Combiflam Tablet: Comprehensive Guide to Uses, Dosage, and Safety
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Unusual bleeding or bruising
If experiencing severe symptoms, call emergency services immediately.
What is cypaflam 400mg/325mg tablet used for?
This medicine is a combination of Ibuprofen 400 mg and Paracetamol 325 mg used for short-term relief of mild to moderate pain and fever. It works by reducing inflammation and pain signals in the body. Take one tablet every 6 to 8 hours with food, not exceeding 3 tablets in 24 hours.
- Generic Name: Ibuprofen + Paracetamol
- Manufacturer: Cyper Drugs & Pharmaceuticals Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 cypaflam 400mg/325mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा इबुप्रोफेन 400 मिलीग्राम और पैरासिटामोल 325 मिलीग्राम का संयोजन है। इसका उपयोग हल्के से मध्यम दर्द जैसे सिरदर्द, दांत दर्द, मासिक धर्म में ऐंठन, मांसपेशियों में दर्द, पीठ दर्द और बुखार को कम करने के लिए किया जाता है। यह दर्द और सूजन को कम करने में मदद करती है। इसे भोजन के साथ लेना चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट दर्द, अपच, चक्कर आना और सिरदर्द शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें पेट या आंतों में रक्तस्राव, एलर्जी प्रतिक्रिया, लीवर या किडनी की समस्या हो सकती है। यदि आपको काला मल, उल्टी में खून, या सांस लेने में कठिनाई हो तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को हमेशा डॉक्टर के निर्देशानुसार ही लें। खुराक से अधिक न लें। इसे भोजन या दूध के साथ लें ताकि पेट में जलन न हो। इस दवा के साथ शराब न लें। यदि आपको पेट अल्सर, किडनी या लीवर की बीमारी, हृदय रोग या अस्थमा है तो डॉक्टर को बताएं। गर्भवती महिलाएं और स्तनपान कराने वाली माताएं बिना डॉक्टर की सलाह के इसका सेवन न करें।
💊 cypaflam 400mg/325mg tablet Uses & Benefits
[{"condition":"Mild to moderate pain","description":"Effective for relieving headache, toothache, menstrual cramps, muscle aches, and back pain.","evidence":"Well-established"},{"condition":"Fever","description":"Reduces fever by acting on the hypothalamus to lower body temperature.","evidence":"Well-established"},{"condition":"Osteoarthritis and rheumatoid arthritis","description":"Provides symptomatic relief of pain and stiffness in joint conditions.","evidence":"Well-established"},{"condition":"Post-operative pain","description":"Used for short-term management of pain after surgical procedures.","evidence":"Well-established"},{"condition":"Dysmenorrhea","description":"Relieves menstrual cramps and associated pain.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Migraine","description":"Sometimes used for acute migraine attacks, but not first-line.","evidence":"Limited"},{"condition":"Soft tissue injuries","description":"Used for pain and inflammation from sprains and strains.","evidence":"Limited"}]
Primary treatment for: Pain and fever
Also treats: Osteoarthritis, Rheumatoid arthritis, Dysmenorrhea, Headache, Dental pain
📋 Drug Information
| Generic Name(s) | Ibuprofen + Paracetamol |
| Brand Name | Adiflam Plus 400 mg/500 mg Tablet |
| Manufacturer | Cyper Drugs & Pharmaceuticals Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | Nonsteroidal Anti-inflammatory Drug (NSAID) + Analgesic/Antipyretic |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary mechanisms. Ibuprofen is a non-selective cyclooxygenase (COX) inhibitor that reversibly blocks both COX-1 and COX-2 enzymes, leading to decreased synthesis of prostaglandins, prostacyclin, and thromboxane. This results in analgesic, antipyretic, and anti-inflammatory effects. Paracetamol, also known as acetaminophen, acts primarily in the central nervous system by inhibiting prostaglandin synthesis and possibly activating descending serotonergic pathways, producing analgesia and antipyresis with minimal anti-inflammatory action. The combination provides enhanced pain relief through different pathways.
