Azmarda 50mg Tablet: A Comprehensive Guide to Uses, Side Effects, and Safety
When to Call Your Doctor IMMEDIATELY
- Swelling of the face, lips, throat, or tongue
- Difficulty breathing or swallowing
- Severe dizziness or fainting
- Decreased urine output or swelling in legs
- Irregular heartbeat or muscle weakness
- Severe abdominal pain with nausea or vomiting
If experiencing severe symptoms, call emergency services immediately.
What is azmarda 50mg tablet used for?
This medicine is a combination of sacubitril and valsartan used to treat heart failure with reduced ejection fraction. It works by relaxing blood vessels and reducing strain on the heart, thereby lowering the risk of hospitalization and death.
- Generic Name: Sacubitril + Valsartan
- Manufacturer: J B Chemicals and Pharmaceuticals Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 azmarda 50mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा सैक्यूबिट्रिल और वाल्सार्टन का संयोजन है, जिसका उपयोग हृदय विफलता (हार्ट फेल्योर) के इलाज के लिए किया जाता है। यह दिल की मांसपेशियों को आराम देकर और रक्त वाहिकाओं को फैलाकर दिल पर दबाव कम करती है। इससे सांस फूलना, थकान और पैरों में सूजन जैसे लक्षणों में सुधार होता है और अस्पताल में भर्ती होने का खतरा कम होता है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में चक्कर आना, कम रक्तचाप, खांसी, और गुर्दे की समस्याएं शामिल हैं। कुछ रोगियों में पोटेशियम का स्तर बढ़ सकता है। गंभीर दुष्प्रभावों में चेहरे, होंठ, गले या जीभ में सूजन (एंजियोएडेमा) शामिल है, जिसके लिए तत्काल चिकित्सा सहायता की आवश्यकता होती है।
सुरक्षा सलाह: इस दवा को केवल डॉक्टर के निर्देशानुसार ही लें। खुराक को बदलें या दवा बंद करने से पहले डॉक्टर से सलाह लें। पोटेशियम सप्लीमेंट या नमक के विकल्प का सेवन बिना डॉक्टर की सलाह के न करें। यदि आप गर्भवती हैं या स्तनपान करा रही हैं, तो डॉक्टर को बताएं। इस दवा से चक्कर आ सकते हैं, इसलिए वाहन चलाने या मशीनरी चलाने से बचें। नियमित रूप से रक्त परीक्षण कराएं।
💊 azmarda 50mg tablet Uses & Benefits
- [{"condition":"Heart failure with reduced ejection fraction (HFrEF)","description":"This medicine is indicated to reduce the risk of cardiovascular death and hospitalization for heart failure in adults with chronic heart failure and reduced ejection fraction.
- It is typically used in place of an ACE inhibitor or ARB.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Heart failure with preserved ejection fraction (HFpEF)","description":"Some clinicians may prescribe this medicine off-label for HFpEF, but its efficacy in this condition is not as well established as in HFrEF.","evidence":"Limited"}]
Primary treatment for: Heart failure with reduced ejection fraction
Also treats: Hypertension, Chronic kidney disease, Diabetes
📋 Drug Information
| Generic Name(s) | Sacubitril + Valsartan |
| Brand Name | Azmarda 50mg Tablet |
| Manufacturer | J B Chemicals and Pharmaceuticals Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | Angiotensin Receptor Neprilysin Inhibitor (ARNI) |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Keep in the original container to protect from moisture. Do not refrigerate or freeze. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | The World Health Organization does not have specific guidelines for this medicine. However, major cardiology societies recommend ARNIs as first-line therapy for HFrEF. |
| ICMR Guideline | The Indian Council of Medical Research (ICMR) does not have specific guidelines for this medicine. However, Indian cardiology societies follow international guidelines recommending ARNIs for HFrEF. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary mechanisms. Sacubitril is a prodrug that is metabolized to LBQ657, which inhibits neprilysin, an enzyme responsible for degrading natriuretic peptides. This leads to increased levels of natriuretic peptides, which promote vasodilation, natriuresis, and diuresis, reducing blood pressure and cardiac workload. Valsartan is an angiotensin II receptor blocker (ARB) that selectively blocks the AT1 receptor, preventing the vasoconstrictor and aldosterone-secreting effects of angiotensin II. Together, these actions reduce vasoconstriction, sodium retention, and cardiac remodeling, improving cardiovascular outcomes in heart failure.
