Ibuprofen 400 mg Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Unusual weight gain or swelling in ankles
- Severe rash or blistering of skin
If experiencing severe symptoms, call emergency services immediately.
What is iburin 400mg tablet used for?
This medicine is an NSAID used to relieve pain, inflammation, and fever. It works by blocking COX enzymes. Take it with food to avoid stomach upset. Do not exceed 3200 mg per day. Consult a doctor if you have heart, kidney, or stomach problems.
- Generic Name: Ibuprofen (400mg)
- Manufacturer: Unichem Laboratories Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 iburin 400mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा इबुप्रोफेन का एक टैबलेट रूप है, जो एक नॉनस्टेरॉइडल एंटी-इंफ्लेमेटरी ड्रग (NSAID) है। इसका उपयोग हल्के से मध्यम दर्द, सूजन और बुखार के इलाज के लिए किया जाता है। यह गठिया, मासिक धर्म में ऐंठन, सिरदर्द, दांत दर्द और मांसपेशियों की चोट जैसी स्थितियों में राहत देती है। यह शरीर में प्रोस्टाग्लैंडिन नामक रसायनों के उत्पादन को रोककर काम करती है, जो दर्द और सूजन का कारण बनते हैं।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट दर्द, सीने में जलन, दस्त, कब्ज, चक्कर आना, सिरदर्द और दाने शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें पेट या आंतों में रक्तस्राव, अल्सर, गुर्दे की समस्या, यकृत की क्षति, गंभीर एलर्जी प्रतिक्रिया और दिल का दौरा या स्ट्रोक का खतरा बढ़ सकता है। यदि आपको काला मल, खून की उल्टी, गंभीर पेट दर्द, सीने में दर्द, सांस लेने में कठिनाई, चेहरे या गले में सूजन, या पेशाब में कमी महसूस हो तो तुरंत चिकित्सा सहायता लें।
सुरक्षा सलाह: इस दवा को अपने डॉक्टर के निर्देशानुसार ही लें। अनुशंसित खुराक या उपचार की अवधि से अधिक न लें। पेट की परेशानी कम करने के लिए इसे भोजन या दूध के साथ लें। इस दवा को लेते समय शराब से बचें क्योंकि इससे पेट में रक्तस्राव का खतरा बढ़ सकता है। बिना डॉक्टर की सलाह के अन्य NSAIDs या दर्द निवारक दवाएं न लें। यदि आपको पेट के अल्सर, गुर्दे की बीमारी, हृदय रोग या उच्च रक्तचाप का इतिहास है, तो इस दवा को लेने से पहले अपने डॉक्टर को बताएं। बिना डॉक्टर की सलाह के इस दवा का उपयोग 10 दिनों से अधिक दर्द के लिए या 3 दिनों से अधिक बुखार के लिए न करें। बच्चों की पहुंच से दूर रखें।
💊 iburin 400mg tablet Uses & Benefits
[{"condition":"Osteoarthritis","description":"Relieves pain and improves joint mobility in knee, hip, and hand osteoarthritis.","evidence":"Well-established"},{"condition":"Rheumatoid arthritis","description":"Reduces joint pain, inflammation" class="semantic-link" title="Medicines for swelling">swelling, and stiffness in rheumatoid arthritis.","evidence":"Well-established"},{"condition":"Primary dysmenorrhea","description":"Relieves menstrual cramps and associated pain.","evidence":"Well-established"},{"condition":"Headache","description":"Provides relief from tension headaches and mild migraines.","evidence":"Well-established"},{"condition":"Dental pain","description":"Manages pain following dental procedures or toothache.","evidence":"Well-established"},{"condition":"Soft tissue injuries","description":"Reduces pain and inflammation from sprains, strains, and contusions.","evidence":"Well-established"},{"condition":"Fever","description":"Lowers fever by acting on the hypothalamus.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Migraine prophylaxis","description":"Sometimes prescribed off-label to prevent migraines.","evidence":"Limited"},{"condition":"Alzheimer's disease","description":"Investigated for potential benefit in slowing cognitive decline, but evidence is inconclusive.","evidence":"Insufficient"}]
Primary treatment for: Pain and inflammation
Also treats: Osteoarthritis, Rheumatoid arthritis, Dysmenorrhea, Headache, Dental pain, Soft tissue injuries, Fever
📋 Drug Information
| Generic Name(s) | Ibuprofen (400mg) |
| Brand Name | iburin 400mg tablet |
| Manufacturer | Unichem Laboratories Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | NSAID's- Non-Selective COX 1&2 Inhibitors (propionic acid) |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by reversibly inhibiting the cyclooxygenase (COX) enzymes, specifically COX-1 and COX-2. These enzymes are responsible for converting arachidonic acid into prostaglandins and thromboxanes. By blocking this conversion, the medicine reduces the production of prostaglandins, which are key mediators of pain, inflammation, and fever. The inhibition is reversible, meaning the effect wears off as the drug is cleared from the body.
