह दवा बेवासीज़ुमैब 400 मिलीग्राम इंजेक्शन है, जिसका उपयोग कई प्रकार के कैंसर के इलाज में किया जाता है। यह ट्यूमर को रक्त की आपूर्ति करने वाली नई रक्त वाहिकाओं के विकास को रोककर काम करती है। इसका उपयोग कोलोरेक्टल कैंसर, फेफड़ों के कैंसर, ग्लियोब्लास्टोमा, गुर्दे के कैंसर, सर्वाइकल कैंसर और अंडाशय के कैंसर के इलाज में किया जाता है। यह दवा केवल एक योग्य डॉक्टर की देखरेख में अस्पताल या क्लिनिक में इंट्रावेनस इन्फ्यूजन के रूप में दी जाती है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में उच्च रक्तचाप, थकान, सिरदर्द, मुँह के छाले, भूख न लगना, दस्त, मतली और नाक बहना शामिल हैं। गंभीर दुष्प्रभावों में गंभीर रक्तस्राव, रक्त के थक्के, स्ट्रोक, दिल का दौरा, गुर्दे की समस्या और मस्तिष्क की एक दुर्लभ स्थिति शामिल है। इस दवा से घाव भरने में देरी हो सकती है। उपचार के दौरान नियमित रूप से रक्तचाप, मूत्र प्रोटीन और रक्त की जांच करानी चाहिए।
सुरक्षा सलाह: यह दवा केवल एक स्वास्थ्य पेशेवर द्वारा क्लिनिकल सेटिंग में दी जानी चाहिए। इसे स्वयं न लगाएं। यदि आप गर्भवती हैं, गर्भवती होने की योजना बना रही हैं या स्तनपान करा रही हैं तो अपने डॉक्टर को बताएं। उपचार के दौरान और अंतिम खुराक के कम से कम छह महीने बाद तक प्रभावी गर्भनिरोधक का उपयोग करें। अपने डॉक्टर को अपनी सभी दवाओं के बारे में बताएं। संक्रमण वाले लोगों के संपर्क से बचें। इस दवा के दौरान कोई भी लाइव वैक्सीन न लें। असामान्य रक्तस्राव, गंभीर सिरदर्द, दृष्टि में बदलाव या सीने में दर्द होने पर तुरंत डॉक्टर को बताएं।
💊 ivzumab 400 solution for injection Uses & Benefits
[{"condition":"Metastatic colorectal cancer","description":"Used in combination with chemotherapy for first-line and second-line treatment of metastatic colorectal cancer.","evidence":"Well-established"},{"condition":"Non-small cell lung cancer","description":"Used in combination with platinum-based chemotherapy for advanced non-squamous non-small cell lung cancer.","evidence":"Well-established"},{"condition":"Glioblastoma","description":"Used as a single agent or in combination for recurrent glioblastoma.","evidence":"Established"},{"condition":"Renal cell carcinoma","description":"Used in combination with interferon alfa for metastatic renal cell carcinoma.","evidence":"Established"},{"condition":"Cervical cancer","description":"Used in combination with chemotherapy for persistent, recurrent, or metastatic cervical cancer.","evidence":"Established"},{"condition":"Ovarian cancer","description":"Used in combination with chemotherapy for platinum-resistant recurrent ovarian cancer.","evidence":"Established"}]
Off-label uses: [{"condition":"Age-related macular degeneration","description":"Used off-label as an intravitreal injection for wet age-related macular degeneration.","evidence":"Well-established"},{"condition":"Diabetic macular edema","description":"Used off-label as an intravitreal injection for diabetic macular edema.","evidence":"Established"},{"condition":"Retinopathy of prematurity","description":"Used off-label as an intravitreal injection for retinopathy of prematurity.","evidence":"Limited"}]
Primary treatment for: Metastatic colorectal cancer
Also treats: Non-small cell lung cancer, Glioblastoma, Renal cell carcinoma, Cervical cancer, Ovarian cancer
📋 Drug Information
| Generic Name(s) | Bevacizumab (400mg) |
| Brand Name | ivzumab 400 solution for injection |
| Manufacturer | RPG Life Sciences Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | Vascular endothelial growth factor (VEGF) inhibitor |
| Route of Administration | Parenteral (intravenous infusion) |
| Storage | Store in a refrigerator at 2°C to 8°C. Do not freeze. Keep the vial in the original carton to protect from light. Do not shake. |
| Shelf Life | Refer to the product label for the exact shelf life. Typically 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by selectively binding to vascular endothelial growth factor (VEGF) and preventing it from interacting with its receptors on the surface of endothelial cells. VEGF is a protein that promotes the growth of new blood vessels, a process called angiogenesis. By blocking VEGF, this medicine inhibits the formation of new blood vessels that supply tumours with oxygen and nutrients. This leads to reduced tumour growth and may also improve the delivery of chemotherapy to the tumour. In the eye, this medicine reduces abnormal blood vessel growth and leakage, which helps in conditions like macular degeneration.
