Azmarda 200mg Tablet (Sacubitril/Valsartan): Comprehensive Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Swelling of the face, lips, throat, or tongue
- Difficulty breathing or swallowing
- Severe dizziness or fainting
- Decreased urine output or swelling in the legs
- Irregular heartbeat or muscle weakness
- Yellowing of the skin or eyes
- Severe abdominal pain with nausea or vomiting
If experiencing severe symptoms, call emergency services immediately.
What is azmarda 200mg tablet used for?
This medicine is a combination of sacubitril and valsartan used to treat heart failure with reduced ejection fraction. It works by relaxing blood vessels and reducing the heart's workload, thereby improving symptoms and reducing hospitalizations.
- Generic Name: Sacubitril + Valsartan
- Manufacturer: J B Chemicals and Pharmaceuticals Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 azmarda 200mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा सैकुबिट्रिल और वाल्सार्टन का संयोजन है, जिसका उपयोग हृदय विफलता (हार्ट फेल्योर) के इलाज के लिए किया जाता है। यह हृदय की कार्यक्षमता में सुधार करती है और अस्पताल में भर्ती होने के जोखिम को कम करती है। यह दवा रक्त वाहिकाओं को आराम देती है और हृदय पर दबाव कम करती है।
साइड इफेक्ट्स: सामान्य दुष्प्रभावों में चक्कर आना, कम रक्तचाप, खांसी और गुर्दे की समस्याएं शामिल हैं। गंभीर दुष्प्रभावों में एंजियोएडेमा (चेहरे, होंठ, गले में सूजन), गंभीर निम्न रक्तचाप, गुर्दे की विफलता और उच्च पोटेशियम स्तर शामिल हो सकते हैं।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। डॉक्टर की सलाह के बिना दवा बंद न करें या खुराक न बदलें। शराब से बचें क्योंकि इससे रक्तचाप कम हो सकता है। यदि आप गर्भवती हैं, गर्भवती होने की योजना बना रही हैं या स्तनपान करा रही हैं तो डॉक्टर को बताएं। नियमित रूप से रक्तचाप, गुर्दे की कार्यक्षमता और पोटेशियम के स्तर की जांच कराएं।
💊 azmarda 200mg tablet Uses & Benefits
[{"condition":"Heart failure with reduced ejection fraction (HFrEF)","description":"This medicine is indicated to reduce the risk of cardiovascular death and hospitalization for heart failure in patients with chronic heart failure and reduced ejection fraction.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Heart failure with preserved ejection fraction (HFpEF)","description":"Sometimes prescribed off-label for heart failure with preserved ejection fraction, but evidence is limited and not universally accepted.","evidence":"Limited"}]
Primary treatment for: Heart failure with reduced ejection fraction
Also treats: Hypertension, Chronic kidney disease, Diabetes
📋 Drug Information
| Generic Name(s) | Sacubitril + Valsartan |
| Brand Name | Azmarda 50mg Tablet |
| Manufacturer | J B Chemicals and Pharmaceuticals Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | Angiotensin Receptor Neprilysin Inhibitor (ARNI) |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Keep in the original container, tightly closed, away from moisture and heat. Do not refrigerate or freeze. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | The World Health Organization does not have specific guidelines for this medicine. However, major cardiology societies recommend ARNIs as first-line therapy for HFrEF. |
| ICMR Guideline | The Indian Council of Medical Research (ICMR) does not have specific guidelines for this medicine. Indian cardiology societies follow international guidelines. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines sacubitril, a neprilysin inhibitor, and valsartan, an angiotensin II receptor blocker. Sacubitril increases levels of natriuretic peptides by inhibiting neprilysin, leading to vasodilation, natriuresis, and diuresis. Valsartan blocks the effects of angiotensin II at the AT1 receptor, reducing vasoconstriction, aldosterone release, and sodium retention. The combined effect reduces cardiovascular death and heart failure hospitalizations.
Mechanism Steps
💡 How to Take azmarda 200mg tablet
Strength: Tablet containing 97 mg sacubitril and 103 mg valsartan (equivalent to 100 mg sacubitril/valsartan).