Mechanism Steps
💡 How to Take azmarda 50mg tablet
Strength: Each tablet contains sacubitril 24 mg and valsartan 26 mg.
Dosage Information
| Adult Dosage | The recommended starting dose of this medicine is 50 mg (sacubitril 24 mg + valsartan 26 mg) taken orally twice daily. After 2-4 weeks, the dose is typically increased to 100 mg (sacubitril 49 mg + valsartan 51 mg) twice daily, and then to the target dose of 200 mg (sacubitril 97 mg + valsartan 103 mg) twice daily as tolerated. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and blood pressure. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | No dose adjustment is required based on age alone. However, elderly patients may be more sensitive to the blood pressure-lowering effects. Monitor blood pressure and renal function closely. |
| Renal Impairment | For patients with mild to moderate renal impairment (eGFR ≥30 mL/min/1.73 m²), no dose adjustment is needed. For severe renal impairment (eGFR <30 mL/min/1.73 m²), the starting dose should be reduced to 50 mg twice daily, and the dose should be titrated slowly. Use with caution. |
| Hepatic Impairment | For patients with mild to moderate hepatic impairment (Child-Pugh A or B), no dose adjustment is required. This medicine is not recommended in patients with severe hepatic impairment (Child-Pugh C). |
| Maximum Daily Dose | The maximum recommended dose is 200 mg (sacubitril 97 mg + valsartan 103 mg) twice daily, totaling 400 mg per day. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of azmarda 50mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| ACE inhibitors | Major | |
| Aliskiren | Major | |
| Potassium-sparing diuretics | Major | |
| NSAIDs | Moderate | |
| Lithium | Major | |
| Statins | Moderate | |
| Metformin | Moderate | |
| Antacids | Minor |
🚨 Major Interactions
- ACE inhibitors (e.g., enalapril, lisinopril)
- Aliskiren
- Potassium-sparing diuretics (e.g., spironolactone, triamterene)
- NSAIDs (e.g., ibuprofen, naproxen)
- Lithium
⚡ Moderate Interactions
- Statins (e.g., atorvastatin)
- Metformin
🍷 Alcohol Interaction
Alcohol may enhance the blood pressure-lowering effect of this medicine, leading to dizziness or fainting. It is advisable to limit or avoid alcohol while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["History of angioedema related to ACE inhibitor or ARB therapy","Concomitant use with ACE inhibitors","Concomitant use with aliskiren in patients with diabetes","Pregnancy","Severe hepatic impairment","Hypersensitivity to sacubitril, valsartan, or any component of the formulation"]
⚠️ Warnings & Precautions
["Angioedema: May cause angioedema, which can be life-threatening. Discontinue immediately if suspected.","Hypotension: May cause symptomatic hypotension, especially in volume-depleted patients. Correct volume depletion before starting.","Renal impairment: May worsen kidney function. Monitor renal function regularly.","Hyperkalemia: May cause high potassium levels. Monitor potassium, especially in patients with renal impairment or diabetes.","Fetal toxicity: Contraindicated in pregnancy. Can cause fetal harm."]
🤱 Lactation Safety
It is not known whether this medicine is excreted in human breast milk. Because of the potential for serious adverse reactions in breastfed infants, a decision should be made whether to discontinue nursing or discontinue the medicine, taking into account the importance of the medicine to the mother.
