Ifipef 400mg Tablet (Pefloxacin): Comprehensive Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Sudden severe pain, swelling, or inability to move a joint, especially the Achilles tendon.
- Numbness, tingling, burning, or weakness in the hands or feet.
- Severe diarrhea that is watery or bloody, with or without fever.
- Yellowing of the skin or eyes, dark urine, or severe abdominal pain.
- Palpitations, fainting, or irregular heartbeat.
- Severe skin rash with blistering or peeling, especially with fever.
- Seizures, severe confusion, or hallucinations.
- Sudden severe chest, back, or abdominal pain.
If experiencing severe symptoms, call emergency services immediately.
What is ifipef 400mg tablet used for?
This medicine is a fluoroquinolone antibiotic containing pefloxacin. It is used to treat various bacterial infections by killing bacteria. It is available as a 400 mg tablet and is taken orally, usually once or twice daily. It is not for use in pregnancy, breastfeeding, or in children.
- Generic Name: Pefloxacin (400mg)
- Manufacturer: J B Chemicals and Pharmaceuticals Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 ifipef 400mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा पेफ्लोक्सासिन नामक एंटीबायोटिक है, जिसका उपयोग बैक्टीरियल संक्रमणों के इलाज के लिए किया जाता है। यह मूत्र मार्ग संक्रमण, श्वसन तंत्र संक्रमण, त्वचा संक्रमण, हड्डियों और जोड़ों के संक्रमण, और कुछ यौन संचारित संक्रमणों के इलाज में प्रभावी है। यह वायरल संक्रमण जैसे सर्दी-जुकाम या फ्लू के लिए प्रभावी नहीं है। इस दवा को डॉक्टर के निर्देशानुसार ही लें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, दस्त, पेट दर्द, सिरदर्द, चक्कर आना और त्वचा पर दाने शामिल हैं। कुछ गंभीर दुष्प्रभाव भी हो सकते हैं जैसे टेंडन टूटना, तंत्रिका क्षति, गंभीर त्वचा प्रतिक्रियाएं, यकृत की क्षति और हृदय की अनियमित धड़कन। यदि आपको कोई असामान्य लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को लेने से पहले अपने डॉक्टर को अपनी सभी स्वास्थ्य समस्याओं और दवाओं के बारे में बताएं। गर्भवती या स्तनपान कराने वाली महिलाएं इस दवा का सेवन न करें। इस दवा को लेते समय धूप से बचें और पर्याप्त पानी पिएं। एंटासिड, आयरन, जिंक या कैल्शियम सप्लीमेंट इस दवा के साथ न लें। शराब का सेवन न करें। दवा का पूरा कोर्स पूरा करें।
💊 ifipef 400mg tablet Uses & Benefits
[{"condition":"Complicated urinary tract infections","description":"This medicine is used to treat urinary tract infections that have spread to the kidneys or are caused by resistant bacteria.","evidence":"Well-established"},{"condition":"Respiratory tract infections","description":"It may be prescribed for certain bacterial respiratory infections, including some cases of pneumonia and bronchitis, when other antibiotics are not suitable.","evidence":"Moderate"},{"condition":"Skin and soft tissue infections","description":"This medicine can treat bacterial infections of the skin, such as cellulitis and abscesses, when caused by susceptible bacteria.","evidence":"Moderate"},{"condition":"Bone and joint infections","description":"It is sometimes used for bone infections (osteomyelitis) and joint infections (septic arthritis) due to its ability to penetrate bone tissue.","evidence":"Moderate"},{"condition":"Gonorrhea","description":"This medicine has been used to treat gonorrhea, a sexually transmitted infection, although other antibiotics are now more commonly recommended.","evidence":"Limited"},{"condition":"Prostatitis","description":"It may be used for bacterial prostatitis because it achieves good concentrations in prostate tissue.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Traveler's diarrhea","description":"Sometimes prescribed off-label for severe traveler's diarrhea caused by susceptible bacteria.","evidence":"Limited"},{"condition":"Intra-abdominal infections","description":"May be used off-label in combination with other antibiotics for certain intra-abdominal infections.","evidence":"Limited"}]
Primary treatment for: Bacterial infections
Also treats: Urinary tract infections, Respiratory tract infections, Skin infections, Bone and joint infections, Prostatitis, Gonorrhea
📋 Drug Information
| Generic Name(s) | Pefloxacin (400mg) |
| Brand Name | ifipef 400mg tablet |
| Manufacturer | J B Chemicals and Pharmaceuticals Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | OPHTHAL OTOLOGICALS |
| Action Class | Quinolones/ Fluroquinolones |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep in the original container, tightly closed. Do not refrigerate unless specifically instructed. Keep out of reach of children and pets. |
| Shelf Life | The shelf life is typically 24 months from the date of manufacture, but refer to the expiry date printed on the package. Do not use after the expiry date. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by inhibiting two key bacterial enzymes: DNA gyrase and topoisomerase IV. These enzymes are essential for bacterial DNA replication, transcription, repair, and recombination. By blocking them, the medicine prevents bacteria from copying their DNA and repairing damage, which leads to bacterial cell death. This action is bactericidal, meaning it kills bacteria rather than just stopping their growth. Because it targets enzymes found only in bacteria, it has selective toxicity and does not affect human cells in the same way.