Mechanism Steps
💡 How to Take iburin 400mg tablet
Strength: Ibuprofen 400 mg immediate-release tablet
Dosage Information
| Adult Dosage | The usual adult dose for pain and fever is 200-400 mg every 4 to 6 hours as needed. For inflammatory conditions like arthritis, the dose may be 400-800 mg three to four times daily. The maximum daily dose is 3200 mg. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients should use the lowest effective dose for the shortest duration due to increased risk of gastrointestinal, renal, and cardiovascular adverse effects. Dose must be individualized by a qualified clinician. |
| Renal Impairment | In patients with mild to moderate renal impairment, use with caution and consider dose reduction. In severe renal impairment, avoid use. Dose must be individualized by a qualified clinician. |
| Hepatic Impairment | In patients with mild to moderate hepatic impairment, use with caution and consider dose reduction. In severe hepatic impairment, avoid use. Dose must be individualized by a qualified clinician. |
| Maximum Daily Dose | 3200 mg per day for adults. Do not exceed this dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of iburin 400mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Aspirin | Major | |
| ACE inhibitors | Major | |
| Lithium | Major | |
| Methotrexate | Major | |
| Diuretics | Moderate | |
| Corticosteroids | Moderate | |
| SSRIs | Moderate | |
| Antacids | Minor | |
| Cholestyramine | Minor |
🚨 Major Interactions
- Warfarin
- Aspirin
- ACE inhibitors
- Lithium
- Methotrexate
⚡ Moderate Interactions
- Diuretics
- Corticosteroids
- SSRIs
- Anticoagulants (e.g., apixaban)
🍷 Alcohol Interaction
Avoid consuming alcohol while taking this medicine. Alcohol increases the risk of gastrointestinal bleeding and can worsen stomach irritation caused by ibuprofen.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to ibuprofen or other NSAIDs","History of asthma, urticaria, or allergic reaction after taking aspirin or other NSAIDs","Active or history of peptic ulcer or gastrointestinal bleeding","Severe heart failure","Severe kidney disease","Severe liver disease","Third trimester of pregnancy","Coronary artery bypass graft (CABG) surgery perioperative period"]
⚠️ Warnings & Precautions
["Cardiovascular risk: NSAIDs may increase the risk of serious cardiovascular thrombotic events. Use with caution in patients with cardiovascular risk factors.","Gastrointestinal risk: NSAIDs can cause serious gastrointestinal adverse events, including bleeding, ulceration, and perforation. Use with caution in the elderly and those with a history of GI disease.","Renal risk: NSAIDs can cause renal papillary necrosis and other renal injury. Use with caution in patients with impaired renal function, heart failure, or dehydration.","Hepatic risk: NSAIDs can cause borderline elevations of liver enzymes and rarely severe hepatic reactions. Monitor liver function.","Skin reactions: Serious skin reactions such as exfoliative dermatitis, Stevens-Johnson syndrome, and toxic epidermal necrolysis can occur. Discontinue at first sign of rash.","Anaphylactoid reactions: Hypersensitivity reactions can occur. Discontinue and seek emergency help if suspected.","Masking of infection: Ibuprofen may mask signs of infection, such as fever.","Use in the elderly: Elderly patients are at higher risk of NSAID-related adverse effects. Use lowest effective dose for shortest duration."]
🤱 Lactation Safety
Ibuprofen is considered safe during breastfeeding as it passes into breast milk in very small amounts. However, consult your doctor before use.
💊 Overdose Management
Overdose of this medicine can cause nausea, vomiting, abdominal pain, lethargy, drowsiness, headache, tinnitus, blurred vision, and in severe cases, metabolic acidosis, coma, and acute kidney failure. If overdose is suspected, seek immediate medical attention. Treatment is supportive and symptomatic. Activated charcoal may be administered if within 1-2 hours of ingestion. Hemodialysis may be considered in severe cases.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose or duration of treatment. Take it with food or milk to reduce stomach upset. Avoid alcohol while taking this medicine as it can increase the risk of stomach bleeding. Do not take other NSAIDs or pain relievers without consulting your doctor. If you have a history of stomach ulcers, kidney disease, heart disease, or high blood pressure, inform your doctor before taking this medicine. Do not use this medicine for more than 10 days for pain or 3 days for fever unless directed by a doctor. Keep out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of gastrointestinal bleeding, kidney problems, and cardiovascular events with NSAID use. Use the lowest effective dose for the shortest duration. Monitor renal function and blood pressure regularly. Avoid concomitant use with other NSAIDs or anticoagulants unless under strict medical supervision.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. NSAIDs like ibuprofen may affect ovulation and are generally avoided during pregnancy, especially in the third trimester. Discuss alternative pain management options with your healthcare provider.