Dosage Information
| Adult Dosage | The usual starting dose of this medicine is one tablet containing 97 mg sacubitril and 103 mg valsartan (equivalent to 100 mg sacubitril/valsartan) taken orally twice daily. The dose may be increased after 2-4 weeks to the target dose of 200 mg (97 mg sacubitril/103 mg valsartan) twice daily, as tolerated. For patients not currently taking an ACE inhibitor or ARB, or with low blood pressure, a lower starting dose of 50 mg (24 mg sacubitril/26 mg valsartan) twice daily may be used. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and blood pressure. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | No dose adjustment is required based on age alone. However, elderly patients may be more sensitive to the blood pressure-lowering effects. Monitor blood pressure and kidney function closely. Dose must be individualized by a qualified clinician. |
| Renal Impairment | For patients with mild to moderate kidney impairment, no dose adjustment is needed. For severe kidney impairment (eGFR <30 mL/min/1.73 m²), a lower starting dose of 50 mg (24 mg sacubitril/26 mg valsartan) twice daily is recommended, and dose should be titrated cautiously. Use in patients on dialysis is not recommended. Dose must be individualized by a qualified clinician. |
| Hepatic Impairment | For patients with mild to moderate liver impairment (Child-Pugh A or B), no dose adjustment is needed. This medicine is contraindicated in severe liver impairment (Child-Pugh C). Dose must be individualized by a qualified clinician. |
| Maximum Daily Dose | The maximum recommended dose is 200 mg (97 mg sacubitril/103 mg valsartan) twice daily, totaling 400 mg per day. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of azmarda 200mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| ACE inhibitors | Major | |
| Potassium-sparing diuretics | Major | |
| NSAIDs | Major | |
| Lithium | Major | |
| Aliskiren | Major | |
| Diuretics | Moderate | |
| Beta-blockers | Moderate | |
| Calcium channel blockers | Moderate | |
| Metformin | Minor | |
| Warfarin | Minor |
🚨 Major Interactions
- ACE inhibitors (e.g., enalapril, lisinopril)
- Potassium-sparing diuretics (e.g., spironolactone, triamterene)
- NSAIDs (e.g., ibuprofen, naproxen)
- Lithium
- Aliskiren
⚡ Moderate Interactions
- Diuretics (e.g., furosemide, hydrochlorothiazide)
- Beta-blockers (e.g., metoprolol, carvedilol)
- Calcium channel blockers (e.g., amlodipine)
🍷 Alcohol Interaction
Alcohol may enhance the blood pressure-lowering effect of this medicine, leading to dizziness, lightheadedness, and fainting. It is advisable to avoid or limit alcohol consumption while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["History of angioedema related to ACE inhibitors or ARBs","Concomitant use with ACE inhibitors","Concomitant use with aliskiren in patients with diabetes","Pregnancy","Severe liver impairment","Hypersensitivity to sacubitril, valsartan, or any component of the formulation"]
⚠️ Warnings & Precautions
["Angioedema: May cause swelling of face, lips, throat, or tongue. Discontinue immediately and seek emergency care if this occurs.","Hypotension: May cause low blood pressure, especially in patients taking diuretics or with volume depletion. Monitor and adjust dose.","Kidney impairment: May worsen kidney function. Monitor regularly.","Hyperkalemia: May increase potassium levels. Avoid potassium supplements and monitor levels.","Fetal toxicity: Contraindicated in pregnancy. Use effective contraception.","Do not use with ACE inhibitors. A 36-hour washout period is required when switching."]
🤱 Lactation Safety
It is not known whether this medicine is excreted in human breast milk. Because of the potential for serious adverse reactions in breastfed infants, breastfeeding is not recommended during treatment with this medicine.
