alciflox d eye/ear drops - Ciprofloxacin (0.3% w/v) + Dexamethasone (0.1% w/v) medicine

alciflox d eye/ear drops

No reviews yet
🏭 Alkem Laboratories Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 20, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Reviewed by
SaathiMed Expert Panel | Sep 20, 2026

What is alciflox d eye/ear drops used for?

This medicine contains Ciprofloxacin (0.3% w/v) + Dexamethasone (0.1% w/v) and is used to treat OPHTHAL OTOLOGICALS. Ciprofloxacin inhibits bacterial DNA gyrase and topoisomerase IV; Dexamethasone suppresses inflammat. Always consult your doctor before use.

  • Generic Name: Ciprofloxacin + Dexamethasone
  • Manufacturer: Alkem Laboratories Ltd
  • Form: Allopathy
  • Pregnancy Category: Category C
  • Prescription Required: Yes
💡 Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

💊 alciflox d eye/ear drops Uses & Benefits

Bacterial infections of the eye (conjunctivitis, keratitis) and ear (otitis externa, otitis media with perforated tympanic membrane) with associated inflammation

Off-label uses: Prophylaxis after ocular surgery; treatment of blepharitis

📋 Drug Information

Generic Name(s)Ciprofloxacin + Dexamethasone
Brand NameAlciflox D Eye/Ear Drops
ManufacturerAlkem Laboratories Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassOPHTHAL OTOLOGICALS
Action ClassAntibiotic + Corticosteroid
Route of AdministrationOphthalmic and otic topical
StorageStore at 15-30°C; protect from light; keep tightly closed
Shelf LifeAs per manufacturer

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionMinimal systemic absorption after ophthalmic/otic administration
DistributionLocal distribution in eye/ear tissues
Protein BindingCiprofloxacin: 20-40%; Dexamethasone: 77%
MetabolismCiprofloxacin: Hepatic (partial); Dexamethasone: Hepatic
Half-LifeCiprofloxacin: 4 hours; Dexamethasone: 3-4 hours
ExcretionCiprofloxacin: Renal (50-70% unchanged); Dexamethasone: Renal
BioavailabilityLow systemic bioavailability due to topical administration
Onset of ActionRapid (within hours)
Peak Plasma TimeNot applicable (topical)
Duration of ActionSeveral hours

How It Works

Ciprofloxacin inhibits bacterial DNA gyrase and topoisomerase IV; Dexamethasone suppresses inflammation by inhibiting phospholipase A2 and reducing prostaglandin synthesis

Mechanism Steps

1Ciprofloxacin enters bacterial cells and binds to DNA gyrase and topoisomerase IV, inhibiting DNA replication and transcription.
2Dexamethasone binds to glucocorticoid receptors, leading to inhibition of phospholipase A2 and reduced arachidonic acid release.
3Decreased prostaglandin and leukotriene synthesis results in anti-inflammatory and immunosuppressive effects.

💡 How to Take alciflox d eye/ear drops

Follow your doctor's prescription exactly.

⚠️ Side Effects of alciflox d eye/ear drops

✅ Common Side Effects

Eye irritation
Stinging
Blurred vision
Taste perversion (ear drops)

🚨 Serious Side Effects

Corneal perforation
Increased intraocular pressure
Cataract formation
Secondary infection

⚠️ Rare Side Effects

Allergic reactions
Anaphylaxis
Tendon rupture (systemic)

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major Increased bleeding risk
NSAIDs Major Increased risk of tendon rupture
Antidiabetic agents Major Enhanced hypoglycemic effect
Corticosteroids Major Additive immunosuppression
Cyclosporine Moderate Increased nephrotoxicity risk
Methotrexate Moderate Increased methotrexate toxicity
Phenytoin Moderate Altered phenytoin levels
Antacids Minor Reduced ciprofloxacin absorption (if oral)
Iron supplements Minor Reduced ciprofloxacin absorption (if oral)
Zinc supplements Minor Reduced ciprofloxacin absorption (if oral)

🚨 Major Interactions

  • Warfarin
  • NSAIDs
  • Antidiabetic agents
  • Corticosteroids

⚡ Moderate Interactions

  • Cyclosporine
  • Methotrexate
  • Phenytoin

🍷 Alcohol Interaction

No known interaction

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to ciprofloxacin, dexamethasone, or any component; viral infections of the eye/ear (e.g., herpes simplex); fungal infections; untreated parasitic infections; corneal perforation

🤱 Lactation Safety

Use with caution; limited data

💊 Overdose Management

Topical overdose unlikely; if ingested, symptomatic treatment

⏰ Missed Dose

Apply as soon as remembered; if near next dose, skip missed dose

🔄 Substitutes for alciflox d eye/ear drops

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

😊 Was this information helpful?

Browse Medicines A-Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Back to Medicines Directory