Mechanism Steps
💡 How to Take ivzumab 400 solution for injection
Strength: Injection: 400 mg in a single-use vial.
Dosage Information
| Adult Dosage | The dose of this medicine is individualized by a qualified clinician based on the indication, patient weight, and clinical condition. For metastatic colorectal cancer, the usual dose is 5 mg/kg every 2 weeks or 7.5 mg/kg every 3 weeks in combination with chemotherapy. For non-small cell lung cancer, the dose is 15 mg/kg every 3 weeks with chemotherapy. For glioblastoma, the dose is 10 mg/kg every 2 weeks. For renal cell carcinoma, the dose is 10 mg/kg every 2 weeks. For cervical cancer, the dose is 15 mg/kg every 3 weeks. For ovarian cancer, the dose is 10 mg/kg every 2 weeks or 15 mg/kg every 3 weeks. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | No specific dose adjustment is recommended for elderly patients based on age alone. However, elderly patients may be more sensitive to the effects of this medicine, especially cardiovascular effects. Dose must be individualized by a qualified clinician. |
| Renal Impairment | No dose adjustment is recommended for patients with renal impairment. However, kidney function should be monitored regularly. |
| Hepatic Impairment | No dose adjustment is recommended for patients with hepatic impairment. However, liver function should be monitored. |
| Maximum Daily Dose | Not applicable as this medicine is given at intervals of 2 to 3 weeks. The maximum single dose is 15 mg/kg. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of ivzumab 400 solution for injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Heparin | Major | |
| Aspirin | Major | |
| Clopidogrel | Major | |
| Ibuprofen | Major | |
| Doxorubicin | Moderate | |
| Cisplatin | Moderate | |
| Paclitaxel | Moderate | |
| Live vaccines | Minor | |
| Sunitinib | Major |
🚨 Major Interactions
- Anticoagulants (e.g., warfarin, heparin)
- Antiplatelet agents (e.g., aspirin, clopidogrel)
- Nonsteroidal anti-inflammatory drugs (NSAIDs)
- Other VEGF inhibitors
⚡ Moderate Interactions
- Anthracyclines (e.g., doxorubicin)
- Platinum-based chemotherapy
- Taxanes
🍷 Alcohol Interaction
Alcohol may increase the risk of liver problems and bleeding. It is advisable to avoid alcohol while receiving this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Recent surgery (within 28 days)","Active bleeding","Severe hypertension","Recent heart attack or stroke","Known hypersensitivity to bevacizumab or any component of the formulation","Pregnancy","Breastfeeding"]
⚠️ Warnings & Precautions
["This medicine can cause severe bleeding. Use with caution in patients with bleeding disorders.","This medicine can cause gastrointestinal perforation. Report severe abdominal pain immediately.","This medicine can cause hypertension. Monitor blood pressure regularly.","This medicine can cause kidney problems. Monitor urine protein regularly.","This medicine can impair wound healing. Stop before and after surgery.","This medicine can cause blood clots. Report chest pain or difficulty breathing.","This medicine can cause PRES. Report severe headache, confusion, or vision changes.","This medicine can cause ovarian failure. Discuss fertility preservation before treatment.","This medicine can cause infusion-related reactions. Monitor during infusion.","This medicine should not be used during pregnancy. Use effective contraception."]
🤱 Lactation Safety
It is not known whether this medicine passes into breast milk. Because of the potential for serious adverse reactions in nursing infants, breastfeeding should be discontinued during treatment and for at least six months after the last dose.
💊 Overdose Management
There is no known antidote for overdose with this medicine. In case of overdose, treatment should be symptomatic and supportive. Patients should be monitored closely for adverse effects.
⏰ Missed Dose
This medicine is given by a healthcare professional. If you miss an appointment for your infusion, contact your doctor or clinic as soon as possible to reschedule. Do not attempt to self-administer a missed dose.