Mechanism Steps
💡 How to Take cypaflam 400mg/325mg tablet
Strength: Tablet: Ibuprofen 400 mg + Paracetamol 325 mg
Dosage Information
| Adult Dosage | The usual adult dose is one tablet (Ibuprofen 400 mg + Paracetamol 325 mg) taken orally every 6 to 8 hours as needed for pain or fever. Do not exceed 3 tablets in 24 hours. The maximum daily dose is 1200 mg ibuprofen and 975 mg paracetamol. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Use the lowest effective dose for the shortest duration. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients (above 65 years) may be more sensitive to the side effects of this medicine, especially gastrointestinal bleeding and renal impairment. Use with caution and at the lowest effective dose for the shortest duration. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Use with caution in patients with renal impairment. Dose reduction may be necessary. Consult a doctor for individualized dosing. |
| Hepatic Impairment | Use with caution in patients with hepatic impairment. Dose reduction may be necessary. Consult a doctor for individualized dosing. |
| Maximum Daily Dose | Maximum daily dose: 3 tablets in 24 hours (Ibuprofen 1200 mg + Paracetamol 975 mg). Do not exceed this dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of cypaflam 400mg/325mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Aspirin | Major | |
| Other NSAIDs | Major | |
| Methotrexate | Major | |
| Lithium | Major | |
| ACE inhibitors | Moderate | |
| Diuretics | Moderate | |
| Corticosteroids | Moderate | |
| SSRIs | Moderate | |
| Zidovudine | Moderate |
🚨 Major Interactions
- Warfarin
- Aspirin
- Other NSAIDs
- Methotrexate
- Lithium
⚡ Moderate Interactions
- ACE inhibitors
- Diuretics
- Corticosteroids
- SSRIs
- Zidovudine
🍷 Alcohol Interaction
Avoid consuming alcohol while taking this medicine. Alcohol increases the risk of gastrointestinal bleeding and can potentiate liver damage, especially with paracetamol. It may also increase drowsiness and dizziness.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to ibuprofen, paracetamol, or any component of the formulation","History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs","Active or history of recurrent peptic ulcer or gastrointestinal bleeding","Severe heart failure, severe liver disease, or severe kidney disease","Third trimester of pregnancy","Children under 12 years or weighing less than 40 kg","Concurrent use with other NSAIDs or paracetamol-containing products"]
⚠️ Warnings & Precautions
["Take with food or milk to reduce stomach upset.","Do not exceed the recommended dose or duration of treatment.","Avoid alcohol while taking this medicine.","Use with caution in elderly patients due to increased risk of side effects.","Consult your doctor if you have a history of stomach ulcers, kidney or liver disease, heart problems, or asthma.","Do not use for more than 3 days for fever or more than 10 days for pain without medical advice.","May cause dizziness; avoid driving or operating machinery until you know how it affects you.","Do not take other medicines containing paracetamol or NSAIDs concurrently."]
🤱 Lactation Safety
Ibuprofen and paracetamol are excreted in breast milk in small amounts. Short-term use is generally considered compatible with breastfeeding, but consult your doctor before use.
💊 Overdose Management
Overdose of this medicine can cause severe liver damage, especially due to paracetamol. Symptoms of overdose may include nausea, vomiting, abdominal pain, confusion, and drowsiness. Seek immediate medical attention even if you feel well. Treatment may include activated charcoal, N-acetylcysteine for paracetamol toxicity, and supportive care. Do not induce vomiting unless instructed by a healthcare professional.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Always take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose or duration of treatment. Take it with food or milk to minimize stomach irritation. Avoid alcohol while taking this medicine, as it can increase the risk of stomach bleeding and liver damage. Do not use this medicine for more than 3 days for fever or more than 10 days for pain without consulting a doctor. If you have a history of stomach ulcers, kidney or liver disease, heart problems, or asthma, inform your doctor before taking this medicine. Do not take other medicines containing paracetamol or NSAIDs while on this medicine to avoid overdose. Pregnant women, especially in the third trimester, and breastfeeding mothers should consult their doctor before use. Keep this medicine out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of gastrointestinal bleeding, kidney impairment, and cardiovascular events. Use the lowest effective dose for the shortest duration and monitor closely.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before taking this medicine. NSAIDs like ibuprofen may affect ovulation and are generally avoided in the third trimester.
