acticort 5mg tablet - Prednisolone (5mg) medicine

acticort 5mg tablet

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Prednisolone (5mg)
🏭 Overseas Healthcare Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 20, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Reviewed by
SaathiMed Expert Panel | Sep 20, 2026

What is acticort 5mg tablet used for?

This medicine contains Prednisolone (5mg) and is used to treat OPHTHAL OTOLOGICALS. Binds to glucocorticoid receptors, modulating gene expression to reduce inflammation and immune resp. Always consult your doctor before use.

  • Generic Name: Prednisolone
  • Manufacturer: Overseas Healthcare Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Category A
  • Prescription Required: Yes
💡 Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

💊 acticort 5mg tablet Uses & Benefits

Allergic conditions, Asthma, Rheumatoid arthritis, Inflammatory bowel disease, Ophthalmic inflammation, Otological inflammation

Off-label uses: COVID-19 (severe cases), Acute respiratory distress syndrome, Adrenal insufficiency (off-label dosing)

📋 Drug Information

Generic Name(s)Prednisolone
Brand NameActicort 10mg Tablet
ManufacturerOverseas Healthcare Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassOPHTHAL OTOLOGICALS
Action ClassGlucocorticoids
Route of AdministrationOral
StorageStore at room temperature (20-25°C), protect from light and moisture.
Shelf LifeAs per manufacturer

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionRapidly absorbed from gastrointestinal tract after oral administration.
DistributionWidely distributed into tissues; crosses placenta and enters breast milk.
Protein Binding70-90% bound to corticosteroid-binding globulin and albumin.
MetabolismHepatic metabolism primarily via CYP3A4 to inactive metabolites.
Half-Life2-4 hours (plasma half-life); biological half-life 18-36 hours.
ExcretionRenal excretion of metabolites; less than 1% unchanged drug.
Bioavailability70-90% after oral administration.
Onset of ActionWithin 1-2 hours for anti-inflammatory effects.
Peak Plasma Time1-2 hours after oral dose.
Duration of Action18-36 hours (biological effects).

How It Works

Binds to glucocorticoid receptors, modulating gene expression to reduce inflammation and immune response.

Mechanism Steps

1Prednisolone diffuses across cell membrane and binds to glucocorticoid receptor (GR) in cytoplasm.
2Receptor-ligand complex translocates to nucleus and binds to glucocorticoid response elements (GREs) on DNA.
3Modulates gene transcription: increases anti-inflammatory proteins (e.g., lipocortin-1) and decreases pro-inflammatory cytokines (e.g., IL-1, TNF-α).
4Inhibits phospholipase A2, reducing arachidonic acid release and subsequent prostaglandin and leukotriene synthesis.
5Suppresses immune cell function (e.g., T-cells, macrophages, eosinophils).

💡 How to Take acticort 5mg tablet

Follow your doctor's prescription exactly.

⚠️ Side Effects of acticort 5mg tablet

✅ Common Side Effects

Increased appetite
Weight gain
Insomnia
Mood changes
Fluid retention
Hypertension
Hyperglycemia

🚨 Serious Side Effects

Adrenal suppression
Osteoporosis
Peptic ulcer
Pancreatitis
Psychiatric disturbances
Increased infection risk

⚠️ Rare Side Effects

Avascular necrosis of femoral head
Cushing's syndrome
Glaucoma
Cataracts
Thromboembolism

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Warfarin Major Increased bleeding risk
Rifampin Major Decreased prednisolone efficacy
Ketoconazole Major Increased prednisolone levels and toxicity
NSAIDs Major Increased risk of GI ulcers and bleeding
Antidiabetic agents Major Reduced hypoglycemic effect
Diuretics Moderate Increased potassium loss
Amphotericin B Moderate Increased risk of hypokalemia
Live vaccines Moderate Risk of disseminated infection
Oral contraceptives Minor Possible increased prednisolone levels

🚨 Major Interactions

  • Warfarin
  • CYP3A4 inducers (e.g., rifampin)
  • CYP3A4 inhibitors (e.g., ketoconazole)
  • NSAIDs
  • Antidiabetic agents

⚡ Moderate Interactions

  • Diuretics
  • Amphotericin B
  • Vaccines (live attenuated)
  • Anticholinesterases

🍷 Alcohol Interaction

May increase risk of gastrointestinal bleeding; avoid concurrent use.

🛡️ Safety & Warnings

🚫 Contraindications

Systemic fungal infections, Hypersensitivity to prednisolone, Live virus vaccination, Peptic ulcer disease (relative)

🤱 Lactation Safety

Excreted in breast milk; caution advised; use only if clearly needed.

💊 Overdose Management

No specific antidote; supportive care; monitor electrolytes and glucose.

⏰ Missed Dose

Take as soon as remembered; if near next dose, skip missed dose; do not double dose.

🔄 Substitutes for acticort 5mg tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

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