💊 Overdose Management
Overdose may cause severe hypotension, dizziness, and fainting. If overdose is suspected, seek immediate medical attention. Treatment is supportive and symptomatic. Hemodialysis is not effective in removing sacubitril or valsartan from the body.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not stop or change the dose without consulting your doctor. Avoid alcohol as it may worsen low blood pressure. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Regular monitoring of blood pressure, kidney function, and potassium levels is necessary. Do not take potassium supplements or salt substitutes containing potassium without doctor's advice. Avoid driving or operating machinery if you feel dizzy after taking this medicine.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the blood pressure-lowering effects of this medicine. Monitor blood pressure and kidney function closely. Dose adjustment may be needed based on tolerability.
🤰 Pregnancy Planning (TTC)
This medicine is contraindicated in pregnancy and can cause fetal harm. Women of childbearing potential should use effective contraception while taking this medicine. If you are planning pregnancy, consult your doctor to switch to a safer alternative before conception.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine before any surgery. It may need to be temporarily stopped before surgery due to the risk of hypotension. Follow your doctor's instructions regarding when to resume.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. It may cause dizziness or low blood pressure during the procedure. Your dentist may take precautions such as monitoring your blood pressure.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Moderate exercise is generally recommended for heart failure patients, but avoid strenuous activities that cause shortness of breath or chest pain. Always consult your doctor before starting any exercise program. Stop exercising and seek medical help if you experience dizziness, chest pain, or severe breathlessness.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or low blood pressure, which can affect your ability to drive or operate machinery. Avoid driving or operating heavy machinery until you know how this medicine affects you. Most patients can continue their normal work activities with appropriate precautions.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience serious side effects such as angioedema, severe hypotension, or kidney problems, seek immediate medical attention. Your doctor may decide to discontinue or adjust the dose based on your condition.
📅 Long-Term Use Effects
Long-term use of this medicine has been shown to reduce cardiovascular death and heart failure hospitalizations. Regular monitoring of blood pressure, kidney function, and potassium levels is necessary. Some patients may experience persistent cough or dizziness. The medicine should be continued as long as tolerated and as advised by the doctor.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Alternative class of medicines for heart failure, but may cause cough.
Evidence: Well-establishedAlternative for patients who cannot tolerate ACE inhibitors.
Evidence: Well-establishedOften used in combination with ARNIs for heart failure.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no specific vaccine interactions with this medicine. However, patients with heart failure should receive annual influenza and pneumococcal vaccinations as recommended by their doctor.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate or freeze
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight and moisture
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature and avoid extreme heat or cold. If crossing time zones, adjust dosing times gradually, but maintain approximately 12-hour intervals. Consult your doctor before traveling if you have any concerns. Check customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working within hours to lower blood pressure, but improvement in heart failure symptoms may take several weeks. Full benefits are usually seen after a few months of consistent use.
A: Yes, this medicine can be taken with or without food. However, it is best to take it consistently at the same times each day.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: No, do not stop taking this medicine without consulting your doctor. Stopping suddenly can worsen heart failure. Your doctor will decide if and when to discontinue.
A: This medicine can affect kidney function, especially in patients with existing kidney disease. Regular monitoring of kidney function is required. Your doctor may adjust the dose if needed.
🤔 Common Patient Concerns
🔄 Substitutes for azmarda 200mg tablet
View AllAlternative brands with exact same active ingredient:
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neptaz 200mg tabletMankind Pharma Ltd ₹372.40 43.5% CHEAPER
-
zayo 200 tabletEris Lifesciences Ltd ₹487.33 26% CHEAPER
-
cidmus 200mg tabletLupin Ltd ₹689.89 4.7% COSTLIER
-
vymada 200mg tabletNovartis India Ltd ₹841.25 27.7% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure heart failure.
Fact: This medicine helps manage heart failure symptoms and reduces hospitalizations, but it does not cure the condition. It must be continued long-term. - Myth: This medicine can be taken with any other blood pressure medicine.
Fact: This medicine should not be taken with ACE inhibitors or aliskiren in diabetes due to increased risk of serious side effects. - Myth: It is safe to stop this medicine once symptoms improve.
Fact: Stopping this medicine suddenly can worsen heart failure. Always consult your doctor before making any changes.