🏥 Post-Surgery Considerations
This medicine can be used for post-operative pain relief as prescribed by your doctor. However, it may increase bleeding risk, so inform your surgeon if you are taking it before surgery.
🦷 Dental Procedures
This medicine can be used for dental pain relief. Inform your dentist if you are taking it before any dental procedure, as it may increase bleeding risk.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While taking this medicine, you can continue light to moderate exercise as tolerated. However, if you experience dizziness or fatigue, avoid strenuous activities. Consult your doctor before starting any new exercise regimen.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It is generally safe for office work, but take breaks and stay hydrated.
🛑 When to Stop This Medicine
Stop taking this medicine and consult your doctor if your pain or fever persists beyond 3 days (for fever) or 10 days (for pain), or if you experience any serious side effects such as stomach bleeding, allergic reactions, or yellowing of the skin or eyes.
📅 Long-Term Use Effects
Long-term use of this medicine can increase the risk of gastrointestinal bleeding, kidney damage, liver damage, and cardiovascular events. Regular monitoring of renal and hepatic function is recommended. Use the lowest effective dose for the shortest duration.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain and improve mobility.
Evidence: Well-establishedApplying heat or cold packs can help relieve localized pain and inflammation.
Evidence: Well-establishedDeep breathing, meditation, and yoga can help manage chronic pain.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine does not interact with vaccines. However, if you have a fever, consult your doctor before vaccination.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from extreme heat or cold. If crossing time zones, continue your regular dosing schedule as needed for pain or fever. Check customs regulations for carrying medicines in your destination country.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts relieving pain within 30 to 60 minutes after taking it orally.
A: It is best to take this medicine with food or milk to reduce the risk of stomach upset and bleeding.
A: Do not take more than 3 tablets in 24 hours. Always follow your doctor's advice.
A: Consult your doctor before use. It is generally avoided in the third trimester.
🤔 Common Patient Concerns
🔄 Substitutes for cypaflam 400mg/325mg tablet
View AllAlternative brands with exact same active ingredient:
-
ibunij 400 mg/325 mg tabletSunij Pharma Pvt Ltd ₹2.64 29.6% CHEAPER
-
Fencin A TabletSuzikem Drugs Pvt Ltd ₹3.75 SAME PRICE
-
lupiflam 400 mg/325 mg tabletLupin Ltd ₹5.02 33.9% COSTLIER
-
ibupar 400 mg/325 mg tabletTroikaa Pharmaceuticals Ltd ₹5.16 37.6% COSTLIER
-
ibugin 400mg/325mg tabletCasca Remedies Pvt Ltd ₹5.44 45.1% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is completely safe and can be taken long-term without any risk.
Fact: This medicine can cause serious side effects like stomach bleeding, kidney problems, and heart issues if taken for prolonged periods or in high doses. It should be used only as directed. - Myth: This medicine can be taken on an empty stomach without any problem.
Fact: Taking this medicine on an empty stomach increases the risk of stomach irritation and bleeding. It should always be taken with food or milk. - Myth: This medicine is safe to take with other painkillers.
Fact: Taking this medicine with other NSAIDs or paracetamol-containing products can lead to overdose and serious side effects. Always consult a doctor before combining.
🔄 Alternative Options
Generic Alternatives
- Ibuprofen 400 mg + Paracetamol 325 mg tablet (generic)
Brand Alternatives
- Combiflam Tablet