💊 Overdose Management
Limited data are available on overdose with this medicine. In case of overdose, symptomatic and supportive treatment should be initiated. If the patient is hypotensive, place them in a supine position and consider intravenous fluids. Hemodialysis is unlikely to be effective in removing sacubitril or valsartan due to high protein binding.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
This medicine should only be taken as prescribed by your doctor. Do not change the dose or stop taking it without consulting your healthcare provider. Avoid using potassium supplements or salt substitutes containing potassium unless directed by your doctor. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. This medicine can cause dizziness; avoid driving or operating heavy machinery until you know how it affects you. Keep all appointments for blood tests to monitor kidney function and potassium levels. Do not take this medicine with ACE inhibitors or aliskiren if you have diabetes. Store at room temperature away from moisture and heat.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the blood pressure-lowering effects of this medicine. Start with a low dose and titrate slowly. Monitor renal function and potassium levels closely.
🤰 Pregnancy Planning (TTC)
This medicine is contraindicated during pregnancy. Women of childbearing potential should use effective contraception. If you are planning pregnancy, consult your doctor to switch to a safer alternative before conception.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine. It may need to be temporarily stopped before surgery due to its blood pressure-lowering effects. Follow your doctor's instructions regarding when to resume.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine, as it may cause dizziness or low blood pressure during dental procedures. Your dentist may take precautions such as monitoring your blood pressure.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Moderate exercise is generally safe and beneficial, but avoid strenuous activities that cause severe breathlessness or dizziness. Always warm up and cool down. If you experience chest pain, severe shortness of breath, or palpitations, stop and seek medical attention.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or fatigue, which can affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. Most patients can continue their normal work with some adjustments.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience serious side effects like angioedema, severe hypotension, or worsening kidney function, your doctor may advise stopping or adjusting the dose. Always seek medical advice before discontinuing.
📅 Long-Term Use Effects
Long-term use of this medicine has been shown to improve survival and reduce hospitalizations in heart failure patients. However, it requires regular monitoring of kidney function, potassium levels, and blood pressure. Some patients may develop tolerance or experience persistent side effects. Regular follow-up with your doctor is essential to adjust the dose and manage any complications.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Alternative class of heart failure medicines, but may cause cough.
Evidence: Well-establishedSimilar to valsartan alone, used if ARNI is not tolerated.
Evidence: Well-establishedOften used in combination with ARNI for heart failure.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no specific vaccine interactions with this medicine. However, patients with heart failure should receive annual influenza and pneumococcal vaccinations as recommended by their doctor.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate or freeze
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight and moisture
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging along with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature and protect from moisture. If crossing time zones, adjust dosing times gradually, but maintain approximately 12-hour intervals between doses. Consult your doctor before traveling if you have any concerns.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working within hours to lower blood pressure, but improvement in heart failure symptoms may take several weeks.
A: Yes, this medicine can be taken with or without food.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
A: No, this medicine is contraindicated during pregnancy as it can harm the fetus. Use effective contraception while taking this medicine.
A: No, do not stop taking this medicine without consulting your doctor. Stopping suddenly can worsen heart failure.
🤔 Common Patient Concerns
🔄 Substitutes for azmarda 50mg tablet
View AllAlternative brands with exact same active ingredient:
-
sacutan 50 tabletMSN Laboratories ₹205.22 70.3% CHEAPER
-
zayo 50 tabletEris Lifesciences Ltd ₹226.66 67.2% CHEAPER
-
valsac 50 tabletNatco Pharma Ltd ₹233.40 66.2% CHEAPER
-
neptaz 50mg tabletMankind Pharma Ltd ₹363.66 47.4% CHEAPER
-
cidmus 50mg tabletDr Reddy's Laboratories Ltd ₹506.34 26.7% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure heart failure.
Fact: This medicine does not cure heart failure but helps manage symptoms and improves survival. - Myth: This medicine can be taken with any other blood pressure medicine.
Fact: It should not be taken with ACE inhibitors or aliskiren due to risk of serious interactions. - Myth: This medicine is safe during pregnancy.
Fact: This medicine is contraindicated during pregnancy as it can harm the fetus.