🏥 Post-Surgery Considerations
After surgery, use this medicine only if prescribed by your surgeon. It may increase the risk of bleeding and interfere with bone healing. In some surgeries, such as coronary artery bypass graft (CABG), NSAIDs are contraindicated. Always inform your surgeon about all medications you are taking.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine before any dental procedure. It may increase the risk of bleeding during and after dental work. Your dentist may advise you to stop it temporarily or take precautions. It can also be used for dental pain relief, but follow your dentist's instructions.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While taking this medicine, you can generally continue your regular exercise routine. However, if you experience dizziness or fatigue, avoid strenuous activities or exercises that require balance. Listen to your body and rest if you feel unwell.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It is generally safe to continue desk work, but take breaks and stay hydrated. If your job involves physical labor, consult your doctor about any necessary modifications.
🛑 When to Stop This Medicine
Stop taking this medicine and consult your doctor if you experience severe side effects such as stomach pain, black stools, vomiting blood, rash, swelling, or difficulty breathing. Do not stop taking prescribed medication without consulting your doctor, especially if you are using it for a chronic condition.
📅 Long-Term Use Effects
Long-term use of this medicine can increase the risk of serious gastrointestinal, cardiovascular, and renal adverse effects. It may cause stomach ulcers, bleeding, kidney damage, and increased blood pressure. Regular monitoring of kidney and liver function, as well as blood counts, is recommended during prolonged therapy. Use the lowest effective dose for the shortest duration possible.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain and improve mobility.
Evidence: Well-establishedMay help relieve certain types of pain, such as back pain and osteoarthritis.
Evidence: ModerateApplying heat or cold packs can reduce pain and inflammation.
Evidence: Well-establishedStress reduction may help manage chronic pain.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine does not interact with vaccines. However, if you have a fever, consult your doctor before vaccination. It is safe to take this medicine after vaccination for pain or fever, but follow your doctor's advice.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging along with a copy of your prescription. Store it at room temperature, away from direct sunlight and moisture. If crossing time zones, continue taking your doses at the same intervals as prescribed. Check local customs regulations regarding carrying medications. Always keep it in your carry-on luggage to avoid loss or temperature extremes.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts relieving pain within 30 to 60 minutes after taking it orally.
A: It is best to take this medicine with food or milk to reduce the risk of stomach upset. Taking it on an empty stomach may increase the chance of gastric irritation.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
A: This medicine is not recommended during the third trimester of pregnancy. Consult your doctor before taking it if you are pregnant or planning to become pregnant.
A: Do not take this medicine with other NSAIDs or pain relievers without consulting your doctor, as it may increase the risk of side effects.
🤔 Common Patient Concerns
🔄 Substitutes for iburin 400mg tablet
View AllAlternative brands with exact same active ingredient:
-
ibuflamar 400mg tabletIndoco Remedies Ltd ₹4.93 21.4% CHEAPER
-
eurobuf 400mg tabletEuro Biogenics ₹5.30 15.5% CHEAPER
-
ibu 400mg tabletOsper Formulations Pvt Ltd ₹5.53 11.8% CHEAPER
-
alfam 400mg tabletAlbert David Ltd ₹5.56 11.3% CHEAPER
-
bruriff 400mg tabletCadila Pharmaceuticals Ltd ₹5.80 7.5% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is completely safe and can be taken without a prescription.
Fact: This medicine is generally safe when used as directed, but it can cause serious side effects, especially with long-term use. It should be taken only as prescribed by a doctor. - Myth: This medicine can be taken on an empty stomach without any issues.
Fact: Taking this medicine on an empty stomach increases the risk of stomach upset and bleeding. It should be taken with food or milk. - Myth: This medicine is safe to take during pregnancy.
Fact: This medicine is not recommended during the third trimester of pregnancy due to risk of complications. Consult your doctor before use.
🔄 Alternative Options
Generic Alternatives
- Ibuprofen 400 mg tablet
Brand Alternatives
- Brufen 400 tablet
- Ibugesic 400 tablet
- Combiflam 400 tablet
- Flexon 400 tablet