Mechanism Steps
💡 How to Take ifipef 400mg tablet
Strength: This medicine is available as a 400 mg immediate-release tablet for oral administration.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 400 mg taken orally once or twice daily, depending on the type and severity of the infection. For uncomplicated urinary tract infections, a single 400 mg dose may be used. For other infections, treatment may last from 7 to 14 days or longer. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not self-adjust the dose. Take with a full glass of water, with or without food, but avoid taking with antacids or mineral supplements. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. Pefloxacin is generally contraindicated in children and adolescents under 18 years due to the risk of cartilage damage. |
| Elderly Dosage | Elderly patients (above 65 years) may have reduced renal function and are at higher risk of tendon rupture, central nervous system effects, and QT prolongation. Dose should be adjusted based on renal function. Use with caution and monitor closely. |
| Renal Impairment | In patients with renal impairment, dose adjustment is required. For creatinine clearance between 20-40 mL/min, the usual dose may be reduced or the dosing interval extended. For creatinine clearance less than 20 mL/min, pefloxacin should be used with extreme caution and dose further reduced. Consult a nephrologist or clinical pharmacist for specific dosing. |
| Hepatic Impairment | In patients with severe hepatic impairment, dose reduction may be necessary. Monitor liver function closely. No specific dosing guidelines are established; individualize based on clinical response and liver function tests. |
| Maximum Daily Dose | The maximum recommended daily dose is 800 mg (400 mg twice daily). Do not exceed this dose without medical supervision. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of ifipef 400mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Antacids | Major | |
| Warfarin | Major | |
| Theophylline | Major | |
| NSAIDs | Major | |
| QT-prolonging drugs | Major | |
| Caffeine | Moderate | |
| Cyclosporine | Moderate | |
| Oral hypoglycemics | Moderate | |
| Phenytoin | Moderate | |
| Cimetidine | Minor |
🚨 Major Interactions
- Antacids, sucralfate, iron, zinc, calcium supplements
- Warfarin
- Theophylline
- NSAIDs (e.g., ibuprofen, naproxen)
- QT-prolonging drugs (e.g., amiodarone, sotalol, some antipsychotics)
⚡ Moderate Interactions
- Caffeine
- Cyclosporine
- Oral hypoglycemics (e.g., glibenclamide)
- Phenytoin
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine. Both pefloxacin and alcohol can affect the central nervous system, leading to increased dizziness, drowsiness, and difficulty concentrating. Alcohol may also increase the risk of liver problems. It is best to abstain from alcohol until you have finished the course and your doctor confirms it is safe.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to pefloxacin or any other fluoroquinolone antibiotic","Pregnancy and breastfeeding","Children and adolescents under 18 years (due to risk of cartilage damage)","History of tendon disorders associated with fluoroquinolone use","Myasthenia gravis (may worsen muscle weakness)","Severe renal impairment (dose adjustment required, but not absolute contraindication)","Concurrent use with other QT-prolonging drugs (relative contraindication)"]
⚠️ Warnings & Precautions
["Fluoroquinolones, including pefloxacin, have been associated with disabling and potentially irreversible serious adverse reactions, including tendonitis, tendon rupture, peripheral neuropathy, and central nervous system effects. Reserve for infections with no alternative treatment options.","Avoid use in patients with a history of tendon disorders or those over 60 years of age, as they are at higher risk.","May exacerbate muscle weakness in patients with myasthenia gravis. Avoid use in these patients.","Can cause photosensitivity; advise patients to avoid excessive sunlight and use sunscreen.","May cause dizziness and lightheadedness; caution patients about driving or operating machinery.","Use with caution in patients with epilepsy or other seizure disorders, as it may lower seizure threshold.","Can cause QT prolongation; avoid in patients with known QT prolongation or uncorrected electrolyte abnormalities.","Serious skin reactions, including Stevens-Johnson syndrome and toxic epidermal necrolysis, have been reported. Discontinue at first sign of rash.","May cause liver injury; monitor liver function in patients with hepatic impairment.","Adjust dose in patients with renal impairment."]
🤱 Lactation Safety
Pefloxacin is excreted in breast milk and may cause serious adverse effects in a nursing infant, including joint problems. Breastfeeding should be discontinued during treatment with this medicine, or an alternative antibiotic should be used. Consult your doctor for guidance.
💊 Overdose Management
There is no specific antidote for pefloxacin overdose. Management should be symptomatic and supportive. In case of overdose, stop the medicine and seek immediate medical attention. Monitor vital signs, cardiac rhythm, and fluid and electrolyte balance. Activated charcoal may be considered if the overdose is recent and the patient is stable. Hemodialysis or peritoneal dialysis does not effectively remove pefloxacin from the body. Contact a poison control center for further guidance.
⏰ Missed Dose
If you miss a dose of this medicine, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one. If you are unsure, consult your doctor or pharmacist.