Additional Safety Advice
This medicine must only be given by a healthcare professional in a clinical setting. Do not attempt to self-administer this injection. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Use effective contraception during treatment and for at least six months after the last dose. Tell your doctor about all other medicines you are taking, especially blood thinners, blood pressure medicines, and other cancer treatments. Avoid close contact with people who have infections, as this medicine can weaken your immune system. Do not receive any live vaccines while on this medicine. Report any unusual bleeding, severe headache, vision changes, or chest pain immediately. Your doctor will monitor your blood pressure, urine protein, and blood counts regularly. Do not stop treatment without consulting your doctor. Keep all appointments for infusions and tests.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the cardiovascular effects of this medicine. Monitor blood pressure and kidney function closely. Dose adjustment is not usually required based on age alone.
🤰 Pregnancy Planning (TTC)
This medicine can harm the developing baby. Women of childbearing potential should use effective contraception during treatment and for at least 6 months after the last dose. Discuss pregnancy planning with your doctor before starting treatment.
🏥 Post-Surgery Considerations
This medicine can impair wound healing. It should be stopped at least 28 days before elective surgery and not restarted until at least 28 days after surgery and until the wound is fully healed.
🦷 Dental Procedures
Inform your dentist that you are receiving this medicine. It may increase the risk of bleeding during dental procedures. Your dentist may recommend postponing non-urgent procedures.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine may cause tiredness or weakness. Avoid strenuous exercise if you feel unwell. Consult your doctor before starting any exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause tiredness, which can affect your ability to work or drive. Avoid driving or operating machinery if you feel tired or unwell. Discuss work adjustments with your employer if needed.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Treatment duration depends on your condition and response. Your doctor will decide when to stop based on your progress and any side effects.
📅 Long-Term Use Effects
Long-term use of this medicine may increase the risk of cardiovascular events, kidney problems, and ovarian failure. Regular monitoring of blood pressure, urine protein, and kidney function is required. Patients should be reviewed periodically to assess the benefit-risk balance of continuing treatment.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Medicines like ramucirumab or aflibercept may be used as alternatives.
Evidence: EstablishedIn some cases, chemotherapy without bevacizumab may be appropriate.
Evidence: Established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Live vaccines should be avoided during treatment with this medicine. Inactivated vaccines may be given, but their effectiveness may be reduced. Consult your doctor before receiving any vaccine.
📦 Storage Guide
✅ DO
Store in a refrigerator at 2°C to 8°C
❌ DON'T
Do not freeze
✅ DO
Keep the vial in the original carton to protect from light
❌ DON'T
Do not shake the vial
✅ DO
Keep out of reach of children
❌ DON'T
Do not use if the solution is discoloured or contains particles
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with the prescription copy. Store it in a refrigerator at 2°C to 8°C during travel. Use a cool pack if needed. Inform airport security about the medication. Check customs regulations for carrying prescription medicines. Plan infusions around travel dates.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: The effects of this medicine on tumour growth may take several weeks to become apparent. Your doctor will monitor your response with regular scans and tests.
A: No, this medicine must be given by a healthcare professional in a clinical setting.
A: Avoid alcohol, live vaccines, and close contact with people who have infections. Also avoid activities that increase the risk of bleeding or injury.
🤔 Common Patient Concerns
🔄 Substitutes for ivzumab 400 solution for injection
View AllAlternative brands with exact same active ingredient:
-
abevmy 400mg injectionMylan Pharmaceuticals Pvt Ltd ₹35,120.00 33.1% CHEAPER
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vegfxta 400mg injectionFresenius Kabi India Pvt Ltd ₹37,500.00 28.6% CHEAPER
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advamab 400 injectionAlkem Laboratories Ltd ₹37,998.00 27.6% CHEAPER
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bevacirel 400mg injectionReliance Life Sciences ₹38,856.34 26% CHEAPER
-
bevnexxa 400mg injectionCelon Laboratories Ltd ₹39,000.00 25.7% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure all types of cancer.
Fact: This medicine is effective only for specific types of cancer and is used in combination with other treatments. It is not a cure for all cancers. - Myth: This medicine can be self-administered at home.
Fact: This medicine must only be given by a healthcare professional in a clinical setting. - Myth: This medicine has no serious side effects.
Fact: This medicine can cause serious side effects such as severe bleeding, blood clots, and gastrointestinal perforation.
🔄 Alternative Options
Generic Alternatives
- Bevacizumab
Brand Alternatives
- Avastin
- Mvasi
- Zirabev