Additional Safety Advice
Before you start this medicine, tell your doctor if you have ever had an allergic reaction to any antibiotic, especially a fluoroquinolone. Also inform your doctor if you have kidney or liver problems, epilepsy or other seizure disorders, myasthenia gravis, heart rhythm problems, or a history of tendon problems. This medicine can make your skin more sensitive to sunlight, so avoid prolonged sun exposure and use sunscreen. Drink plenty of water while taking this medicine to help prevent crystals in the urine. Do not take antacids, sucralfate, or supplements containing iron, zinc, or calcium within two hours before or after this medicine, as they can reduce its absorption. Avoid alcohol while taking this medicine because it can increase the risk of dizziness and liver problems. If you are pregnant, planning to become pregnant, or breastfeeding, do not take this medicine without consulting your doctor. Keep all follow-up appointments so your doctor can monitor your response and check for side effects.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of tendon rupture, central nervous system effects, and QT prolongation. Renal function declines with age, so dose adjustment may be necessary. Use with caution and monitor closely for any adverse effects.
🤰 Pregnancy Planning (TTC)
This medicine is contraindicated during pregnancy and should not be used if you are trying to conceive. If you are planning pregnancy, discuss alternative antibiotics with your doctor before starting treatment. Use effective contraception while taking this medicine.
🏥 Post-Surgery Considerations
If you are scheduled for surgery, inform your surgeon that you are taking this medicine. It may interact with anesthetics or other medications used during surgery. Your doctor may advise you to stop the medicine temporarily before surgery.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. It may interact with certain antibiotics or anesthetics used in dentistry. Your dentist may recommend postponing non-urgent procedures until you complete the course.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine can cause dizziness and tendon problems. Avoid strenuous exercise or activities that put stress on your tendons, especially if you experience any joint pain. Consult your doctor before resuming intense physical activity.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness, drowsiness, or difficulty concentrating. Avoid driving or operating heavy machinery until you know how it affects you. It is advisable to take it when you can rest if you experience these side effects. Inform your employer if your work involves operating machinery.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor, even if you feel better. Stopping early can allow the infection to return and may lead to antibiotic resistance. If you experience serious side effects, contact your doctor immediately; they will advise whether to stop or switch to another medicine.
📅 Long-Term Use Effects
Long-term use of this medicine can lead to antibiotic resistance, making future infections harder to treat. It may also increase the risk of tendon problems, nerve damage, and liver or kidney issues. Regular monitoring of kidney and liver function may be required if prolonged therapy is necessary. Use only for the shortest duration needed to treat the infection.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Depending on the infection, safer antibiotics such as amoxicillin, nitrofurantoin, or cephalosporins may be used.
Evidence: Well-establishedFor urinary tract infections, drinking plenty of water can help flush out bacteria.
Evidence: SupportiveMay help prevent antibiotic-associated diarrhea, but should be taken at least 2 hours apart from the antibiotic.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you are scheduled to receive a live vaccine, inform your doctor, as antibiotics generally do not affect vaccine efficacy but the underlying infection may be a consideration.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging along with a copy of your prescription. Keep it in your carry-on luggage to avoid loss or temperature extremes. Store at room temperature and protect from light and moisture. If crossing time zones, adjust dosing times gradually, but consult your doctor for specific advice. Check local customs regulations regarding prescription medicines before you travel.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling better within 2-3 days, but it is important to complete the full course as prescribed. The infection may take longer to fully clear.
A: Yes, you can take it with or without food. If it upsets your stomach, take it with a meal. However, avoid taking it with dairy products or calcium-fortified foods within 2 hours of the dose.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: No, this medicine is contraindicated during pregnancy as it may harm the developing baby. Consult your doctor for safer alternatives.
A: It is best to avoid alcohol as it can increase dizziness, drowsiness, and the risk of liver problems.
🤔 Common Patient Concerns
🔄 Substitutes for ifipef 400mg tablet
View AllAlternative brands with exact same active ingredient:
-
Floxaquin P 400mg TabletThemis Medicare Ltd ₹15.60 17.9% CHEAPER
-
pif 400mg tabletTorrent Pharmaceuticals Ltd ₹19.51 2.7% COSTLIER
-
perti 400mg tabletDr Reddy's Laboratories Ltd ₹24.06 26.6% COSTLIER
-
qucin 400mg infusionAristo Pharmaceuticals Pvt Ltd ₹32.02 68.5% COSTLIER
-
pef 400mg tabletAgron Remedies Pvt Ltd ₹33.00 73.7% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Antibiotics can cure viral infections like the common cold.
Fact: This medicine is effective only against bacterial infections. It does not treat viral infections. - Myth: You can stop taking antibiotics as soon as you feel better.
Fact: You must complete the full course as prescribed to prevent the infection from returning and to avoid antibiotic resistance. - Myth: Fluoroquinolones are safe for everyone.
Fact: They carry serious risks and are not recommended for children, pregnant women, or those with certain health conditions.
🔄 Alternative Options
Generic Alternatives
- Pefloxacin 400 mg tablet
Brand Alternatives
- Ifipef 400mg Tablet